CR2 (complement C3d receptor 2)

2009-08-01  

Identity

HGNC
LOCATION
1q32.2
LOCUSID
ALIAS
C3DR,CD21,CR,CVID7,SLEB9
FUSION GENES

Other Information

Locus ID:

NCBI: 1380
MIM: 120650
HGNC: 2336
Ensembl: ENSG00000117322

Variants:

dbSNP: 1380
ClinVar: 1380
TCGA: ENSG00000117322
COSMIC: CR2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000117322ENST00000367057P20023
ENSG00000117322ENST00000367058P20023
ENSG00000117322ENST00000367059Q5SR47
ENSG00000117322ENST00000640301A0A1W2PPV2

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Complement and coagulation cascadesKEGGko04610
Hematopoietic cell lineageKEGGko04640
B cell receptor signaling pathwayKEGGko04662
Complement and coagulation cascadesKEGGhsa04610
Hematopoietic cell lineageKEGGhsa04640
B cell receptor signaling pathwayKEGGhsa04662
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
196665052009Circulating CD21low B cells in common variable immunodeficiency resemble tissue homing, innate-like B cells.88
188422942008Association between the SERPING1 gene and age-related macular degeneration: a two-stage case-control study.65
211068522011Exosomes containing glycoprotein 350 released by EBV-transformed B cells selectively target B cells through CD21 and block EBV infection in vitro.48
128130232003Complement receptor 2-mediated targeting of complement inhibitors to sites of complement activation.47
232798832013Expansion of autoreactive unresponsive CD21-/low B cells in Sjögren's syndrome-associated lymphoproliferation.45
215277152011A crystal structure of the complex between human complement receptor 2 and its ligand C3d.36
220844332011Expansion of functionally anergic CD21-/low marginal zone-like B cell clones in hepatitis C virus infection-related autoimmunity.33
89962521997Follicular dendritic cells specifically express the long CR2/CD21 isoform.29
167855342006Characterization of human complement receptor type 2 (CR2/CD21) as a receptor for IFN-alpha: a potential role in systemic lupus erythematosus.28
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27

Citation

Dessen P

CR2 (complement C3d receptor 2)

Atlas Genet Cytogenet Oncol Haematol. 2009-08-01

Online version: http://atlasgeneticsoncology.org/gene/51049/cr2