CLK1 (CDC like kinase 1)

2006-10-01  

Identity

HGNC
LOCATION
2q33.1
LOCUSID
ALIAS
CLK,CLK/STY,STY
FUSION GENES

Other Information

Locus ID:

NCBI: 1195
MIM: 601951
HGNC: 2068
Ensembl: ENSG00000013441

Variants:

dbSNP: 1195
ClinVar: 1195
TCGA: ENSG00000013441
COSMIC: CLK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000013441ENST00000321356P49759
ENSG00000013441ENST00000409403F8WBF5
ENSG00000013441ENST00000409769B8ZZR0
ENSG00000013441ENST00000432425P49759
ENSG00000013441ENST00000434813P49759
ENSG00000013441ENST00000621181A0A087WVK0

Expression (GTEx)

0
50
100
150
200
250
300
350

Pathways

PathwaySourceExternal ID
LegionellosisKEGGko05134
LegionellosisKEGGhsa05134

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
162237272005Mass spectrometric and kinetic analysis of ASF/SF2 phosphorylation by SRPK1 and Clk/Sty.41
127735582003Regulation and substrate specificity of the SR protein kinase Clk/Sty.28
237073822013Partitioning RS domain phosphorylation in an SR protein through the CLK and SRPK protein kinases.28
259615052015A nuclear role for the respiratory enzyme CLK-1 in regulating mitochondrial stress responses and longevity.23
191684422009Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells.21
216828872011Differential effect of CLK SR Kinases on HIV-1 gene expression: potential novel targets for therapy.21
270151102016An extensive program of periodic alternative splicing linked to cell cycle progression.19
273976832016Release of SR Proteins from CLK1 by SRPK1: A Symbiotic Kinase System for Phosphorylation Control of Pre-mRNA Splicing.16
248699192014N-terminus of the protein kinase CLK1 induces SR protein hyperphosphorylation.14
255290262015Conserved proline-directed phosphorylation regulates SR protein conformation and splicing function.10

Citation

Dessen P

CLK1 (CDC like kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43215/clk1