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DCLK1 (doublecortin like kinase 1)

Identity

Alias_namesDCAMKL1
doublecortin and CaM kinase-like 1
doublecortin-like kinase 1
Alias_symbol (synonym)KIAA0369
DCLK
DCDC3A
Other aliasCL1
CLICK1
HGNC (Hugo) DCLK1
LocusID (NCBI) 9201
Atlas_Id 43223
Location 13q13.3  [Link to chromosome band 13q13]
Location_base_pair Starts at 35768652 and ends at 35855861 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DCLK1 (13q13.3) / COL3A1 (2q32.2)DCLK1 (13q13.3) / KTN1 (14q22.3)DCLK1 (13q13.3) / RCBTB1 (13q14.2)
DCLK1 (13q13.3) / RPS4Y1 (Yp11.31)DCLK1 (13q13.3) / SERPINE3 (13q14.3)GGACT (13q32.3) / DCLK1 (13q13.3)
NFIA (1p31.3) / DCLK1 (13q13.3)GGACT 13q32.3 / DCLK1 13q13.3DCLK1 13q13.3 / RCBTB1 13q14.2
DCLK1 13q13.3 / SERPINE3 13q14.3NFIA 1p31.3 / DCLK1 13q13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DCLK1   2700
Cards
Entrez_Gene (NCBI)DCLK1  9201  doublecortin like kinase 1
AliasesCL1; CLICK1; DCAMKL1; DCDC3A; 
DCLK
GeneCards (Weizmann)DCLK1
Ensembl hg19 (Hinxton)ENSG00000133083 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000133083 [Gene_View]  chr13:35768652-35855861 [Contig_View]  DCLK1 [Vega]
ICGC DataPortalENSG00000133083
TCGA cBioPortalDCLK1
AceView (NCBI)DCLK1
Genatlas (Paris)DCLK1
WikiGenes9201
SOURCE (Princeton)DCLK1
Genetics Home Reference (NIH)DCLK1
Genomic and cartography
GoldenPath hg38 (UCSC)DCLK1  -     chr13:35768652-35855861 -  13q13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DCLK1  -     13q13.3   [Description]    (hg19-Feb_2009)
EnsemblDCLK1 - 13q13.3 [CytoView hg19]  DCLK1 - 13q13.3 [CytoView hg38]
Mapping of homologs : NCBIDCLK1 [Mapview hg19]  DCLK1 [Mapview hg38]
OMIM604742   
Gene and transcription
Genbank (Entrez)AB002367 AF052152 AF070534 AK123427 AK295102
RefSeq transcript (Entrez)NM_001195415 NM_001195416 NM_001195430 NM_001330071 NM_001330072 NM_004734
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DCLK1
Cluster EST : UnigeneHs.728619 [ NCBI ]
CGAP (NCI)Hs.728619
Alternative Splicing GalleryENSG00000133083
Gene ExpressionDCLK1 [ NCBI-GEO ]   DCLK1 [ EBI - ARRAY_EXPRESS ]   DCLK1 [ SEEK ]   DCLK1 [ MEM ]
Gene Expression Viewer (FireBrowse)DCLK1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9201
GTEX Portal (Tissue expression)DCLK1
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15075   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO15075  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15075
Splice isoforms : SwissVarO15075
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusO15075
Domaine pattern : Prosite (Expaxy)DC (PS50309)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Ca/CaM-dep_Ca-dep_prot_Kinase    Doublecortin_dom    Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)DCX (PF03607)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam03607    pfam00069   
Domain families : Smart (EMBL)DCX (SM00537)  S_TKc (SM00220)  
Conserved Domain (NCBI)DCLK1
DMDM Disease mutations9201
Blocks (Seattle)DCLK1
PDB (SRS)1MFW    1MG4    1UF0    5JZJ    5JZN   
PDB (PDBSum)1MFW    1MG4    1UF0    5JZJ    5JZN   
PDB (IMB)1MFW    1MG4    1UF0    5JZJ    5JZN   
PDB (RSDB)1MFW    1MG4    1UF0    5JZJ    5JZN   
Structural Biology KnowledgeBase1MFW    1MG4    1UF0    5JZJ    5JZN   
SCOP (Structural Classification of Proteins)1MFW    1MG4    1UF0    5JZJ    5JZN   
CATH (Classification of proteins structures)1MFW    1MG4    1UF0    5JZJ    5JZN   
SuperfamilyO15075
Human Protein AtlasENSG00000133083
Peptide AtlasO15075
HPRD09202
IPIIPI00004560   IPI00217247   IPI00472852   IPI00217249   IPI01015525   IPI00978334   IPI00644293   
Protein Interaction databases
DIP (DOE-UCLA)O15075
IntAct (EBI)O15075
FunCoupENSG00000133083
BioGRIDDCLK1
STRING (EMBL)DCLK1
ZODIACDCLK1
Ontologies - Pathways
QuickGOO15075
