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DHX58 (DExH-box helicase 58)

Identity

Alias_namesDEXH (Asp-Glu-X-His) box polypeptide 58
Alias_symbol (synonym)LGP2
D11LGP2
Other aliasD11lgp2e
RLR-3
HGNC (Hugo) DHX58
LocusID (NCBI) 79132
Atlas_Id 41150
Location 17q21.2  [Link to chromosome band 17q21]
Location_base_pair Starts at 42101406 and ends at 42112733 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DHX58 (17q21.2) / DIP2C (10p15.3)MACF1 (1p34.3) / DHX58 (17q21.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DHX58   29517
Cards
Entrez_Gene (NCBI)DHX58  79132  DExH-box helicase 58
AliasesD11LGP2; D11lgp2e; LGP2; RLR-3
GeneCards (Weizmann)DHX58
Ensembl hg19 (Hinxton)ENSG00000108771 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000108771 [Gene_View]  chr17:42101406-42112733 [Contig_View]  DHX58 [Vega]
ICGC DataPortalENSG00000108771
TCGA cBioPortalDHX58
AceView (NCBI)DHX58
Genatlas (Paris)DHX58
WikiGenes79132
SOURCE (Princeton)DHX58
Genetics Home Reference (NIH)DHX58
Genomic and cartography
GoldenPath hg38 (UCSC)DHX58  -     chr17:42101406-42112733 -  17q21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DHX58  -     17q21.2   [Description]    (hg19-Feb_2009)
EnsemblDHX58 - 17q21.2 [CytoView hg19]  DHX58 - 17q21.2 [CytoView hg38]
Mapping of homologs : NCBIDHX58 [Mapview hg19]  DHX58 [Mapview hg38]
OMIM608588   
Gene and transcription
Genbank (Entrez)AK021416 AK097669 AK225549 AK296840 AK300900
RefSeq transcript (Entrez)NM_024119
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DHX58
Cluster EST : UnigeneHs.55918 [ NCBI ]
CGAP (NCI)Hs.55918
Alternative Splicing GalleryENSG00000108771
Gene ExpressionDHX58 [ NCBI-GEO ]   DHX58 [ EBI - ARRAY_EXPRESS ]   DHX58 [ SEEK ]   DHX58 [ MEM ]
Gene Expression Viewer (FireBrowse)DHX58 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79132
GTEX Portal (Tissue expression)DHX58
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96C10   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96C10  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96C10
Splice isoforms : SwissVarQ96C10
Catalytic activity : Enzyme3.6.4.13 [ Enzyme-Expasy ]   3.6.4.133.6.4.13 [ IntEnz-EBI ]   3.6.4.13 [ BRENDA ]   3.6.4.13 [ KEGG ]   
PhosPhoSitePlusQ96C10
Domaine pattern : Prosite (Expaxy)HELICASE_ATP_BIND_1 (PS51192)    HELICASE_CTER (PS51194)    RLR_CTR (PS51789)   
Domains : Interpro (EBI)GAF_dom-like    Helicase/UvrB_N    Helicase_ATP-bd    Helicase_C    P-loop_NTPase    RIG-I_C-RD   
Domain families : Pfam (Sanger)Helicase_C (PF00271)    ResIII (PF04851)    RIG-I_C-RD (PF11648)   
Domain families : Pfam (NCBI)pfam00271    pfam04851    pfam11648   
Domain families : Smart (EMBL)DEXDc (SM00487)  HELICc (SM00490)  
Conserved Domain (NCBI)DHX58
DMDM Disease mutations79132
Blocks (Seattle)DHX58
PDB (SRS)2RQA    2W4R    3EQT   
PDB (PDBSum)2RQA    2W4R    3EQT   
PDB (IMB)2RQA    2W4R    3EQT   
PDB (RSDB)2RQA    2W4R    3EQT   
Structural Biology KnowledgeBase2RQA    2W4R    3EQT   
SCOP (Structural Classification of Proteins)2RQA    2W4R    3EQT   
CATH (Classification of proteins structures)2RQA    2W4R    3EQT   
SuperfamilyQ96C10
Human Protein AtlasENSG00000108771
Peptide AtlasQ96C10
HPRD13115
IPIIPI00303746   IPI00902528   IPI00792703   IPI00794515   
Protein Interaction databases
DIP (DOE-UCLA)Q96C10
IntAct (EBI)Q96C10
FunCoupENSG00000108771
BioGRIDDHX58
STRING (EMBL)DHX58
ZODIACDHX58
Ontologies - Pathways
QuickGOQ96C10
Ontology : AmiGODNA binding  double-stranded RNA binding  single-stranded RNA binding  helicase activity  protein binding  ATP binding  cytoplasm  zinc ion binding  response to virus  negative regulation of type I interferon production  positive regulation of type I interferon production  negative regulation of MDA-5 signaling pathway  negative regulation of RIG-I signaling pathway  negative regulation of RIG-I signaling pathway  innate immune response  regulation of innate immune response  negative regulation of innate immune response  defense response to virus  positive regulation of MDA-5 signaling pathway  positive regulation of RIG-I signaling pathway  
Ontology : EGO-EBIDNA binding  double-stranded RNA binding  single-stranded RNA binding  helicase activity  protein binding  ATP binding  cytoplasm  zinc ion binding  response to virus  negative regulation of type I interferon production  positive regulation of type I interferon production  negative regulation of MDA-5 signaling pathway  negative regulation of RIG-I signaling pathway  negative regulation of RIG-I signaling pathway  innate immune response  regulation of innate immune response  negative regulation of innate immune response  defense response to virus  positive regulation of MDA-5 signaling pathway  positive regulation of RIG-I signaling pathway  
Pathways : KEGGRIG-I-like receptor signaling pathway   
NDEx NetworkDHX58
Atlas of Cancer Signalling NetworkDHX58
Wikipedia pathwaysDHX58
Orthology - Evolution
OrthoDB79132
GeneTree (enSembl)ENSG00000108771
Phylogenetic Trees/Animal Genes : TreeFamDHX58
HOVERGENQ96C10
HOGENOMQ96C10
Homologs : HomoloGeneDHX58
Homology/Alignments : Family Browser (UCSC)DHX58
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDHX58 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DHX58
dbVarDHX58
ClinVarDHX58
1000_GenomesDHX58 
Exome Variant ServerDHX58
ExAC (Exome Aggregation Consortium)DHX58 (select the gene name)
Genetic variants : HAPMAP79132
Genomic Variants (DGV)DHX58 [DGVbeta]
DECIPHERDHX58 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDHX58 
Mutations
ICGC Data PortalDHX58 
TCGA Data PortalDHX58 
Broad Tumor PortalDHX58
OASIS PortalDHX58 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDHX58  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDHX58
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DHX58
DgiDB (Drug Gene Interaction Database)DHX58
DoCM (Curated mutations)DHX58 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DHX58 (select a term)
intoGenDHX58
Cancer3DDHX58(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608588   
Orphanet
MedgenDHX58
Genetic Testing Registry DHX58
NextProtQ96C10 [Medical]
TSGene79132
GENETestsDHX58
Target ValidationDHX58
Huge Navigator DHX58 [HugePedia]
snp3D : Map Gene to Disease79132
BioCentury BCIQDHX58
ClinGenDHX58
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD79132
Chemical/Pharm GKB GenePA162383566
Clinical trialDHX58
Miscellaneous
canSAR (ICR)DHX58 (select the gene name)
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDHX58
EVEXDHX58
GoPubMedDHX58
iHOPDHX58
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 16:59:32 CEST 2017

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