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CLK1 (CDC like kinase 1)

Identity

Alias (NCBI)CLK
CLK/STY
STY
HGNC (Hugo) CLK1
HGNC Previous nameCDC-like kinase 1
LocusID (NCBI) 1195
Atlas_Id 43215
Location 2q33.1  [Link to chromosome band 2q33]
Location_base_pair Starts at 200853009 and ends at 200864658 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ANAPC1 (2q13) / CLK1 (2q33.1)CLK1 (2q33.1) / PAPPA (9q33.1)PPIL3 (2q33.1) / CLK1 (2q33.1)
S100A4 (1q21.3) / CLK1 (2q33.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)CLK1   2068
Cards
Entrez_Gene (NCBI)CLK1    CDC like kinase 1
AliasesCLK; CLK/STY; STY
GeneCards (Weizmann)CLK1
Ensembl hg19 (Hinxton)ENSG00000013441 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000013441 [Gene_View]  ENSG00000013441 [Sequence]  chr2:200853009-200864658 [Contig_View]  CLK1 [Vega]
ICGC DataPortalENSG00000013441
TCGA cBioPortalCLK1
AceView (NCBI)CLK1
Genatlas (Paris)CLK1
SOURCE (Princeton)CLK1
Genetics Home Reference (NIH)CLK1
Genomic and cartography
GoldenPath hg38 (UCSC)CLK1  -     chr2:200853009-200864658 -  2q33.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CLK1  -     2q33.1   [Description]    (hg19-Feb_2009)
GoldenPathCLK1 - 2q33.1 [CytoView hg19]  CLK1 - 2q33.1 [CytoView hg38]
ImmunoBaseENSG00000013441
Genome Data Viewer NCBICLK1 [Mapview hg19]  
OMIM601951   
Gene and transcription
Genbank (Entrez)AI251890 AK025306 AK289365 AK294295 AK307301
RefSeq transcript (Entrez)NM_001024646 NM_001162407 NM_004071
Consensus coding sequences : CCDS (NCBI)CLK1
Gene ExpressionCLK1 [ NCBI-GEO ]   CLK1 [ EBI - ARRAY_EXPRESS ]   CLK1 [ SEEK ]   CLK1 [ MEM ]
Gene Expression Viewer (FireBrowse)CLK1 [ Firebrowse - Broad ]
GenevisibleExpression of CLK1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1195
GTEX Portal (Tissue expression)CLK1
Human Protein AtlasENSG00000013441-CLK1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49759   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP49759  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49759
Catalytic activity : Enzyme2.7.12.1 [ Enzyme-Expasy ]   2.7.12.12.7.12.1 [ IntEnz-EBI ]   2.7.12.1 [ BRENDA ]   2.7.12.1 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP49759
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)CLK1
PDB (RSDB)1Z57    2VAG    5J1V    5J1W    5X8I    6FT8    6FT9    6FYO    6G33    6I5H    6I5I    6I5K    6I5L    6KHD    6Q8K    6Q8P    6QTY    6R3D    6R6E    6R6X    6R8J    6RAA    6TW2    6YTA    6YTD    6YTE    6YTG    6YTI    6Z4Z    6Z50    6ZLN   
PDB Europe1Z57    2VAG    5J1V    5J1W    5X8I    6FT8    6FT9    6FYO    6G33    6I5H    6I5I    6I5K    6I5L    6KHD    6Q8K    6Q8P    6QTY    6R3D    6R6E    6R6X    6R8J    6RAA    6TW2    6YTA    6YTD    6YTE    6YTG    6YTI    6Z4Z    6Z50    6ZLN   
PDB (PDBSum)1Z57    2VAG    5J1V    5J1W    5X8I    6FT8    6FT9    6FYO    6G33    6I5H    6I5I    6I5K    6I5L    6KHD    6Q8K    6Q8P    6QTY    6R3D    6R6E    6R6X    6R8J    6RAA    6TW2    6YTA    6YTD    6YTE    6YTG    6YTI    6Z4Z    6Z50    6ZLN   
PDB (IMB)1Z57    2VAG    5J1V    5J1W    5X8I    6FT8    6FT9    6FYO    6G33    6I5H    6I5I    6I5K    6I5L    6KHD    6Q8K    6Q8P    6QTY    6R3D    6R6E    6R6X    6R8J    6RAA    6TW2    6YTA    6YTD    6YTE    6YTG    6YTI    6Z4Z    6Z50    6ZLN   
Structural Biology KnowledgeBase1Z57    2VAG    5J1V    5J1W    5X8I    6FT8    6FT9    6FYO    6G33    6I5H    6I5I    6I5K    6I5L    6KHD    6Q8K    6Q8P    6QTY    6R3D    6R6E    6R6X    6R8J    6RAA    6TW2    6YTA    6YTD    6YTE    6YTG    6YTI    6Z4Z    6Z50    6ZLN   
