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DDB1 (damage specific DNA binding protein 1)

Identity

Alias (NCBI)DDBA
UV-DDB1
XAP1
XPCE
XPE
XPE-BF
HGNC (Hugo) DDB1
HGNC Previous namedamage-specific DNA binding protein 1 (127kD)
LocusID (NCBI) 1642
Atlas_Id 40278
Location 11q12.2  [Link to chromosome band 11q12]
Location_base_pair Starts at 61299452 and ends at 61333105 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DDB1 (11q12.2)::ADCY2 (5p15.31)DDB1 (11q12.2)::DDB1 (11q12.2)DDB1 (11q12.2)::FOXP1 (3p13)
DDB1 (11q12.2)::MALAT1 (11q13.1)DDB1 (11q12.2)::PPM1M (3p21.2)DDB1 (11q12.2)::SIGMAR1 (9p13.3)
DDB1 (11q12.2)::TMEM258 (11q12.2)DDB1 (11q12.2)::ZNF408 (11p11.2)PRPF19 (11q12.2)::DDB1 (11q12.2)
RASSF4 (10q11.21)::DDB1 (11q12.2)DDB1 11q12.2 C11orf10PRPF19 11q12.2::DDB1 11q12.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

 

Nomenclature
HGNC (Hugo)DDB1   2717
LRG (Locus Reference Genomic)LRG_474
Cards
Entrez_Gene (NCBI)DDB1    damage specific DNA binding protein 1
AliasesDDBA; UV-DDB1; XAP1; XPCE; 
XPE; XPE-BF
GeneCards (Weizmann)DDB1
Ensembl hg19 (Hinxton)ENSG00000167986 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000167986 [Gene_View]  ENSG00000167986 [Sequence]  chr11:61299452-61333105 [Contig_View]  DDB1 [Vega]
ICGC DataPortalENSG00000167986
TCGA cBioPortalDDB1
AceView (NCBI)DDB1
Genatlas (Paris)DDB1
SOURCE (Princeton)DDB1
Genetics Home Reference (NIH)DDB1
Genomic and cartography
GoldenPath hg38 (UCSC)DDB1  -     chr11:61299452-61333105 -  11q12.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DDB1  -     11q12.2   [Description]    (hg19-Feb_2009)
GoldenPathDDB1 - 11q12.2 [CytoView hg19]  DDB1 - 11q12.2 [CytoView hg38]
ImmunoBaseENSG00000167986
Genome Data Viewer NCBIDDB1 [Mapview hg19]  
OMIM600045   
Gene and transcription
Genbank (Entrez)AA665872 AJ002955 AK294341 AK294493 AK299650
RefSeq transcript (Entrez)NM_001923
Consensus coding sequences : CCDS (NCBI)DDB1
Gene ExpressionDDB1 [ NCBI-GEO ]   DDB1 [ EBI - ARRAY_EXPRESS ]   DDB1 [ SEEK ]   DDB1 [ MEM ]
Gene Expression Viewer (FireBrowse)DDB1 [ Firebrowse - Broad ]
GenevisibleExpression of DDB1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1642
GTEX Portal (Tissue expression)DDB1
Human Protein AtlasENSG00000167986-DDB1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16531   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ16531  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ16531
PhosPhoSitePlusQ16531
Domains : Interpro (EBI)Cleavage/polyA-sp_fac_asu_C    Cleavage/polyA-sp_fac_asu_N    DDB1    WD40/YVTN_repeat-like_dom_sf    WD40_repeat_dom_sf   
Domain families : Pfam (Sanger)CPSF_A (PF03178)    MMS1_N (PF10433)   
Domain families : Pfam (NCBI)pfam03178    pfam10433   
Conserved Domain (NCBI)DDB1
PDB (RSDB)2B5L    2B5M    2B5N    2HYE    3E0C    3EI1    3EI2    3EI3    3EI4    3I7H    3I7K    3I7L    3I7N    3I7O    3I7P    3I89    3I8C    3I8E    4A08    4A09    4A0A    4A0B    4A0K    4A0L    4A11    4CI1    4CI2    4CI3    4E54    4E5Z    4TZ4    5FQD    5HXB    5JK7    5V3O    6BN7    6BN8    6BN9    6BNB    6BOY    6DSZ    6FCV    6H0F    6H0G    6PAI    6Q0R    6Q0V    6Q0W    6R8Y    6R8Z    6R90    6R91    6R92    6SJ7    6TD3    6UD7    6UE5    6UML   
