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DACT1 (dishevelled-binding antagonist of beta-catenin 1)

Identity

Alias_namesdapper homolog 1, antagonist of beta-catenin (xenopus)
dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)
Alias_symbol (synonym)DAPPER1
THYEX3
HDPR1
DAPPER
FRODO
Other aliasDPR1
HGNC (Hugo) DACT1
LocusID (NCBI) 51339
Atlas_Id 46315
Location 14q23.1  [Link to chromosome band 14q23]
Location_base_pair Starts at 59104757 and ends at 59115038 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
DACT1 (14q23.1) / COL1A1 (17q21.33)RAD51B (14q24.1) / DACT1 (14q23.1)RAD51B 14q24.1 / DACT1 14q23.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DACT1   17748
Cards
Entrez_Gene (NCBI)DACT1  51339  dishevelled-binding antagonist of beta-catenin 1
AliasesDAPPER; DAPPER1; DPR1; FRODO; 
HDPR1; THYEX3
GeneCards (Weizmann)DACT1
Ensembl hg19 (Hinxton)ENSG00000165617 [Gene_View]  chr14:59104757-59115038 [Contig_View]  DACT1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000165617 [Gene_View]  chr14:59104757-59115038 [Contig_View]  DACT1 [Vega]
ICGC DataPortalENSG00000165617
TCGA cBioPortalDACT1
AceView (NCBI)DACT1
Genatlas (Paris)DACT1
WikiGenes51339
SOURCE (Princeton)DACT1
Genetics Home Reference (NIH)DACT1
Genomic and cartography
GoldenPath hg19 (UCSC)DACT1  -     chr14:59104757-59115038 +  14q23.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)DACT1  -     14q23.1   [Description]    (hg38-Dec_2013)
EnsemblDACT1 - 14q23.1 [CytoView hg19]  DACT1 - 14q23.1 [CytoView hg38]
Mapping of homologs : NCBIDACT1 [Mapview hg19]  DACT1 [Mapview hg38]
OMIM607861   
Gene and transcription
Genbank (Entrez)AF251079 AI803159 AK299879 AK316164 AK316169
RefSeq transcript (Entrez)NM_001079520 NM_016651
RefSeq genomic (Entrez)NC_000014 NC_018925 NG_032025 NT_026437 NW_004929393
Consensus coding sequences : CCDS (NCBI)DACT1
Cluster EST : UnigeneHs.714204 [ NCBI ]
CGAP (NCI)Hs.714204
Alternative Splicing GalleryENSG00000165617
Gene ExpressionDACT1 [ NCBI-GEO ]   DACT1 [ EBI - ARRAY_EXPRESS ]   DACT1 [ SEEK ]   DACT1 [ MEM ]
Gene Expression Viewer (FireBrowse)DACT1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51339
GTEX Portal (Tissue expression)DACT1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NYF0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NYF0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NYF0
Splice isoforms : SwissVarQ9NYF0
PhosPhoSitePlusQ9NYF0
Domains : Interpro (EBI)Dact1    Dapper   
Domain families : Pfam (Sanger)Dapper (PF15268)   
Domain families : Pfam (NCBI)pfam15268   
Conserved Domain (NCBI)DACT1
DMDM Disease mutations51339
Blocks (Seattle)DACT1
SuperfamilyQ9NYF0
Human Protein AtlasENSG00000165617
Peptide AtlasQ9NYF0
HPRD09709
IPIIPI00171594   IPI00894478   IPI00816599   IPI00894250   
Protein Interaction databases
DIP (DOE-UCLA)Q9NYF0
IntAct (EBI)Q9NYF0
FunCoupENSG00000165617
BioGRIDDACT1
STRING (EMBL)DACT1
ZODIACDACT1
Ontologies - Pathways
QuickGOQ9NYF0
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II transcription factor binding  protein kinase C binding  protein kinase C binding  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  beta-catenin binding  beta-catenin binding  Wnt signaling pathway  neural tube development  cell junction  positive regulation of Wnt signaling pathway  negative regulation of Wnt signaling pathway  negative regulation of Wnt signaling pathway  negative regulation of Wnt signaling pathway  beta-catenin destruction complex  regulation of protein stability  negative regulation of protein binding  positive regulation of protein binding  regulation of catenin import into nucleus  positive regulation of catenin import into nucleus  histone deacetylase binding  synapse  positive regulation of protein catabolic process  negative regulation of JNK cascade  embryonic hindgut morphogenesis  protein kinase A binding  delta-catenin binding  delta-catenin binding  negative regulation of canonical Wnt signaling pathway  negative regulation of canonical Wnt