Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CDK3 (cyclin dependent kinase 3)

Identity

Other alias-
HGNC (Hugo) CDK3
LocusID (NCBI) 1018
Atlas_Id 43201
Location 17q25.1  [Link to chromosome band 17q25]
Location_base_pair Starts at 76000906 and ends at 76005999 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TEN1 (17q25.1) / CDK3 (17q25.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CDK3   1772
Cards
Entrez_Gene (NCBI)CDK3  1018  cyclin dependent kinase 3
Aliases
GeneCards (Weizmann)CDK3
Ensembl hg19 (Hinxton)ENSG00000250506 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000250506 [Gene_View]  chr17:76000906-76005999 [Contig_View]  CDK3 [Vega]
ICGC DataPortalENSG00000250506
TCGA cBioPortalCDK3
AceView (NCBI)CDK3
Genatlas (Paris)CDK3
WikiGenes1018
SOURCE (Princeton)CDK3
Genetics Home Reference (NIH)CDK3
Genomic and cartography
GoldenPath hg38 (UCSC)CDK3  -     chr17:76000906-76005999 +  17q25.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CDK3  -     17q25.1   [Description]    (hg19-Feb_2009)
EnsemblCDK3 - 17q25.1 [CytoView hg19]  CDK3 - 17q25.1 [CytoView hg38]
Mapping of homologs : NCBICDK3 [Mapview hg19]  CDK3 [Mapview hg38]
OMIM123828   
Gene and transcription
Genbank (Entrez)AU146328 BC128406 BC160074 BU784937 BX098771
RefSeq transcript (Entrez)NM_001258
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CDK3
Cluster EST : UnigeneHs.706766 [ NCBI ]
CGAP (NCI)Hs.706766
Alternative Splicing GalleryENSG00000250506
Gene ExpressionCDK3 [ NCBI-GEO ]   CDK3 [ EBI - ARRAY_EXPRESS ]   CDK3 [ SEEK ]   CDK3 [ MEM ]
Gene Expression Viewer (FireBrowse)CDK3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1018
GTEX Portal (Tissue expression)CDK3
Human Protein AtlasENSG00000250506-CDK3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ00526   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ00526  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ00526
Splice isoforms : SwissVarQ00526
Catalytic activity : Enzyme2.7.11.22 [ Enzyme-Expasy ]   2.7.11.222.7.11.22 [ IntEnz-EBI ]   2.7.11.22 [ BRENDA ]   2.7.11.22 [ KEGG ]   
PhosPhoSitePlusQ00526
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)CDK3
DMDM Disease mutations1018
Blocks (Seattle)CDK3
PDB (SRS)1LFN   
PDB (PDBSum)1LFN   
PDB (IMB)1LFN   
PDB (RSDB)1LFN   
Structural Biology KnowledgeBase1LFN   
SCOP (Structural Classification of Proteins)1LFN   
CATH (Classification of proteins structures)1LFN   
SuperfamilyQ00526
Human Protein Atlas [tissue]ENSG00000250506-CDK3 [tissue]
Peptide AtlasQ00526
HPRD00446
IPIIPI00023503   
Protein Interaction databases
DIP (DOE-UCLA)Q00526
IntAct (EBI)Q00526
FunCoupENSG00000250506
BioGRIDCDK3
STRING (EMBL)CDK3
ZODIACCDK3
Ontologies - Pathways
QuickGOQ00526
Ontology : AmiGOG1/S transition of mitotic cell cycle  cyclin-dependent protein kinase holoenzyme complex  cyclin-dependent protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  protein phosphorylation  cellular response to DNA damage stimulus  signal transduction  multicellular organism development  cell proliferation  positive regulation of cell proliferation  response to organic substance  regulation of G2/M transition of mitotic cell cycle  regulation of gene expression  cyclin binding  G0 to G1 transition  cell division  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  cyclin-dependent protein kinase holoenzyme complex  cyclin-dependent protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  protein phosphorylation  cellular response to DNA damage stimulus  signal transduction  multicellular organism development  cell proliferation  positive regulation of cell proliferation  response to organic substance  regulation of G2/M transition of mitotic cell cycle  regulation of gene expression  cyclin binding  G0 to G1 transition  cell division  
Pathways : BIOCARTAEstrogen-responsive protein Efp controls cell cycle and breast tumors growth [Genes]   
NDEx NetworkCDK3
Atlas of Cancer Signalling NetworkCDK3
Wikipedia pathwaysCDK3
Orthology - Evolution
OrthoDB1018
GeneTree (enSembl)ENSG00000250506
Phylogenetic Trees/Animal Genes : TreeFamCDK3
HOVERGENQ00526
HOGENOMQ00526
Homologs : HomoloGeneCDK3
Homology/Alignments : Family Browser (UCSC)CDK3
Gene fusions - Rearrangements
Tumor Fusion PortalCDK3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCDK3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CDK3
dbVarCDK3
ClinVarCDK3
1000_GenomesCDK3 
Exome Variant ServerCDK3
ExAC (Exome Aggregation Consortium)ENSG00000250506
GNOMAD BrowserENSG00000250506
Genetic variants : HAPMAP1018
Genomic Variants (DGV)CDK3 [DGVbeta]
DECIPHERCDK3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCDK3 
Mutations
ICGC Data PortalCDK3 
TCGA Data PortalCDK3 
Broad Tumor PortalCDK3
OASIS PortalCDK3 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDCDK3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CDK3
DgiDB (Drug Gene Interaction Database)CDK3
DoCM (Curated mutations)CDK3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CDK3 (select a term)
intoGenCDK3
Cancer3DCDK3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM123828   
Orphanet
DisGeNETCDK3
MedgenCDK3
Genetic Testing Registry CDK3
NextProtQ00526 [Medical]
TSGene1018
GENETestsCDK3
Target ValidationCDK3
Huge Navigator CDK3 [HugePedia]
snp3D : Map Gene to Disease1018
BioCentury BCIQCDK3
ClinGenCDK3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1018
Chemical/Pharm GKB GenePA26309
Clinical trialCDK3
Miscellaneous
canSAR (ICR)CDK3 (select the gene name)
Probes
Litterature
PubMed45 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCDK3
EVEXCDK3
GoPubMedCDK3
iHOPCDK3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:07:05 CET 2017

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