PDB Europe2B5L    2B5M    2B5N    2HYE    3E0C    3EI1    3EI2    3EI3    3EI4    3I7H    3I7K    3I7L    3I7N    3I7O    3I7P    3I89    3I8C    3I8E    4A08    4A09    4A0A    4A0B    4A0K    4A0L    4A11    4CI1    4CI2    4CI3    4E54    4E5Z    4TZ4    5FQD    5HXB    5JK7    5V3O    6BN7    6BN8    6BN9    6BNB    6BOY    6DSZ    6FCV    6H0F    6H0G    6PAI    6Q0R    6Q0V    6Q0W    6R8Y    6R8Z    6R90    6R91    6R92    6SJ7    6TD3    6UD7    6UE5    6UML   
PDB (PDBSum)2B5L    2B5M    2B5N    2HYE    3E0C    3EI1    3EI2    3EI3    3EI4    3I7H    3I7K    3I7L    3I7N    3I7O    3I7P    3I89    3I8C    3I8E    4A08    4A09    4A0A    4A0B    4A0K    4A0L    4A11    4CI1    4CI2    4CI3    4E54    4E5Z    4TZ4    5FQD    5HXB    5JK7    5V3O    6BN7    6BN8    6BN9    6BNB    6BOY    6DSZ    6FCV    6H0F    6H0G    6PAI    6Q0R    6Q0V    6Q0W    6R8Y    6R8Z    6R90    6R91    6R92    6SJ7    6TD3    6UD7    6UE5    6UML   
PDB (IMB)2B5L    2B5M    2B5N    2HYE    3E0C    3EI1    3EI2    3EI3    3EI4    3I7H    3I7K    3I7L    3I7N    3I7O    3I7P    3I89    3I8C    3I8E    4A08    4A09    4A0A    4A0B    4A0K    4A0L    4A11    4CI1    4CI2    4CI3    4E54    4E5Z    4TZ4    5FQD    5HXB    5JK7    5V3O    6BN7    6BN8    6BN9    6BNB    6BOY    6DSZ    6FCV    6H0F    6H0G    6PAI    6Q0R    6Q0V    6Q0W    6R8Y    6R8Z    6R90    6R91    6R92    6SJ7    6TD3    6UD7    6UE5    6UML   
Structural Biology KnowledgeBase2B5L    2B5M    2B5N    2HYE    3E0C    3EI1    3EI2    3EI3    3EI4    3I7H    3I7K    3I7L    3I7N    3I7O    3I7P    3I89    3I8C    3I8E    4A08    4A09    4A0A    4A0B    4A0K    4A0L    4A11    4CI1    4CI2    4CI3    4E54    4E5Z    4TZ4    5FQD    5HXB    5JK7    5V3O    6BN7    6BN8    6BN9    6BNB    6BOY    6DSZ    6FCV    6H0F    6H0G    6PAI    6Q0R    6Q0V    6Q0W    6R8Y    6R8Z    6R90    6R91    6R92    6SJ7    6TD3    6UD7    6UE5    6UML   
SCOP (Structural Classification of Proteins)2B5L    2B5M    2B5N    2HYE    3E0C    3EI1    3EI2    3EI3    3EI4    3I7H    3I7K    3I7L    3I7N    3I7O    3I7P    3I89    3I8C    3I8E    4A08    4A09    4A0A    4A0B    4A0K    4A0L    4A11    4CI1    4CI2    4CI3    4E54    4E5Z    4TZ4    5FQD    5HXB    5JK7    5V3O    6BN7    6BN8    6BN9    6BNB    6BOY    6DSZ    6FCV    6H0F    6H0G    6PAI    6Q0R    6Q0V    6Q0W    6R8Y    6R8Z    6R90    6R91    6R92    6SJ7    6TD3    6UD7    6UE5    6UML   
CATH (Classification of proteins structures)2B5L    2B5M    2B5N    2HYE    3E0C    3EI1    3EI2    3EI3    3EI4    3I7H    3I7K    3I7L    3I7N    3I7O    3I7P    3I89    3I8C    3I8E    4A08    4A09    4A0A    4A0B    4A0K    4A0L    4A11    4CI1    4CI2    4CI3    4E54    4E5Z    4TZ4    5FQD    5HXB    5JK7    5V3O    6BN7    6BN8    6BN9    6BNB    6BOY    6DSZ    6FCV    6H0F    6H0G    6PAI    6Q0R    6Q0V    6Q0W    6R8Y    6R8Z    6R90    6R91    6R92    6SJ7    6TD3    6UD7    6UE5    6UML   
SuperfamilyQ16531
AlphaFold pdb e-kbQ16531   
Human Protein Atlas [tissue]ENSG00000167986-DDB1 [tissue]
