DNAJB12 (DnaJ heat shock protein family (Hsp40) member B12)

2007-04-01  

Identity

HGNC
LOCATION
10q22.1
LOCUSID
ALIAS
DJ10
FUSION GENES

Other Information

Locus ID:

NCBI: 54788
MIM: 608376
HGNC: 14891
Ensembl: ENSG00000148719

Variants:

dbSNP: 54788
ClinVar: 54788
TCGA: ENSG00000148719
COSMIC: DNAJB12

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000148719ENST00000338820J3KPS0
ENSG00000148719ENST00000394903J3KPS0
ENSG00000148719ENST00000444643Q9NXW2
ENSG00000148719ENST00000461919V9GY70
ENSG00000148719ENST00000463786V9GYN7

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
211482932011The endoplasmic reticulum-associated Hsp40 DNAJB12 and Hsc70 cooperate to facilitate RMA1 E3-dependent degradation of nascent CFTRDeltaF508.55
211501292010A novel ER J-protein DNAJB12 accelerates ER-associated degradation of membrane proteins including CFTR.23
279166612017Tetrameric Assembly of K+ Channels Requires ER-Located Chaperone Proteins.15
247329122014Expression of DNAJB12 or DNAJB14 causes coordinate invasion of the nucleus by membranes associated with a novel nuclear pore structure.7
285362682017Endoplasmic reticulum stress-induced degradation of DNAJB12 stimulates BOK accumulation and primes cancer cells for apoptosis.4

Citation

Dessen P

DNAJB12 (DnaJ heat shock protein family (Hsp40) member B12)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47243/dnajb12