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CHI3L1 (chitinase 3 like 1)

Identity

Alias_nameschitinase 3-like 1 (cartilage glycoprotein-39)
Alias_symbol (synonym)GP39
YKL40
Other aliasASRT7
CGP-39
GP-39
HC-gp39
HCGP-3P
YKL-40
YYL-40
hCGP-39
HGNC (Hugo) CHI3L1
LocusID (NCBI) 1116
Atlas_Id 40075
Location 1q32.1  [Link to chromosome band 1q32]
Location_base_pair Starts at 203178931 and ends at 203186794 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CHI3L1 (1q32.1) / CBS (21q22.3)CHI3L1 (1q32.1) / CHI3L1 (1q32.1)CHI3L1 (1q32.1) / ESYT1 (12q13.2)
CHI3L1 (1q32.1) / NEDD4L (18q21.31)CHI3L1 (1q32.1) / THBS3 (1q22)CHI3L1 (1q32.1) / WISP1 (8q24.22)
LOC100507412 (-) / CHI3L1 (1q32.1)SMTN (22q12.2) / CHI3L1 (1q32.1)XPNPEP1 (10q25.1) / CHI3L1 (1q32.1)
CHI3L1 1q32.1 / CBS 21q22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;21)(q32;q22) CHI3L1/CBS


