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DACT1 (dishevelled binding antagonist of beta catenin 1)

Identity

Alias (NCBI)DAPPER
DAPPER1
DPR1
FRODO
HDPR1
TBS2
THYEX3
HGNC (Hugo) DACT1
HGNC Alias symbDAPPER1
THYEX3
HDPR1
DAPPER
FRODO
HGNC Previous namedapper homolog 1, antagonist of beta-catenin (xenopus)
 dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)
LocusID (NCBI) 51339
Atlas_Id 46315
Location 14q23.1  [Link to chromosome band 14q23]
Location_base_pair Starts at 58637962 and ends at 58648320 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DACT1 (14q23.1) / COL1A1 (17q21.33)RAD51B (14q24.1) / DACT1 (14q23.1)RAD51B 14q24.1 / DACT1 14q23.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)DACT1   17748
Cards
Entrez_Gene (NCBI)DACT1    dishevelled binding antagonist of beta catenin 1
AliasesDAPPER; DAPPER1; DPR1; FRODO; 
HDPR1; TBS2; THYEX3
GeneCards (Weizmann)DACT1
Ensembl hg19 (Hinxton)ENSG00000165617 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000165617 [Gene_View]  ENSG00000165617 [Sequence]  chr14:58637962-58648320 [Contig_View]  DACT1 [Vega]
ICGC DataPortalENSG00000165617
TCGA cBioPortalDACT1
AceView (NCBI)DACT1
Genatlas (Paris)DACT1
SOURCE (Princeton)DACT1
Genetics Home Reference (NIH)DACT1
Genomic and cartography
GoldenPath hg38 (UCSC)DACT1  -     chr14:58637962-58648320 +  14q23.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DACT1  -     14q23.1   [Description]    (hg19-Feb_2009)
GoldenPathDACT1 - 14q23.1 [CytoView hg19]  DACT1 - 14q23.1 [CytoView hg38]
ImmunoBaseENSG00000165617
Genome Data Viewer NCBIDACT1 [Mapview hg19]  
OMIM607861   617466   
Gene and transcription
Genbank (Entrez)AF251079 AI803159 AK299879 AK316164 AK316169
RefSeq transcript (Entrez)NM_001079520 NM_016651
Consensus coding sequences : CCDS (NCBI)DACT1
Gene ExpressionDACT1 [ NCBI-GEO ]   DACT1 [ EBI - ARRAY_EXPRESS ]   DACT1 [ SEEK ]   DACT1 [ MEM ]
Gene Expression Viewer (FireBrowse)DACT1 [ Firebrowse - Broad ]
GenevisibleExpression of DACT1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51339
GTEX Portal (Tissue expression)DACT1
Human Protein AtlasENSG00000165617-DACT1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NYF0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NYF0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NYF0
PhosPhoSitePlusQ9NYF0
Domains : Interpro (EBI)Dact1    Dapper   
Domain families : Pfam (Sanger)Dapper (PF15268)   
Domain families : Pfam (NCBI)pfam15268   
Conserved Domain (NCBI)DACT1
SuperfamilyQ9NYF0
AlphaFold pdb e-kbQ9NYF0   
Human Protein Atlas [tissue]ENSG00000165617-DACT1 [tissue]
HPRD09709
Protein Interaction databases
DIP (DOE-UCLA)Q9NYF0
IntAct (EBI)Q9NYF0
BioGRIDDACT1
STRING (EMBL)DACT1
ZODIACDACT1
Ontologies - Pathways
QuickGOQ9NYF0
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  protein kinase C binding  protein binding  nucleus  nucleoplasm  cytoplasm  cytoplasm  cytosol  beta-catenin binding  beta-catenin binding  Wnt signaling pathway  neural tube development  positive regulation of Wnt signaling pathway  negative regulation of Wnt signaling pathway  negative regulation of Wnt signaling pathway  negative regulation of Wnt signaling pathway  regulation of protein stability  negative regulation of protein binding  positive regulation of protein binding  histone deacetylase binding  synapse  positive regulation of protein catabolic process  negative regulation of JNK cascade  negative regulation of JNK cascade  embryonic hindgut morphogenesis  protein kinase A binding  regulation of canonical Wnt signaling pathway  RNA polymerase II-specific DNA-binding transcription factor binding  delta-catenin binding  negative regulation of canonical Wnt signaling pathway  negative regulation of canonical Wnt signaling pathway  negative regulation of canonical Wnt signaling pathway  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  