CCR7 (C-C motif chemokine receptor 7)

2007-02-01  

Identity

HGNC
LOCATION
17q21.2
LOCUSID
ALIAS
BLR2,CC-CKR-7,CCR-7,CD197,CDw197,CMKBR7,EBI1
FUSION GENES

Other Information

Locus ID:

NCBI: 1236
MIM: 600242
HGNC: 1608
Ensembl: ENSG00000126353

Variants:

dbSNP: 1236
ClinVar: 1236
TCGA: ENSG00000126353
COSMIC: CCR7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000126353ENST00000246657P32248
ENSG00000126353ENST00000246657A0N0Q0
ENSG00000126353ENST00000578085J3KTN5
ENSG00000126353ENST00000579344J3KSS9

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Chemokine receptors bind chemokinesREACTOMER-HSA-380108
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
241388842013Circulating precursor CCR7(lo)PD-1(hi) CXCR5⁺ CD4⁺ T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure.203
121492182002Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells.135
274248072016Critical Role for CD103(+)/CD141(+) Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma.130
217396712011Regional and mucosal memory T cells.105
120700012002Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among V alpha 24(+)V beta 11(+) NKT cell subsets with distinct cytokine-producing capacity.85
180657282007Three-gene prognostic classifier for early-stage non small-cell lung cancer.82
259619252016TGF-β1-induced EMT promotes targeted migration of breast cancer cells through the lymphatic system by the activation of CCR7/CCL21-mediated chemotaxis.82
151227022004Expression of CCR7 in multiple sclerosis: implications for CNS immunity.81
162723032005Stepwise differentiation of CD4 memory T cells defined by expression of CCR7 and CD27.81
195362652009CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia.80

Citation

Dessen P

CCR7 (C-C motif chemokine receptor 7)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46422/ccr7