Atlas of Genetics and Cytogenetics in Oncology and Haematology

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CR2 (complement C3d receptor 2)

Identity

Alias_namescomplement component (3d/Epstein Barr virus) receptor 2
complement component 3d receptor 2
Alias_symbol (synonym)CD21
C3DR
Other aliasCR
CVID7
SLEB9
HGNC (Hugo) CR2
LocusID (NCBI) 1380
Atlas_Id 51049
Location 1q32.2  [Link to chromosome band 1q32]
Location_base_pair Starts at 207454300 and ends at 207489895 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DUSP12 (1q23.3) / CR2 (1q32.2)TESK2 (1p34.1) / CR2 (1q32.2)DUSP12 1q23.3 / CR2 1q32.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;1)(q23;q32) DUSP12/CR2

External links

Nomenclature
HGNC (Hugo)CR2   2336
LRG (Locus Reference Genomic)LRG_348
Cards
Entrez_Gene (NCBI)CR2  1380  complement C3d receptor 2
AliasesC3DR; CD21; CR; CVID7; 
SLEB9
GeneCards (Weizmann)CR2
Ensembl hg19 (Hinxton)ENSG00000117322 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000117322 [Gene_View]  ENSG00000117322 [Sequence]  chr1:207454300-207489895 [Contig_View]  CR2 [Vega]
ICGC DataPortalENSG00000117322
TCGA cBioPortalCR2
AceView (NCBI)CR2
Genatlas (Paris)CR2
WikiGenes1380
SOURCE (Princeton)CR2
Genetics Home Reference (NIH)CR2
Genomic and cartography
GoldenPath hg38 (UCSC)CR2  -     chr1:207454300-207489895 +  1q32.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CR2  -     1q32.2   [Description]    (hg19-Feb_2009)
GoldenPathCR2 - 1q32.2 [CytoView hg19]  CR2 - 1q32.2 [CytoView hg38]
ImmunoBaseENSG00000117322
Mapping of homologs : NCBICR2 [Mapview hg19]  CR2 [Mapview hg38]
OMIM120650   240500   610927   614699   
Gene and transcription
Genbank (Entrez)AI765035 AK223627 AK301496 AU133057 AW303499
RefSeq transcript (Entrez)NM_001006658 NM_001877
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CR2
Cluster EST : UnigeneHs.445757 [ NCBI ]
CGAP (NCI)Hs.445757
Alternative Splicing GalleryENSG00000117322
Gene ExpressionCR2 [ NCBI-GEO ]   CR2 [ EBI - ARRAY_EXPRESS ]   CR2 [ SEEK ]   CR2 [ MEM ]
Gene Expression Viewer (FireBrowse)CR2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1380
GTEX Portal (Tissue expression)CR2
Human Protein AtlasENSG00000117322-CR2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP20023   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP20023  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP20023
Splice isoforms : SwissVarP20023
PhosPhoSitePlusP20023
Domaine pattern : Prosite (Expaxy)SUSHI (PS50923)   
Domains : Interpro (EBI)Sushi/SCR/CCP_sf    Sushi_SCR_CCP_dom   
Domain families : Pfam (Sanger)Sushi (PF00084)   
Domain families : Pfam (NCBI)pfam00084   
Domain families : Smart (EMBL)CCP (SM00032)  
Conserved Domain (NCBI)CR2
DMDM Disease mutations1380
Blocks (Seattle)CR2
PDB (RSDB)1GHQ    1LY2    1W2R    1W2S    2ATY    2GSX    3OED   
PDB Europe1GHQ    1LY2    1W2R    1W2S    2ATY    2GSX    3OED   
PDB (PDBSum)1GHQ    1LY2    1W2R    1W2S    2ATY    2GSX    3OED   
PDB (IMB)1GHQ    1LY2    1W2R    1W2S    2ATY    2GSX    3OED   
Structural Biology KnowledgeBase1GHQ    1LY2    1W2R    1W2S    2ATY    2GSX    3OED   
SCOP (Structural Classification of Proteins)1GHQ    1LY2    1W2R    1W2S    2ATY    2GSX    3OED   
CATH (Classification of proteins structures)1GHQ    1LY2    1W2R    1W2S    2ATY    2GSX    3OED   
SuperfamilyP20023
Human Protein Atlas [tissue]ENSG00000117322-CR2 [tissue]
Peptide AtlasP20023
HPRD00399
IPIIPI00292859   IPI00216985   IPI00216986   IPI00216987   IPI00953263   IPI00844261   
