DDX39B (DExD-box helicase 39B)

2011-02-01  

Identity

HGNC
LOCATION
6p21.33
LOCUSID
ALIAS
BAT1,D6S81E,UAP56
FUSION GENES

Other Information

Locus ID:

NCBI: 7919
MIM: 142560
HGNC: 13917
Ensembl: ENSG00000198563

Variants:

dbSNP: 7919
ClinVar: 7919
TCGA: ENSG00000198563
COSMIC: DDX39B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198563ENST00000376177Q5STU3
ENSG00000198563ENST00000396172Q13838
ENSG00000198563ENST00000396172A0A024RCM3
ENSG00000198563ENST00000417023H0Y400
ENSG00000198563ENST00000418897F6SXL5
ENSG00000198563ENST00000419020F6S2B7
ENSG00000198563ENST00000419338A0A0A0MT12
ENSG00000198563ENST00000427214F6WLT2
ENSG00000198563ENST00000428098F6TRA5
ENSG00000198563ENST00000428450F6R6M7
ENSG00000198563ENST00000431908F6UJC5
ENSG00000198563ENST00000449757F6QYI9
ENSG00000198563ENST00000456662F6S4E6
ENSG00000198563ENST00000456976F6U6E2
ENSG00000198563ENST00000458640Q13838
ENSG00000198563ENST00000458640A0A024RCM3
ENSG00000198563ENST00000484566H0YCC6

Expression (GTEx)

0
50
100
150
200
250
300
350

Pathways

PathwaySourceExternal ID
SpliceosomeKEGGko03040
SpliceosomeKEGGhsa03040
RNA transportKEGGko03013
RNA transportKEGGhsa03013
mRNA surveillance pathwayKEGGko03015
mRNA surveillance pathwayKEGGhsa03015
Influenza AKEGGko05164
Influenza AKEGGhsa05164
TREX complexKEGGhsa_M00406
Exon junction complex (EJC)KEGGhsa_M00430
TREX complexKEGGM00406
Exon junction complex (EJC)KEGGM00430
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Polymerase II Transcription TerminationREACTOMER-HSA-73856
Cleavage of Growing Transcript in the Termination RegionREACTOMER-HSA-109688
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA 3'-end processingREACTOMER-HSA-72187
Transport of Mature Transcript to CytoplasmREACTOMER-HSA-72202
Transport of Mature mRNA derived from an Intron-Containing TranscriptREACTOMER-HSA-159236

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
382252622024Structural differences between the closely related RNA helicases, UAP56 and URH49, fashion distinct functional apo-complexes.2
383779422024Terminal regions of UAP56 and URH49 are required for their distinct complex formation functioning to an essential role in mRNA processing and export.0
382252622024Structural differences between the closely related RNA helicases, UAP56 and URH49, fashion distinct functional apo-complexes.2
383779422024Terminal regions of UAP56 and URH49 are required for their distinct complex formation functioning to an essential role in mRNA processing and export.0
370528532023DDX39B facilitates the malignant progression of hepatocellular carcinoma via activation of SREBP1-mediated de novo lipid synthesis.2
375788632023Structural basis for high-order complex of SARNP and DDX39B to facilitate mRNP assembly.3
370528532023DDX39B facilitates the malignant progression of hepatocellular carcinoma via activation of SREBP1-mediated de novo lipid synthesis.2
375788632023Structural basis for high-order complex of SARNP and DDX39B to facilitate mRNP assembly.3
359739892022DDX39B drives colorectal cancer progression by promoting the stability and nuclear translocation of PKM2.19
361097932022RETSAT associates with DDX39B to promote fork restarting and resistance to gemcitabine based chemotherapy in pancreatic ductal adenocarcinoma.3
359739892022DDX39B drives colorectal cancer progression by promoting the stability and nuclear translocation of PKM2.19
361097932022RETSAT associates with DDX39B to promote fork restarting and resistance to gemcitabine based chemotherapy in pancreatic ductal adenocarcinoma.3
334365632021The DDX39B/FUT3/TGFβR-I axis promotes tumor metastasis and EMT in colorectal cancer.28
343825242021DDX39B Predicts Poor Survival and Associated with Clinical Benefit of Anti-PD-L1 Therapy in ccRCC.3
334365632021The DDX39B/FUT3/TGFβR-I axis promotes tumor metastasis and EMT in colorectal cancer.28

Citation

Dessen P

DDX39B (DExD-box helicase 39B)

Atlas Genet Cytogenet Oncol Haematol. 2011-02-01

Online version: http://atlasgeneticsoncology.org/gene/52094/ddx39b