Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CNKSR1 (connector enhancer of kinase suppressor of Ras 1)

Identity

Alias_symbol (synonym)CNK1
KSR
CNK
Other alias
HGNC (Hugo) CNKSR1
LocusID (NCBI) 10256
Atlas_Id 46650
Location 1p36.11  [Link to chromosome band 1p36]
Location_base_pair Starts at 26177490 and ends at 26189884 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CNKSR1 (1p36.11) / CNKSR1 (1p36.11)CNKSR1 (1p36.11) / MAN1C1 (1p36.11)CNKSR1 1p36.11 / MAN1C1 1p36.11

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CNKSR1   19700
Cards
Entrez_Gene (NCBI)CNKSR1  10256  connector enhancer of kinase suppressor of Ras 1
AliasesCNK; CNK1
GeneCards (Weizmann)CNKSR1
Ensembl hg19 (Hinxton)ENSG00000142675 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000142675 [Gene_View]  chr1:26177490-26189884 [Contig_View]  CNKSR1 [Vega]
ICGC DataPortalENSG00000142675
TCGA cBioPortalCNKSR1
AceView (NCBI)CNKSR1
Genatlas (Paris)CNKSR1
WikiGenes10256
SOURCE (Princeton)CNKSR1
Genetics Home Reference (NIH)CNKSR1
Genomic and cartography
GoldenPath hg38 (UCSC)CNKSR1  -     chr1:26177490-26189884 +  1p36.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CNKSR1  -     1p36.11   [Description]    (hg19-Feb_2009)
EnsemblCNKSR1 - 1p36.11 [CytoView hg19]  CNKSR1 - 1p36.11 [CytoView hg38]
Mapping of homologs : NCBICNKSR1 [Mapview hg19]  CNKSR1 [Mapview hg38]
OMIM603272   
Gene and transcription
Genbank (Entrez)AB209335 AF100153 AK001900 AK222817 AK222904
RefSeq transcript (Entrez)NM_001297647 NM_001297648 NM_006314
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CNKSR1
Cluster EST : UnigeneHs.16232 [ NCBI ]
CGAP (NCI)Hs.16232
Alternative Splicing GalleryENSG00000142675
Gene ExpressionCNKSR1 [ NCBI-GEO ]   CNKSR1 [ EBI - ARRAY_EXPRESS ]   CNKSR1 [ SEEK ]   CNKSR1 [ MEM ]
Gene Expression Viewer (FireBrowse)CNKSR1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10256
GTEX Portal (Tissue expression)CNKSR1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ969H4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ969H4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ969H4
Splice isoforms : SwissVarQ969H4
PhosPhoSitePlusQ969H4
Domaine pattern : Prosite (Expaxy)CRIC (PS51290)    PDZ (PS50106)    PH_DOMAIN (PS50003)    SAM_DOMAIN (PS50105)   
Domains : Interpro (EBI)CRIC_domain    PDZ    PH_dom-like    PH_domain    SAM    SAM/pointed   
Domain families : Pfam (Sanger)CRIC_ras_sig (PF10534)    PH (PF00169)    SAM_1 (PF00536)   
Domain families : Pfam (NCBI)pfam10534    pfam00169    pfam00536   
Domain families : Smart (EMBL)PH (SM00233)  SAM (SM00454)  
Conserved Domain (NCBI)CNKSR1
DMDM Disease mutations10256
Blocks (Seattle)CNKSR1
PDB (SRS)1WWV   
PDB (PDBSum)1WWV   
PDB (IMB)1WWV   
PDB (RSDB)1WWV   
Structural Biology KnowledgeBase1WWV   
SCOP (Structural Classification of Proteins)1WWV   
CATH (Classification of proteins structures)1WWV   
SuperfamilyQ969H4
Human Protein AtlasENSG00000142675
Peptide AtlasQ969H4
IPIIPI00299824   IPI00451417   IPI00910061   IPI00984646   IPI00975875   IPI00985210   IPI00909109   IPI00976460   
Protein Interaction databases
DIP (DOE-UCLA)Q969H4
IntAct (EBI)Q969H4
FunCoupENSG00000142675
BioGRIDCNKSR1
STRING (EMBL)CNKSR1
ZODIACCNKSR1
Ontologies - Pathways
QuickGOQ969H4
Ontology : AmiGOprotein binding  plasma membrane  cell-cell junction  cell cortex  transmembrane receptor protein tyrosine kinase signaling pathway  Ras protein signal transduction  Rho protein signal transduction  protein binding, bridging  
Ontology : EGO-EBIprotein binding  plasma membrane  cell-cell junction  cell cortex  transmembrane receptor protein tyrosine kinase signaling pathway  Ras protein signal transduction  Rho protein signal transduction  protein binding, bridging  
NDEx NetworkCNKSR1
Atlas of Cancer Signalling NetworkCNKSR1
Wikipedia pathwaysCNKSR1
Orthology - Evolution
OrthoDB10256
GeneTree (enSembl)ENSG00000142675
Phylogenetic Trees/Animal Genes : TreeFamCNKSR1
HOVERGENQ969H4
HOGENOMQ969H4
Homologs : HomoloGeneCNKSR1
Homology/Alignments : Family Browser (UCSC)CNKSR1
Gene fusions - Rearrangements
Fusion : MitelmanCNKSR1/MAN1C1 [1p36.11/1p36.11]  
Fusion: TCGACNKSR1 1p36.11 MAN1C1 1p36.11 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCNKSR1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CNKSR1
dbVarCNKSR1
ClinVarCNKSR1
1000_GenomesCNKSR1 
Exome Variant ServerCNKSR1
ExAC (Exome Aggregation Consortium)CNKSR1 (select the gene name)
Genetic variants : HAPMAP10256
Genomic Variants (DGV)CNKSR1 [DGVbeta]
DECIPHERCNKSR1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCNKSR1 
Mutations
ICGC Data PortalCNKSR1 
TCGA Data PortalCNKSR1 
Broad Tumor PortalCNKSR1
OASIS PortalCNKSR1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCNKSR1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCNKSR1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CNKSR1
DgiDB (Drug Gene Interaction Database)CNKSR1
DoCM (Curated mutations)CNKSR1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CNKSR1 (select a term)
intoGenCNKSR1
Cancer3DCNKSR1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603272   
Orphanet
MedgenCNKSR1
Genetic Testing Registry CNKSR1
NextProtQ969H4 [Medical]
TSGene10256
GENETestsCNKSR1
Target ValidationCNKSR1
Huge Navigator CNKSR1 [HugePedia]
snp3D : Map Gene to Disease10256
BioCentury BCIQCNKSR1
ClinGenCNKSR1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10256
Chemical/Pharm GKB GenePA134901167
Clinical trialCNKSR1
Miscellaneous
canSAR (ICR)CNKSR1 (select the gene name)
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCNKSR1
EVEXCNKSR1
GoPubMedCNKSR1
iHOPCNKSR1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:28:56 CEST 2017

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