Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CUL4B (cullin 4B)

Identity

Other namesCUL-4B
MRXHF2
MRXS15
MRXSC
SFM2
HGNC (Hugo) CUL4B
LocusID (NCBI) 8450
Atlas_Id 40215
Location Xq24  [Link to chromosome band Xq24]
Location_base_pair Starts at 119658446 and ends at 119694817 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CUL4B (Xq24) / DHX33 (17p13.2)SEPT6 (Xq24) / CUL4B (Xq24)VPS13B (8q22.2) / CUL4B (Xq24)
SEPT6 Xq24 / CUL4B Xq24

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CUL4B   2555
Cards
Entrez_Gene (NCBI)CUL4B  8450  cullin 4B
AliasesCUL-4B; MRXHF2; MRXS15; MRXSC; 
SFM2
GeneCards (Weizmann)CUL4B
Ensembl hg19 (Hinxton)ENSG00000158290 [Gene_View]  chrX:119658446-119694817 [Contig_View]  CUL4B [Vega]
Ensembl hg38 (Hinxton)ENSG00000158290 [Gene_View]  chrX:119658446-119694817 [Contig_View]  CUL4B [Vega]
ICGC DataPortalENSG00000158290
TCGA cBioPortalCUL4B
AceView (NCBI)CUL4B
Genatlas (Paris)CUL4B
WikiGenes8450
SOURCE (Princeton)CUL4B
Genomic and cartography
GoldenPath hg19 (UCSC)CUL4B  -     chrX:119658446-119694817 -  Xq24   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CUL4B  -     Xq24   [Description]    (hg38-Dec_2013)
EnsemblCUL4B - Xq24 [CytoView hg19]  CUL4B - Xq24 [CytoView hg38]
Mapping of homologs : NCBICUL4B [Mapview hg19]  CUL4B [Mapview hg38]
OMIM300304   300354   
Gene and transcription
Genbank (Entrez)AB014595 AF212995 AK123688 AK299081 AK315037
RefSeq transcript (Entrez)NM_001079872 NM_003588
RefSeq genomic (Entrez)NC_000023 NC_018934 NG_009388 NT_011786 NW_004929446
Consensus coding sequences : CCDS (NCBI)CUL4B
Cluster EST : UnigeneHs.102914 [ NCBI ]
CGAP (NCI)Hs.102914
Alternative Splicing GalleryENSG00000158290
Gene ExpressionCUL4B [ NCBI-GEO ]   CUL4B [ EBI - ARRAY_EXPRESS ]   CUL4B [ SEEK ]   CUL4B [ MEM ]
Gene Expression Viewer (FireBrowse)CUL4B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8450
GTEX Portal (Tissue expression)CUL4B
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13620 (Uniprot)
NextProtQ13620  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13620
Splice isoforms : SwissVarQ13620 (Swissvar)
PhosPhoSitePlusQ13620
Domaine pattern : Prosite (Expaxy)CULLIN_1 (PS01256)    CULLIN_2 (PS50069)   
Domains : Interpro (EBI)CUL4B    Cullin_CS    Cullin_homology    Cullin_N    Cullin_neddylation_domain    Cullin_repeat-like_dom    WHTH_DNA-bd_dom   
Domain families : Pfam (Sanger)Cullin (PF00888)    Cullin_Nedd8 (PF10557)   
Domain families : Pfam (NCBI)pfam00888    pfam10557   
Domain families : Smart (EMBL)CULLIN (SM00182)  Cullin_Nedd8 (SM00884)  
DMDM Disease mutations8450
Blocks (Seattle)CUL4B
PDB (SRS)2DO7    4A0C    4A0L    4A64   
PDB (PDBSum)2DO7    4A0C    4A0L    4A64   
PDB (IMB)2DO7    4A0C    4A0L    4A64   
PDB (RSDB)2DO7    4A0C    4A0L    4A64   
Structural Biology KnowledgeBase2DO7    4A0C    4A0L    4A64   
SCOP (Structural Classification of Proteins)2DO7    4A0C    4A0L    4A64   
CATH (Classification of proteins structures)2DO7    4A0C    4A0L    4A64   
SuperfamilyQ13620
Human Protein AtlasENSG00000158290
Peptide AtlasQ13620
HPRD02251
IPIIPI00179057   IPI00480142   IPI00965290   IPI00643885   IPI00644450   
Protein Interaction databases
DIP (DOE-UCLA)Q13620
IntAct (EBI)Q13620
FunCoupENSG00000158290
BioGRIDCUL4B
STRING (EMBL)CUL4B
ZODIACCUL4B
Ontologies - Pathways
QuickGOQ13620
