CLDN2 (claudin 2)

2007-07-01  

Identity

HGNC
LOCATION
Xq22.3
LOCUSID
ALIAS
OAZON

Other Information

Locus ID:

NCBI: 9075
MIM: 300520
HGNC: 2041
Ensembl: ENSG00000165376

Variants:

dbSNP: 9075
ClinVar: 9075
TCGA: ENSG00000165376
COSMIC: CLDN2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000165376ENST00000336803P57739
ENSG00000165376ENST00000540876P57739
ENSG00000165376ENST00000541806P57739

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Tight junctionKEGGko04530
Leukocyte transendothelial migrationKEGGko04670
Cell adhesion molecules (CAMs)KEGGhsa04514
Tight junctionKEGGhsa04530
Leukocyte transendothelial migrationKEGGhsa04670
Hepatitis CKEGGko05160
Hepatitis CKEGGhsa05160
Cell-Cell communicationREACTOMER-HSA-1500931
Cell junction organizationREACTOMER-HSA-446728
Cell-cell junction organizationREACTOMER-HSA-421270
Tight junction interactionsREACTOMER-HSA-420029

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
181981872008The density of small tight junction pores varies among cell types and is increased by expression of claudin-2.134
127001402003Claudin extracellular domains determine paracellular charge selectivity and resistance but not tight junction fibril architecture.116
187113532008Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation.96
182875302008Tight junction proteins claudin-2 and -12 are critical for vitamin D-dependent Ca2+ absorption between enterocytes.88
231436022012Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis.78
213836922011Claudin-2 expression increases tumorigenicity of colon cancer cells: role of epidermal growth factor receptor activation.57
246627422014Interleukin-6 modulation of intestinal epithelial tight junction permeability is mediated by JNK pathway activation of claudin-2 gene.54
153896422005Differential expression of claudin-2 along the human intestine: Implication of GATA-4 in the maintenance of claudin-2 in differentiating cells.52
119348812002Cloning of the human claudin-2 5'-flanking region revealed a TATA-less promoter with conserved binding sites in mouse and human for caudal-related homeodomain proteins and hepatocyte nuclear factor-1alpha.47
210764732011Claudin-2 is selectively enriched in and promotes the formation of breast cancer liver metastases through engagement of integrin complexes.46

Citation

Dessen P

CLDN2 (claudin 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-07-01

Online version: http://atlasgeneticsoncology.org/gene/47621/cldn2