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CDC45 (cell division cycle 45)

Identity

Alias_namesCDC45L2
CDC45L
CDC45 (cell division cycle 45, S.cerevisiae, homolog)-like
CDC45 cell division cycle 45-like (S. cerevisiae)
cell division cycle 45 homolog (S. cerevisiae)
Other aliasMGORS7
PORC-PI-1
HGNC (Hugo) CDC45
LocusID (NCBI) 8318
Atlas_Id 51414
Location 22q11.21  [Link to chromosome band 22q11]
Location_base_pair Starts at 19479826 and ends at 19520612 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CDC45 (22q11.21) / RIT2 (18q12.3)H2AFV (7p13) / CDC45 (22q11.21)LIMK2 (22q12.2) / CDC45 (22q11.21)
H2AFV 7p13 / CDC45 22q11.21LIMK2 22q12.2 / CDC45 22q11.21

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)CDC45   1739
Cards
Entrez_Gene (NCBI)CDC45  8318  cell division cycle 45
AliasesCDC45L; CDC45L2; MGORS7; PORC-PI-1
GeneCards (Weizmann)CDC45
Ensembl hg19 (Hinxton)ENSG00000093009 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000093009 [Gene_View]  chr22:19479826-19520612 [Contig_View]  CDC45 [Vega]
ICGC DataPortalENSG00000093009
TCGA cBioPortalCDC45
AceView (NCBI)CDC45
Genatlas (Paris)CDC45
WikiGenes8318
SOURCE (Princeton)CDC45
Genetics Home Reference (NIH)CDC45
Genomic and cartography
GoldenPath hg38 (UCSC)CDC45  -     chr22:19479826-19520612 +  22q11.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CDC45  -     22q11.21   [Description]    (hg19-Feb_2009)
EnsemblCDC45 - 22q11.21 [CytoView hg19]  CDC45 - 22q11.21 [CytoView hg38]
Mapping of homologs : NCBICDC45 [Mapview hg19]  CDC45 [Mapview hg38]
OMIM603465   617063   
Gene and transcription
Genbank (Entrez)AF053074 AF062495 AF081535 AJ223728 AK293123
RefSeq transcript (Entrez)NM_001178010 NM_001178011 NM_003504
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CDC45
Cluster EST : UnigeneHs.742418 [ NCBI ]
CGAP (NCI)Hs.742418
Alternative Splicing GalleryENSG00000093009
Gene ExpressionCDC45 [ NCBI-GEO ]   CDC45 [ EBI - ARRAY_EXPRESS ]   CDC45 [ SEEK ]   CDC45 [ MEM ]
Gene Expression Viewer (FireBrowse)CDC45 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8318
GTEX Portal (Tissue expression)CDC45
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75419   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75419  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75419
Splice isoforms : SwissVarO75419
PhosPhoSitePlusO75419
Domains : Interpro (EBI)CDC45   
Domain families : Pfam (Sanger)CDC45 (PF02724)   
Domain families : Pfam (NCBI)pfam02724   
Conserved Domain (NCBI)CDC45
DMDM Disease mutations8318
Blocks (Seattle)CDC45
PDB (SRS)5DGO   
PDB (PDBSum)5DGO   
PDB (IMB)5DGO   
PDB (RSDB)5DGO   
Structural Biology KnowledgeBase5DGO   
SCOP (Structural Classification of Proteins)5DGO   
CATH (Classification of proteins structures)5DGO   
SuperfamilyO75419
Human Protein AtlasENSG00000093009
Peptide AtlasO75419
HPRD09145
IPIIPI00025695   IPI00953112   IPI00879106   IPI00909930   IPI00878645   IPI00878959   
Protein Interaction databases
DIP (DOE-UCLA)O75419
IntAct (EBI)O75419
FunCoupENSG00000093009
BioGRIDCDC45
STRING (EMBL)CDC45
ZODIACCDC45
Ontologies - Pathways
QuickGOO75419
