Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

DLG5 (discs large MAGUK scaffold protein 5)

Identity

Alias_namesdiscs, large homolog 5 (Drosophila)
discs large homolog 5
Alias_symbol (synonym)P-dlg
KIAA0583
Other aliasLP-DLG
P-DLG5
PDLG
HGNC (Hugo) DLG5
LocusID (NCBI) 9231
Atlas_Id 40335
Location 10q22.3  [Link to chromosome band 10q22]
Location_base_pair Starts at 77790791 and ends at 77926590 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CLUH (17p13.3) / DLG5 (10q22.3)DLG5 (10q22.3) / DLG5 (10q22.3)DLG5 (10q22.3) / EIF4A2 (3q27.3)
DLG5 (10q22.3) / PCDH15 (10q21.1)DLG5 (10q22.3) / RHOBTB3 (5q15)KCNMA1 (10q22.3) / DLG5 (10q22.3)
SEMA6A (5q23.1) / DLG5 (10q22.3)SSBP1 (7q34) / DLG5 (10q22.3)DLG5 10q22.3 / PCDH15 10q21.1
KCNMA1 10q22.3 / DLG5 10q22.3KIAA0664 DLG5 10q22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  t(10;10)(q21;q22) DLG5/PCDH15
KCNMA1/DLG5 (10q22)
t(10;17)(q22;p13) CLUH/DLG5


