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CCR7 (C-C motif chemokine receptor 7)

Identity

Alias_namesCMKBR7
EBI1
chemokine (C-C motif) receptor 7
Alias_symbol (synonym)BLR2
CDw197
CD197
Other aliasCC-CKR-7
CCR-7
HGNC (Hugo) CCR7
LocusID (NCBI) 1236
Atlas_Id 46422
Location 17q21.2  [Link to chromosome band 17q21]
Location_base_pair Starts at 40553770 and ends at 40565484 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
SYNRG (17q12) / CCR7 (17q21.2)SYNRG 17q12 / CCR7 17q21.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CCR7   1608
Cards
Entrez_Gene (NCBI)CCR7  1236  C-C motif chemokine receptor 7
AliasesBLR2; CC-CKR-7; CCR-7; CD197; 
CDw197; CMKBR7; EBI1
GeneCards (Weizmann)CCR7
Ensembl hg19 (Hinxton)ENSG00000126353 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000126353 [Gene_View]  chr17:40553770-40565484 [Contig_View]  CCR7 [Vega]
ICGC DataPortalENSG00000126353
TCGA cBioPortalCCR7
AceView (NCBI)CCR7
Genatlas (Paris)CCR7
WikiGenes1236
SOURCE (Princeton)CCR7
Genetics Home Reference (NIH)CCR7
Genomic and cartography
GoldenPath hg38 (UCSC)CCR7  -     chr17:40553770-40565484 -  17q21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CCR7  -     17q21.2   [Description]    (hg19-Feb_2009)
EnsemblCCR7 - 17q21.2 [CytoView hg19]  CCR7 - 17q21.2 [CytoView hg38]
Mapping of homologs : NCBICCR7 [Mapview hg19]  CCR7 [Mapview hg38]
OMIM600242   
Gene and transcription
Genbank (Entrez)AK127810 AK310277 AK312732 AY587876 BC035343
RefSeq transcript (Entrez)NM_001301714 NM_001301716 NM_001301717 NM_001301718 NM_001838
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CCR7
Cluster EST : UnigeneHs.370036 [ NCBI ]
CGAP (NCI)Hs.370036
Alternative Splicing GalleryENSG00000126353
Gene ExpressionCCR7 [ NCBI-GEO ]   CCR7 [ EBI - ARRAY_EXPRESS ]   CCR7 [ SEEK ]   CCR7 [ MEM ]
Gene Expression Viewer (FireBrowse)CCR7 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1236
GTEX Portal (Tissue expression)CCR7
Protein : pattern, domain, 3D structure
UniProt/SwissProtP32248   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP32248  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP32248
Splice isoforms : SwissVarP32248
PhosPhoSitePlusP32248
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)Chemokine_CCR7    Chemokine_rcpt    GPCR_Rhodpsn    GPCR_Rhodpsn_7TM   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Conserved Domain (NCBI)CCR7
DMDM Disease mutations1236
Blocks (Seattle)CCR7
SuperfamilyP32248
Human Protein AtlasENSG00000126353
Peptide AtlasP32248
HPRD02588
IPIIPI00027687   
Protein Interaction databases
DIP (DOE-UCLA)P32248
IntAct (EBI)P32248
FunCoupENSG00000126353
BioGRIDCCR7
STRING (EMBL)CCR7
ZODIACCCR7
Ontologies - Pathways
QuickGOP32248
Ontology : AmiGOestablishment of T cell polarity  positive regulation of cell-matrix adhesion  dendritic cell chemotaxis  myeloid dendritic cell chemotaxis  myeloid dendritic cell chemotaxis  positive regulation of dendritic cell antigen processing and presentation  positive regulation of hypersensitivity  positive regulation of humoral immune response  G-protein coupled receptor activity  intracellular  plasma membrane  plasma membrane  inflammatory response  immune response  G-protein coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  external side of plasma membrane  cell surface  integral component of membrane  C-C chemokine receptor activity  positive regulation of actin filament polymerization  positive regulation of pseudopodium assembly  ruffle organization  response to lipopolysaccharide  regulation of interferon-gamma production  positive regulation of interleukin-12 production  response to prostaglandin E  chemokine (C-C motif) ligand 19 binding  chemokine (C-C motif) ligand 21 binding  chemokine (C-C motif) ligand 19 signaling pathway  chemokine (C-C motif) ligand 21 signaling pathway  C-C motif chemokine 19 receptor activity  C-C motif chemokine 21 receptor activity  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of phosphatidylinositol 3-kinase activity  negative thymic T cell selection  positive regulation of cell adhesion  positive regulation of protein kinase activity  positive regulation of JNK cascade  homeostasis of number of cells  regulation of interleukin-1 beta secretion  positive regulation of T cell receptor signaling pathway  release of sequestered calcium ion into cytosol  positive regulation of filopodium assembly  positive regulation of protein kinase B signaling  positive regulation of ERK1 and ERK2 cascade  cellular response to cytokine stimulus  response to nitric oxide  interleukin-12 secretion  positive regulation of neutrophil chemotaxis  activation of GTPase activity  lymphocyte migration into lymph node  mature conventional dendritic cell differentiation  negative regulation of leukocyte apoptotic process  positive regulation of cell motility  positive regulation of dendritic cell chemotaxis  positive regulation of immunological synapse formation  positive regulation of T cell costimulation  positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation  regulation of dendritic cell dendrite assembly  
