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CSH1 (chorionic somatomammotropin hormone 1)

Identity

Alias (NCBI)CS-1
CSA
CSMT
GHB3
PL
hCS-1
hCS-A
HGNC (Hugo) CSH1
HGNC Alias symbhCS-A
CSA
PL
CSMT
FLJ75407
HGNC Alias namechorionic somatomammotropin A
 placental lactogen
 choriomammotropin
LocusID (NCBI) 1442
Atlas_Id 50632
Location 17q23.3  [Link to chromosome band 17q23]
Location_base_pair Starts at 63894918 and ends at 63896574 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ACER2 (9p22.1)::CSH1 (17q23.3)CSH1 (17q23.3)::CALD1 (7q33)CSH1 (17q23.3)::FBXW2 (9q33.2)
CSH1 (17q23.3)::FCGR2A (1q23.3)CSH1 (17q23.3)::NFYA (6p21.1)CSH1 (17q23.3)::PAPPA (9q33.1)
CSH1 (17q23.3)::RRBP1 (20p12.1)CSH1 (17q23.3)::SVEP1 (9q31.3)FCHO2 (5q13.2)::CSH1 (17q23.3)
ISYNA1 (19p13.11)::CSH1 (17q23.3)PRRC2B (9q34.13)::CSH1 (17q23.3)SERPINB6 (6p25.2)::CSH1 (17q23.3)
SLC36A4 (11q21)::CSH1 (17q23.3)UBA52 (19p13.11)::CSH1 (17q23.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)CSH1   2440
Cards
Entrez_Gene (NCBI)CSH1    chorionic somatomammotropin hormone 1
AliasesCS-1; CSA; CSMT; GHB3; 
PL; hCS-1; hCS-A
GeneCards (Weizmann)CSH1
Ensembl hg19 (Hinxton)ENSG00000136488 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000136488 [Gene_View]  ENSG00000136488 [Sequence]  chr17:63894918-63896574 [Contig_View]  CSH1 [Vega]
ICGC DataPortalENSG00000136488
TCGA cBioPortalCSH1
AceView (NCBI)CSH1
Genatlas (Paris)CSH1
SOURCE (Princeton)CSH1
Genetics Home Reference (NIH)CSH1
Genomic and cartography
GoldenPath hg38 (UCSC)CSH1  -     chr17:63894918-63896574 -  17q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CSH1  -     17q23.3   [Description]    (hg19-Feb_2009)
GoldenPathCSH1 - 17q23.3 [CytoView hg19]  CSH1 - 17q23.3 [CytoView hg38]
ImmunoBaseENSG00000136488
Genome Data Viewer NCBICSH1 [Mapview hg19]  
OMIM150200   
Gene and transcription
Genbank (Entrez)AK291587 AU134786 BC002717 BC005921 BC020756
RefSeq transcript (Entrez)NM_001317 NM_022640 NM_022641
Consensus coding sequences : CCDS (NCBI)CSH1
Gene ExpressionCSH1 [ NCBI-GEO ]   CSH1 [ EBI - ARRAY_EXPRESS ]   CSH1 [ SEEK ]   CSH1 [ MEM ]
Gene Expression Viewer (FireBrowse)CSH1 [ Firebrowse - Broad ]
GenevisibleExpression of CSH1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1442
GTEX Portal (Tissue expression)CSH1
Human Protein AtlasENSG00000136488-CSH1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP0DML2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP0DML2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP0DML2
PhosPhoSitePlusP0DML2
Domaine pattern : Prosite (Expaxy)SOMATOTROPIN_1 (PS00266)    SOMATOTROPIN_2 (PS00338)   
Domains : Interpro (EBI)4_helix_cytokine-like_core    Somatotropin/Prolactin    Somatotropin_CS   
Domain families : Pfam (Sanger)Hormone_1 (PF00103)   
Domain families : Pfam (NCBI)pfam00103   
Conserved Domain (NCBI)CSH1
PDB (RSDB)1Z7C   
PDB Europe1Z7C   
PDB (PDBSum)1Z7C   
PDB (IMB)1Z7C   
Structural Biology KnowledgeBase1Z7C   
SCOP (Structural Classification of Proteins)1Z7C   
CATH (Classification of proteins structures)1Z7C   
SuperfamilyP0DML2
AlphaFold pdb e-kbP0DML2   
Human Protein Atlas [tissue]ENSG00000136488-CSH1 [tissue]
