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COX10 (COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor)

Identity

Other names-
HGNC (Hugo) COX10
LocusID (NCBI) 1352
Atlas_Id 47082
Location 17p12
Location_base_pair Starts at 13972719 and ends at 14111996 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)COX10   2260
Cards
Entrez_Gene (NCBI)COX10  1352  COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor
GeneCards (Weizmann)COX10
Ensembl hg19 (Hinxton)ENSG00000006695 [Gene_View]  chr17:13972719-14111996 [Contig_View]  COX10 [Vega]
Ensembl hg38 (Hinxton)ENSG00000006695 [Gene_View]  chr17:13972719-14111996 [Contig_View]  COX10 [Vega]
ICGC DataPortalENSG00000006695
TCGA cBioPortalCOX10
AceView (NCBI)COX10
Genatlas (Paris)COX10
WikiGenes1352
SOURCE (Princeton)COX10
Genomic and cartography
GoldenPath hg19 (UCSC)COX10  -     chr17:13972719-14111996 +  17p12   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)COX10  -     17p12   [Description]    (hg38-Dec_2013)
EnsemblCOX10 - 17p12 [CytoView hg19]  COX10 - 17p12 [CytoView hg38]
Mapping of homologs : NCBICOX10 [Mapview hg19]  COX10 [Mapview hg38]
OMIM220110   256000   602125   
Gene and transcription
Genbank (Entrez)AK294213 AK295925 AK312718 BC000060 BC006394
RefSeq transcript (Entrez)NM_001303
RefSeq genomic (Entrez)NC_000017 NC_018928 NG_008034 NT_010718 NW_004929405
Consensus coding sequences : CCDS (NCBI)COX10
Cluster EST : UnigeneHs.462278 [ NCBI ]
CGAP (NCI)Hs.462278
Alternative Splicing : Fast-db (Paris)GSHG0012241
Alternative Splicing GalleryENSG00000006695
Gene ExpressionCOX10 [ NCBI-GEO ]     COX10 [ SEEK ]   COX10 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ12887 (Uniprot)
NextProtQ12887  [Medical]
With graphics : InterProQ12887
Splice isoforms : SwissVarQ12887 (Swissvar)
Catalytic activity : Enzyme2.5.1.- [ Enzyme-Expasy ]   2.5.1.-2.5.1.- [ IntEnz-EBI ]   2.5.1.- [ BRENDA ]   2.5.1.- [ KEGG ]   
Domaine pattern : Prosite (Expaxy)UBIA (PS00943)   
Domains : Interpro (EBI)Protohaem_IX_farnesylTrfase    Protohaem_IX_farnesylTrfase_mt    UbiA_prenyltransferase   
Related proteins : CluSTrQ12887
Domain families : Pfam (Sanger)UbiA (PF01040)   
Domain families : Pfam (NCBI)pfam01040   
DMDM Disease mutations1352
Blocks (Seattle)Q12887
Human Protein AtlasENSG00000006695
Peptide AtlasQ12887
HPRD03673
IPIIPI00290099   IPI01009495   IPI01010758   IPI00795355   
Protein Interaction databases
DIP (DOE-UCLA)Q12887
IntAct (EBI)Q12887
FunCoupENSG00000006695
BioGRIDCOX10
IntegromeDBCOX10
STRING (EMBL)COX10
Ontologies - Pathways
QuickGOQ12887
Ontology : AmiGOmitochondrial fission  cytochrome-c oxidase activity  farnesyltranstransferase activity  mitochondrion  mitochondrial inner membrane  mitochondrial electron transport, cytochrome c to oxygen  porphyrin-containing compound metabolic process  heme biosynthetic process  heme a biosynthetic process  protoheme IX farnesyltransferase activity  respiratory chain complex IV assembly  aerobic respiration  integral component of membrane  small molecule metabolic process  cellular respiration  heme O biosynthetic process  cytochrome complex  hydrogen ion transmembrane transport  
Ontology : EGO-EBImitochondrial fission  cytochrome-c oxidase activity  farnesyltranstransferase activity  mitochondrion  mitochondrial inner membrane  mitochondrial electron transport, cytochrome c to oxygen  porphyrin-containing compound metabolic process  heme biosynthetic process  heme a biosynthetic process  protoheme IX farnesyltransferase activity  respiratory chain complex IV assembly  aerobic respiration  integral component of membrane  small molecule metabolic process  cellular respiration  heme O biosynthetic process  cytochrome complex  hydrogen ion transmembrane transport  
Pathways : KEGGOxidative phosphorylation    Porphyrin and chlorophyll metabolism   
Protein Interaction DatabaseCOX10
DoCM (Curated mutations)COX10
Wikipedia pathwaysCOX10
Gene fusion - Rearrangements
Gene fusion: TCGA
Polymorphisms : SNP, variants
NCBI Variation ViewerCOX10 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)COX10
dbVarCOX10
ClinVarCOX10
1000_GenomesCOX10 
Exome Variant ServerCOX10
SNP (GeneSNP Utah)COX10
SNP : HGBaseCOX10
Genetic variants : HAPMAPCOX10
Genomic Variants (DGV)COX10 [DGVbeta]
Mutations
ICGC Data PortalCOX10 
TCGA Data PortalCOX10 
Tumor PortalCOX10
Somatic Mutations in Cancer : COSMICCOX10 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)17:13972719-14111996
CONAN: Copy Number AnalysisCOX10 
Mutations and Diseases : HGMDCOX10
OMIM220110    256000    602125   
MedgenCOX10
NextProtQ12887 [Medical]
GENETestsCOX10
Disease Genetic AssociationCOX10
Huge Navigator COX10 [HugePedia]  COX10 [HugeCancerGEM]
snp3D : Map Gene to Disease1352
DGIdb (Drug Gene Interaction db)COX10
General knowledge
Homologs : HomoloGeneCOX10
Homology/Alignments : Family Browser (UCSC)COX10
Phylogenetic Trees/Animal Genes : TreeFamCOX10
Chemical/Protein Interactions : CTD1352
Chemical/Pharm GKB GenePA26776
Clinical trialCOX10
Cancer Resource (Charite)ENSG00000006695
Other databases
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
CoreMineCOX10
GoPubMedCOX10
iHOPCOX10
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Apr 13 14:14:53 CEST 2015

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