Ontology : EGO-EBIestablishment of T cell polarity  positive regulation of cell-matrix adhesion  dendritic cell chemotaxis  myeloid dendritic cell chemotaxis  myeloid dendritic cell chemotaxis  positive regulation of dendritic cell antigen processing and presentation  positive regulation of hypersensitivity  positive regulation of humoral immune response  G-protein coupled receptor activity  intracellular  plasma membrane  plasma membrane  inflammatory response  immune response  G-protein coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  external side of plasma membrane  cell surface  integral component of membrane  C-C chemokine receptor activity  positive regulation of actin filament polymerization  positive regulation of pseudopodium assembly  ruffle organization  response to lipopolysaccharide  regulation of interferon-gamma production  positive regulation of interleukin-12 production  response to prostaglandin E  chemokine (C-C motif) ligand 19 binding  chemokine (C-C motif) ligand 21 binding  chemokine (C-C motif) ligand 19 signaling pathway  chemokine (C-C motif) ligand 21 signaling pathway  C-C motif chemokine 19 receptor activity  C-C motif chemokine 21 receptor activity  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of phosphatidylinositol 3-kinase activity  negative thymic T cell selection  positive regulation of cell adhesion  positive regulation of protein kinase activity  positive regulation of JNK cascade  homeostasis of number of cells  regulation of interleukin-1 beta secretion  positive regulation of T cell receptor signaling pathway  release of sequestered calcium ion into cytosol  positive regulation of filopodium assembly  positive regulation of protein kinase B signaling  positive regulation of ERK1 and ERK2 cascade  cellular response to cytokine stimulus  response to nitric oxide  interleukin-12 secretion  positive regulation of neutrophil chemotaxis  activation of GTPase activity  lymphocyte migration into lymph node  mature conventional dendritic cell differentiation  negative regulation of leukocyte apoptotic process  positive regulation of cell motility  positive regulation of dendritic cell chemotaxis  positive regulation of immunological synapse formation  positive regulation of T cell costimulation  positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation  regulation of dendritic cell dendrite assembly  
Pathways : BIOCARTASelective expression of chemokine receptors during T-cell polarization [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    Chemokine signaling pathway    Transcriptional misregulation in cancer   
NDEx NetworkCCR7
Atlas of Cancer Signalling NetworkCCR7
Wikipedia pathwaysCCR7
Orthology - Evolution
OrthoDB1236
GeneTree (enSembl)ENSG00000126353
Phylogenetic Trees/Animal Genes : TreeFamCCR7
HOVERGENP32248
HOGENOMP32248
Homologs : HomoloGeneCCR7
Homology/Alignments : Family Browser (UCSC)CCR7
Gene fusions - Rearrangements
Fusion : MitelmanSYNRG/CCR7 [17q12/17q21.2]  [t(17;17)(q12;q21)]  
Fusion: TCGASYNRG 17q12 CCR7 17q21.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCCR7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CCR7
dbVarCCR7
ClinVarCCR7
1000_GenomesCCR7 
Exome Variant ServerCCR7
ExAC (Exome Aggregation Consortium)CCR7 (select the gene name)
Genetic variants : HAPMAP1236
Genomic Variants (DGV)CCR7 [DGVbeta]
DECIPHERCCR7 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCCR7 
Mutations
ICGC Data PortalCCR7 
TCGA Data PortalCCR7 
Broad Tumor PortalCCR7
OASIS PortalCCR7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCCR7  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCCR7
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CCR7
DgiDB (Drug Gene Interaction Database)CCR7
DoCM (Curated mutations)CCR7 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CCR7 (select a term)
intoGenCCR7
Cancer3DCCR7(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600242   
Orphanet
MedgenCCR7
Genetic Testing Registry CCR7
NextProtP32248 [Medical]
TSGene1236
GENETestsCCR7
Huge Navigator CCR7 [HugePedia]
snp3D : Map Gene to Disease1236
BioCentury BCIQCCR7
ClinGenCCR7
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1236
Chemical/Pharm GKB GenePA26172
Clinical trialCCR7
Miscellaneous
canSAR (ICR)CCR7 (select the gene name)
Probes
Litterature
PubMed247 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCCR7
EVEXCCR7
GoPubMedCCR7
iHOPCCR7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:09:27 CEST 2017

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