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DAD1 (defender against cell death 1)

Identity

Alias_symbol (synonym)OST2
Other alias
HGNC (Hugo) DAD1
LocusID (NCBI) 1603
Atlas_Id 40259
Location 14q11.2  [Link to chromosome band 14q11]
Location_base_pair Starts at 22564907 and ends at 22589237 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DAD1 (14q11.2) / YWHAE (17p13.3)GNB1 (1p36.33) / DAD1 (14q11.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)DAD1   2664
Cards
Entrez_Gene (NCBI)DAD1  1603  defender against cell death 1
AliasesOST2
GeneCards (Weizmann)DAD1
Ensembl hg19 (Hinxton)ENSG00000129562 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000129562 [Gene_View]  ENSG00000129562 [Sequence]  chr14:22564907-22589237 [Contig_View]  DAD1 [Vega]
ICGC DataPortalENSG00000129562
TCGA cBioPortalDAD1
AceView (NCBI)DAD1
Genatlas (Paris)DAD1
WikiGenes1603
SOURCE (Princeton)DAD1
Genetics Home Reference (NIH)DAD1
Genomic and cartography
GoldenPath hg38 (UCSC)DAD1  -     chr14:22564907-22589237 -  14q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DAD1  -     14q11.2   [Description]    (hg19-Feb_2009)
EnsemblDAD1 - 14q11.2 [CytoView hg19]  DAD1 - 14q11.2 [CytoView hg38]
Mapping of homologs : NCBIDAD1 [Mapview hg19]  DAD1 [Mapview hg38]
OMIM600243   
Gene and transcription
Genbank (Entrez)AK223129 BC007403 BC009798 BC038575 BP198316
RefSeq transcript (Entrez)NM_001344
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DAD1
Cluster EST : UnigeneHs.82890 [ NCBI ]
CGAP (NCI)Hs.82890
Alternative Splicing GalleryENSG00000129562
Gene ExpressionDAD1 [ NCBI-GEO ]   DAD1 [ EBI - ARRAY_EXPRESS ]   DAD1 [ SEEK ]   DAD1 [ MEM ]
Gene Expression Viewer (FireBrowse)DAD1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1603
GTEX Portal (Tissue expression)DAD1
Human Protein AtlasENSG00000129562-DAD1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP61803   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP61803  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP61803
Splice isoforms : SwissVarP61803
PhosPhoSitePlusP61803
Domains : Interpro (EBI)DAD/Ost2   
Domain families : Pfam (Sanger)DAD (PF02109)   
Domain families : Pfam (NCBI)pfam02109   
Conserved Domain (NCBI)DAD1
DMDM Disease mutations1603
Blocks (Seattle)DAD1
SuperfamilyP61803
Human Protein Atlas [tissue]ENSG00000129562-DAD1 [tissue]
Peptide AtlasP61803
HPRD02589
IPIIPI00009407   IPI01013359   IPI01013056   IPI01012107   
Protein Interaction databases
DIP (DOE-UCLA)P61803
IntAct (EBI)P61803
FunCoupENSG00000129562
BioGRIDDAD1
STRING (EMBL)DAD1
ZODIACDAD1
Ontologies - Pathways
QuickGOP61803
Ontology : AmiGOblastocyst development  oligosaccharyl transferase activity  oligosaccharyl transferase activity  dolichyl-diphosphooligosaccharide-protein glycotransferase activity  endoplasmic reticulum membrane  protein glycosylation  protein N-linked glycosylation  apoptotic process  response to nutrient  oligosaccharyltransferase complex  oligosaccharyltransferase complex  membrane  integral component of membrane  protein N-linked glycosylation via asparagine  response to drug  negative regulation of apoptotic process  
Ontology : EGO-EBIblastocyst development  oligosaccharyl transferase activity  oligosaccharyl transferase activity  dolichyl-diphosphooligosaccharide-protein glycotransferase activity  endoplasmic reticulum membrane  protein glycosylation  protein N-linked glycosylation  apoptotic process  response to nutrient  oligosaccharyltransferase complex  oligosaccharyltransferase complex  membrane  integral component of membrane  protein N-linked glycosylation via asparagine  response to drug  negative regulation of apoptotic process  
Pathways : KEGGN-Glycan biosynthesis    Protein processing in endoplasmic reticulum   
NDEx NetworkDAD1
Atlas of Cancer Signalling NetworkDAD1
Wikipedia pathwaysDAD1
Orthology - Evolution
OrthoDB1603
GeneTree (enSembl)ENSG00000129562
Phylogenetic Trees/Animal Genes : TreeFamDAD1
HOGENOMP61803
Homologs : HomoloGeneDAD1
Homology/Alignments : Family Browser (UCSC)DAD1
Gene fusions - Rearrangements
Fusion : QuiverDAD1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDAD1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DAD1
dbVarDAD1
ClinVarDAD1
1000_GenomesDAD1 
Exome Variant ServerDAD1
ExAC (Exome Aggregation Consortium)ENSG00000129562
GNOMAD BrowserENSG00000129562
Varsome BrowserDAD1
Genetic variants : HAPMAP1603
Genomic Variants (DGV)DAD1 [DGVbeta]
DECIPHERDAD1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDAD1 
Mutations
ICGC Data PortalDAD1 
TCGA Data PortalDAD1 
Broad Tumor PortalDAD1
OASIS PortalDAD1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDAD1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDAD1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DAD1
DgiDB (Drug Gene Interaction Database)DAD1
DoCM (Curated mutations)DAD1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DAD1 (select a term)
intoGenDAD1
Cancer3DDAD1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600243   
Orphanet
DisGeNETDAD1
MedgenDAD1
Genetic Testing Registry DAD1
NextProtP61803 [Medical]
TSGene1603
GENETestsDAD1
Target ValidationDAD1
Huge Navigator DAD1 [HugePedia]
snp3D : Map Gene to Disease1603
BioCentury BCIQDAD1
ClinGenDAD1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1603
Chemical/Pharm GKB GenePA27136
Clinical trialDAD1
Miscellaneous
canSAR (ICR)DAD1 (select the gene name)
DataMed IndexDAD1
Probes
Litterature
PubMed35 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDAD1
EVEXDAD1
GoPubMedDAD1
iHOPDAD1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 17 18:08:54 CET 2019
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