CD14 (CD14 molecule)

2003-11-01  

Identity

HGNC
LOCATION
5q31.3
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 929
MIM: 158120
HGNC: 1628
Ensembl: ENSG00000170458

Variants:

dbSNP: 929
ClinVar: 929
TCGA: ENSG00000170458
COSMIC: CD14

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170458ENST00000302014P08571
ENSG00000170458ENST00000401743P08571
ENSG00000170458ENST00000498971D6RFL4
ENSG00000170458ENST00000512545D6RD81
ENSG00000170458ENST00000519715E7EVL5

Expression (GTEx)

0
50
100
150
200
250
300
350

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
Toll-like receptor signaling pathwayKEGGko04620
Hematopoietic cell lineageKEGGko04640
Regulation of actin cytoskeletonKEGGko04810
Pathogenic Escherichia coli infectionKEGGko05130
MAPK signaling pathwayKEGGhsa04010
Toll-like receptor signaling pathwayKEGGhsa04620
Hematopoietic cell lineageKEGGhsa04640
Regulation of actin cytoskeletonKEGGhsa04810
Pathogenic Escherichia coli infectionKEGGhsa05130
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
AmoebiasisKEGGko05146
AmoebiasisKEGGhsa05146
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
PertussisKEGGko05133
PertussisKEGGhsa05133
Salmonella infectionKEGGko05132
Salmonella infectionKEGGhsa05132
LegionellosisKEGGko05134
LegionellosisKEGGhsa05134
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202
NF-kappa B signaling pathwayKEGGhsa04064
NF-kappa B signaling pathwayKEGGko04064
DiseaseREACTOMER-HSA-1643685
Diseases of Immune SystemREACTOMER-HSA-5260271
Diseases associated with the TLR signaling cascadeREACTOMER-HSA-5602358
IRAK4 deficiency (TLR2/4)REACTOMER-HSA-5603041
MyD88 deficiency (TLR2/4)REACTOMER-HSA-5602498
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing-Cross presentationREACTOMER-HSA-1236975
ER-Phagosome pathwayREACTOMER-HSA-1236974
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Toll Like Receptor 3 (TLR3) CascadeREACTOMER-HSA-168164
MyD88-independent TLR3/TLR4 cascadeREACTOMER-HSA-166166
TRIF-mediated TLR3/TLR4 signalingREACTOMER-HSA-937061
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilonREACTOMER-HSA-936964
IKK complex recruitment mediated by RIP1REACTOMER-HSA-937041
TRIF-mediated programmed cell deathREACTOMER-HSA-2562578
TRAF6 mediated induction of TAK1 complexREACTOMER-HSA-937072
Toll Like Receptor 7/8 (TLR7/8) CascadeREACTOMER-HSA-168181
MyD88 dependent cascade initiated on endosomeREACTOMER-HSA-975155
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationREACTOMER-HSA-975138
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulationREACTOMER-HSA-975163
Toll Like Receptor 9 (TLR9) CascadeREACTOMER-HSA-168138
Toll Like Receptor 4 (TLR4) CascadeREACTOMER-HSA-166016
Transfer of LPS from LBP carrier to CD14REACTOMER-HSA-166020
Activated TLR4 signallingREACTOMER-HSA-166054
MyD88:Mal cascade initiated on plasma membraneREACTOMER-HSA-166058
Toll Like Receptor 2 (TLR2) CascadeREACTOMER-HSA-181438
Toll Like Receptor TLR1:TLR2 CascadeREACTOMER-HSA-168179
Toll Like Receptor TLR6:TLR2 CascadeREACTOMER-HSA-168188
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Caspase activation via extrinsic apoptotic signalling pathwayREACTOMER-HSA-5357769
Ligand-dependent caspase activationREACTOMER-HSA-140534
Regulation of TLR by endogenous ligandREACTOMER-HSA-5686938
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164713366Tumor necrosis factor alpha (TNF-alpha) inhibitorsChemicalClinicalAnnotationassociatedPD24776844
PA443750Colitis, UlcerativeDiseaseClinicalAnnotationassociatedPD24776844

References

Pubmed IDYearTitleCitations
208323402010Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptors.379
126637652003Human cytomegalovirus activates inflammatory cytokine responses via CD14 and Toll-like receptor 2.219
184978802008Unique CD14 intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-gamma axis.200
125942072003Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved.173
229997282012CD14++CD16+ monocytes independently predict cardiovascular events: a cohort study of 951 patients referred for elective coronary angiography.140
123244692002Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction.138
124041742002Human toll-like receptor 4 mutations but not CD14 polymorphisms are associated with an increased risk of gram-negative infections.123
195721482010Population alterations of L-arginase- and inducible nitric oxide synthase-expressed CD11b+/CD14⁻/CD15+/CD33+ myeloid-derived suppressor cells and CD8+ T lymphocytes in patients with advanced-stage non-small cell lung cancer.103
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100
151434732004Association between common Toll-like receptor 4 mutations and severe respiratory syncytial virus disease.96

Citation

Dessen P

CD14 (CD14 molecule)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/966/cd14