Ontology : AmiGOneuron migration  protein kinase activity  protein serine/threonine kinase activity  signal transducer activity, downstream of receptor  ATP binding  intracellular  integral component of plasma membrane  protein phosphorylation  nervous system development  central nervous system development  response to virus  postsynaptic density  endosomal transport  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  central nervous system projection neuron axonogenesis  forebrain development  intracellular signal transduction  axon extension  neuron projection morphogenesis  dendrite morphogenesis  negative regulation of protein localization to nucleus  
Ontology : EGO-EBIneuron migration  protein kinase activity  protein serine/threonine kinase activity  signal transducer activity, downstream of receptor  ATP binding  intracellular  integral component of plasma membrane  protein phosphorylation  nervous system development  central nervous system development  response to virus  postsynaptic density  endosomal transport  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  central nervous system projection neuron axonogenesis  forebrain development  intracellular signal transduction  axon extension  neuron projection morphogenesis  dendrite morphogenesis  negative regulation of protein localization to nucleus  
NDEx NetworkDCLK1
Atlas of Cancer Signalling NetworkDCLK1
Wikipedia pathwaysDCLK1
Orthology - Evolution
OrthoDB9201
GeneTree (enSembl)ENSG00000133083
Phylogenetic Trees/Animal Genes : TreeFamDCLK1
HOVERGENO15075
HOGENOMO15075
Homologs : HomoloGeneDCLK1
Homology/Alignments : Family Browser (UCSC)DCLK1
Gene fusions - Rearrangements
Fusion : MitelmanDCLK1/COL3A1 [13q13.3/2q32.2]  
Fusion : MitelmanDCLK1/RCBTB1 [13q13.3/13q14.2]  [t(13;13)(q13;q14)]  
Fusion : MitelmanDCLK1/SERPINE3 [13q13.3/13q14.3]  [t(13;13)(q13;q14)]  
Fusion : MitelmanGGACT/DCLK1 [13q32.3/13q13.3]  [t(13;13)(q13;q32)]  
Fusion : MitelmanNFIA/DCLK1 [1p31.3/13q13.3]  [t(1;13)(p31;q13)]  
Fusion: TCGAGGACT 13q32.3 DCLK1 13q13.3 PRAD
Fusion: TCGADCLK1 13q13.3 RCBTB1 13q14.2 BRCA
Fusion: TCGADCLK1 13q13.3 SERPINE3 13q14.3 BRCA
Fusion: TCGANFIA 1p31.3 DCLK1 13q13.3 BRCA
Fusion Cancer (Beijing)DCLK1 [13q13.3]  -  RPS4Y1 [Yp11.31]  [FUSC002061]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDCLK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DCLK1
dbVarDCLK1
ClinVarDCLK1
1000_GenomesDCLK1 
Exome Variant ServerDCLK1
ExAC (Exome Aggregation Consortium)DCLK1 (select the gene name)
Genetic variants : HAPMAP9201
Genomic Variants (DGV)DCLK1 [DGVbeta]
DECIPHERDCLK1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDCLK1 
Mutations
ICGC Data PortalDCLK1 
TCGA Data PortalDCLK1 
Broad Tumor PortalDCLK1
OASIS PortalDCLK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDCLK1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDCLK1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DCLK1
DgiDB (Drug Gene Interaction Database)DCLK1
DoCM (Curated mutations)DCLK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DCLK1 (select a term)
intoGenDCLK1
Cancer3DDCLK1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604742   
Orphanet
MedgenDCLK1
Genetic Testing Registry DCLK1
NextProtO15075 [Medical]
TSGene9201
GENETestsDCLK1
Target ValidationDCLK1
Huge Navigator DCLK1 [HugePedia]
snp3D : Map Gene to Disease9201
BioCentury BCIQDCLK1
ClinGenDCLK1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9201
Chemical/Pharm GKB GenePA162383325
Clinical trialDCLK1
Miscellaneous
canSAR (ICR)DCLK1 (select the gene name)
Probes
Litterature
PubMed68 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDCLK1
EVEXDCLK1
GoPubMedDCLK1
iHOPDCLK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:30:42 CEST 2017

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