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CLDN8 (claudin 8)

Identity

Other aliasHEL-S-79
HGNC (Hugo) CLDN8
LocusID (NCBI) 9073
Atlas_Id 49807
Location 21q22.11  [Link to chromosome band 21q22]
Location_base_pair Starts at 30214006 and ends at 30216151 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CLDN8   2050
Cards
Entrez_Gene (NCBI)CLDN8  9073  claudin 8
AliasesHEL-S-79
GeneCards (Weizmann)CLDN8
Ensembl hg19 (Hinxton)ENSG00000156284 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000156284 [Gene_View]  chr21:30214006-30216151 [Contig_View]  CLDN8 [Vega]
ICGC DataPortalENSG00000156284
TCGA cBioPortalCLDN8
AceView (NCBI)CLDN8
Genatlas (Paris)CLDN8
WikiGenes9073
SOURCE (Princeton)CLDN8
Genetics Home Reference (NIH)CLDN8
Genomic and cartography
GoldenPath hg38 (UCSC)CLDN8  -     chr21:30214006-30216151 -  21q22.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CLDN8  -     21q22.11   [Description]    (hg19-Feb_2009)
EnsemblCLDN8 - 21q22.11 [CytoView hg19]  CLDN8 - 21q22.11 [CytoView hg38]
Mapping of homologs : NCBICLDN8 [Mapview hg19]  CLDN8 [Mapview hg38]
OMIM611231   
Gene and transcription
Genbank (Entrez)AK022269 AK223512 AL049977 AW235670 AY358707
RefSeq transcript (Entrez)NM_012132 NM_199328
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CLDN8
Cluster EST : UnigeneHs.162209 [ NCBI ]
CGAP (NCI)Hs.162209
Alternative Splicing GalleryENSG00000156284
Gene ExpressionCLDN8 [ NCBI-GEO ]   CLDN8 [ EBI - ARRAY_EXPRESS ]   CLDN8 [ SEEK ]   CLDN8 [ MEM ]
Gene Expression Viewer (FireBrowse)CLDN8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9073
GTEX Portal (Tissue expression)CLDN8
Human Protein AtlasENSG00000156284-CLDN8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP56748   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP56748  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP56748
Splice isoforms : SwissVarP56748
PhosPhoSitePlusP56748
Domaine pattern : Prosite (Expaxy)CLAUDIN (PS01346)   
Domains : Interpro (EBI)Claudin    Claudin8    Claudin_CS    PMP22/EMP/MP20/Claudin   
Domain families : Pfam (Sanger)PMP22_Claudin (PF00822)   
Domain families : Pfam (NCBI)pfam00822   
Conserved Domain (NCBI)CLDN8
DMDM Disease mutations9073
Blocks (Seattle)CLDN8
SuperfamilyP56748
Human Protein Atlas [tissue]ENSG00000156284-CLDN8 [tissue]
Peptide AtlasP56748
HPRD10835
IPIIPI01011546   IPI00011085   
Protein Interaction databases
DIP (DOE-UCLA)P56748
IntAct (EBI)P56748
FunCoupENSG00000156284
BioGRIDCLDN8
STRING (EMBL)CLDN8
ZODIACCLDN8
Ontologies - Pathways
QuickGOP56748
Ontology : AmiGOstructural molecule activity  protein binding  endoplasmic reticulum  plasma membrane  bicellular tight junction  integral component of membrane  basolateral plasma membrane  apicolateral plasma membrane  calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules  identical protein binding  
Ontology : EGO-EBIstructural molecule activity  protein binding  endoplasmic reticulum  plasma membrane  bicellular tight junction  integral component of membrane  basolateral plasma membrane  apicolateral plasma membrane  calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules  identical protein binding  
Pathways : KEGGCell adhesion molecules (CAMs)    Tight junction    Leukocyte transendothelial migration    Hepatitis C   
NDEx NetworkCLDN8
Atlas of Cancer Signalling NetworkCLDN8
Wikipedia pathwaysCLDN8
Orthology - Evolution
OrthoDB9073
GeneTree (enSembl)ENSG00000156284
Phylogenetic Trees/Animal Genes : TreeFamCLDN8
HOVERGENP56748
HOGENOMP56748
Homologs : HomoloGeneCLDN8
Homology/Alignments : Family Browser (UCSC)CLDN8
Gene fusions - Rearrangements
Tumor Fusion PortalCLDN8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCLDN8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CLDN8
dbVarCLDN8
ClinVarCLDN8
1000_GenomesCLDN8 
Exome Variant ServerCLDN8
ExAC (Exome Aggregation Consortium)ENSG00000156284
GNOMAD BrowserENSG00000156284
Genetic variants : HAPMAP9073
Genomic Variants (DGV)CLDN8 [DGVbeta]
DECIPHERCLDN8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCLDN8 
Mutations
ICGC Data PortalCLDN8 
TCGA Data PortalCLDN8 
Broad Tumor PortalCLDN8
OASIS PortalCLDN8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCLDN8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCLDN8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CLDN8
DgiDB (Drug Gene Interaction Database)CLDN8
DoCM (Curated mutations)CLDN8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CLDN8 (select a term)
intoGenCLDN8
Cancer3DCLDN8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611231   
Orphanet
DisGeNETCLDN8
MedgenCLDN8
Genetic Testing Registry CLDN8
NextProtP56748 [Medical]
TSGene9073
GENETestsCLDN8
Target ValidationCLDN8
Huge Navigator CLDN8 [HugePedia]
snp3D : Map Gene to Disease9073
BioCentury BCIQCLDN8
ClinGenCLDN8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9073
Chemical/Pharm GKB GenePA26576
Clinical trialCLDN8
Miscellaneous
canSAR (ICR)CLDN8 (select the gene name)
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCLDN8
EVEXCLDN8
GoPubMedCLDN8
iHOPCLDN8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:08:02 CET 2017

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