External links

Nomenclature
HGNC (Hugo)DLG5   2904
Cards
Entrez_Gene (NCBI)DLG5  9231  discs large MAGUK scaffold protein 5
AliasesLP-DLG; P-DLG5; PDLG
GeneCards (Weizmann)DLG5
Ensembl hg19 (Hinxton)ENSG00000151208 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000151208 [Gene_View]  ENSG00000151208 [Sequence]  chr10:77790791-77926590 [Contig_View]  DLG5 [Vega]
ICGC DataPortalENSG00000151208
TCGA cBioPortalDLG5
AceView (NCBI)DLG5
Genatlas (Paris)DLG5
WikiGenes9231
SOURCE (Princeton)DLG5
Genetics Home Reference (NIH)DLG5
Genomic and cartography
GoldenPath hg38 (UCSC)DLG5  -     chr10:77790791-77926590 -  10q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DLG5  -     10q22.3   [Description]    (hg19-Feb_2009)
EnsemblDLG5 - 10q22.3 [CytoView hg19]  DLG5 - 10q22.3 [CytoView hg38]
Mapping of homologs : NCBIDLG5 [Mapview hg19]  DLG5 [Mapview hg38]
OMIM604090   
Gene and transcription
Genbank (Entrez)AB011155 AB091676 AK055172 AK055265 AK122931
RefSeq transcript (Entrez)NM_004747
RefSeq genomic (Entrez)NC_000010 NG_011484 NT_187580
Consensus coding sequences : CCDS (NCBI)DLG5
Cluster EST : UnigeneHs.652690 [ NCBI ]
CGAP (NCI)Hs.652690
Alternative Splicing GalleryENSG00000151208
Gene ExpressionDLG5 [ NCBI-GEO ]   DLG5 [ EBI - ARRAY_EXPRESS ]   DLG5 [ SEEK ]   DLG5 [ MEM ]
Gene Expression Viewer (FireBrowse)DLG5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9231
GTEX Portal (Tissue expression)DLG5
Human Protein AtlasENSG00000151208-DLG5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TDM6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TDM6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TDM6
Splice isoforms : SwissVarQ8TDM6
PhosPhoSitePlusQ8TDM6
Domaine pattern : Prosite (Expaxy)CARD (PS50209)    GUANYLATE_KINASE_2 (PS50052)    PDZ (PS50106)    SH3 (PS50002)   
Domains : Interpro (EBI)CARD    DEATH-like_dom_sf    DLG5_SH3    DUF622    GK/Ca_channel_bsu    Guanylate_kin-like_dom    P-loop_NTPase    PDZ    PDZ_sf    SH3-like_dom_sf    SH3_domain   
Domain families : Pfam (Sanger)Guanylate_kin (PF00625)    PDZ (PF00595)    Takusan (PF04822)   
Domain families : Pfam (NCBI)pfam00625    pfam00595    pfam04822   
Domain families : Smart (EMBL)GuKc (SM00072)  PDZ (SM00228)  SH3 (SM00326)  
Conserved Domain (NCBI)DLG5
DMDM Disease mutations9231
Blocks (Seattle)DLG5
PDB (SRS)1UIT   
PDB (PDBSum)1UIT   
PDB (IMB)1UIT   
PDB (RSDB)1UIT   
Structural Biology KnowledgeBase1UIT   
SCOP (Structural Classification of Proteins)1UIT   
CATH (Classification of proteins structures)1UIT   
SuperfamilyQ8TDM6
Human Protein Atlas [tissue]ENSG00000151208-DLG5 [tissue]
Peptide AtlasQ8TDM6
HPRD04972
IPIIPI00411901   IPI00514780   IPI00854753   IPI00854821   IPI00854862   
Protein Interaction databases
DIP (DOE-UCLA)Q8TDM6
IntAct (EBI)Q8TDM6
FunCoupENSG00000151208
BioGRIDDLG5
STRING (EMBL)DLG5
ZODIACDLG5
Ontologies - Pathways
QuickGOQ8TDM6
Ontology : AmiGOepithelial to mesenchymal transition  protein binding  cytoplasm  plasma membrane  cell-cell adherens junction  signal transduction  beta-catenin binding  cytoskeletal protein binding  negative regulation of cell proliferation  postsynaptic density  maintenance of cell polarity  cell junction  receptor signaling complex scaffold activity  negative regulation of cell migration  polarized epithelial cell differentiation  midbrain development  negative regulation of hippo signaling  positive regulation of hippo signaling  intracellular signal transduction  ciliary basal body  negative regulation of T cell proliferation  regulation of apoptotic process  apical protein localization  zonula adherens assembly  establishment or maintenance of epithelial cell apical/basal polarity  postsynaptic membrane  positive regulation of smoothened signaling pathway  positive regulation of synapse assembly  epithelial tube branching involved in lung morphogenesis  positive regulation of dendritic spine development  protein-containing complex assembly  protein localization to adherens junction  metanephric collecting duct development  cell-cell adhesion  
Ontology : EGO-EBIepithelial to mesenchymal transition  protein binding  cytoplasm  plasma membrane  cell-cell adherens junction  signal transduction  beta-catenin binding  cytoskeletal protein binding  negative regulation of cell proliferation  postsynaptic density  maintenance of cell polarity  cell junction  receptor signaling complex scaffold activity  negative regulation of cell migration  polarized epithelial cell differentiation  midbrain development  negative regulation of hippo signaling  positive regulation of hippo signaling  intracellular signal transduction  ciliary basal body  negative regulation of T cell proliferation  regulation of apoptotic process  apical protein localization  zonula adherens assembly  establishment or maintenance of epithelial cell apical/basal polarity  postsynaptic membrane  positive regulation of smoothened signaling pathway  positive regulation of synapse assembly  epithelial tube branching involved in lung morphogenesis  positive regulation of dendritic spine development  protein-containing complex assembly  protein localization to adherens junction  metanephric collecting duct development  cell-cell adhesion  
NDEx NetworkDLG5
Atlas of Cancer Signalling NetworkDLG5
Wikipedia pathwaysDLG5
Orthology - Evolution
OrthoDB9231
GeneTree (enSembl)ENSG00000151208
Phylogenetic Trees/Animal Genes : TreeFamDLG5
HOVERGENQ8TDM6
HOGENOMQ8TDM6
Homologs : HomoloGeneDLG5
Homology/Alignments : Family Browser (UCSC)DLG5
Gene fusions - Rearrangements
Fusion : MitelmanCLUH/DLG5 [17p13.3/10q22.3]  [t(10;17)(q22;p13)]  
Fusion : MitelmanDLG5/PCDH15 [10q22.3/10q21.1]  [t(10;10)(q21;q22)]  
Fusion : MitelmanKCNMA1/DLG5 [10q22.3/10q22.3]  [t(10;10)(q22;q22)]  
Fusion PortalDLG5 10q22.3 PCDH15 10q21.1 BRCA
Fusion PortalKCNMA1 10q22.3 DLG5 10q22.3 BRCA OV
Fusion PortalKIAA0664 DLG5 10q22.3 BRCA
Fusion : QuiverDLG5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDLG5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DLG5
dbVarDLG5
ClinVarDLG5
1000_GenomesDLG5 
Exome Variant ServerDLG5
ExAC (Exome Aggregation Consortium)ENSG00000151208
GNOMAD BrowserENSG00000151208
Varsome BrowserDLG5
Genetic variants : HAPMAP9231
Genomic Variants (DGV)DLG5 [DGVbeta]
DECIPHERDLG5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDLG5 
Mutations
ICGC Data PortalDLG5 
TCGA Data PortalDLG5 
Broad Tumor PortalDLG5
OASIS PortalDLG5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDLG5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDLG5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DLG5
DgiDB (Drug Gene Interaction Database)DLG5
DoCM (Curated mutations)DLG5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DLG5 (select a term)
intoGenDLG5
Cancer3DDLG5(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604090   
Orphanet
DisGeNETDLG5
MedgenDLG5
Genetic Testing Registry DLG5
NextProtQ8TDM6 [Medical]
TSGene9231
GENETestsDLG5
Target ValidationDLG5
Huge Navigator DLG5 [HugePedia]
snp3D : Map Gene to Disease9231
BioCentury BCIQDLG5
ClinGenDLG5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9231
Chemical/Pharm GKB GenePA27360
Clinical trialDLG5
Miscellaneous
canSAR (ICR)DLG5 (select the gene name)
Probes
Litterature
PubMed90 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDLG5
EVEXDLG5
GoPubMedDLG5
iHOPDLG5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:02:37 CET 2018

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.