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CSNK1E (casein kinase 1 epsilon)

Identity

Alias_namescasein kinase 1
Alias_symbol (synonym)HCKIE
CKIE
CKIepsilon
Other aliasCKIe
HGNC (Hugo) CSNK1E
LocusID (NCBI) 1454
Atlas_Id 40170
Location 22q13.1  [Link to chromosome band 22q13]
Location_base_pair Starts at 38290691 and ends at 38317408 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CSNK1E (22q13.1) / CSNK1E (22q13.1)CSNK1E (22q13.1) / DNAL4 (22q13.1)CSNK1E (22q13.1) / DYNLRB1 (20q11.22)
CSNK1E (22q13.1) / KDELR3 (22q13.1)CSNK1E (22q13.1) / MOB3A (19p13.3)CSNK1E (22q13.1) / SPATA21 (1p36.13)
DSE (6q22.1) / CSNK1E (22q13.1)GNAL (18p11.21) / CSNK1E (22q13.1)PLXNB2 (22q13.33) / CSNK1E (22q13.1)
CSNK1E 22q13.1 / DNAL4 22q13.1CSNK1E 22q13.1 / KDELR3 22q13.1GNAL 18p11.21 / CSNK1E 22q13.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 5 ]
  t(1;22)(p36;q13) CSNK1E/SPATA21
t(18;22)(p11;q13) GNAL/CSNK1E
t(20;22)(q11;q13) CSNK1E/DYNLRB1
CSNK1E/DNAL4 (22q13)
CSNK1E/KDELR3 (22q13)