signaling pathway  negative regulation of canonical Wnt signaling pathway  regulation of nodal signaling pathway  positive regulation of cellular protein catabolic process  positive regulation of cellular protein catabolic process  negative regulation of beta-catenin-TCF complex assembly  regulation of Wnt signaling pathway, planar cell polarity pathway  regulation of Wnt signaling pathway, planar cell polarity pathway  negative regulation of G1/S transition of mitotic cell cycle  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II transcription factor binding  protein kinase C binding  protein kinase C binding  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  beta-catenin binding  beta-catenin binding  Wnt signaling pathway  neural tube development  cell junction  positive regulation of Wnt signaling pathway  negative regulation of Wnt signaling pathway  negative regulation of Wnt signaling pathway  negative regulation of Wnt signaling pathway  beta-catenin destruction complex  regulation of protein stability  negative regulation of protein binding  positive regulation of protein binding  regulation of catenin import into nucleus  positive regulation of catenin import into nucleus  histone deacetylase binding  synapse  positive regulation of protein catabolic process  negative regulation of JNK cascade  embryonic hindgut morphogenesis  protein kinase A binding  delta-catenin binding  delta-catenin binding  negative regulation of canonical Wnt signaling pathway  negative regulation of canonical Wnt signaling pathway  negative regulation of canonical Wnt signaling pathway  regulation of nodal signaling pathway  positive regulation of cellular protein catabolic process  positive regulation of cellular protein catabolic process  negative regulation of beta-catenin-TCF complex assembly  regulation of Wnt signaling pathway, planar cell polarity pathway  regulation of Wnt signaling pathway, planar cell polarity pathway  negative regulation of G1/S transition of mitotic cell cycle  
NDEx NetworkDACT1
Atlas of Cancer Signalling NetworkDACT1
Wikipedia pathwaysDACT1
Orthology - Evolution
OrthoDB51339
GeneTree (enSembl)ENSG00000165617
Phylogenetic Trees/Animal Genes : TreeFamDACT1
HOVERGENQ9NYF0
HOGENOMQ9NYF0
Homologs : HomoloGeneDACT1
Homology/Alignments : Family Browser (UCSC)DACT1
Gene fusions - Rearrangements
Fusion : MitelmanRAD51B/DACT1 [14q24.1/14q23.1]  [t(14;14)(q23;q24)]  
Fusion: TCGARAD51B 14q24.1 DACT1 14q23.1 HNSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDACT1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DACT1
dbVarDACT1
ClinVarDACT1
1000_GenomesDACT1 
Exome Variant ServerDACT1
ExAC (Exome Aggregation Consortium)DACT1 (select the gene name)
Genetic variants : HAPMAP51339
Genomic Variants (DGV)DACT1 [DGVbeta]
DECIPHER (Syndromes)14:59104757-59115038  ENSG00000165617
CONAN: Copy Number AnalysisDACT1 
Mutations
ICGC Data PortalDACT1 
TCGA Data PortalDACT1 
Broad Tumor PortalDACT1
OASIS PortalDACT1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDACT1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDACT1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
BioMutasearch DACT1
DgiDB (Drug Gene Interaction Database)DACT1
DoCM (Curated mutations)DACT1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DACT1 (select a term)
intoGenDACT1
Cancer3DDACT1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607861   
Orphanet20207    10817   
MedgenDACT1
Genetic Testing Registry DACT1
NextProtQ9NYF0 [Medical]
TSGene51339
GENETestsDACT1
Huge Navigator DACT1 [HugePedia]
snp3D : Map Gene to Disease51339
BioCentury BCIQDACT1
ClinGenDACT1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51339
Chemical/Pharm GKB GenePA134957283
Clinical trialDACT1
Miscellaneous
canSAR (ICR)DACT1 (select the gene name)
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDACT1
EVEXDACT1
GoPubMedDACT1
iHOPDACT1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:02:39 CET 2017

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