DCLK1 (doublecortin like kinase 1)

2006-10-01  

Identity

HGNC
LOCATION
13q13.3
LOCUSID
ALIAS
CL1,CLICK1,DCAMKL1,DCDC3A,DCLK
FUSION GENES

Other Information

Locus ID:

NCBI: 9201
MIM: 604742
HGNC: 2700
Ensembl: ENSG00000133083

Variants:

dbSNP: 9201
ClinVar: 9201
TCGA: ENSG00000133083
COSMIC: DCLK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000133083ENST00000255448O15075
ENSG00000133083ENST00000360631O15075
ENSG00000133083ENST00000379892Q5VZY9
ENSG00000133083ENST00000379893O15075
ENSG00000133083ENST00000615680O15075

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
232021262013Dclk1 distinguishes between tumor and normal stem cells in the intestine.137
240960052014DCLK1 marks a morphologically distinct subpopulation of cells with stem cell properties in preinvasive pancreatic cancer.104
212852512011DCAMKL-1 regulates epithelial-mesenchymal transition in human pancreatic cells through a miR-200a-dependent mechanism.91
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
240401202013DCLK1 regulates pluripotency and angiogenic factors via microRNA-dependent mechanisms in pancreatic cancer.58
126925302003The DCX-domain tandems of doublecortin and doublecortin-like kinase.51
248800792014XMD8-92 inhibits pancreatic tumor xenograft growth via a DCLK1-dependent mechanism.40
246260932014Curcumin promotes autophagic survival of a subset of colon cancer stem cells, which are ablated by DCLK1-siRNA.38
219376402011Hepatitis C virus-induced cancer stem cell-like signatures in cell culture and murine tumor xenografts.35
219169952012Identification of the putative intestinal stem cell marker doublecortin and CaM kinase-like-1 in Barrett's esophagus and esophageal adenocarcinoma.29

Citation

Dessen P

DCLK1 (doublecortin like kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43223/dclk1