CIAO1 (cytosolic iron-sulfur assembly component 1)

2003-02-01  

Identity

HGNC
LOCATION
2q11.2
LOCUSID
ALIAS
CIA1,WDR39
FUSION GENES

Other Information

Locus ID:

NCBI: 9391
MIM: 604333
HGNC: 14280
Ensembl: ENSG00000144021

Variants:

dbSNP: 9391
ClinVar: 9391
TCGA: ENSG00000144021
COSMIC: CIAO1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000144021ENST00000488633O76071

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Cytosolic iron-sulfur cluster assemblyREACTOMER-HSA-2564830

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
238910042013Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins.47
242458042014Viperin is an iron-sulfur protein that inhibits genome synthesis of tick-borne encephalitis virus via radical SAM domain activity.31
293095862018Cytosolic HSC20 integrates de novo iron-sulfur cluster biogenesis with the CIAO1-mediated transfer to recipients.8
286154502017Cellular requirements for iron-sulfur cluster insertion into the antiviral radical SAM protein viperin.7
272356252016Human DNA polymerase ε is phosphorylated at serine-1940 after DNA damage and interacts with the iron-sulfur complex chaperones CIAO1 and MMS19.3

Citation

Dessen P

CIAO1 (cytosolic iron-sulfur assembly component 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40082/ciao1