External links

Nomenclature
HGNC (Hugo)CHI3L1   1932
Cards
Entrez_Gene (NCBI)CHI3L1  1116  chitinase 3 like 1
AliasesASRT7; CGP-39; GP-39; GP39; 
HC-gp39; HCGP-3P; YKL-40; YKL40; YYL-40; hCGP-39
GeneCards (Weizmann)CHI3L1
Ensembl hg19 (Hinxton)ENSG00000133048 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000133048 [Gene_View]  ENSG00000133048 [Sequence]  chr1:203178931-203186794 [Contig_View]  CHI3L1 [Vega]
ICGC DataPortalENSG00000133048
TCGA cBioPortalCHI3L1
AceView (NCBI)CHI3L1
Genatlas (Paris)CHI3L1
WikiGenes1116
SOURCE (Princeton)CHI3L1
Genetics Home Reference (NIH)CHI3L1
Genomic and cartography
GoldenPath hg38 (UCSC)CHI3L1  -     chr1:203178931-203186794 -  1q32.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CHI3L1  -     1q32.1   [Description]    (hg19-Feb_2009)
EnsemblCHI3L1 - 1q32.1 [CytoView hg19]  CHI3L1 - 1q32.1 [CytoView hg38]
Mapping of homologs : NCBICHI3L1 [Mapview hg19]  CHI3L1 [Mapview hg38]
OMIM181500   601525   611960   
Gene and transcription
Genbank (Entrez)AB209459 AK095458 AK130142 AK130200 AK225266
RefSeq transcript (Entrez)NM_001276
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CHI3L1
Cluster EST : UnigeneHs.733359 [ NCBI ]
CGAP (NCI)Hs.733359
Alternative Splicing GalleryENSG00000133048
Gene ExpressionCHI3L1 [ NCBI-GEO ]   CHI3L1 [ EBI - ARRAY_EXPRESS ]   CHI3L1 [ SEEK ]   CHI3L1 [ MEM ]
Gene Expression Viewer (FireBrowse)CHI3L1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1116
GTEX Portal (Tissue expression)CHI3L1
Human Protein AtlasENSG00000133048-CHI3L1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP36222   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP36222  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP36222
Splice isoforms : SwissVarP36222
PhosPhoSitePlusP36222
Domains : Interpro (EBI)CHI3L1    Chitinase_II    Chitinase_insertion_sf    Glyco_hydro18_cat    Glycoside_hydrolase_SF   
Domain families : Pfam (Sanger)Glyco_hydro_18 (PF00704)   
Domain families : Pfam (NCBI)pfam00704   
Domain families : Smart (EMBL)Glyco_18 (SM00636)  
Conserved Domain (NCBI)CHI3L1
DMDM Disease mutations1116
Blocks (Seattle)CHI3L1
PDB (SRS)1HJV    1HJW    1HJX    1LA7    1NWR    1NWS    1NWT    1NWU   
PDB (PDBSum)1HJV    1HJW    1HJX    1LA7    1NWR    1NWS    1NWT    1NWU   
PDB (IMB)1HJV    1HJW    1HJX    1LA7    1NWR    1NWS    1NWT    1NWU   
PDB (RSDB)1HJV    1HJW    1HJX    1LA7    1NWR    1NWS    1NWT    1NWU   
Structural Biology KnowledgeBase1HJV    1HJW    1HJX    1LA7    1NWR    1NWS    1NWT    1NWU   
SCOP (Structural Classification of Proteins)1HJV    1HJW    1HJX    1LA7    1NWR    1NWS    1NWT    1NWU   
CATH (Classification of proteins structures)1HJV    1HJW    1HJX    1LA7    1NWR    1NWS    1NWT    1NWU   
SuperfamilyP36222
Human Protein Atlas [tissue]ENSG00000133048-CHI3L1 [tissue]
Peptide AtlasP36222
HPRD03314
IPIIPI00002147   IPI00903151   IPI00556431   IPI00647823   
Protein Interaction databases
DIP (DOE-UCLA)P36222
IntAct (EBI)P36222
FunCoupENSG00000133048
BioGRIDCHI3L1
STRING (EMBL)CHI3L1
ZODIACCHI3L1
Ontologies - Pathways
QuickGOP36222
Ontology : AmiGOchitinase activity  chitinase activity  extracellular matrix structural constituent  extracellular region  extracellular region  extracellular space  extracellular space  cytoplasm  endoplasmic reticulum  carbohydrate metabolic process  chitin catabolic process  apoptotic process  inflammatory response  activation of NF-kappaB-inducing kinase activity  chitin binding  chitin binding  response to mechanical stimulus  positive regulation of peptidyl-threonine phosphorylation  carbohydrate binding  lung development  extracellular matrix  response to tumor necrosis factor  specific granule lumen  neutrophil degranulation  positive regulation of angiogenesis  perinuclear region of cytoplasm  cartilage development  positive regulation of protein kinase B signaling  extracellular exosome  positive regulation of ERK1 and ERK2 cascade  response to interleukin-1  response to interleukin-6  cellular response to interleukin-1  cellular response to tumor necrosis factor  interleukin-8 secretion  
Ontology : EGO-EBIchitinase activity  chitinase activity  extracellular matrix structural constituent  extracellular region  extracellular region  extracellular space  extracellular space  cytoplasm  endoplasmic reticulum  carbohydrate metabolic process  chitin catabolic process  apoptotic process  inflammatory response  activation of NF-kappaB-inducing kinase activity  chitin binding  chitin binding  response to mechanical stimulus  positive regulation of peptidyl-threonine phosphorylation  carbohydrate binding  lung development  extracellular matrix  response to tumor necrosis factor  specific granule lumen  neutrophil degranulation  positive regulation of angiogenesis  perinuclear region of cytoplasm  cartilage development  positive regulation of protein kinase B signaling  extracellular exosome  positive regulation of ERK1 and ERK2 cascade  response to interleukin-1  response to interleukin-6  cellular response to interleukin-1  cellular response to tumor necrosis factor  interleukin-8 secretion  
NDEx NetworkCHI3L1
Atlas of Cancer Signalling NetworkCHI3L1
Wikipedia pathwaysCHI3L1
Orthology - Evolution
OrthoDB1116
GeneTree (enSembl)ENSG00000133048
Phylogenetic Trees/Animal Genes : TreeFamCHI3L1
HOVERGENP36222
HOGENOMP36222
Homologs : HomoloGeneCHI3L1
Homology/Alignments : Family Browser (UCSC)CHI3L1
Gene fusions - Rearrangements
Fusion : MitelmanCHI3L1/CBS [1q32.1/21q22.3]  
Fusion PortalCHI3L1 1q32.1 CBS 21q22.3 THCA
Fusion : QuiverCHI3L1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCHI3L1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CHI3L1
dbVarCHI3L1
ClinVarCHI3L1
1000_GenomesCHI3L1 
Exome Variant ServerCHI3L1
ExAC (Exome Aggregation Consortium)ENSG00000133048
GNOMAD BrowserENSG00000133048
Varsome BrowserCHI3L1
Genetic variants : HAPMAP1116
Genomic Variants (DGV)CHI3L1 [DGVbeta]
DECIPHERCHI3L1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCHI3L1 
Mutations
ICGC Data PortalCHI3L1 
TCGA Data PortalCHI3L1 
Broad Tumor PortalCHI3L1
OASIS PortalCHI3L1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCHI3L1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCHI3L1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CHI3L1
DgiDB (Drug Gene Interaction Database)CHI3L1
DoCM (Curated mutations)CHI3L1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CHI3L1 (select a term)
intoGenCHI3L1
Cancer3DCHI3L1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM181500    601525    611960   
Orphanet
DisGeNETCHI3L1
MedgenCHI3L1
Genetic Testing Registry CHI3L1
NextProtP36222 [Medical]
TSGene1116
GENETestsCHI3L1
Target ValidationCHI3L1
Huge Navigator CHI3L1 [HugePedia]
snp3D : Map Gene to Disease1116
BioCentury BCIQCHI3L1
ClinGenCHI3L1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1116
Chemical/Pharm GKB GenePA26463
Clinical trialCHI3L1
Miscellaneous
canSAR (ICR)CHI3L1 (select the gene name)
Probes
Litterature
PubMed353 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCHI3L1
EVEXCHI3L1
GoPubMedCHI3L1
iHOPCHI3L1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Aug 27 11:15:17 CEST 2018

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