HPRD10952
Protein Interaction databases
DIP (DOE-UCLA)Q16531
IntAct (EBI)Q16531
BioGRIDDDB1
STRING (EMBL)DDB1
ZODIACDDB1
Ontologies - Pathways
QuickGOQ16531
Ontology : AmiGOnucleotide-excision repair, DNA damage recognition  nucleotide-excision repair, DNA duplex unwinding  chromosome, telomeric region  DNA binding  damaged DNA binding  protein binding  extracellular space  nucleus  nucleus  nucleoplasm  nucleoplasm  cytoplasm  DNA repair  transcription-coupled nucleotide-excision repair  nucleotide-excision repair  nucleotide-excision repair, preincision complex stabilization  nucleotide-excision repair, preincision complex assembly  nucleotide-excision repair, DNA incision, 3'-to lesion  nucleotide-excision repair, DNA incision, 5'-to lesion  ubiquitin-dependent protein catabolic process  ubiquitin-dependent protein catabolic process  cellular response to DNA damage stimulus  proteasomal protein catabolic process  Wnt signaling pathway  protein ubiquitination  protein ubiquitination  protein-macromolecule adaptor activity  Cul4A-RING E3 ubiquitin ligase complex  Cul4B-RING E3 ubiquitin ligase complex  protein-containing complex  nucleotide-excision repair, DNA incision  histone H2A monoubiquitination  site of double-strand break  regulation of circadian rhythm  DNA damage response, detection of DNA damage  negative regulation of apoptotic process  proteasome-mediated ubiquitin-dependent protein catabolic process  proteasome-mediated ubiquitin-dependent protein catabolic process  post-translational protein modification  protein-containing complex binding  positive regulation of viral genome replication  positive regulation of gluconeogenesis  positive regulation of protein catabolic process  positive regulation by virus of viral protein levels in host cell  rhythmic process  biological process involved in interaction with symbiont  extracellular exosome  global genome nucleotide-excision repair  UV-damage excision repair  WD40-repeat domain binding  Cul4-RING E3 ubiquitin ligase complex  Cul4-RING E3 ubiquitin ligase complex  cullin family protein binding  regulation of mitotic cell cycle phase transition  positive regulation of viral release from host cell  
Ontology : EGO-EBInucleotide-excision repair, DNA damage recognition  nucleotide-excision repair, DNA duplex unwinding  chromosome, telomeric region  DNA binding  damaged DNA binding  protein binding  extracellular space  nucleus  nucleus  nucleoplasm  nucleoplasm  cytoplasm  DNA repair  transcription-coupled nucleotide-excision repair  nucleotide-excision repair  nucleotide-excision repair, preincision complex stabilization  nucleotide-excision repair, preincision complex assembly  nucleotide-excision repair, DNA incision, 3'-to lesion  nucleotide-excision repair, DNA incision, 5'-to lesion  ubiquitin-dependent protein catabolic process  ubiquitin-dependent protein catabolic process  cellular response to DNA damage stimulus  proteasomal protein catabolic process  Wnt signaling pathway  protein ubiquitination  protein ubiquitination  protein-macromolecule adaptor activity  Cul4A-RING E3 ubiquitin