CDC45 (cell division cycle 45)

2010-04-01  

Identity

HGNC
LOCATION
22q11.21
LOCUSID
ALIAS
CDC45L,CDC45L2,MGORS7,PORC-PI-1
FUSION GENES

Other Information

Locus ID:

NCBI: 8318
MIM: 603465
HGNC: 1739
Ensembl: ENSG00000093009

Variants:

dbSNP: 8318
ClinVar: 8318
TCGA: ENSG00000093009
COSMIC: CDC45

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000093009ENST00000263201O75419
ENSG00000093009ENST00000404724O75419
ENSG00000093009ENST00000407835O75419
ENSG00000093009ENST00000428937H7BZ91
ENSG00000093009ENST00000437685O75419
ENSG00000093009ENST00000438587C9J911
ENSG00000093009ENST00000455750C9K087

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
Cell cycleKEGGhsa04110
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
G2/M CheckpointsREACTOMER-HSA-69481
Activation of ATR in response to replication stressREACTOMER-HSA-176187
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G1-G1/S phasesREACTOMER-HSA-453279
G1/S TransitionREACTOMER-HSA-69206
G1/S-Specific TranscriptionREACTOMER-HSA-69205
Activation of the pre-replicative complexREACTOMER-HSA-68962
E2F mediated regulation of DNA replicationREACTOMER-HSA-113510
S PhaseREACTOMER-HSA-69242
Synthesis of DNAREACTOMER-HSA-69239
DNA strand elongationREACTOMER-HSA-69190
Unwinding of DNAREACTOMER-HSA-176974
M/G1 TransitionREACTOMER-HSA-68874
DNA Replication Pre-InitiationREACTOMER-HSA-69002
DNA ReplicationREACTOMER-HSA-69306

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
170468322006Phosphorylation of MCM4 by Cdc7 kinase facilitates its interaction with Cdc45 on the chromatin.95
198052162009Assembly of the Cdc45-Mcm2-7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins.88
224743842012Properties of the human Cdc45/Mcm2-7/GINS helicase complex and its action with DNA polymerase epsilon in rolling circle DNA synthesis.66
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
201244172010Human Timeless and Tipin stabilize replication forks and facilitate sister-chromatid cohesion.58
169120452006The Chk1-mediated S-phase checkpoint targets initiation factor Cdc45 via a Cdc25A/Cdk2-independent mechanism.42
273747702016Mutations in CDC45, Encoding an Essential Component of the Pre-initiation Complex, Cause Meier-Gorlin Syndrome and Craniosynostosis.32
271891872016Structure of human Cdc45 and implications for CMG helicase function.29
221477082012Structural and functional insights into the DNA replication factor Cdc45 reveal an evolutionary relationship to the DHH family of phosphoesterases.28
175737752007Interactions of human Cdc45 with the Mcm2-7 complex, the GINS complex, and DNA polymerases delta and epsilon during S phase.27

Citation

Dessen P

CDC45 (cell division cycle 45)

Atlas Genet Cytogenet Oncol Haematol. 2010-04-01

Online version: http://atlasgeneticsoncology.org/gene/51414/cdc45