Ontology : AmiGOnucleotide-excision repair, DNA damage recognition  nucleotide-excision repair, DNA duplex unwinding  damaged DNA binding  protein binding  nucleoplasm  nucleoplasm  cytoplasm  cytosol  transcription-coupled nucleotide-excision repair  nucleotide-excision repair, preincision complex stabilization  nucleotide-excision repair, preincision complex assembly  nucleotide-excision repair, DNA incision, 3'-to lesion  nucleotide-excision repair, DNA incision, 5'-to lesion  cell cycle  neuron projection development  Cul4B-RING E3 ubiquitin ligase complex  ubiquitin protein ligase binding  nucleotide-excision repair, DNA incision  histone H2A monoubiquitination  DNA damage response, detection of DNA damage  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  positive regulation of protein catabolic process  ubiquitin protein ligase activity  extracellular exosome  global genome nucleotide-excision repair  UV-damage excision repair  positive regulation of G1/S transition of mitotic cell cycle  
Ontology : EGO-EBInucleotide-excision repair, DNA damage recognition  nucleotide-excision repair, DNA duplex unwinding  damaged DNA binding  protein binding  nucleoplasm  nucleoplasm  cytoplasm  cytosol  transcription-coupled nucleotide-excision repair  nucleotide-excision repair, preincision complex stabilization  nucleotide-excision repair, preincision complex assembly  nucleotide-excision repair, DNA incision, 3'-to lesion  nucleotide-excision repair, DNA incision, 5'-to lesion  cell cycle  neuron projection development  Cul4B-RING E3 ubiquitin ligase complex  ubiquitin protein ligase binding  nucleotide-excision repair, DNA incision  histone H2A monoubiquitination  DNA damage response, detection of DNA damage  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  positive regulation of protein catabolic process  ubiquitin protein ligase activity  extracellular exosome  global genome nucleotide-excision repair  UV-damage excision repair  positive regulation of G1/S transition of mitotic cell cycle  
Pathways : KEGGNucleotide excision repair    Ubiquitin mediated proteolysis   
NDEx NetworkCUL4B
Atlas of Cancer Signalling NetworkCUL4B
Wikipedia pathwaysCUL4B
Orthology - Evolution
OrthoDB8450
GeneTree (enSembl)ENSG00000158290
Phylogenetic Trees/Animal Genes : TreeFamCUL4B
Homologs : HomoloGeneCUL4B
Homology/Alignments : Family Browser (UCSC)CUL4B
Gene fusions - Rearrangements
Fusion: TCGASEPT6 Xq24 CUL4B Xq24 BLCA
Polymorphisms : SNP, variants
NCBI Variation ViewerCUL4B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CUL4B
dbVarCUL4B
ClinVarCUL4B
1000_GenomesCUL4B 
Exome Variant ServerCUL4B
ExAC (Exome Aggregation Consortium)CUL4B (select the gene name)
Genetic variants : HAPMAP8450
Genomic Variants (DGV)CUL4B [DGVbeta]
Mutations
ICGC Data PortalCUL4B 
TCGA Data PortalCUL4B 
Broad Tumor PortalCUL4B
OASIS PortalCUL4B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCUL4B 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CUL4B
DgiDB (Drug Gene Interaction Database)CUL4B
DoCM (Curated mutations)CUL4B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CUL4B (select a term)
intoGenCUL4B
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)X:119658446-119694817  ENSG00000158290
CONAN: Copy Number AnalysisCUL4B 
Mutations and Diseases : HGMDCUL4B
OMIM300304    300354   
MedgenCUL4B
Genetic Testing Registry CUL4B
NextProtQ13620 [Medical]
TSGene8450
GENETestsCUL4B
Huge Navigator CUL4B [HugePedia]
snp3D : Map Gene to Disease8450
BioCentury BCIQCUL4B
ClinGenCUL4B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8450
Chemical/Pharm GKB GenePA27051
Clinical trialCUL4B
Miscellaneous
canSAR (ICR)CUL4B (select the gene name)
Probes
Litterature
PubMed109 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCUL4B
EVEXCUL4B
GoPubMedCUL4B
iHOPCUL4B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 19 18:44:45 CEST 2016

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