Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CTSK (cathepsin K)

Identity

Alias (NCBI)CTS02
CTSO
CTSO1
CTSO2
PKND
PYCD
HGNC (Hugo) CTSK
HGNC Alias symbPKND
HGNC Previous nameCTSO2
 CTSO
 PYCD
HGNC Previous namecathepsin K (pycnodysostosis)
LocusID (NCBI) 1513
Atlas_Id 40207
Location 1q21.3  [Link to chromosome band 1q21]
Location_base_pair Starts at 150796208 and ends at 150808260 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ANP32E (1q21.2)::CTSK (1q21.3)ARNT (1q21.3)::CTSK (1q21.3)CTSK (1q21.3)::CTSK (1q21.3)
ANP32E 1q21.2::CTSK 1q21.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)CTSK   2536
Cards
Entrez_Gene (NCBI)CTSK    cathepsin K
AliasesCTS02; CTSO; CTSO1; CTSO2; 
PKND; PYCD
GeneCards (Weizmann)CTSK
Ensembl hg19 (Hinxton)ENSG00000143387 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000143387 [Gene_View]  ENSG00000143387 [Sequence]  chr1:150796208-150808260 [Contig_View]  CTSK [Vega]
ICGC DataPortalENSG00000143387
TCGA cBioPortalCTSK
AceView (NCBI)CTSK
Genatlas (Paris)CTSK
SOURCE (Princeton)CTSK
Genetics Home Reference (NIH)CTSK
Genomic and cartography
GoldenPath hg38 (UCSC)CTSK  -     chr1:150796208-150808260 -  1q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CTSK  -     1q21.3   [Description]    (hg19-Feb_2009)
GoldenPathCTSK - 1q21.3 [CytoView hg19]  CTSK - 1q21.3 [CytoView hg38]
ImmunoBaseENSG00000143387
Genome Data Viewer NCBICTSK [Mapview hg19]  
OMIM265800   601105   
Gene and transcription
Genbank (Entrez)AK130134 AK308229 AK312880 AU118043 AU119985
RefSeq transcript (Entrez)NM_000396
Consensus coding sequences : CCDS (NCBI)CTSK
Gene ExpressionCTSK [ NCBI-GEO ]   CTSK [ EBI - ARRAY_EXPRESS ]   CTSK [ SEEK ]   CTSK [ MEM ]
Gene Expression Viewer (FireBrowse)CTSK [ Firebrowse - Broad ]
GenevisibleExpression of CTSK in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1513
GTEX Portal (Tissue expression)CTSK
Human Protein AtlasENSG00000143387-CTSK [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP43235   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP43235  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP43235
Catalytic activity : Enzyme3.4.22.38 [ Enzyme-Expasy ]   3.4.22.383.4.22.38 [ IntEnz-EBI ]   3.4.22.38 [ BRENDA ]   3.4.22.38 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP43235
Domaine pattern : Prosite (Expaxy)THIOL_PROTEASE_ASN (PS00640)    THIOL_PROTEASE_CYS (PS00139)    THIOL_PROTEASE_HIS (PS00639)   
Domains : Interpro (EBI)Papain-like_cys_pep_sf    Pept_asp_AS    Pept_cys_AS    Pept_his_AS    Peptidase_C1A_C    Peptidase_C1A_cathepsin-K    Peptidase_C1A_papain-like    Prot_inhib_I29   
Domain families : Pfam (Sanger)Inhibitor_I29 (PF08246)    Peptidase_C1 (PF00112)   
Domain families : Pfam (NCBI)pfam08246    pfam00112   
Domain families : Smart (EMBL)Inhibitor_I29 (SM00848)  Pept_C1 (SM00645)  
Conserved Domain (NCBI)CTSK
PDB (RSDB)1ATK    1AU0    1AU2    1AU3    1AU4    1AYU    1AYV    1AYW    1BGO    1BY8    1MEM    1NL6    1NLJ    1Q6K    1SNK    1TU6    1U9V    1U9W    1U9X    1VSN    1YK7    1YK8    1YT7    2ATO    2AUX    2AUZ    2BDL    2R6N    3C9E    3H7D    3KW9    3KWB    3KWZ    3KX1    3O0U    3O1G    3OVZ    4DMX    4DMY    4N79    4N8W    4X6H    4X6I    4X6J    4YV8    4YVA    5J94    5JA7    5JH3    5TDI    5TUN    5Z5O    6ASH    6HGY    6PXF    6QBS    6QL8    6QLM    6QLW    6QLX    6QM0    7PCK   
