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CNR1 (cannabinoid receptor 1 (brain))

Identity

Other namesCANN6
CB-R
CB1
CB1A
CB1K5
CB1R
CNR
HGNC (Hugo) CNR1
LocusID (NCBI) 1268
Location 6q15
Location_base_pair Starts at 88849585 and ends at 88875767 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)CNR1   2159
Cards
Entrez_Gene (NCBI)CNR1  1268  cannabinoid receptor 1 (brain)
GeneCards (Weizmann)CNR1
Ensembl (Hinxton)ENSG00000118432 [Gene_View]  chr6:88849585-88875767 [Contig_View]  CNR1 [Vega]
ICGC DataPortalENSG00000118432
cBioPortalCNR1
AceView (NCBI)CNR1
Genatlas (Paris)CNR1
WikiGenes1268
SOURCE (Princeton)NM_001160226 NM_001160258 NM_001160259 NM_001160260 NM_016083 NM_033181
Genomic and cartography
GoldenPath (UCSC)CNR1  -  6q15   chr6:88849585-88875767 -  6q15   [Description]    (hg19-Feb_2009)
EnsemblCNR1 - 6q15 [CytoView]
Mapping of homologs : NCBICNR1 [Mapview]
OMIM114610   
Gene and transcription
Genbank (Entrez)AF107262 AK313908 AY766182 AY995204 BC074811
RefSeq transcript (Entrez)NM_001160226 NM_001160258 NM_001160259 NM_001160260 NM_016083 NM_033181
RefSeq genomic (Entrez)AC_000138 NC_000006 NC_018917 NT_025741 NW_001838987 NW_004929327
Consensus coding sequences : CCDS (NCBI)CNR1
Cluster EST : UnigeneHs.75110 [ NCBI ]
CGAP (NCI)Hs.75110
Alternative Splicing : Fast-db (Paris)GSHG0033446
Alternative Splicing GalleryENSG00000118432
Gene ExpressionCNR1 [ NCBI-GEO ]     CNR1 [ SEEK ]   CNR1 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP21554 (Uniprot)
NextProtP21554  [Medical]
With graphics : InterProP21554
Splice isoforms : SwissVarP21554 (Swissvar)
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)Canbinoid_rcpt_1 [organisation]   Cnbnoid_rcpt [organisation]   GPCR_Rhodpsn [organisation]   GPCR_Rhodpsn_7TM [organisation]  
Related proteins : CluSTrP21554
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
DMDM Disease mutations1268
Blocks (Seattle)P21554
PDB (SRS)1LVQ    1LVR    2B0Y    2KOE   
PDB (PDBSum)1LVQ    1LVR    2B0Y    2KOE   
PDB (IMB)1LVQ    1LVR    2B0Y    2KOE   
PDB (RSDB)1LVQ    1LVR    2B0Y    2KOE   
Human Protein AtlasENSG00000118432 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP21554
HPRD00259
IPIIPI00009396   IPI00215993   IPI00655874   IPI01018356   IPI00985031   
Protein Interaction databases
DIP (DOE-UCLA)P21554
IntAct (EBI)P21554
FunCoupENSG00000118432
BioGRIDCNR1
InParanoidP21554
Interologous Interaction database P21554
IntegromeDBCNR1
STRING (EMBL)CNR1
Ontologies - Pathways
Ontology : AmiGOpositive regulation of acute inflammatory response to antigenic stimulus  cannabinoid receptor activity  plasma membrane  integral component of plasma membrane  G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  adenylate cyclase-modulating G-protein coupled receptor signaling pathway  spermatogenesis  aging  response to nutrient  memory  drug binding  positive regulation of neuron projection development  sensory perception of pain  positive regulation of fever generation  negative regulation of fatty acid beta-oxidation  regulation of synaptic transmission, GABAergic  response to lipopolysaccharide  negative regulation of mast cell activation  negative regulation of dopamine secretion  response to nicotine  cannabinoid signaling pathway  response to cocaine  positive regulation of apoptotic process  response to morphine  response to ethanol  negative regulation of action potential  negative regulation of blood pressure  positive regulation of blood pressure  regulation of insulin secretion  negative regulation of nitric-oxide synthase activity  regulation of synaptic transmission, glutamatergic  maternal process involved in female pregnancy  regulation of feeding behavior  regulation of penile erection  
Ontology : EGO-EBIpositive regulation of acute inflammatory response to antigenic stimulus  cannabinoid receptor activity  plasma membrane  integral component of plasma membrane  G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  adenylate cyclase-modulating G-protein coupled receptor signaling pathway  spermatogenesis  aging  response to nutrient  memory  drug binding  positive regulation of neuron projection development  sensory perception of pain  positive regulation of fever generation  negative regulation of fatty acid beta-oxidation  regulation of synaptic transmission, GABAergic  response to lipopolysaccharide  negative regulation of mast cell activation  negative regulation of dopamine secretion  response to nicotine  cannabinoid signaling pathway  response to cocaine  positive regulation of apoptotic process  response to morphine  response to ethanol  negative regulation of action potential  negative regulation of blood pressure  positive regulation of blood pressure  regulation of insulin secretion  negative regulation of nitric-oxide synthase activity  regulation of synaptic transmission, glutamatergic  maternal process involved in female pregnancy  regulation of feeding behavior  regulation of penile erection  
Pathways : BIOCARTAMetabolism of Anandamide, an Endogenous Cannabinoid [Genes]   
Pathways : KEGGRap1 signaling pathway    Neuroactive ligand-receptor interaction    Retrograde endocannabinoid signaling   
Protein Interaction DatabaseCNR1
Wikipedia pathwaysCNR1
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)CNR1
snp3D : Map Gene to Disease1268
SNP (GeneSNP Utah)CNR1
SNP : HGBaseCNR1
Genetic variants : HAPMAPCNR1
Exome VariantCNR1
1000_GenomesCNR1 
ICGC programENSG00000118432 
Somatic Mutations in Cancer : COSMICCNR1 
CONAN: Copy Number AnalysisCNR1 
Mutations and Diseases : HGMDCNR1
Mutations and Diseases : intOGenCNR1
Genomic VariantsCNR1  CNR1 [DGVbeta]
dbVarCNR1
ClinVarCNR1
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM114610   
MedgenCNR1
GENETestsCNR1
Disease Genetic AssociationCNR1
Huge Navigator CNR1 [HugePedia]  CNR1 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneCNR1
Homology/Alignments : Family Browser (UCSC)CNR1
Phylogenetic Trees/Animal Genes : TreeFamCNR1
Chemical/Protein Interactions : CTD1268
Chemical/Pharm GKB GenePA26681
Clinical trialCNR1
Cancer Resource (Charite)ENSG00000118432
Other databases
Probes
Litterature
PubMed338 Pubmed reference(s) in Entrez
CoreMineCNR1
iHOPCNR1
OncoSearchCNR1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 26 16:42:43 CEST 2014

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