SCOP (Structural Classification of Proteins)1Z57    2VAG    5J1V    5J1W    5X8I    6FT8    6FT9    6FYO    6G33    6I5H    6I5I    6I5K    6I5L    6KHD    6Q8K    6Q8P    6QTY    6R3D    6R6E    6R6X    6R8J    6RAA    6TW2    6YTA    6YTD    6YTE    6YTG    6YTI    6Z4Z    6Z50    6ZLN   
CATH (Classification of proteins structures)1Z57    2VAG    5J1V    5J1W    5X8I    6FT8    6FT9    6FYO    6G33    6I5H    6I5I    6I5K    6I5L    6KHD    6Q8K    6Q8P    6QTY    6R3D    6R6E    6R6X    6R8J    6RAA    6TW2    6YTA    6YTD    6YTE    6YTG    6YTI    6Z4Z    6Z50    6ZLN   
SuperfamilyP49759
AlphaFold pdb e-kbP49759   
Human Protein Atlas [tissue]ENSG00000013441-CLK1 [tissue]
HPRD09058
Protein Interaction databases
DIP (DOE-UCLA)P49759
IntAct (EBI)P49759
BioGRIDCLK1
STRING (EMBL)CLK1
ZODIACCLK1
Ontologies - Pathways
QuickGOP49759
Ontology : AmiGOprotein serine/threonine kinase activity  protein serine/threonine/tyrosine kinase activity  transmembrane receptor protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  peptidyl-tyrosine phosphorylation  regulation of RNA splicing  protein autophosphorylation  protein serine kinase activity  protein threonine kinase activity  
Ontology : EGO-EBIprotein serine/threonine kinase activity  protein serine/threonine/tyrosine kinase activity  transmembrane receptor protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  peptidyl-tyrosine phosphorylation  regulation of RNA splicing  protein autophosphorylation  protein serine kinase activity  protein threonine kinase activity  
Pathways : KEGGLegionellosis   
NDEx NetworkCLK1
Atlas of Cancer Signalling NetworkCLK1
Wikipedia pathwaysCLK1
Orthology - Evolution
OrthoDB1195
GeneTree (enSembl)ENSG00000013441
Phylogenetic Trees/Animal Genes : TreeFamCLK1
Homologs : HomoloGeneCLK1
Homology/Alignments : Family Browser (UCSC)CLK1
Gene fusions - Rearrangements
Fusion : QuiverCLK1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCLK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CLK1
dbVarCLK1
ClinVarCLK1
MonarchCLK1
1000_GenomesCLK1 
Exome Variant ServerCLK1
GNOMAD BrowserENSG00000013441
Varsome BrowserCLK1
ACMGCLK1 variants
VarityP49759
Genomic Variants (DGV)CLK1 [DGVbeta]
DECIPHERCLK1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCLK1 
Mutations
ICGC Data PortalCLK1 
TCGA Data PortalCLK1 
Broad Tumor PortalCLK1
OASIS PortalCLK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCLK1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCLK1
Mutations and Diseases : HGMDCLK1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCLK1
DgiDB (Drug Gene Interaction Database)CLK1
DoCM (Curated mutations)CLK1
CIViC (Clinical Interpretations of Variants in Cancer)CLK1
Cancer3DCLK1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601951   
Orphanet
DisGeNETCLK1
MedgenCLK1
Genetic Testing Registry CLK1
NextProtP49759 [Medical]
GENETestsCLK1
Target ValidationCLK1
Huge Navigator CLK1 [HugePedia]
ClinGenCLK1
Clinical trials, drugs, therapy
MyCancerGenomeCLK1
Protein Interactions : CTDCLK1
Pharm GKB GenePA26594
PharosP49759
Clinical trialCLK1
Miscellaneous
canSAR (ICR)CLK1
HarmonizomeCLK1
DataMed IndexCLK1
Probes
Litterature
PubMed58 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCLK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:04:21 CEST 2021

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