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DDX21 (DExD-box helicase 21)

Identity

Alias (NCBI)GUA
GURDB
RH-II/GU
RH-II/GuA
HGNC (Hugo) DDX21
HGNC Alias symbRH-II/GU
GURDB
HGNC Alias namenucleolar RNA helicase 2
HGNC Previous nameDEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 21
 DEAD-box helicase 21
LocusID (NCBI) 9188
Atlas_Id 46952
Location 10q22.1  [Link to chromosome band 10q22]
Location_base_pair Starts at 68956170 and ends at 68985068 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AD_1 () / DDX21 (10q22.1)ARID4B (1q42.3) / DDX21 (10q22.1)ASTN2 (9q33.1) / DDX21 (10q22.1)
ATP5G2 (12q13.13) / DDX21 (10q22.1)DDX21 (10q22.1) / BEX2 (Xq22.1)DDX21 (10q22.1) / CUTA (6p21.32)
DDX21 (10q22.1) / DDX21 (10q22.1)DDX21 (10q22.1) / SPATS2L (2q33.1)DDX21 (10q22.1) / SULF2 (20q13.12)
MRPS18C (4q21.23) / DDX21 (10q22.1)RPL23AP53 (8p23.3) / DDX21 (10q22.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)DDX21   2744
Cards
Entrez_Gene (NCBI)DDX21    DExD-box helicase 21
AliasesGUA; GURDB; RH-II/GU; RH-II/GuA
GeneCards (Weizmann)DDX21
Ensembl hg19 (Hinxton)ENSG00000165732 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000165732 [Gene_View]  ENSG00000165732 [Sequence]  chr10:68956170-68985068 [Contig_View]  DDX21 [Vega]
ICGC DataPortalENSG00000165732
TCGA cBioPortalDDX21
AceView (NCBI)DDX21
Genatlas (Paris)DDX21
SOURCE (Princeton)DDX21
Genetics Home Reference (NIH)DDX21
Genomic and cartography
GoldenPath hg38 (UCSC)DDX21  -     chr10:68956170-68985068 +  10q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DDX21  -     10q22.1   [Description]    (hg19-Feb_2009)
GoldenPathDDX21 - 10q22.1 [CytoView hg19]  DDX21 - 10q22.1 [CytoView hg38]
ImmunoBaseENSG00000165732
Genome Data Viewer NCBIDDX21 [Mapview hg19]  
OMIM606357   
Gene and transcription
Genbank (Entrez)AA446317 AB062394 AK025629 AK315585 BC004182
RefSeq transcript (Entrez)NM_001256910 NM_004728
Consensus coding sequences : CCDS (NCBI)DDX21
Gene ExpressionDDX21 [ NCBI-GEO ]   DDX21 [ EBI - ARRAY_EXPRESS ]   DDX21 [ SEEK ]   DDX21 [ MEM ]
Gene Expression Viewer (FireBrowse)DDX21 [ Firebrowse - Broad ]
GenevisibleExpression of DDX21 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9188
GTEX Portal (Tissue expression)DDX21
Human Protein AtlasENSG00000165732-DDX21 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NR30   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NR30  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NR30
PhosPhoSitePlusQ9NR30
Domaine pattern : Prosite (Expaxy)HELICASE_ATP_BIND_1 (PS51192)    HELICASE_CTER (PS51194)    Q_MOTIF (PS51195)   
Domains : Interpro (EBI)DEAD/DEAH_box_helicase_dom    GUCT    Helicase_ATP-bd    Helicase_C    P-loop_NTPase    RBD_domain_sf    RNA_helicase_DEAD_Q_motif   
Domain families : Pfam (Sanger)DEAD (PF00270)    GUCT (PF08152)    Helicase_C (PF00271)   
Domain families : Pfam (NCBI)pfam00270    pfam08152    pfam00271   
Domain families : Smart (EMBL)DEXDc (SM00487)  HELICc (SM00490)  
Conserved Domain (NCBI)DDX21
PDB (RSDB)2M3D    6L5L    6L5M    6L5N    6L5O   
PDB Europe2M3D    6L5L    6L5M    6L5N    6L5O   
PDB (PDBSum)2M3D    6L5L    6L5M    6L5N    6L5O   
PDB (IMB)2M3D    6L5L    6L5M    6L5N    6L5O   
Structural Biology KnowledgeBase2M3D    6L5L    6L5M    6L5N    6L5O   
SCOP (Structural Classification of Proteins)2M3D    6L5L    6L5M    6L5N    6L5O   
CATH (Classification of proteins structures)2M3D    6L5L    6L5M    6L5N    6L5O   
SuperfamilyQ9NR30
AlphaFold pdb e-kbQ9NR30   
Human Protein Atlas [tissue]ENSG00000165732-DDX21 [tissue]
