Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CGA (glycoprotein hormones, alpha polypeptide)

Identity

Alias_symbol (synonym)HCG
GPHa
GPHA1
FSHA
LHA
TSHA
Other aliasCG-ALPHA
HGNC (Hugo) CGA
LocusID (NCBI) 1081
Atlas_Id 46217
Location 6q14.3  [Link to chromosome band 6q14]
Location_base_pair Starts at 87085498 and ends at 87095147 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ATXN1 (6p22.3) / CGA (6q14.3)CASP10 (2q33.1) / CGA (6q14.3)CGA (6q14.3) / CDC42BPB (14q32.32)
CGA (6q14.3) / CGA (6q14.3)CGA (6q14.3) / KDM5A (12p13.33)CGA (6q14.3) / MFSD2A (1p34.2)
CGA (6q14.3) / PRG2 (11q12.1)CGA (6q14.3) / PSMC2 (7q22.1)CGA (6q14.3) / RAB1A (2p14)
CGA (6q14.3) / ZNF397 (18q12.2)GUK1 (1q42.13) / CGA (6q14.3)SF1 (11q13.1) / CGA (6q14.3)
SMAD6 (15q22.31) / CGA (6q14.3)SMAP1 (6q13) / CGA (6q14.3)ZFYVE9 (1p32.3) / CGA (6q14.3)
ZNF292 (6q14.3) / CGA (6q14.3)ATXN1 6p22.3 / CGA 6q14.3SMAP1 6q13 / CGA 6q14.3
ZNF292 6q14.3 / CGA 6q14.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 5 ]
  Lung: Translocations in Adenocarcinoma
t(1;6)(p32;q14) ZFYVE9/CGA
t(6;6)(p22;q14) ATXN1/CGA
t(6;6)(q13;q14) SMAP1/CGA
ZNF292/CGA (6q14)


