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DCAF7 (DDB1 and CUL4 associated factor 7)

Identity

Alias_namesWDR68
WD repeat domain 68
Alias_symbol (synonym)HAN11
SWAN-1
Other aliasAN11
HGNC (Hugo) DCAF7
LocusID (NCBI) 10238
Atlas_Id 52484
Location 17q23.3  [Link to chromosome band 17q23]
Location_base_pair Starts at 63550435 and ends at 63594281 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DCAF7 (17q23.3) / DCAF7 (17q23.3)DCAF7 (17q23.3) / PRR11 (17q22)DCAF7 (17q23.3) / VMP1 (17q23.1)
DDX42 (17q23.3) / DCAF7 (17q23.3)DSCAM (21q22.2) / DCAF7 (17q23.3)KDM6A (Xp11.3) / DCAF7 (17q23.3)
PAPPA (9q33.1) / DCAF7 (17q23.3)DCAF7 17q23.3 / VMP1 17q23.1DDX42 17q23.3 / DCAF7 17q23.3
KDM6A Xp11.3 / DCAF7 17q23.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  Myeloid proliferations in Down syndrome


External links

Nomenclature
HGNC (Hugo)DCAF7   30915
Cards
Entrez_Gene (NCBI)DCAF7  10238  DDB1 and CUL4 associated factor 7
AliasesAN11; HAN11; SWAN-1; WDR68
GeneCards (Weizmann)DCAF7
Ensembl hg19 (Hinxton)ENSG00000136485 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000136485 [Gene_View]  chr17:63550435-63594281 [Contig_View]  DCAF7 [Vega]
ICGC DataPortalENSG00000136485
TCGA cBioPortalDCAF7
AceView (NCBI)DCAF7
Genatlas (Paris)DCAF7
WikiGenes10238
SOURCE (Princeton)DCAF7
Genetics Home Reference (NIH)DCAF7
Genomic and cartography
GoldenPath hg38 (UCSC)DCAF7  -     chr17:63550435-63594281 +  17q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DCAF7  -     17q23.3   [Description]    (hg19-Feb_2009)
EnsemblDCAF7 - 17q23.3 [CytoView hg19]  DCAF7 - 17q23.3 [CytoView hg38]
Mapping of homologs : NCBIDCAF7 [Mapview hg19]  DCAF7 [Mapview hg38]
OMIM605973   
Gene and transcription
Genbank (Entrez)###############################################################################################################################################################################################################################################################
RefSeq transcript (Entrez)NM_001003725 NM_005828
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DCAF7
Cluster EST : UnigeneHs.410596 [ NCBI ]
CGAP (NCI)Hs.410596
Alternative Splicing GalleryENSG00000136485
Gene ExpressionDCAF7 [ NCBI-GEO ]   DCAF7 [ EBI - ARRAY_EXPRESS ]   DCAF7 [ SEEK ]   DCAF7 [ MEM ]
Gene Expression Viewer (FireBrowse)DCAF7 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10238
GTEX Portal (Tissue expression)DCAF7
Protein : pattern, domain, 3D structure
UniProt/SwissProtP61962   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP61962  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP61962
Splice isoforms : SwissVarP61962
PhosPhoSitePlusP61962
Domaine pattern : Prosite (Expaxy)WD_REPEATS_1 (PS00678)    WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)WD40/YVTN_repeat-like_dom    WD40_repeat    WD40_repeat_CS    WD40_repeat_dom   
Domain families : Pfam (Sanger)WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam00400   
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)DCAF7
DMDM Disease mutations10238
Blocks (Seattle)DCAF7
SuperfamilyP61962
Human Protein AtlasENSG00000136485
Peptide AtlasP61962
HPRD09340
IPIIPI00006754   IPI00908632   IPI00910594   
Protein Interaction databases
DIP (DOE-UCLA)P61962
IntAct (EBI)P61962
FunCoupENSG00000136485
BioGRIDDCAF7
STRING (EMBL)DCAF7
ZODIACDCAF7
Ontologies - Pathways
QuickGOP61962
Ontology : AmiGOprotein binding  nucleoplasm  cytoplasm  cytosol  multicellular organism development  nuclear matrix  protein ubiquitination  protein ubiquitination  nuclear body  protein complex  Cul4-RING E3 ubiquitin ligase complex  
Ontology : EGO-EBIprotein binding  nucleoplasm  cytoplasm  cytosol  multicellular organism development  nuclear matrix  protein ubiquitination  protein ubiquitination  nuclear body  protein complex  Cul4-RING E3 ubiquitin ligase complex  
NDEx NetworkDCAF7
Atlas of Cancer Signalling NetworkDCAF7
Wikipedia pathwaysDCAF7
Orthology - Evolution
OrthoDB10238
GeneTree (enSembl)ENSG00000136485
Phylogenetic Trees/Animal Genes : TreeFamDCAF7
HOVERGENP61962
HOGENOMP61962
Homologs : HomoloGeneDCAF7
Homology/Alignments : Family Browser (UCSC)DCAF7
Gene fusions - Rearrangements
Fusion : MitelmanDCAF7/PRR11 [17q23.3/17q22]  
Fusion : MitelmanDCAF7/VMP1 [17q23.3/17q23.1]  [t(17;17)(q23;q23)]  
Fusion : MitelmanDDX42/DCAF7 [17q23.3/17q23.3]  [t(17;17)(q23;q23)]  
Fusion : MitelmanKDM6A/DCAF7 [Xp11.3/17q23.3]  [t(X;17)(p11;q23)]  
Fusion: TCGADCAF7 17q23.3 VMP1 17q23.1 BRCA
Fusion: TCGADDX42 17q23.3 DCAF7 17q23.3 BRCA
Fusion: TCGAKDM6A Xp11.3 DCAF7 17q23.3 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDCAF7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DCAF7
dbVarDCAF7
ClinVarDCAF7
1000_GenomesDCAF7 
Exome Variant ServerDCAF7
ExAC (Exome Aggregation Consortium)DCAF7 (select the gene name)
Genetic variants : HAPMAP10238
Genomic Variants (DGV)DCAF7 [DGVbeta]
DECIPHERDCAF7 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDCAF7 
Mutations
ICGC Data PortalDCAF7 
TCGA Data PortalDCAF7 
Broad Tumor PortalDCAF7
OASIS PortalDCAF7 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDDCAF7
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DCAF7
DgiDB (Drug Gene Interaction Database)DCAF7
DoCM (Curated mutations)DCAF7 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DCAF7 (select a term)
intoGenDCAF7
Cancer3DDCAF7(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605973   
Orphanet
MedgenDCAF7
Genetic Testing Registry DCAF7
NextProtP61962 [Medical]
TSGene10238
GENETestsDCAF7
Target ValidationDCAF7
Huge Navigator DCAF7 [HugePedia]
snp3D : Map Gene to Disease10238
BioCentury BCIQDCAF7
ClinGenDCAF7
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10238
Chemical/Pharm GKB GenePA165431770
Clinical trialDCAF7
Miscellaneous
canSAR (ICR)DCAF7 (select the gene name)
Probes
Litterature
PubMed55 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDCAF7
EVEXDCAF7
GoPubMedDCAF7
iHOPDCAF7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Tue Aug 1 16:59:14 CEST 2017

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