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DDX21 (DExD-box helicase 21)

Identity

Alias_namesDEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 21
DEAD-box helicase 21
Alias_symbol (synonym)RH-II/GU
GURDB
Other aliasGUA
RH-II/GuA
HGNC (Hugo) DDX21
LocusID (NCBI) 9188
Atlas_Id 46952
Location 10q22.1  [Link to chromosome band 10q22]
Location_base_pair Starts at 68956440 and ends at 68985069 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
AD_1 () / DDX21 (10q22.1)ARID4B (1q42.3) / DDX21 (10q22.1)ASTN2 (9q33.1) / DDX21 (10q22.1)
ATP5G2 (12q13.13) / DDX21 (10q22.1)DDX21 (10q22.1) / BEX2 (Xq22.1)DDX21 (10q22.1) / CUTA (6p21.32)
DDX21 (10q22.1) / DDX21 (10q22.1)DDX21 (10q22.1) / SPATS2L (2q33.1)DDX21 (10q22.1) / SULF2 (20q13.12)
MRPS18C (4q21.23) / DDX21 (10q22.1)RPL23AP53 (8p23.3) / DDX21 (10q22.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DDX21   2744
Cards
Entrez_Gene (NCBI)DDX21  9188  DExD-box helicase 21
AliasesGUA; GURDB; RH-II/GU; RH-II/GuA
GeneCards (Weizmann)DDX21
Ensembl hg19 (Hinxton)ENSG00000165732 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000165732 [Gene_View]  chr10:68956440-68985069 [Contig_View]  DDX21 [Vega]
ICGC DataPortalENSG00000165732
TCGA cBioPortalDDX21
AceView (NCBI)DDX21
Genatlas (Paris)DDX21
WikiGenes9188
SOURCE (Princeton)DDX21
Genetics Home Reference (NIH)DDX21
Genomic and cartography
GoldenPath hg38 (UCSC)DDX21  -     chr10:68956440-68985069 +  10q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DDX21  -     10q22.1   [Description]    (hg19-Feb_2009)
EnsemblDDX21 - 10q22.1 [CytoView hg19]  DDX21 - 10q22.1 [CytoView hg38]
Mapping of homologs : NCBIDDX21 [Mapview hg19]  DDX21 [Mapview hg38]
OMIM606357   
Gene and transcription
Genbank (Entrez)AA446317 AB062394 AK025629 AK315585 BC004182
RefSeq transcript (Entrez)NM_001256910 NM_004728
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DDX21
Cluster EST : UnigeneHs.223141 [ NCBI ]
CGAP (NCI)Hs.223141
Alternative Splicing GalleryENSG00000165732
Gene ExpressionDDX21 [ NCBI-GEO ]   DDX21 [ EBI - ARRAY_EXPRESS ]   DDX21 [ SEEK ]   DDX21 [ MEM ]
Gene Expression Viewer (FireBrowse)DDX21 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9188
GTEX Portal (Tissue expression)DDX21
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NR30   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NR30  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NR30
Splice isoforms : SwissVarQ9NR30
PhosPhoSitePlusQ9NR30
Domaine pattern : Prosite (Expaxy)HELICASE_ATP_BIND_1 (PS51192)    HELICASE_CTER (PS51194)    Q_MOTIF (PS51195)   
Domains : Interpro (EBI)DEAD/DEAH_box_helicase_dom    GUCT    Helicase_ATP-bd    Helicase_C    P-loop_NTPase    RNA_helicase_DEAD_Q_motif    RRM_dom   
Domain families : Pfam (Sanger)DEAD (PF00270)    GUCT (PF08152)    Helicase_C (PF00271)   
Domain families : Pfam (NCBI)pfam00270    pfam08152    pfam00271   
Domain families : Smart (EMBL)DEXDc (SM00487)  HELICc (SM00490)  
Conserved Domain (NCBI)DDX21
DMDM Disease mutations9188
Blocks (Seattle)DDX21
PDB (SRS)2M3D   
PDB (PDBSum)2M3D   
PDB (IMB)2M3D   
PDB (RSDB)2M3D   
Structural Biology KnowledgeBase2M3D   
SCOP (Structural Classification of Proteins)2M3D   
CATH (Classification of proteins structures)2M3D   