PDB Europe1ATK    1AU0    1AU2    1AU3    1AU4    1AYU    1AYV    1AYW    1BGO    1BY8    1MEM    1NL6    1NLJ    1Q6K    1SNK    1TU6    1U9V    1U9W    1U9X    1VSN    1YK7    1YK8    1YT7    2ATO    2AUX    2AUZ    2BDL    2R6N    3C9E    3H7D    3KW9    3KWB    3KWZ    3KX1    3O0U    3O1G    3OVZ    4DMX    4DMY    4N79    4N8W    4X6H    4X6I    4X6J    4YV8    4YVA    5J94    5JA7    5JH3    5TDI    5TUN    5Z5O    6ASH    6HGY    6PXF    6QBS    6QL8    6QLM    6QLW    6QLX    6QM0    7PCK   
PDB (PDBSum)1ATK    1AU0    1AU2    1AU3    1AU4    1AYU    1AYV    1AYW    1BGO    1BY8    1MEM    1NL6    1NLJ    1Q6K    1SNK    1TU6    1U9V    1U9W    1U9X    1VSN    1YK7    1YK8    1YT7    2ATO    2AUX    2AUZ    2BDL    2R6N    3C9E    3H7D    3KW9    3KWB    3KWZ    3KX1    3O0U    3O1G    3OVZ    4DMX    4DMY    4N79    4N8W    4X6H    4X6I    4X6J    4YV8    4YVA    5J94    5JA7    5JH3    5TDI    5TUN    5Z5O    6ASH    6HGY    6PXF    6QBS    6QL8    6QLM    6QLW    6QLX    6QM0    7PCK   
PDB (IMB)1ATK    1AU0    1AU2    1AU3    1AU4    1AYU    1AYV    1AYW    1BGO    1BY8    1MEM    1NL6    1NLJ    1Q6K    1SNK    1TU6    1U9V    1U9W    1U9X    1VSN    1YK7    1YK8    1YT7    2ATO    2AUX    2AUZ    2BDL    2R6N    3C9E    3H7D    3KW9    3KWB    3KWZ    3KX1    3O0U    3O1G    3OVZ    4DMX    4DMY    4N79    4N8W    4X6H    4X6I    4X6J    4YV8    4YVA    5J94    5JA7    5JH3    5TDI    5TUN    5Z5O    6ASH    6HGY    6PXF    6QBS    6QL8    6QLM    6QLW    6QLX    6QM0    7PCK   
Structural Biology KnowledgeBase1ATK    1AU0    1AU2    1AU3    1AU4    1AYU    1AYV    1AYW    1BGO    1BY8    1MEM    1NL6    1NLJ    1Q6K    1SNK    1TU6    1U9V    1U9W    1U9X    1VSN    1YK7    1YK8    1YT7    2ATO    2AUX    2AUZ    2BDL    2R6N    3C9E    3H7D    3KW9    3KWB    3KWZ    3KX1    3O0U    3O1G    3OVZ    4DMX    4DMY    4N79    4N8W    4X6H    4X6I    4X6J    4YV8    4YVA    5J94    5JA7    5JH3    5TDI    5TUN    5Z5O    6ASH    6HGY    6PXF    6QBS    6QL8    6QLM    6QLW    6QLX    6QM0    7PCK   
SCOP (Structural Classification of Proteins)1ATK    1AU0    1AU2    1AU3    1AU4    1AYU    1AYV    1AYW    1BGO    1BY8    1MEM    1NL6    1NLJ    1Q6K    1SNK    1TU6    1U9V    1U9W    1U9X    1VSN    1YK7    1YK8    1YT7    2ATO    2AUX    2AUZ    2BDL    2R6N    3C9E    3H7D    3KW9    3KWB    3KWZ    3KX1    3O0U    3O1G    3OVZ    4DMX    4DMY    4N79    4N8W    4X6H    4X6I    4X6J    4YV8    4YVA    5J94    5JA7    5JH3    5TDI    5TUN    5Z5O    6ASH    6HGY    6PXF    6QBS    6QL8    6QLM    6QLW    6QLX    6QM0    7PCK   
CATH (Classification of proteins structures)1ATK    1AU0    1AU2    1AU3    1AU4    1AYU    1AYV    1AYW    1BGO    1BY8    1MEM    1NL6    1NLJ    1Q6K    1SNK    1TU6    1U9V    1U9W    1U9X    1VSN    1YK7    1YK8    1YT7    2ATO    2AUX    2AUZ    2BDL    2R6N    3C9E    3H7D    3KW9    3KWB    3KWZ    3KX1    3O0U    3O1G    3OVZ    4DMX    4DMY    4N79    4N8W    4X6H    4X6I    4X6J    4YV8    4YVA    5J94    5JA7    5JH3    5TDI    5TUN    5Z5O    6ASH    6HGY    6PXF    6QBS    6QL8    6QLM    6QLW    6QLX    6QM0    7PCK   
SuperfamilyP43235
AlphaFold pdb e-kbP43235   
Human Protein Atlas [tissue]ENSG00000143387-CTSK [tissue]
HPRD03064
Protein Interaction databases
DIP (DOE-UCLA)P43235
IntAct (EBI)P43235
BioGRIDCTSK
STRING (EMBL)CTSK
ZODIACCTSK
Ontologies - Pathways
QuickGOP43235
