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CLCA1 (chloride channel accessory 1)

Identity

Alias (NCBI)CACC
CACC1
CLCRG1
CaCC-1
GOB5
hCLCA1
hCaCC-1
HGNC (Hugo) CLCA1
HGNC Alias symbCaCC
CLCRG1
HGNC Previous namechloride channel, calcium activated, family member 1
 chloride channel regulator 1
LocusID (NCBI) 1179
Atlas_Id 43899
Location 1p22.3  [Link to chromosome band 1p22]
Location_base_pair Starts at 86468927 and ends at 86500259 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)CLCA1   2015
Cards
Entrez_Gene (NCBI)CLCA1    chloride channel accessory 1
AliasesCACC; CACC1; CLCRG1; CaCC-1; 
GOB5; hCLCA1; hCaCC-1
GeneCards (Weizmann)CLCA1
Ensembl hg19 (Hinxton)ENSG00000016490 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000016490 [Gene_View]  ENSG00000016490 [Sequence]  chr1:86468927-86500259 [Contig_View]  CLCA1 [Vega]
ICGC DataPortalENSG00000016490
TCGA cBioPortalCLCA1
AceView (NCBI)CLCA1
Genatlas (Paris)CLCA1
SOURCE (Princeton)CLCA1
Genetics Home Reference (NIH)CLCA1
Genomic and cartography
GoldenPath hg38 (UCSC)CLCA1  -     chr1:86468927-86500259 +  1p22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CLCA1  -     1p22.3   [Description]    (hg19-Feb_2009)
GoldenPathCLCA1 - 1p22.3 [CytoView hg19]  CLCA1 - 1p22.3 [CytoView hg38]
ImmunoBaseENSG00000016490
Genome Data Viewer NCBICLCA1 [Mapview hg19]  
OMIM603906   
Gene and transcription
Genbank (Entrez)AA508854 AF039400 AF127036 AK024970 AK097057
RefSeq transcript (Entrez)NM_001285
Consensus coding sequences : CCDS (NCBI)CLCA1
Gene ExpressionCLCA1 [ NCBI-GEO ]   CLCA1 [ EBI - ARRAY_EXPRESS ]   CLCA1 [ SEEK ]   CLCA1 [ MEM ]
Gene Expression Viewer (FireBrowse)CLCA1 [ Firebrowse - Broad ]
GenevisibleExpression of CLCA1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1179
GTEX Portal (Tissue expression)CLCA1
Human Protein AtlasENSG00000016490-CLCA1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtA8K7I4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtA8K7I4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProA8K7I4
PhosPhoSitePlusA8K7I4
Domaine pattern : Prosite (Expaxy)VWFA (PS50234)   
Domains : Interpro (EBI)CLCA_chordata    CLCA_N    Ig-like_fold    VWF_A    vWFA_dom_sf   
Domain families : Pfam (Sanger)CLCA (PF08434)    VWA_2 (PF13519)   
Domain families : Pfam (NCBI)pfam08434    pfam13519   
Domain families : Smart (EMBL)VWA (SM00327)  
Conserved Domain (NCBI)CLCA1
PDB (RSDB)6PYO    6PYX   
PDB Europe6PYO    6PYX   
PDB (PDBSum)6PYO    6PYX   
PDB (IMB)6PYO    6PYX   
Structural Biology KnowledgeBase6PYO    6PYX   
SCOP (Structural Classification of Proteins)6PYO    6PYX   
CATH (Classification of proteins structures)6PYO    6PYX   
SuperfamilyA8K7I4
AlphaFold pdb e-kbA8K7I4   
Human Protein Atlas [tissue]ENSG00000016490-CLCA1 [tissue]
HPRD04880
Protein Interaction databases
DIP (DOE-UCLA)A8K7I4
IntAct (EBI)A8K7I4
BioGRIDCLCA1
STRING (EMBL)CLCA1
ZODIACCLCA1
Ontologies - Pathways
QuickGOA8K7I4
Ontology : AmiGOintracellular calcium activated chloride channel activity  chloride channel activity  extracellular space  plasma membrane  integral component of plasma membrane  microvillus  proteolysis  calcium ion transport  chloride transport  metallopeptidase activity  ion transmembrane transport  zymogen granule membrane  metal ion binding  cellular response to hypoxia  
Ontology : EGO-EBIintracellular calcium activated chloride channel activity  chloride channel activity  extracellular space  plasma membrane  integral component of plasma membrane  microvillus  proteolysis  calcium ion transport  chloride transport  metallopeptidase activity  ion transmembrane transport  zymogen granule membrane  metal ion binding  cellular response to hypoxia  
Pathways : KEGGOlfactory transduction    Pancreatic secretion   
NDEx NetworkCLCA1
Atlas of Cancer Signalling NetworkCLCA1
Wikipedia pathwaysCLCA1
Orthology - Evolution
OrthoDB1179
GeneTree (enSembl)ENSG00000016490
Phylogenetic Trees/Animal Genes : TreeFamCLCA1
Homologs : HomoloGeneCLCA1
Homology/Alignments : Family Browser (UCSC)CLCA1
Gene fusions - Rearrangements
Fusion : QuiverCLCA1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCLCA1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CLCA1
dbVarCLCA1
ClinVarCLCA1
MonarchCLCA1
1000_GenomesCLCA1 
Exome Variant ServerCLCA1
GNOMAD BrowserENSG00000016490
Varsome BrowserCLCA1
ACMGCLCA1 variants
VarityA8K7I4
Genomic Variants (DGV)CLCA1 [DGVbeta]
DECIPHERCLCA1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCLCA1 
Mutations
ICGC Data PortalCLCA1 
TCGA Data PortalCLCA1 
Broad Tumor PortalCLCA1
OASIS PortalCLCA1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCLCA1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCLCA1
Mutations and Diseases : HGMDCLCA1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCLCA1
DgiDB (Drug Gene Interaction Database)CLCA1
DoCM (Curated mutations)CLCA1
CIViC (Clinical Interpretations of Variants in Cancer)CLCA1
Cancer3DCLCA1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603906   
Orphanet
DisGeNETCLCA1
MedgenCLCA1
Genetic Testing Registry CLCA1
NextProtA8K7I4 [Medical]
GENETestsCLCA1
Target ValidationCLCA1
Huge Navigator CLCA1 [HugePedia]
ClinGenCLCA1
Clinical trials, drugs, therapy
MyCancerGenomeCLCA1
Protein Interactions : CTDCLCA1
Pharm GKB GenePA26542
PharosA8K7I4
Clinical trialCLCA1
Miscellaneous
canSAR (ICR)CLCA1
HarmonizomeCLCA1
DataMed IndexCLCA1
Probes
Litterature
PubMed52 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCLCA1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:04:11 CEST 2021

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