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CLK1 (CDC like kinase 1)

Identity

Alias_namesCDC-like kinase 1
Other aliasCLK
CLK/STY
STY
HGNC (Hugo) CLK1
LocusID (NCBI) 1195
Atlas_Id 43215
Location 2q33.1  [Link to chromosome band 2q33]
Location_base_pair Starts at 200853009 and ends at 200864561 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ANAPC1 (2q13) / CLK1 (2q33.1)CLK1 (2q33.1) / PAPPA (9q33.1)PPIL3 (2q33.1) / CLK1 (2q33.1)
S100A4 (1q21.3) / CLK1 (2q33.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CLK1   2068
Cards
Entrez_Gene (NCBI)CLK1  1195  CDC like kinase 1
AliasesCLK; CLK/STY; STY
GeneCards (Weizmann)CLK1
Ensembl hg19 (Hinxton)ENSG00000013441 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000013441 [Gene_View]  chr2:200853009-200864561 [Contig_View]  CLK1 [Vega]
ICGC DataPortalENSG00000013441
TCGA cBioPortalCLK1
AceView (NCBI)CLK1
Genatlas (Paris)CLK1
WikiGenes1195
SOURCE (Princeton)CLK1
Genetics Home Reference (NIH)CLK1
Genomic and cartography
GoldenPath hg38 (UCSC)CLK1  -     chr2:200853009-200864561 -  2q33.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CLK1  -     2q33.1   [Description]    (hg19-Feb_2009)
EnsemblCLK1 - 2q33.1 [CytoView hg19]  CLK1 - 2q33.1 [CytoView hg38]
Mapping of homologs : NCBICLK1 [Mapview hg19]  CLK1 [Mapview hg38]
OMIM601951   
Gene and transcription
Genbank (Entrez)AI251890 AK025306 AK289365 AK294295 AK307301
RefSeq transcript (Entrez)NM_001024646 NM_001162407 NM_004071
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CLK1
Cluster EST : UnigeneHs.433732 [ NCBI ]
CGAP (NCI)Hs.433732
Alternative Splicing GalleryENSG00000013441
Gene ExpressionCLK1 [ NCBI-GEO ]   CLK1 [ EBI - ARRAY_EXPRESS ]   CLK1 [ SEEK ]   CLK1 [ MEM ]
Gene Expression Viewer (FireBrowse)CLK1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1195
GTEX Portal (Tissue expression)CLK1
Human Protein AtlasENSG00000013441-CLK1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49759   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP49759  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49759
Splice isoforms : SwissVarP49759
Catalytic activity : Enzyme2.7.12.1 [ Enzyme-Expasy ]   2.7.12.12.7.12.1 [ IntEnz-EBI ]   2.7.12.1 [ BRENDA ]   2.7.12.1 [ KEGG ]   
PhosPhoSitePlusP49759
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)CLK1
DMDM Disease mutations1195
Blocks (Seattle)CLK1
PDB (SRS)1Z57    2VAG    5J1V    5J1W   
PDB (PDBSum)1Z57    2VAG    5J1V    5J1W   
PDB (IMB)1Z57    2VAG    5J1V    5J1W   
PDB (RSDB)1Z57    2VAG    5J1V    5J1W   
Structural Biology KnowledgeBase1Z57    2VAG    5J1V    5J1W   
SCOP (Structural Classification of Proteins)1Z57    2VAG    5J1V    5J1W   
CATH (Classification of proteins structures)1Z57    2VAG    5J1V    5J1W   
SuperfamilyP49759
Human Protein Atlas [tissue]ENSG00000013441-CLK1 [tissue]
Peptide AtlasP49759
HPRD09058
IPIIPI00028061   IPI00966856   IPI00936499   IPI00916159   IPI00915761   
Protein Interaction databases
DIP (DOE-UCLA)P49759
IntAct (EBI)P49759
FunCoupENSG00000013441
BioGRIDCLK1
STRING (EMBL)CLK1
ZODIACCLK1
Ontologies - Pathways
QuickGOP49759
Ontology : AmiGOprotein serine/threonine kinase activity  protein serine/threonine/tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cell proliferation  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  peptidyl-tyrosine phosphorylation  regulation of RNA splicing  protein autophosphorylation  
Ontology : EGO-EBIprotein serine/threonine kinase activity  protein serine/threonine/tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cell proliferation  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  peptidyl-tyrosine phosphorylation  regulation of RNA splicing  protein autophosphorylation  
Pathways : KEGGLegionellosis   
NDEx NetworkCLK1
Atlas of Cancer Signalling NetworkCLK1
Wikipedia pathwaysCLK1
Orthology - Evolution
OrthoDB1195
GeneTree (enSembl)ENSG00000013441
Phylogenetic Trees/Animal Genes : TreeFamCLK1
HOVERGENP49759
HOGENOMP49759
Homologs : HomoloGeneCLK1
Homology/Alignments : Family Browser (UCSC)CLK1
Gene fusions - Rearrangements
Tumor Fusion PortalCLK1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCLK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CLK1
dbVarCLK1
ClinVarCLK1
1000_GenomesCLK1 
Exome Variant ServerCLK1
ExAC (Exome Aggregation Consortium)ENSG00000013441
GNOMAD BrowserENSG00000013441
Genetic variants : HAPMAP1195
Genomic Variants (DGV)CLK1 [DGVbeta]
DECIPHERCLK1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCLK1 
Mutations
ICGC Data PortalCLK1 
TCGA Data PortalCLK1 
Broad Tumor PortalCLK1
OASIS PortalCLK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCLK1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCLK1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CLK1
DgiDB (Drug Gene Interaction Database)CLK1
DoCM (Curated mutations)CLK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CLK1 (select a term)
intoGenCLK1
Cancer3DCLK1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601951   
Orphanet
DisGeNETCLK1
MedgenCLK1
Genetic Testing Registry CLK1
NextProtP49759 [Medical]
TSGene1195
GENETestsCLK1
Target ValidationCLK1
Huge Navigator CLK1 [HugePedia]
snp3D : Map Gene to Disease1195
BioCentury BCIQCLK1
ClinGenCLK1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1195
Chemical/Pharm GKB GenePA26594
Clinical trialCLK1
Miscellaneous
canSAR (ICR)CLK1 (select the gene name)
Probes
Litterature
PubMed44 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCLK1
EVEXCLK1
GoPubMedCLK1
iHOPCLK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:08:06 CET 2017

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