External links

Nomenclature
HGNC (Hugo)CSNK1E   2453
Cards
Entrez_Gene (NCBI)CSNK1E  1454  casein kinase 1 epsilon
AliasesCKIe; CKIepsilon; HCKIE
GeneCards (Weizmann)CSNK1E
Ensembl hg19 (Hinxton)ENSG00000213923 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000213923 [Gene_View]  ENSG00000213923 [Sequence]  chr22:38290691-38317408 [Contig_View]  CSNK1E [Vega]
ICGC DataPortalENSG00000213923
TCGA cBioPortalCSNK1E
AceView (NCBI)CSNK1E
Genatlas (Paris)CSNK1E
WikiGenes1454
SOURCE (Princeton)CSNK1E
Genetics Home Reference (NIH)CSNK1E
Genomic and cartography
GoldenPath hg38 (UCSC)CSNK1E  -     chr22:38290691-38317408 -  22q13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CSNK1E  -     22q13.1   [Description]    (hg19-Feb_2009)
EnsemblCSNK1E - 22q13.1 [CytoView hg19]  CSNK1E - 22q13.1 [CytoView hg38]
Mapping of homologs : NCBICSNK1E [Mapview hg19]  CSNK1E [Mapview hg38]
OMIM600863   
Gene and transcription
Genbank (Entrez)AB024597 AB091043 AK223498 BC006490 BC013088
RefSeq transcript (Entrez)NM_001894 NM_152221
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CSNK1E
Cluster EST : UnigeneHs.474833 [ NCBI ]
CGAP (NCI)Hs.474833
Alternative Splicing GalleryENSG00000213923
Gene ExpressionCSNK1E [ NCBI-GEO ]   CSNK1E [ EBI - ARRAY_EXPRESS ]   CSNK1E [ SEEK ]   CSNK1E [ MEM ]
Gene Expression Viewer (FireBrowse)CSNK1E [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1454
GTEX Portal (Tissue expression)CSNK1E
Human Protein AtlasENSG00000213923-CSNK1E [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49674   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP49674  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49674
Splice isoforms : SwissVarP49674
PhosPhoSitePlusP49674
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)CSNK1E
DMDM Disease mutations1454
Blocks (Seattle)CSNK1E
PDB (SRS)4HNI    4HOK   
PDB (PDBSum)4HNI    4HOK   
PDB (IMB)4HNI    4HOK   
PDB (RSDB)4HNI    4HOK   
Structural Biology KnowledgeBase4HNI    4HOK   
SCOP (Structural Classification of Proteins)4HNI    4HOK   
CATH (Classification of proteins structures)4HNI    4HOK   
SuperfamilyP49674
Human Protein Atlas [tissue]ENSG00000213923-CSNK1E [tissue]
Peptide AtlasP49674
HPRD02919
IPIIPI00027729   IPI00848174   IPI00878751   IPI00878583   IPI00878432   IPI00878570   IPI00878374   IPI00879513   IPI00879402   IPI00892867   
Protein Interaction databases
DIP (DOE-UCLA)P49674
IntAct (EBI)P49674
FunCoupENSG00000213923
BioGRIDCSNK1E
STRING (EMBL)CSNK1E
ZODIACCSNK1E
Ontologies - Pathways
QuickGOP49674
Ontology : AmiGOG2/M transition of mitotic cell cycle  RNA binding  protein kinase activity  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  cytoplasm  cytosol  DNA repair  protein phosphorylation  protein phosphorylation  endocytosis  signal transduction  regulation of G2/M transition of mitotic cell cycle  peptidyl-serine phosphorylation  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  negative regulation of protein binding  positive regulation of proteasomal ubiquitin-dependent protein catabolic process  positive regulation of proteasomal ubiquitin-dependent protein catabolic process  circadian regulation of gene expression  regulation of circadian rhythm  canonical Wnt signaling pathway  canonical Wnt signaling pathway  canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  ciliary basal body-plasma membrane docking  regulation of cellular protein localization  positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation  positive regulation of non-canonical Wnt signaling pathway  
Ontology : EGO-EBIG2/M transition of mitotic cell cycle  RNA binding  protein kinase activity  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  cytoplasm  cytosol  DNA repair  protein phosphorylation  protein phosphorylation  endocytosis  signal transduction  regulation of G2/M transition of mitotic cell cycle  peptidyl-serine phosphorylation  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  negative regulation of protein binding  positive regulation of proteasomal ubiquitin-dependent protein catabolic process  positive regulation of proteasomal ubiquitin-dependent protein catabolic process  circadian regulation of gene expression  regulation of circadian rhythm  canonical Wnt signaling pathway  canonical Wnt signaling pathway  canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  ciliary basal body-plasma membrane docking  regulation of cellular protein localization  positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation  positive regulation of non-canonical Wnt signaling pathway  
Pathways : KEGGFoxO signaling pathway    Wnt signaling pathway    Hedgehog signaling pathway    Hippo signaling pathway    Circadian rhythm   
NDEx NetworkCSNK1E
Atlas of Cancer Signalling NetworkCSNK1E
Wikipedia pathwaysCSNK1E
Orthology - Evolution
OrthoDB1454
GeneTree (enSembl)ENSG00000213923
Phylogenetic Trees/Animal Genes : TreeFamCSNK1E
HOVERGENP49674
HOGENOMP49674
Homologs : HomoloGeneCSNK1E
Homology/Alignments : Family Browser (UCSC)CSNK1E
Gene fusions - Rearrangements
Fusion : MitelmanCSNK1E/DNAL4 [22q13.1/22q13.1]  
Fusion : MitelmanCSNK1E/DYNLRB1 [22q13.1/20q11.22]  [t(20;22)(q11;q13)]  
Fusion : MitelmanCSNK1E/KDELR3 [22q13.1/22q13.1]  [t(22;22)(q13;q13)]  
Fusion : MitelmanCSNK1E/SPATA21 [22q13.1/1p36.13]  [t(1;22)(p36;q13)]  
Fusion : MitelmanGNAL/CSNK1E [18p11.21/22q13.1]  [t(18;22)(p11;q13)]  
Fusion PortalCSNK1E 22q13.1 DNAL4 22q13.1 BRCA
Fusion PortalCSNK1E 22q13.1 KDELR3 22q13.1 OV
Fusion PortalGNAL 18p11.21 CSNK1E 22q13.1 BRCA
Fusion : QuiverCSNK1E
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCSNK1E [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CSNK1E
dbVarCSNK1E
ClinVarCSNK1E
1000_GenomesCSNK1E 
Exome Variant ServerCSNK1E
ExAC (Exome Aggregation Consortium)ENSG00000213923
GNOMAD BrowserENSG00000213923
Varsome BrowserCSNK1E
Genetic variants : HAPMAP1454
Genomic Variants (DGV)CSNK1E [DGVbeta]
DECIPHERCSNK1E [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCSNK1E 
Mutations
ICGC Data PortalCSNK1E 
TCGA Data PortalCSNK1E 
Broad Tumor PortalCSNK1E
OASIS PortalCSNK1E [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCSNK1E  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCSNK1E
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CSNK1E
DgiDB (Drug Gene Interaction Database)CSNK1E
DoCM (Curated mutations)CSNK1E (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CSNK1E (select a term)
intoGenCSNK1E
Cancer3DCSNK1E(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600863   
Orphanet
DisGeNETCSNK1E
MedgenCSNK1E
Genetic Testing Registry CSNK1E
NextProtP49674 [Medical]
TSGene1454
GENETestsCSNK1E
Target ValidationCSNK1E
Huge Navigator CSNK1E [HugePedia]
snp3D : Map Gene to Disease1454
BioCentury BCIQCSNK1E
ClinGenCSNK1E
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1454
Chemical/Pharm GKB GenePA26953
Clinical trialCSNK1E
Miscellaneous
canSAR (ICR)CSNK1E (select the gene name)
Probes
Litterature
PubMed152 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCSNK1E
EVEXCSNK1E
GoPubMedCSNK1E
iHOPCSNK1E
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:00:28 CET 2018

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