ligase complex  Cul4B-RING E3 ubiquitin ligase complex  protein-containing complex  nucleotide-excision repair, DNA incision  histone H2A monoubiquitination  site of double-strand break  regulation of circadian rhythm  DNA damage response, detection of DNA damage  negative regulation of apoptotic process  proteasome-mediated ubiquitin-dependent protein catabolic process  proteasome-mediated ubiquitin-dependent protein catabolic process  post-translational protein modification  protein-containing complex binding  positive regulation of viral genome replication  positive regulation of gluconeogenesis  positive regulation of protein catabolic process  positive regulation by virus of viral protein levels in host cell  rhythmic process  biological process involved in interaction with symbiont  extracellular exosome  global genome nucleotide-excision repair  UV-damage excision repair  WD40-repeat domain binding  Cul4-RING E3 ubiquitin ligase complex  Cul4-RING E3 ubiquitin ligase complex  cullin family protein binding  regulation of mitotic cell cycle phase transition  positive regulation of viral release from host cell  
Pathways : KEGGNucleotide excision repair    Ubiquitin mediated proteolysis    Hepatitis B    Viral carcinogenesis   
NDEx NetworkDDB1
Atlas of Cancer Signalling NetworkDDB1
Wikipedia pathwaysDDB1
Orthology - Evolution
OrthoDB1642
GeneTree (enSembl)ENSG00000167986
Phylogenetic Trees/Animal Genes : TreeFamDDB1
Homologs : HomoloGeneDDB1
Homology/Alignments : Family Browser (UCSC)DDB1
Gene fusions - Rearrangements
Fusion : MitelmanDDB1::TMEM258 [11q12.2/11q12.2]  
Fusion : MitelmanPRPF19::DDB1 [11q12.2/11q12.2]  
Fusion : QuiverDDB1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDDB1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DDB1
dbVarDDB1
ClinVarDDB1
MonarchDDB1
1000_GenomesDDB1 
Exome Variant ServerDDB1
GNOMAD BrowserENSG00000167986
Varsome BrowserDDB1
ACMGDDB1 variants
VarityQ16531
Genomic Variants (DGV)DDB1 [DGVbeta]
DECIPHERDDB1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDDB1 
Mutations
ICGC Data PortalDDB1 
TCGA Data PortalDDB1 
Broad Tumor PortalDDB1
OASIS PortalDDB1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDDB1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDDB1
Mutations and Diseases : HGMDDDB1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaDDB1
DgiDB (Drug Gene Interaction Database)DDB1
DoCM (Curated mutations)DDB1
CIViC (Clinical Interpretations of Variants in Cancer)DDB1
Cancer3DDDB1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600045   
Orphanet
DisGeNETDDB1
MedgenDDB1
Genetic Testing Registry DDB1
NextProtQ16531 [Medical]
GENETestsDDB1
Target ValidationDDB1
Huge Navigator DDB1 [HugePedia]
ClinGenDDB1
Clinical trials, drugs, therapy
MyCancerGenomeDDB1
Protein Interactions : CTDDDB1
Pharm GKB GenePA27187
PharosQ16531
Clinical trialDDB1
Miscellaneous
canSAR (ICR)DDB1
HarmonizomeDDB1
ARCHS4DDB1
DataMed IndexDDB1
Probes
Litterature
PubMed457 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXDDB1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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