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CLDN2 (claudin 2)

Identity

Other alias-
HGNC (Hugo) CLDN2
LocusID (NCBI) 9075
Atlas_Id 47621
Location Xq22.3  [Link to chromosome band Xq22]
Location_base_pair Starts at 106900164 and ends at 106930861 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CLDN2   2041
Cards
Entrez_Gene (NCBI)CLDN2  9075  claudin 2
Aliases
GeneCards (Weizmann)CLDN2
Ensembl hg19 (Hinxton)ENSG00000165376 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000165376 [Gene_View]  chrX:106900164-106930861 [Contig_View]  CLDN2 [Vega]
ICGC DataPortalENSG00000165376
TCGA cBioPortalCLDN2
AceView (NCBI)CLDN2
Genatlas (Paris)CLDN2
WikiGenes9075
SOURCE (Princeton)CLDN2
Genetics Home Reference (NIH)CLDN2
Genomic and cartography
GoldenPath hg38 (UCSC)CLDN2  -     chrX:106900164-106930861 +  Xq22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CLDN2  -     Xq22.3   [Description]    (hg19-Feb_2009)
EnsemblCLDN2 - Xq22.3 [CytoView hg19]  CLDN2 - Xq22.3 [CytoView hg38]
Mapping of homologs : NCBICLDN2 [Mapview hg19]  CLDN2 [Mapview hg38]
OMIM300520   
Gene and transcription
Genbank (Entrez)AA973123 AF177340 AF250558 AK075371 AK075405
RefSeq transcript (Entrez)NM_001171092 NM_001171095 NM_020384
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CLDN2
Cluster EST : UnigeneHs.522746 [ NCBI ]
CGAP (NCI)Hs.522746
Alternative Splicing GalleryENSG00000165376
Gene ExpressionCLDN2 [ NCBI-GEO ]   CLDN2 [ EBI - ARRAY_EXPRESS ]   CLDN2 [ SEEK ]   CLDN2 [ MEM ]
Gene Expression Viewer (FireBrowse)CLDN2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9075
GTEX Portal (Tissue expression)CLDN2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP57739   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP57739  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP57739
Splice isoforms : SwissVarP57739
PhosPhoSitePlusP57739
Domaine pattern : Prosite (Expaxy)CLAUDIN (PS01346)   
Domains : Interpro (EBI)Claudin    Claudin2    Claudin_CS    PMP22/EMP/MP20/Claudin   
Domain families : Pfam (Sanger)PMP22_Claudin (PF00822)   
Domain families : Pfam (NCBI)pfam00822   
Conserved Domain (NCBI)CLDN2
DMDM Disease mutations9075
Blocks (Seattle)CLDN2
PDB (SRS)4YYX   
PDB (PDBSum)4YYX   
PDB (IMB)4YYX   
PDB (RSDB)4YYX   
Structural Biology KnowledgeBase4YYX   
SCOP (Structural Classification of Proteins)4YYX   
CATH (Classification of proteins structures)4YYX   
SuperfamilyP57739
Human Protein AtlasENSG00000165376
Peptide AtlasP57739
HPRD06471
IPIIPI00027998   
Protein Interaction databases
DIP (DOE-UCLA)P57739
IntAct (EBI)P57739
FunCoupENSG00000165376
BioGRIDCLDN2
STRING (EMBL)CLDN2
ZODIACCLDN2
Ontologies - Pathways
QuickGOP57739
Ontology : AmiGOstructural molecule activity  protein binding  plasma membrane  bicellular tight junction  integral component of membrane  calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules  identical protein binding  extracellular exosome  
Ontology : EGO-EBIstructural molecule activity  protein binding  plasma membrane  bicellular tight junction  integral component of membrane  calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules  identical protein binding  extracellular exosome  
Pathways : KEGGCell adhesion molecules (CAMs)    Tight junction    Leukocyte transendothelial migration    Hepatitis C   
NDEx NetworkCLDN2
Atlas of Cancer Signalling NetworkCLDN2
Wikipedia pathwaysCLDN2
Orthology - Evolution
OrthoDB9075
GeneTree (enSembl)ENSG00000165376
Phylogenetic Trees/Animal Genes : TreeFamCLDN2
HOVERGENP57739
HOGENOMP57739
Homologs : HomoloGeneCLDN2
Homology/Alignments : Family Browser (UCSC)CLDN2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCLDN2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CLDN2
dbVarCLDN2
ClinVarCLDN2
1000_GenomesCLDN2 
Exome Variant ServerCLDN2
ExAC (Exome Aggregation Consortium)CLDN2 (select the gene name)
Genetic variants : HAPMAP9075
Genomic Variants (DGV)CLDN2 [DGVbeta]
DECIPHERCLDN2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCLDN2 
Mutations
ICGC Data PortalCLDN2 
TCGA Data PortalCLDN2 
Broad Tumor PortalCLDN2
OASIS PortalCLDN2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCLDN2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCLDN2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch CLDN2
DgiDB (Drug Gene Interaction Database)CLDN2
DoCM (Curated mutations)CLDN2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CLDN2 (select a term)
intoGenCLDN2
Cancer3DCLDN2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300520   
Orphanet
MedgenCLDN2
Genetic Testing Registry CLDN2
NextProtP57739 [Medical]
TSGene9075
GENETestsCLDN2
Target ValidationCLDN2
Huge Navigator CLDN2 [HugePedia]
snp3D : Map Gene to Disease9075
BioCentury BCIQCLDN2
ClinGenCLDN2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9075
Chemical/Pharm GKB GenePA26567
Clinical trialCLDN2
Miscellaneous
canSAR (ICR)CLDN2 (select the gene name)
Probes
Litterature
PubMed85 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCLDN2
EVEXCLDN2
GoPubMedCLDN2
iHOPCLDN2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:28:38 CEST 2017

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