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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret
Donations are also welcome

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CUL4B (cullin 4B)

Identity

Other namesCUL-4B
MRXHF2
MRXS15
MRXSC
SFM2
HGNC (Hugo) CUL4B
LocusID (NCBI) 8450
Location Xq24
Location_base_pair Starts at 119658446 and ends at 119694817 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)CUL4B   2555
Cards
Entrez_Gene (NCBI)CUL4B  8450  cullin 4B
GeneCards (Weizmann)CUL4B
Ensembl hg19 (Hinxton)ENSG00000158290 [Gene_View]  chrX:119658446-119694817 [Contig_View]  CUL4B [Vega]
Ensembl hg38 (Hinxton)ENSG00000158290 [Gene_View]  chrX:119658446-119694817 [Contig_View]  CUL4B [Vega]
ICGC DataPortalENSG00000158290
cBioPortalCUL4B
AceView (NCBI)CUL4B
Genatlas (Paris)CUL4B
WikiGenes8450
SOURCE (Princeton)CUL4B
Genomic and cartography
GoldenPath hg19 (UCSC)CUL4B  -     chrX:119658446-119694817 -  Xq24   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CUL4B  -     Xq24   [Description]    (hg38-Dec_2013)
EnsemblCUL4B - Xq24 [CytoView hg19]  CUL4B - Xq24 [CytoView hg38]
Mapping of homologs : NCBICUL4B [Mapview hg19]  CUL4B [Mapview hg38]
OMIM300304   300354   
Gene and transcription
Genbank (Entrez)AB014595 AF212995 AK123688 AK299081 AK315037
RefSeq transcript (Entrez)NM_001079872 NM_003588
RefSeq genomic (Entrez)AC_000155 NC_000023 NC_018934 NG_009388 NT_011786 NW_001842396 NW_004929446
Consensus coding sequences : CCDS (NCBI)CUL4B
Cluster EST : UnigeneHs.102914 [ NCBI ]
CGAP (NCI)Hs.102914
Alternative Splicing : Fast-db (Paris)GSHG0032306
Alternative Splicing GalleryENSG00000158290
Gene ExpressionCUL4B [ NCBI-GEO ]     CUL4B [ SEEK ]   CUL4B [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13620 (Uniprot)
NextProtQ13620  [Medical]
With graphics : InterProQ13620
Splice isoforms : SwissVarQ13620 (Swissvar)
Domaine pattern : Prosite (Expaxy)CULLIN_1 (PS01256)    CULLIN_2 (PS50069)   
Domains : Interpro (EBI)Cullin_CS    Cullin_homology    Cullin_N    Cullin_neddylation_domain    Cullin_repeat-like_dom    WHTH_DNA-bd_dom   
Related proteins : CluSTrQ13620
Domain families : Pfam (Sanger)Cullin (PF00888)    Cullin_Nedd8 (PF10557)   
Domain families : Pfam (NCBI)pfam00888    pfam10557   
Domain families : Smart (EMBL)CULLIN (SM00182)  Cullin_Nedd8 (SM00884)  
DMDM Disease mutations8450
Blocks (Seattle)Q13620
PDB (SRS)2DO7    4A0C    4A0L    4A64   
PDB (PDBSum)2DO7    4A0C    4A0L    4A64   
PDB (IMB)2DO7    4A0C    4A0L    4A64   
PDB (RSDB)2DO7    4A0C    4A0L    4A64   
Human Protein AtlasENSG00000158290
Peptide AtlasQ13620
HPRD02251
IPIIPI00179057   IPI00480142   IPI00965290   IPI00643885   IPI00644450   
Protein Interaction databases
DIP (DOE-UCLA)Q13620
IntAct (EBI)Q13620
FunCoupENSG00000158290
BioGRIDCUL4B
IntegromeDBCUL4B
STRING (EMBL)CUL4B
Ontologies - Pathways
QuickGOQ13620
Ontology : AmiGOdamaged DNA binding  protein binding  nucleus  nucleolus  cytoplasm  plasma membrane  ubiquitin-dependent protein catabolic process  cell cycle  Cul4B-RING E3 ubiquitin ligase complex  ubiquitin protein ligase binding  histone H2A monoubiquitination  positive regulation of protein catabolic process  extracellular vesicular exosome  UV-damage excision repair  positive regulation of G1/S transition of mitotic cell cycle  
Ontology : EGO-EBIdamaged DNA binding  protein binding  nucleus  nucleolus  cytoplasm  plasma membrane  ubiquitin-dependent protein catabolic process  cell cycle  Cul4B-RING E3 ubiquitin ligase complex  ubiquitin protein ligase binding  histone H2A monoubiquitination  positive regulation of protein catabolic process  extracellular vesicular exosome  UV-damage excision repair  positive regulation of G1/S transition of mitotic cell cycle  
Pathways : KEGGNucleotide excision repair    Ubiquitin mediated proteolysis   
Protein Interaction DatabaseCUL4B
DoCM (Curated mutations)CUL4B
Wikipedia pathwaysCUL4B
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerCUL4B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CUL4B
dbVarCUL4B
ClinVarCUL4B
1000_GenomesCUL4B 
Exome Variant ServerCUL4B
SNP (GeneSNP Utah)CUL4B
SNP : HGBaseCUL4B
Genetic variants : HAPMAPCUL4B
Genomic Variants (DGV)CUL4B [DGVbeta]
Mutations
ICGC Data PortalENSG00000158290 
Somatic Mutations in Cancer : COSMICCUL4B 
CONAN: Copy Number AnalysisCUL4B 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)X:119658446-119694817
Mutations and Diseases : HGMDCUL4B
OMIM300304    300354   
MedgenCUL4B
NextProtQ13620 [Medical]
GENETestsCUL4B
Disease Genetic AssociationCUL4B
Huge Navigator CUL4B [HugePedia]  CUL4B [HugeCancerGEM]
snp3D : Map Gene to Disease8450
DGIdb (Drug Gene Interaction db)CUL4B
General knowledge
Homologs : HomoloGeneCUL4B
Homology/Alignments : Family Browser (UCSC)CUL4B
Phylogenetic Trees/Animal Genes : TreeFamCUL4B
Chemical/Protein Interactions : CTD8450
Chemical/Pharm GKB GenePA27051
Clinical trialCUL4B
Cancer Resource (Charite)ENSG00000158290
Other databases
Probes
Litterature
PubMed90 Pubmed reference(s) in Entrez
CoreMineCUL4B
GoPubMedCUL4B
iHOPCUL4B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Feb 14 15:21:23 CET 2015

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