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CGA (glycoprotein hormones, alpha polypeptide)

Identity

Alias (NCBI)CG-ALPHA
FSHA
GPA1
GPHA1
GPHa
HCG
LHA
TSHA
HGNC (Hugo) CGA
HGNC Alias symbHCG
GPHa
GPHA1
FSHA
LHA
TSHA
GPA1
HGNC Alias namefollicle-stimulating hormone alpha subunit
 chorionic gonadotropin, alpha polypeptide
 luteinizing hormone alpha chain
 lutropin alpha chain
 thyroid-stimulating hormone alpha chain
 glycoprotein hormones alpha chain
LocusID (NCBI) 1081
Atlas_Id 46217
Location 6q14.3  [Link to chromosome band 6q14]
Location_base_pair Starts at 87085498 and ends at 87095106 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ATXN1 (6p22.3) / CGA (6q14.3)CASP10 (2q33.1) / CGA (6q14.3)CGA (6q14.3) / CDC42BPB (14q32.32)
CGA (6q14.3) / CGA (6q14.3)CGA (6q14.3) / KDM5A (12p13.33)CGA (6q14.3) / MFSD2A (1p34.2)
CGA (6q14.3) / PRG2 (11q12.1)CGA (6q14.3) / PSMC2 (7q22.1)CGA (6q14.3) / RAB1A (2p14)
CGA (6q14.3) / ZNF397 (18q12.2)GUK1 (1q42.13) / CGA (6q14.3)SF1 (11q13.1) / CGA (6q14.3)
SMAD6 (15q22.31) / CGA (6q14.3)SMAP1 (6q13) / CGA (6q14.3)ZFYVE9 (1p32.3) / CGA (6q14.3)
ZNF292 (6q14.3) / CGA (6q14.3)ATXN1 6p22.3 / CGA 6q14.3SMAP1 6q13 / CGA 6q14.3
ZNF292 6q14.3 / CGA 6q14.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)CGA   1885
Cards
Entrez_Gene (NCBI)CGA    glycoprotein hormones, alpha polypeptide
AliasesCG-ALPHA; FSHA; GPA1; GPHA1; 
GPHa; HCG; LHA; TSHA
GeneCards (Weizmann)CGA
Ensembl hg19 (Hinxton)ENSG00000135346 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000135346 [Gene_View]  ENSG00000135346 [Sequence]  chr6:87085498-87095106 [Contig_View]  CGA [Vega]
ICGC DataPortalENSG00000135346
TCGA cBioPortalCGA
AceView (NCBI)CGA
Genatlas (Paris)CGA
SOURCE (Princeton)CGA
Genetics Home Reference (NIH)CGA
Genomic and cartography
GoldenPath hg38 (UCSC)CGA  -     chr6:87085498-87095106 -  6q14.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CGA  -     6q14.3   [Description]    (hg19-Feb_2009)
GoldenPathCGA - 6q14.3 [CytoView hg19]  CGA - 6q14.3 [CytoView hg38]
ImmunoBaseENSG00000135346
Genome Data Viewer NCBICGA [Mapview hg19]  
OMIM118850   
Gene and transcription
Genbank (Entrez)AB019569 AI200485 AK311972 BC010957 BC020782
RefSeq transcript (Entrez)NM_000735 NM_001252383
Consensus coding sequences : CCDS (NCBI)CGA
Gene ExpressionCGA [ NCBI-GEO ]   CGA [ EBI - ARRAY_EXPRESS ]   CGA [ SEEK ]   CGA [ MEM ]
Gene Expression Viewer (FireBrowse)CGA [ Firebrowse - Broad ]
GenevisibleExpression of CGA in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1081
GTEX Portal (Tissue expression)CGA
Human Protein AtlasENSG00000135346-CGA [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01215   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP01215  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP01215
PhosPhoSitePlusP01215
Domaine pattern : Prosite (Expaxy)GLYCO_HORMONE_ALPHA_1 (PS00779)    GLYCO_HORMONE_ALPHA_2 (PS00780)    GLYCO_HORMONE_ALPHA_3 (PS50277)   
Domains : Interpro (EBI)Cystine-knot_cytokine    Glyco_hormone   
Domain families : Pfam (Sanger)Hormone_6 (PF00236)   
Domain families : Pfam (NCBI)pfam00236   
Domain families : Smart (EMBL)GHA (SM00067)  
Conserved Domain (NCBI)CGA
PDB (RSDB)1DZ7    1E9J    1FL7    1HCN    1HD4    1HRP    1QFW    1XUL    1XWD    4AY9    4MQW   
PDB Europe1DZ7    1E9J    1FL7    1HCN    1HD4    1HRP    1QFW    1XUL    1XWD    4AY9    4MQW   
PDB (PDBSum)1DZ7    1E9J    1FL7    1HCN    1HD4    1HRP    1QFW    1XUL    1XWD    4AY9    4MQW   
PDB (IMB)1DZ7    1E9J    1FL7    1HCN    1HD4    1HRP    1QFW    1XUL    1XWD    4AY9    4MQW   
Structural Biology KnowledgeBase1DZ7    1E9J    1FL7    1HCN    1HD4    1HRP    1QFW    1XUL    1XWD    4AY9    4MQW   
SCOP (Structural Classification of Proteins)1DZ7    1E9J    1FL7    1HCN    1HD4    1HRP    1QFW    1XUL    1XWD    4AY9    4MQW   
CATH (Classification of proteins structures)1DZ7    1E9J    1FL7    1HCN    1HD4    1HRP    1QFW    1XUL    1XWD    4AY9    4MQW   
SuperfamilyP01215
AlphaFold pdb e-kbP01215   
Human Protein Atlas [tissue]ENSG00000135346-CGA [tissue]
HPRD00342
Protein Interaction databases
DIP (DOE-UCLA)P01215
IntAct (EBI)P01215
BioGRIDCGA
STRING (EMBL)CGA
ZODIACCGA
Ontologies - Pathways
QuickGOP01215
