CLCA1 (chloride channel accessory 1)

2007-02-01  

Identity

HGNC
CLCA1
LOCATION
1p22.3
LOCUSID
1179
ALIAS
CACC,CACC1,CLCRG1,CaCC-1,GOB5,hCLCA1,hCaCC-1

Other Information

Locus ID:

NCBI: 1179
MIM: 603906
HGNC: 2015
Ensembl: ENSG00000016490

Variants:

dbSNP: 1179
ClinVar: 1179
TCGA: ENSG00000016490
COSMIC: CLCA1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000016490ENST00000234701A8K7I4
ENSG00000016490ENST00000394711A8K7I4

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Pancreatic secretionKEGGko04972
Pancreatic secretionKEGGhsa04972
Renin secretionKEGGhsa04924
Renin secretionKEGGko04924
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Ion channel transportREACTOMER-HSA-983712
Stimuli-sensing channelsREACTOMER-HSA-2672351

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
159196552005hCLCA1 and mCLCA3 are secreted non-integral membrane proteins and therefore are not ion channels.54
257813442015Secreted CLCA1 modulates TMEM16A to activate Ca(2+)-dependent chloride currents in human cells.37
231120502012Self-cleavage of human CLCA1 protein by a novel internal metalloprotease domain controls calcium-activated chloride channel activation.29
198345352009Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging.27
118422922002A calcium-activated chloride channel (HCLCA1) is strongly related to IL-9 expression and mucus production in bronchial epithelium of patients with asthma.25
164708492006Novel conserved hydrolase domain in the CLCA family of alleged calcium-activated chloride channels.24
154902402004The CLCA gene locus as a modulator of the gastrointestinal basic defect in cystic fibrosis.22
193072982009Human ClCa1 modulates anionic conduction of calcium-dependent chloride currents.20
194235402009Common variation in genes related to innate immunity and risk of adult glioma.19

Citation

Dessen P

CLCA1 (chloride channel accessory 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43899/clca1