Ontology : AmiGOautophagy of mitochondrion  intramembranous ossification  fibronectin binding  cysteine-type endopeptidase activity  cysteine-type endopeptidase activity  serine-type endopeptidase activity  protein binding  collagen binding  extracellular region  extracellular space  extracellular space  nucleoplasm  lysosome  lysosome  proteolysis  thyroid hormone generation  immune response  cysteine-type peptidase activity  external side of plasma membrane  apical plasma membrane  extracellular matrix disassembly  collagen catabolic process  collagen catabolic process  endolysosome lumen  lysosomal lumen  intracellular membrane-bounded organelle  proteoglycan binding  bone resorption  proteolysis involved in cellular protein catabolic process  proteolysis involved in cellular protein catabolic process  negative regulation of cartilage development  
Ontology : EGO-EBIautophagy of mitochondrion  intramembranous ossification  fibronectin binding  cysteine-type endopeptidase activity  cysteine-type endopeptidase activity  serine-type endopeptidase activity  protein binding  collagen binding  extracellular region  extracellular space  extracellular space  nucleoplasm  lysosome  lysosome  proteolysis  thyroid hormone generation  immune response  cysteine-type peptidase activity  external side of plasma membrane  apical plasma membrane  extracellular matrix disassembly  collagen catabolic process  collagen catabolic process  endolysosome lumen  lysosomal lumen  intracellular membrane-bounded organelle  proteoglycan binding  bone resorption  proteolysis involved in cellular protein catabolic process  proteolysis involved in cellular protein catabolic process  negative regulation of cartilage development  
Pathways : KEGGKEGG_LYSOSOME    KEGG_TOLL_LIKE_RECEPTOR_SIGNALING   
NDEx NetworkCTSK
Atlas of Cancer Signalling NetworkCTSK
Wikipedia pathwaysCTSK
Orthology - Evolution
OrthoDB1513
GeneTree (enSembl)ENSG00000143387
Phylogenetic Trees/Animal Genes : TreeFamCTSK
Homologs : HomoloGeneCTSK
Homology/Alignments : Family Browser (UCSC)CTSK
Gene fusions - Rearrangements
Fusion : MitelmanANP32E::CTSK [1q21.2/1q21.3]  
Fusion : QuiverCTSK
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCTSK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CTSK
dbVarCTSK
ClinVarCTSK
MonarchCTSK
1000_GenomesCTSK 
Exome Variant ServerCTSK
GNOMAD BrowserENSG00000143387
Varsome BrowserCTSK
ACMGCTSK variants
VarityP43235
Genomic Variants (DGV)CTSK [DGVbeta]
DECIPHERCTSK [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCTSK 
Mutations
ICGC Data PortalCTSK 
TCGA Data PortalCTSK 
Broad Tumor PortalCTSK
OASIS PortalCTSK [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCTSK  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCTSK
Mutations and Diseases : HGMDCTSK
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCTSK
DgiDB (Drug Gene Interaction Database)CTSK
DoCM (Curated mutations)CTSK
CIViC (Clinical Interpretations of Variants in Cancer)CTSK
Cancer3DCTSK
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM265800    601105   
Orphanet571   
DisGeNETCTSK
MedgenCTSK
Genetic Testing Registry CTSK
NextProtP43235 [Medical]
GENETestsCTSK
Target ValidationCTSK
Huge Navigator CTSK [HugePedia]
ClinGenCTSK
Clinical trials, drugs, therapy
MyCancerGenomeCTSK
Protein Interactions : CTDCTSK
Pharm GKB GenePA27034
PharosP43235
Clinical trialCTSK
Miscellaneous
canSAR (ICR)CTSK
HarmonizomeCTSK
ARCHS4CTSK
DataMed IndexCTSK
Probes
Litterature
PubMed194 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCTSK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 20 12:29:29 CET 2022

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