DDX39B (DExD-box helicase 39B)

2011-02-01 Affiliation

Identity

HGNC

DDX39B

LOCATION

6p21.33

LOCUSID

7919

ALIAS

BAT1,D6S81E,UAP56

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 7919
MIM: 142560
HGNC: 13917
Ensembl: ENSG00000198563

Variants:

dbSNP: 7919
ClinVar: 7919
TCGA: ENSG00000198563
COSMIC: DDX39B

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000198563	ENST00000376177	Q5STU3
ENSG00000198563	ENST00000396172	Q13838
ENSG00000198563	ENST00000396172	A0A024RCM3
ENSG00000198563	ENST00000417023	H0Y400
ENSG00000198563	ENST00000418897	F6SXL5
ENSG00000198563	ENST00000419020	F6S2B7
ENSG00000198563	ENST00000419338	A0A0A0MT12
ENSG00000198563	ENST00000427214	F6WLT2
ENSG00000198563	ENST00000428098	F6TRA5
ENSG00000198563	ENST00000428450	F6R6M7
ENSG00000198563	ENST00000431908	F6UJC5
ENSG00000198563	ENST00000449757	F6QYI9
ENSG00000198563	ENST00000456662	F6S4E6
ENSG00000198563	ENST00000456976	F6U6E2
ENSG00000198563	ENST00000458640	Q13838
ENSG00000198563	ENST00000458640	A0A024RCM3
ENSG00000198563	ENST00000484566	H0YCC6

Expression (GTEx)

100

150

200

250

300

350

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Spliceosome	KEGG	ko03040
Spliceosome	KEGG	hsa03040
RNA transport	KEGG	ko03013
RNA transport	KEGG	hsa03013
mRNA surveillance pathway	KEGG	ko03015
mRNA surveillance pathway	KEGG	hsa03015
Influenza A	KEGG	ko05164
Influenza A	KEGG	hsa05164
TREX complex	KEGG	hsa_M00406
Exon junction complex (EJC)	KEGG	hsa_M00430
TREX complex	KEGG	M00406
Exon junction complex (EJC)	KEGG	M00430
Gene Expression	REACTOME	R-HSA-74160
RNA Polymerase II Transcription	REACTOME	R-HSA-73857
RNA Polymerase II Transcription Termination	REACTOME	R-HSA-73856
Cleavage of Growing Transcript in the Termination Region	REACTOME	R-HSA-109688
Processing of Capped Intron-Containing Pre-mRNA	REACTOME	R-HSA-72203
mRNA 3'-end processing	REACTOME	R-HSA-72187
Transport of Mature Transcript to Cytoplasm	REACTOME	R-HSA-72202
Transport of Mature mRNA derived from an Intron-Containing Transcript	REACTOME	R-HSA-159236

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
15998806	2005	Recruitment of the human TREX complex to mRNA during splicing.	174
19115949	2009	Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02).	119
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
16478985	2006	The UL69 transactivator protein of human cytomegalovirus interacts with DEXD/H-Box RNA helicase UAP56 to promote cytoplasmic accumulation of unspliced RNA.	55
19851445	2009	High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.	51
15585580	2004	Crystal structure of the human ATP-dependent splicing and export factor UAP56.	48
18593880	2008	Distinct activities of the DExD/H-box splicing factor hUAP56 facilitate stepwise assembly of the spliceosome.	40
21680511	2011	The cellular RNA helicase UAP56 is required for prevention of double-stranded RNA formation during influenza A virus infection.	38
20573985	2010	The closely related RNA helicases, UAP56 and URH49, preferentially form distinct mRNA export machineries and coordinately regulate mitotic progression.	37

Citation

Dessen P

DDX39B (DExD-box helicase 39B)

Atlas Genet Cytogenet Oncol Haematol. 2011-02-01

Online version: http://atlasgeneticsoncology.org/gene/52094/ddx39b