Protein Interaction databases
DIP (DOE-UCLA)P20023
IntAct (EBI)P20023
FunCoupENSG00000117322
BioGRIDCR2
STRING (EMBL)CR2
ZODIACCR2
Ontologies - Pathways
QuickGOP20023
Ontology : AmiGOvirus receptor activity  complement binding  complement receptor mediated signaling pathway  DNA binding  complement receptor activity  transmembrane signaling receptor activity  protein binding  plasma membrane  immune response  complement activation, classical pathway  integral component of membrane  B cell differentiation  regulation of complement activation  B cell proliferation  protein homodimerization activity  receptor complex  innate immune response  viral entry into host cell  extracellular exosome  
Ontology : EGO-EBIvirus receptor activity  complement binding  complement receptor mediated signaling pathway  DNA binding  complement receptor activity  transmembrane signaling receptor activity  protein binding  plasma membrane  immune response  complement activation, classical pathway  integral component of membrane  B cell differentiation  regulation of complement activation  B cell proliferation  protein homodimerization activity  receptor complex  innate immune response  viral entry into host cell  extracellular exosome  
Pathways : KEGGComplement and coagulation cascades    Hematopoietic cell lineage    B cell receptor signaling pathway    Epstein-Barr virus infection   
NDEx NetworkCR2
Atlas of Cancer Signalling NetworkCR2
Wikipedia pathwaysCR2
Orthology - Evolution
OrthoDB1380
GeneTree (enSembl)ENSG00000117322
Phylogenetic Trees/Animal Genes : TreeFamCR2
HOGENOMP20023
Homologs : HomoloGeneCR2
Homology/Alignments : Family Browser (UCSC)CR2
Gene fusions - Rearrangements
Fusion : MitelmanDUSP12/CR2 [1q23.3/1q32.2]  [t(1;1)(q23;q32)]  
Fusion PortalDUSP12 1q23.3 CR2 1q32.2 LUSC
Fusion : QuiverCR2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCR2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CR2
dbVarCR2
ClinVarCR2
1000_GenomesCR2 
Exome Variant ServerCR2
ExAC (Exome Aggregation Consortium)ENSG00000117322
GNOMAD BrowserENSG00000117322
Varsome BrowserCR2
Genetic variants : HAPMAP1380
Genomic Variants (DGV)CR2 [DGVbeta]
DECIPHERCR2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCR2 
Mutations
ICGC Data PortalCR2 
TCGA Data PortalCR2 
Broad Tumor PortalCR2
OASIS PortalCR2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCR2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCR2
Mutations and Diseases : HGMDCR2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
BioMutasearch CR2
DgiDB (Drug Gene Interaction Database)CR2
DoCM (Curated mutations)CR2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CR2 (select a term)
intoGenCR2
Cancer3DCR2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM120650    240500    610927    614699   
Orphanet3469   
DisGeNETCR2
MedgenCR2
Genetic Testing Registry CR2
NextProtP20023 [Medical]
TSGene1380
GENETestsCR2
Target ValidationCR2
Huge Navigator CR2 [HugePedia]
snp3D : Map Gene to Disease1380
BioCentury BCIQCR2
ClinGenCR2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1380
Chemical/Pharm GKB GenePA26857
Clinical trialCR2
Miscellaneous
canSAR (ICR)CR2 (select the gene name)
DataMed IndexCR2
Probes
Litterature
PubMed132 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCR2
EVEXCR2
GoPubMedCR2
iHOPCR2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 17:38:36 CET 2019
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