Ontology : AmiGODNA replication checkpoint  G1/S transition of mitotic cell cycle  regulation of transcription involved in G1/S transition of mitotic cell cycle  double-strand break repair via break-induced replication  chromatin binding  DNA replication origin binding  single-stranded DNA binding  protein binding  nucleus  nucleoplasm  nuclear pre-replicative complex  cytoplasm  centrosome  DNA replication  pre-replicative complex assembly involved in nuclear cell cycle DNA replication  DNA replication initiation  DNA replication preinitiation complex  replication fork protection complex  regulation of chromatin silencing at telomere  DNA duplex unwinding  3'-5' DNA helicase activity  positive regulation of G1/S transition of mitotic cell cycle  mitotic DNA replication preinitiation complex assembly  
Ontology : EGO-EBIDNA replication checkpoint  G1/S transition of mitotic cell cycle  regulation of transcription involved in G1/S transition of mitotic cell cycle  double-strand break repair via break-induced replication  chromatin binding  DNA replication origin binding  single-stranded DNA binding  protein binding  nucleus  nucleoplasm  nuclear pre-replicative complex  cytoplasm  centrosome  DNA replication  pre-replicative complex assembly involved in nuclear cell cycle DNA replication  DNA replication initiation  DNA replication preinitiation complex  replication fork protection complex  regulation of chromatin silencing at telomere  DNA duplex unwinding  3'-5' DNA helicase activity  positive regulation of G1/S transition of mitotic cell cycle  mitotic DNA replication preinitiation complex assembly  
Pathways : KEGGCell cycle   
NDEx NetworkCDC45
Atlas of Cancer Signalling NetworkCDC45
Wikipedia pathwaysCDC45
Orthology - Evolution
OrthoDB8318
GeneTree (enSembl)ENSG00000093009
Phylogenetic Trees/Animal Genes : TreeFamCDC45
HOVERGENO75419
HOGENOMO75419
Homologs : HomoloGeneCDC45
Homology/Alignments : Family Browser (UCSC)CDC45
Gene fusions - Rearrangements
Fusion : MitelmanCDC45/RIT2 [22q11.21/18q12.3]  
Fusion : MitelmanH2AFV/CDC45 [7p13/22q11.21]  [t(7;22)(p13;q11)]  
Fusion : MitelmanLIMK2/CDC45 [22q12.2/22q11.21]  [t(22;22)(q11;q12)]  
Fusion: TCGAH2AFV 7p13 CDC45 22q11.21 PRAD
Fusion: TCGALIMK2 22q12.2 CDC45 22q11.21 BLCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCDC45 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CDC45
dbVarCDC45
ClinVarCDC45
1000_GenomesCDC45 
Exome Variant ServerCDC45
ExAC (Exome Aggregation Consortium)CDC45 (select the gene name)
Genetic variants : HAPMAP8318
Genomic Variants (DGV)CDC45 [DGVbeta]
DECIPHERCDC45 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCDC45 
Mutations
ICGC Data PortalCDC45 
TCGA Data PortalCDC45 
Broad Tumor PortalCDC45
OASIS PortalCDC45 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCDC45  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCDC45
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CDC45
DgiDB (Drug Gene Interaction Database)CDC45
DoCM (Curated mutations)CDC45 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CDC45 (select a term)
intoGenCDC45
Cancer3DCDC45(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603465    617063   
Orphanet2357   
MedgenCDC45
Genetic Testing Registry CDC45
NextProtO75419 [Medical]
TSGene8318
GENETestsCDC45
Target ValidationCDC45
Huge Navigator CDC45 [HugePedia]
snp3D : Map Gene to Disease8318
BioCentury BCIQCDC45
ClinGenCDC45
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8318
Chemical/Pharm GKB GenePA371
Clinical trialCDC45
Miscellaneous
canSAR (ICR)CDC45 (select the gene name)
Probes
Litterature
PubMed57 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCDC45
EVEXCDC45
GoPubMedCDC45
iHOPCDC45
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 18 13:49:20 CEST 2017

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