HPRD05895
Protein Interaction databases
DIP (DOE-UCLA)Q9NR30
IntAct (EBI)Q9NR30
BioGRIDDDX21
STRING (EMBL)DDX21
ZODIACDDX21
Ontologies - Pathways
QuickGOQ9NR30
Ontology : AmiGOosteoblast differentiation  positive regulation of myeloid dendritic cell cytokine production  RNA binding  RNA binding  RNA helicase activity  RNA helicase activity  RNA helicase activity  double-stranded RNA binding  protein binding  ATP binding  nucleoplasm  nucleoplasm  chromosome  nucleolus  nucleolus  mitochondrion  cytosol  rRNA processing  transcription by RNA polymerase II  membrane  hydrolase activity  rRNA binding  snoRNA binding  miRNA binding  identical protein binding  positive regulation of I-kappaB kinase/NF-kappaB signaling  response to exogenous dsRNA  innate immune response  positive regulation of gene expression, epigenetic  defense response to virus  R-loop disassembly  7SK snRNA binding  
Ontology : EGO-EBIosteoblast differentiation  positive regulation of myeloid dendritic cell cytokine production  RNA binding  RNA binding  RNA helicase activity  RNA helicase activity  RNA helicase activity  double-stranded RNA binding  protein binding  ATP binding  nucleoplasm  nucleoplasm  chromosome  nucleolus  nucleolus  mitochondrion  cytosol  rRNA processing  transcription by RNA polymerase II  membrane  hydrolase activity  rRNA binding  snoRNA binding  miRNA binding  identical protein binding  positive regulation of I-kappaB kinase/NF-kappaB signaling  response to exogenous dsRNA  innate immune response  positive regulation of gene expression, epigenetic  defense response to virus  R-loop disassembly  7SK snRNA binding  
NDEx NetworkDDX21
Atlas of Cancer Signalling NetworkDDX21
Wikipedia pathwaysDDX21
Orthology - Evolution
OrthoDB9188
GeneTree (enSembl)ENSG00000165732
Phylogenetic Trees/Animal Genes : TreeFamDDX21
Homologs : HomoloGeneDDX21
Homology/Alignments : Family Browser (UCSC)DDX21
Gene fusions - Rearrangements
Fusion Cancer (Beijing)AD_1 [DDX21]  -  10q22.1 [FUSC001107]  [FUSC001107]
Fusion : QuiverDDX21
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDDX21 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DDX21
dbVarDDX21
ClinVarDDX21
MonarchDDX21
1000_GenomesDDX21 
Exome Variant ServerDDX21
GNOMAD BrowserENSG00000165732
Varsome BrowserDDX21
ACMGDDX21 variants
VarityQ9NR30
Genomic Variants (DGV)DDX21 [DGVbeta]
DECIPHERDDX21 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDDX21 
Mutations
ICGC Data PortalDDX21 
TCGA Data PortalDDX21 
Broad Tumor PortalDDX21
OASIS PortalDDX21 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDDX21  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDDX21
Mutations and Diseases : HGMDDDX21
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaDDX21
DgiDB (Drug Gene Interaction Database)DDX21
DoCM (Curated mutations)DDX21
CIViC (Clinical Interpretations of Variants in Cancer)DDX21
Cancer3DDDX21
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606357   
Orphanet
DisGeNETDDX21
MedgenDDX21
Genetic Testing Registry DDX21
NextProtQ9NR30 [Medical]
GENETestsDDX21
Target ValidationDDX21
Huge Navigator DDX21 [HugePedia]
ClinGenDDX21
Clinical trials, drugs, therapy
MyCancerGenomeDDX21
Protein Interactions : CTDDDX21
Pharm GKB GenePA27210
PharosQ9NR30
Clinical trialDDX21
Miscellaneous
canSAR (ICR)DDX21
HarmonizomeDDX21
DataMed IndexDDX21
Probes
Litterature
PubMed197 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXDDX21
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:06:21 CEST 2021

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