HPRD08350
Protein Interaction databases
DIP (DOE-UCLA)P0DML2
IntAct (EBI)P0DML2
BioGRIDCSH1
STRING (EMBL)CSH1
ZODIACCSH1
Ontologies - Pathways
QuickGOP0DML2
Ontology : AmiGOgrowth hormone receptor binding  hormone activity  protein binding  extracellular region  extracellular space  endoplasmic reticulum  growth factor activity  response to nutrient levels  endosome lumen  vesicle  positive regulation of tyrosine phosphorylation of STAT protein  positive regulation of growth  positive regulation of receptor signaling pathway via JAK-STAT  metal ion binding  animal organ development  growth hormone receptor signaling pathway  growth hormone receptor signaling pathway via JAK-STAT  
Ontology : EGO-EBIgrowth hormone receptor binding  hormone activity  protein binding  extracellular region  extracellular space  endoplasmic reticulum  growth factor activity  response to nutrient levels  endosome lumen  vesicle  positive regulation of tyrosine phosphorylation of STAT protein  positive regulation of growth  positive regulation of receptor signaling pathway via JAK-STAT  metal ion binding  animal organ development  growth hormone receptor signaling pathway  growth hormone receptor signaling pathway via JAK-STAT  
Pathways : KEGGNeuroactive ligand-receptor interaction    PI3K-Akt signaling pathway    Jak-STAT signaling pathway   
NDEx NetworkCSH1
Atlas of Cancer Signalling NetworkCSH1
Wikipedia pathwaysCSH1
Orthology - Evolution
OrthoDB1442
GeneTree (enSembl)ENSG00000136488
Phylogenetic Trees/Animal Genes : TreeFamCSH1
Homologs : HomoloGeneCSH1
Homology/Alignments : Family Browser (UCSC)CSH1
Gene fusions - Rearrangements
Fusion : QuiverCSH1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCSH1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CSH1
dbVarCSH1
ClinVarCSH1
MonarchCSH1
1000_GenomesCSH1 
Exome Variant ServerCSH1
GNOMAD BrowserENSG00000136488
Varsome BrowserCSH1
ACMGCSH1 variants
VarityP0DML2
Genomic Variants (DGV)CSH1 [DGVbeta]
DECIPHERCSH1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCSH1 
Mutations
ICGC Data PortalCSH1 
TCGA Data PortalCSH1 
Broad Tumor PortalCSH1
OASIS PortalCSH1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCSH1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCSH1
Mutations and Diseases : HGMDCSH1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCSH1
DgiDB (Drug Gene Interaction Database)CSH1
DoCM (Curated mutations)CSH1
CIViC (Clinical Interpretations of Variants in Cancer)CSH1
Cancer3DCSH1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM150200   
Orphanet
DisGeNETCSH1
MedgenCSH1
Genetic Testing Registry CSH1
NextProtP0DML2 [Medical]
GENETestsCSH1
Target ValidationCSH1
Huge Navigator CSH1 [HugePedia]
ClinGenCSH1
Clinical trials, drugs, therapy
MyCancerGenomeCSH1
Protein Interactions : CTDCSH1
Pharm GKB GenePA26943
PharosP0DML2
Clinical trialCSH1
Miscellaneous
canSAR (ICR)CSH1
HarmonizomeCSH1
ARCHS4CSH1
DataMed IndexCSH1
Probes
Litterature
PubMed88 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCSH1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Jan 17 15:20:29 CET 2022

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