CD58 (CD58 molecule)

2003-11-01 Affiliation

Identity

HGNC

CD58

LOCATION

1p13.1

LOCUSID

965

ALIAS

LFA-3,LFA3,ag3

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 965
MIM: 153420
HGNC: 1688
Ensembl: ENSG00000116815

Variants:

dbSNP: 965
ClinVar: 965
TCGA: ENSG00000116815
COSMIC: CD58

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000116815	ENST00000369487	B1AMW1
ENSG00000116815	ENST00000369489	P19256
ENSG00000116815	ENST00000457047	P19256
ENSG00000116815	ENST00000464088	P19256
ENSG00000116815	ENST00000526981	H0YDI1

Expression (GTEx)

100

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cell adhesion molecules (CAMs)	KEGG	ko04514
Cell adhesion molecules (CAMs)	KEGG	hsa04514
Epstein-Barr virus infection	KEGG	hsa05169
Epstein-Barr virus infection	KEGG	ko05169
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Hemostasis	REACTOME	R-HSA-109582
Cell surface interactions at the vascular wall	REACTOME	R-HSA-202733
Neutrophil degranulation	REACTOME	R-HSA-6798695

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD
PA444987	Multiple Sclerosis	Disease	ClinicalAnnotation	associated	PD
PA450037	interferon beta-1a	Chemical	ClinicalAnnotation	associated	PD
PA450039	interferon beta-1b	Chemical	ClinicalAnnotation	associated	PD

References

Pubmed ID	Year	Title	Citations
19898481	2009	Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk.	131
19898481	2009	Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk.	131
22137796	2011	Combined genetic inactivation of β2-Microglobulin and CD58 reveals frequent escape from immune recognition in diffuse large B cell lymphoma.	109
19110536	2009	Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus.	82
19879194	2009	Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score.	80
19237575	2009	The role of the CD58 locus in multiple sclerosis.	66
19237575	2009	The role of the CD58 locus in multiple sclerosis.	66
18650830	2008	Replication of KIAA0350, IL2RA, RPL5 and CD58 as multiple sclerosis susceptibility genes in Australians.	44
19865102	2010	Multiple sclerosis susceptibility alleles in African Americans.	35
12496412	2003	Coexpression of CD58 or CD48 with intercellular adhesion molecule 1 on target cells enhances adhesion of resting NK cells.	32

Citation

Dessen P

CD58 (CD58 molecule)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/984/cd58