regulation of nodal signaling pathway  positive regulation of cellular protein catabolic process  positive regulation of cellular protein catabolic process  negative regulation of beta-catenin-TCF complex assembly  regulation of Wnt signaling pathway, planar cell polarity pathway  regulation of Wnt signaling pathway, planar cell polarity pathway  negative regulation of G1/S transition of mitotic cell cycle  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  protein kinase C binding  protein binding  nucleus  nucleoplasm  cytoplasm  cytoplasm  cytosol  beta-catenin binding  beta-catenin binding  Wnt signaling pathway  neural tube development  positive regulation of Wnt signaling pathway  negative regulation of Wnt signaling pathway  negative regulation of Wnt signaling pathway  negative regulation of Wnt signaling pathway  regulation of protein stability  negative regulation of protein binding  positive regulation of protein binding  histone deacetylase binding  synapse  positive regulation of protein catabolic process  negative regulation of JNK cascade  negative regulation of JNK cascade  embryonic hindgut morphogenesis  protein kinase A binding  regulation of canonical Wnt signaling pathway  RNA polymerase II-specific DNA-binding transcription factor binding  delta-catenin binding  negative regulation of canonical Wnt signaling pathway  negative regulation of canonical Wnt signaling pathway  negative regulation of canonical Wnt signaling pathway  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  regulation of nodal signaling pathway  positive regulation of cellular protein catabolic process  positive regulation of cellular protein catabolic process  negative regulation of beta-catenin-TCF complex assembly  regulation of Wnt signaling pathway, planar cell polarity pathway  regulation of Wnt signaling pathway, planar cell polarity pathway  negative regulation of G1/S transition of mitotic cell cycle  
NDEx NetworkDACT1
Atlas of Cancer Signalling NetworkDACT1
Wikipedia pathwaysDACT1
Orthology - Evolution
OrthoDB51339
GeneTree (enSembl)ENSG00000165617
Phylogenetic Trees/Animal Genes : TreeFamDACT1
Homologs : HomoloGeneDACT1
Homology/Alignments : Family Browser (UCSC)DACT1
Gene fusions - Rearrangements
Fusion : MitelmanRAD51B/DACT1 [14q24.1/14q23.1]  
Fusion : QuiverDACT1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDACT1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DACT1
dbVarDACT1
ClinVarDACT1
MonarchDACT1
1000_GenomesDACT1 
Exome Variant ServerDACT1
GNOMAD BrowserENSG00000165617
Varsome BrowserDACT1
ACMGDACT1 variants
VarityQ9NYF0
Genomic Variants (DGV)DACT1 [DGVbeta]
DECIPHERDACT1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDACT1 
Mutations
ICGC Data PortalDACT1 
TCGA Data PortalDACT1 
Broad Tumor PortalDACT1
OASIS PortalDACT1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDACT1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDACT1
Mutations and Diseases : HGMDDACT1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaDACT1
DgiDB (Drug Gene Interaction Database)DACT1
DoCM (Curated mutations)DACT1
CIViC (Clinical Interpretations of Variants in Cancer)DACT1
Cancer3DDACT1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607861    617466   
Orphanet20207    10817   
DisGeNETDACT1
MedgenDACT1
Genetic Testing Registry DACT1
NextProtQ9NYF0 [Medical]
GENETestsDACT1
Target ValidationDACT1
Huge Navigator DACT1 [HugePedia]
ClinGenDACT1
Clinical trials, drugs, therapy
MyCancerGenomeDACT1
Protein Interactions : CTDDACT1
Pharm GKB GenePA134957283
PharosQ9NYF0
Clinical trialDACT1
Miscellaneous
canSAR (ICR)DACT1
HarmonizomeDACT1
DataMed IndexDACT1
Probes
Litterature
PubMed43 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXDACT1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:06:04 CEST 2021

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