Ontology : AmiGOnegative regulation of inflammatory response to antigenic stimulus  hormone activity  protein binding  extracellular region  extracellular space  extracellular space  Golgi lumen  regulation of transcription by RNA polymerase II  thyroid hormone generation  G protein-coupled receptor signaling pathway  G protein-coupled receptor signaling pathway  positive regulation of cell population proliferation  gonad development  regulation of signaling receptor activity  positive regulation of steroid biosynthetic process  positive regulation of steroid biosynthetic process  peptide hormone processing  follicle-stimulating hormone activity  follicle-stimulating hormone activity  follicle-stimulating hormone complex  follicle-stimulating hormone complex  positive regulation of cell migration  thyroid gland development  luteinizing hormone secretion  cellular response to hormone stimulus  positive regulation of transcription by RNA polymerase II  negative regulation of organ growth  follicle-stimulating hormone secretion  developmental growth  
Ontology : EGO-EBInegative regulation of inflammatory response to antigenic stimulus  hormone activity  protein binding  extracellular region  extracellular space  extracellular space  Golgi lumen  regulation of transcription by RNA polymerase II  thyroid hormone generation  G protein-coupled receptor signaling pathway  G protein-coupled receptor signaling pathway  positive regulation of cell population proliferation  gonad development  regulation of signaling receptor activity  positive regulation of steroid biosynthetic process  positive regulation of steroid biosynthetic process  peptide hormone processing  follicle-stimulating hormone activity  follicle-stimulating hormone activity  follicle-stimulating hormone complex  follicle-stimulating hormone complex  positive regulation of cell migration  thyroid gland development  luteinizing hormone secretion  cellular response to hormone stimulus  positive regulation of transcription by RNA polymerase II  negative regulation of organ growth  follicle-stimulating hormone secretion  developmental growth  
Pathways : KEGGNeuroactive ligand-receptor interaction    GnRH signaling pathway    Ovarian steroidogenesis    Prolactin signaling pathway    Thyroid hormone synthesis    Autoimmune thyroid disease   
NDEx NetworkCGA
Atlas of Cancer Signalling NetworkCGA
Wikipedia pathwaysCGA
Orthology - Evolution
OrthoDB1081
GeneTree (enSembl)ENSG00000135346
Phylogenetic Trees/Animal Genes : TreeFamCGA
Homologs : HomoloGeneCGA
Homology/Alignments : Family Browser (UCSC)CGA
Gene fusions - Rearrangements
Fusion : MitelmanATXN1/CGA [6p22.3/6q14.3]  
Fusion : MitelmanSMAP1/CGA [6q13/6q14.3]  
Fusion : MitelmanZFYVE9/CGA [1p32.3/6q14.3]  
Fusion : MitelmanZNF292/CGA [6q14.3/6q14.3]  
Fusion : QuiverCGA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCGA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CGA
dbVarCGA
ClinVarCGA
MonarchCGA
1000_GenomesCGA 
Exome Variant ServerCGA
GNOMAD BrowserENSG00000135346
Varsome BrowserCGA
ACMGCGA variants
VarityP01215
Genomic Variants (DGV)CGA [DGVbeta]
DECIPHERCGA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCGA 
Mutations
ICGC Data PortalCGA 
TCGA Data PortalCGA 
Broad Tumor PortalCGA
OASIS PortalCGA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCGA  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCGA
Mutations and Diseases : HGMDCGA
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCGA
DgiDB (Drug Gene Interaction Database)CGA
DoCM (Curated mutations)CGA
CIViC (Clinical Interpretations of Variants in Cancer)CGA
Cancer3DCGA
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM118850   
Orphanet
DisGeNETCGA
MedgenCGA
Genetic Testing Registry CGA
NextProtP01215 [Medical]
GENETestsCGA
Target ValidationCGA
Huge Navigator CGA [HugePedia]
ClinGenCGA
Clinical trials, drugs, therapy
MyCancerGenomeCGA
Protein Interactions : CTDCGA
Pharm GKB GenePA26433
PharosP01215
Clinical trialCGA
Miscellaneous
canSAR (ICR)CGA
HarmonizomeCGA
DataMed IndexCGA
Probes
Litterature
PubMed177 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCGA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:03:44 CEST 2021

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