SuperfamilyQ9NR30
Human Protein AtlasENSG00000165732
Peptide AtlasQ9NR30
HPRD05895
IPIIPI00015953   IPI00477179   IPI01010381   
Protein Interaction databases
DIP (DOE-UCLA)Q9NR30
IntAct (EBI)Q9NR30
FunCoupENSG00000165732
BioGRIDDDX21
STRING (EMBL)DDX21
ZODIACDDX21
Ontologies - Pathways
QuickGOQ9NR30
Ontology : AmiGOosteoblast differentiation  RNA binding  double-stranded RNA binding  ATP-dependent RNA helicase activity  ATP-dependent RNA helicase activity  protein binding  ATP binding  nucleus  nucleoplasm  nucleolus  rRNA processing  transcription from RNA polymerase II promoter  response to virus  RNA secondary structure unwinding  membrane  rRNA binding  snoRNA binding  response to exogenous dsRNA  positive regulation of gene expression, epigenetic  7SK snRNA binding  
Ontology : EGO-EBIosteoblast differentiation  RNA binding  double-stranded RNA binding  ATP-dependent RNA helicase activity  ATP-dependent RNA helicase activity  protein binding  ATP binding  nucleus  nucleoplasm  nucleolus  rRNA processing  transcription from RNA polymerase II promoter  response to virus  RNA secondary structure unwinding  membrane  rRNA binding  snoRNA binding  response to exogenous dsRNA  positive regulation of gene expression, epigenetic  7SK snRNA binding  
NDEx NetworkDDX21
Atlas of Cancer Signalling NetworkDDX21
Wikipedia pathwaysDDX21
Orthology - Evolution
OrthoDB9188
GeneTree (enSembl)ENSG00000165732
Phylogenetic Trees/Animal Genes : TreeFamDDX21
HOVERGENQ9NR30
HOGENOMQ9NR30
Homologs : HomoloGeneDDX21
Homology/Alignments : Family Browser (UCSC)DDX21
Gene fusions - Rearrangements
Fusion Cancer (Beijing)AD_1 [DDX21]  -  10q22.1 [FUSC001107]  [FUSC001107]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDDX21 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DDX21
dbVarDDX21
ClinVarDDX21
1000_GenomesDDX21 
Exome Variant ServerDDX21
ExAC (Exome Aggregation Consortium)DDX21 (select the gene name)
Genetic variants : HAPMAP9188
Genomic Variants (DGV)DDX21 [DGVbeta]
DECIPHERDDX21 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDDX21 
Mutations
ICGC Data PortalDDX21 
TCGA Data PortalDDX21 
Broad Tumor PortalDDX21
OASIS PortalDDX21 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDDX21  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDDX21
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DDX21
DgiDB (Drug Gene Interaction Database)DDX21
DoCM (Curated mutations)DDX21 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DDX21 (select a term)
intoGenDDX21
Cancer3DDDX21(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606357   
Orphanet
MedgenDDX21
Genetic Testing Registry DDX21
NextProtQ9NR30 [Medical]
TSGene9188
GENETestsDDX21
Target ValidationDDX21
Huge Navigator DDX21 [HugePedia]
snp3D : Map Gene to Disease9188
BioCentury BCIQDDX21
ClinGenDDX21
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9188
Chemical/Pharm GKB GenePA27210
Clinical trialDDX21
Miscellaneous
canSAR (ICR)DDX21 (select the gene name)
Probes
Litterature
PubMed97 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDDX21
EVEXDDX21
GoPubMedDDX21
iHOPDDX21
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:51:26 CEST 2017

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