External links

Nomenclature
HGNC (Hugo)CGA   1885
Cards
Entrez_Gene (NCBI)CGA  1081  glycoprotein hormones, alpha polypeptide
AliasesCG-ALPHA; FSHA; GPHA1; GPHa; 
HCG; LHA; TSHA
GeneCards (Weizmann)CGA
Ensembl hg19 (Hinxton)ENSG00000135346 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000135346 [Gene_View]  ENSG00000135346 [Sequence]  chr6:87085498-87095147 [Contig_View]  CGA [Vega]
ICGC DataPortalENSG00000135346
TCGA cBioPortalCGA
AceView (NCBI)CGA
Genatlas (Paris)CGA
WikiGenes1081
SOURCE (Princeton)CGA
Genetics Home Reference (NIH)CGA
Genomic and cartography
GoldenPath hg38 (UCSC)CGA  -     chr6:87085498-87095147 -  6q14.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CGA  -     6q14.3   [Description]    (hg19-Feb_2009)
EnsemblCGA - 6q14.3 [CytoView hg19]  CGA - 6q14.3 [CytoView hg38]
Mapping of homologs : NCBICGA [Mapview hg19]  CGA [Mapview hg38]
OMIM118850   
Gene and transcription
Genbank (Entrez)AB019569 AI200485 AK311972 BC010957 BC020782
RefSeq transcript (Entrez)NM_000735 NM_001252383
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CGA
Cluster EST : UnigeneHs.119689 [ NCBI ]
CGAP (NCI)Hs.119689
Alternative Splicing GalleryENSG00000135346
Gene ExpressionCGA [ NCBI-GEO ]   CGA [ EBI - ARRAY_EXPRESS ]   CGA [ SEEK ]   CGA [ MEM ]
Gene Expression Viewer (FireBrowse)CGA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1081
GTEX Portal (Tissue expression)CGA
Human Protein AtlasENSG00000135346-CGA [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01215   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP01215  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP01215
Splice isoforms : SwissVarP01215
PhosPhoSitePlusP01215
Domaine pattern : Prosite (Expaxy)GLYCO_HORMONE_ALPHA_1 (PS00779)    GLYCO_HORMONE_ALPHA_2 (PS00780)    GLYCO_HORMONE_ALPHA_3 (PS50277)   
Domains : Interpro (EBI)Cystine-knot_cytokine    Glyco_hormone   
Domain families : Pfam (Sanger)Hormone_6 (PF00236)   
Domain families : Pfam (NCBI)pfam00236   
Domain families : Smart (EMBL)GHA (SM00067)  
Conserved Domain (NCBI)CGA
DMDM Disease mutations1081
Blocks (Seattle)CGA
PDB (SRS)1DZ7    1E9J    1FL7    1HCN    1HD4    1HRP    1QFW    1XUL    1XWD    4AY9    4MQW   
PDB (PDBSum)1DZ7    1E9J    1FL7    1HCN    1HD4    1HRP    1QFW    1XUL    1XWD    4AY9    4MQW   
PDB (IMB)1DZ7    1E9J    1FL7    1HCN    1HD4    1HRP    1QFW    1XUL    1XWD    4AY9    4MQW   
PDB (RSDB)1DZ7    1E9J    1FL7    1HCN    1HD4    1HRP    1QFW    1XUL    1XWD    4AY9    4MQW   
Structural Biology KnowledgeBase1DZ7    1E9J    1FL7    1HCN    1HD4    1HRP    1QFW    1XUL    1XWD    4AY9    4MQW   
SCOP (Structural Classification of Proteins)1DZ7    1E9J    1FL7    1HCN    1HD4    1HRP    1QFW    1XUL    1XWD    4AY9    4MQW   
CATH (Classification of proteins structures)1DZ7    1E9J    1FL7    1HCN    1HD4    1HRP    1QFW    1XUL    1XWD    4AY9    4MQW   
SuperfamilyP01215
Human Protein Atlas [tissue]ENSG00000135346-CGA [tissue]
Peptide AtlasP01215
HPRD00342
IPIIPI00000833   
Protein Interaction databases
DIP (DOE-UCLA)P01215
IntAct (EBI)P01215
FunCoupENSG00000135346
BioGRIDCGA
STRING (EMBL)CGA
ZODIACCGA
Ontologies - Pathways
QuickGOP01215
Ontology : AmiGOhormone activity  protein binding  extracellular region  extracellular space  Golgi lumen  regulation of transcription by RNA polymerase II  G protein-coupled receptor signaling pathway  G protein-coupled receptor signaling pathway  positive regulation of cell proliferation  regulation of signaling receptor activity  positive regulation of steroid biosynthetic process  peptide hormone processing  follicle-stimulating hormone activity  follicle-stimulating hormone complex  positive regulation of cell migration  positive regulation of transcription by RNA polymerase II  
Ontology : EGO-EBIhormone activity  protein binding  extracellular region  extracellular space  Golgi lumen  regulation of transcription by RNA polymerase II  G protein-coupled receptor signaling pathway  G protein-coupled receptor signaling pathway  positive regulation of cell proliferation  regulation of signaling receptor activity  positive regulation of steroid biosynthetic process  peptide hormone processing  follicle-stimulating hormone activity  follicle-stimulating hormone complex  positive regulation of cell migration  positive regulation of transcription by RNA polymerase II  
Pathways : KEGGNeuroactive ligand-receptor interaction    GnRH signaling pathway    Ovarian steroidogenesis    Prolactin signaling pathway    Thyroid hormone synthesis    Autoimmune thyroid disease   
NDEx NetworkCGA
Atlas of Cancer Signalling NetworkCGA
Wikipedia pathwaysCGA
Orthology - Evolution
OrthoDB1081
GeneTree (enSembl)ENSG00000135346
Phylogenetic Trees/Animal Genes : TreeFamCGA
HOVERGENP01215
HOGENOMP01215
Homologs : HomoloGeneCGA
Homology/Alignments : Family Browser (UCSC)CGA
Gene fusions - Rearrangements
Fusion : MitelmanATXN1/CGA [6p22.3/6q14.3]  [t(6;6)(p22;q14)]  
Fusion : MitelmanSMAP1/CGA [6q13/6q14.3]  [t(6;6)(q13;q14)]  
Fusion : MitelmanZFYVE9/CGA [1p32.3/6q14.3]  [t(1;6)(p32;q14)]  
Fusion : MitelmanZNF292/CGA [6q14.3/6q14.3]  [t(6;6)(q14;q14)]  
Fusion PortalATXN1 6p22.3 CGA 6q14.3 LUAD
Fusion PortalSMAP1 6q13 CGA 6q14.3 PRAD
Fusion PortalZNF292 6q14.3 CGA 6q14.3 BRCA
Fusion : QuiverCGA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCGA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CGA
dbVarCGA
ClinVarCGA
1000_GenomesCGA 
Exome Variant ServerCGA
ExAC (Exome Aggregation Consortium)ENSG00000135346
GNOMAD BrowserENSG00000135346
Varsome BrowserCGA
Genetic variants : HAPMAP1081
Genomic Variants (DGV)CGA [DGVbeta]
DECIPHERCGA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCGA 
Mutations
ICGC Data PortalCGA 
TCGA Data PortalCGA 
Broad Tumor PortalCGA
OASIS PortalCGA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCGA  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCGA
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CGA
DgiDB (Drug Gene Interaction Database)CGA
DoCM (Curated mutations)CGA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CGA (select a term)
intoGenCGA
Cancer3DCGA(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM118850   
Orphanet
DisGeNETCGA
MedgenCGA
Genetic Testing Registry CGA
NextProtP01215 [Medical]
TSGene1081
GENETestsCGA
Target ValidationCGA
Huge Navigator CGA [HugePedia]
snp3D : Map Gene to Disease1081
BioCentury BCIQCGA
ClinGenCGA
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1081
Chemical/Pharm GKB GenePA26433
Clinical trialCGA
Miscellaneous
canSAR (ICR)CGA (select the gene name)
Probes
Litterature
PubMed164 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCGA
EVEXCGA
GoPubMedCGA
iHOPCGA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 10:57:56 CET 2018

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