Atlas of Genetics and Cytogenetics in Oncology and Haematology

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DISC1 (DISC1 scaffold protein)


Alias (NCBI)C1orf136
HGNC Previous namedisrupted in schizophrenia 1
LocusID (NCBI) 27185
Atlas_Id 46081
Location 1q42.2  [Link to chromosome band 1q42]
Location_base_pair Starts at 231626790 and ends at 232041272 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LYST (1q42.3) / DISC1 (1q42.2)OBSCN (1q42.13) / DISC1 (1q42.2)PBX1 (1q23.3) / DISC1 (1q42.2)
TSNAX (1q42.2) / DISC1 (1q42.2)LYST 1q42.3 / DISC1 1q42.2OBSCN 1q42.13 / DISC1 1q42.2
PBX1 1q23.3 / DISC1 1q42.2


Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(5;16)(q32;p13) NDE1/PDGFRB

External links

HGNC (Hugo)DISC1   2888
Entrez_Gene (NCBI)DISC1    DISC1 scaffold protein
AliasesC1orf136; SCZD9
GeneCards (Weizmann)DISC1
Ensembl hg19 (Hinxton)ENSG00000162946 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000162946 [Gene_View]  ENSG00000162946 [Sequence]  chr1:231626790-232041272 [Contig_View]  DISC1 [Vega]
ICGC DataPortalENSG00000162946
TCGA cBioPortalDISC1
Genatlas (Paris)DISC1
SOURCE (Princeton)DISC1
Genetics Home Reference (NIH)DISC1
Genomic and cartography
GoldenPath hg38 (UCSC)DISC1  -     chr1:231626790-232041272 +  1q42.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DISC1  -     1q42.2   [Description]    (hg19-Feb_2009)
GoldenPathDISC1 - 1q42.2 [CytoView hg19]  DISC1 - 1q42.2 [CytoView hg38]
Genome Data Viewer NCBIDISC1 [Mapview hg19]  
OMIM604906   605210   
Gene and transcription
Genbank (Entrez)AB007926 AF222980 AI075754 AJ506177 AJ506178
RefSeq transcript (Entrez)NM_001012957 NM_001012958 NM_001012959 NM_001039383 NM_001164537 NM_001164538 NM_001164539 NM_001164540 NM_001164541 NM_001164542 NM_001164544 NM_001164545 NM_001164546 NM_001164547 NM_001164548 NM_001164549 NM_001164550 NM_001164551 NM_001164552 NM_001164553 NM_001164554 NM_001164555 NM_001164556 NM_018662
Consensus coding sequences : CCDS (NCBI)DISC1
Gene ExpressionDISC1 [ NCBI-GEO ]   DISC1 [ EBI - ARRAY_EXPRESS ]   DISC1 [ SEEK ]   DISC1 [ MEM ]
Gene Expression Viewer (FireBrowse)DISC1 [ Firebrowse - Broad ]
GenevisibleExpression of DISC1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)27185
GTEX Portal (Tissue expression)DISC1
Human Protein AtlasENSG00000162946-DISC1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)DISC1
Human Protein Atlas [tissue]ENSG00000162946-DISC1 [tissue]
Protein Interaction databases
Ontologies - Pathways
PubMed277 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:06:47 CEST 2021

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