CTSK (cathepsin K)

2003-06-01 Affiliation

Identity

HGNC

CTSK

LOCATION

1q21.3

LOCUSID

1513

ALIAS

CTS02,CTSO,CTSO1,CTSO2,PKND,PYCD

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1513
MIM: 601105
HGNC: 2536
Ensembl: ENSG00000143387

Variants:

dbSNP: 1513
ClinVar: 1513
TCGA: ENSG00000143387
COSMIC: CTSK

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000143387	ENST00000271651	P43235
ENSG00000143387	ENST00000443913	Q5QP40

Expression (GTEx)

100

200

300

400

500

600

700

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Apoptosis	KEGG	ko04210
Toll-like receptor signaling pathway	KEGG	ko04620
Apoptosis	KEGG	hsa04210
Toll-like receptor signaling pathway	KEGG	hsa04620
Lysosome	KEGG	ko04142
Lysosome	KEGG	hsa04142
Osteoclast differentiation	KEGG	ko04380
Osteoclast differentiation	KEGG	hsa04380
Rheumatoid arthritis	KEGG	ko05323
Rheumatoid arthritis	KEGG	hsa05323
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
MHC class II antigen presentation	REACTOME	R-HSA-2132295
Innate Immune System	REACTOME	R-HSA-168249
Toll-Like Receptors Cascades	REACTOME	R-HSA-168898
Trafficking and processing of endosomal TLR	REACTOME	R-HSA-1679131
Extracellular matrix organization	REACTOME	R-HSA-1474244
Degradation of the extracellular matrix	REACTOME	R-HSA-1474228
Activation of Matrix Metalloproteinases	REACTOME	R-HSA-1592389
Collagen degradation	REACTOME	R-HSA-1442490

References

Pubmed ID	Year	Title	Citations
15304486	2004	Essential role of p38 mitogen-activated protein kinase in cathepsin K gene expression during osteoclastogenesis through association of NFATc1 and PU.1.	114
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
14645229	2004	Regulation of collagenase activities of human cathepsins by glycosaminoglycans.	56
15161653	2004	Pivotal role of cathepsin K in lung fibrosis.	55
12039963	2002	Collagenase activity of cathepsin K depends on complex formation with chondroitin sulfate.	48
11733367	2001	Cathepsin k is a critical protease in synovial fibroblast-mediated collagen degradation.	36
15929988	2005	Proteolytic excision of a repressive loop domain in tartrate-resistant acid phosphatase by cathepsin K in osteoclasts.	34
18765527	2008	Epithelial and stromal cathepsin K and CXCL14 expression in breast tumor progression.	34
12125807	2002	Pycnodysostosis: role and regulation of cathepsin K in osteoclast function and human disease.	32
17227755	2007	Interaction between human cathepsins K, L, and S and elastins: mechanism of elastinolysis and inhibition by macromolecular inhibitors.	32

Citation

Dessen P

CTSK (cathepsin K)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40207/ctsk