Atlas of Genetics and Cytogenetics in Oncology and Haematology

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DNAJB12 (DnaJ heat shock protein family (Hsp40) member B12)

Identity

Alias_namesDnaJ (Hsp40) homolog, subfamily B, member 12
Alias_symbol (synonym)DJ10
FLJ20027
Other alias
HGNC (Hugo) DNAJB12
LocusID (NCBI) 54788
Atlas_Id 47243
Location 10q22.1  [Link to chromosome band 10q22]
Location_base_pair Starts at 72332830 and ends at 72355149 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DNAJB12 (10q22.1) / SLC25A16 (10q21.3)SMPDL3B (1p35.3) / DNAJB12 (10q22.1)DNAJB12 10q22.1 / SLC25A16 10q21.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(10;10)(q21;q22) DNAJB12/SLC25A16

External links

Nomenclature
HGNC (Hugo)DNAJB12   14891
Cards
Entrez_Gene (NCBI)DNAJB12  54788  DnaJ heat shock protein family (Hsp40) member B12
AliasesDJ10
GeneCards (Weizmann)DNAJB12
Ensembl hg19 (Hinxton)ENSG00000148719 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000148719 [Gene_View]  ENSG00000148719 [Sequence]  chr10:72332830-72355149 [Contig_View]  DNAJB12 [Vega]
ICGC DataPortalENSG00000148719
TCGA cBioPortalDNAJB12
AceView (NCBI)DNAJB12
Genatlas (Paris)DNAJB12
WikiGenes54788
SOURCE (Princeton)DNAJB12
Genetics Home Reference (NIH)DNAJB12
Genomic and cartography
GoldenPath hg38 (UCSC)DNAJB12  -     chr10:72332830-72355149 -  10q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DNAJB12  -     10q22.1   [Description]    (hg19-Feb_2009)
GoldenPathDNAJB12 - 10q22.1 [CytoView hg19]  DNAJB12 - 10q22.1 [CytoView hg38]
ImmunoBaseENSG00000148719
Mapping of homologs : NCBIDNAJB12 [Mapview hg19]  DNAJB12 [Mapview hg38]
OMIM608376   
Gene and transcription
Genbank (Entrez)AK000034 AK025942 AK027259 AK123129 AK225051
RefSeq transcript (Entrez)NM_001002762 NM_001365080 NM_001365081 NM_017626
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DNAJB12
Cluster EST : UnigeneHs.500013 [ NCBI ]
CGAP (NCI)Hs.500013
Alternative Splicing GalleryENSG00000148719
Gene ExpressionDNAJB12 [ NCBI-GEO ]   DNAJB12 [ EBI - ARRAY_EXPRESS ]   DNAJB12 [ SEEK ]   DNAJB12 [ MEM ]
Gene Expression Viewer (FireBrowse)DNAJB12 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54788
GTEX Portal (Tissue expression)DNAJB12
Human Protein AtlasENSG00000148719-DNAJB12 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NXW2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NXW2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NXW2
Splice isoforms : SwissVarQ9NXW2
PhosPhoSitePlusQ9NXW2
Domaine pattern : Prosite (Expaxy)DNAJ_1 (PS00636)    DNAJ_2 (PS50076)   
Domains : Interpro (EBI)DnaJ_domain    DnaJ_domain_CS    DUF1977_DnaJ-like    J_dom_sf   
Domain families : Pfam (Sanger)DnaJ (PF00226)    DUF1977 (PF09320)   
Domain families : Pfam (NCBI)pfam00226    pfam09320   
Domain families : Smart (EMBL)DnaJ (SM00271)  
Conserved Domain (NCBI)DNAJB12
DMDM Disease mutations54788
Blocks (Seattle)DNAJB12
PDB (RSDB)2CTP   
PDB Europe2CTP   
PDB (PDBSum)2CTP   
PDB (IMB)2CTP   
Structural Biology KnowledgeBase2CTP   
SCOP (Structural Classification of Proteins)2CTP   
CATH (Classification of proteins structures)2CTP   
SuperfamilyQ9NXW2
Human Protein Atlas [tissue]ENSG00000148719-DNAJB12 [tissue]
Peptide AtlasQ9NXW2
HPRD07086
IPIIPI01011752   IPI00014400   
Protein Interaction databases
DIP (DOE-UCLA)Q9NXW2
IntAct (EBI)Q9NXW2
FunCoupENSG00000148719
BioGRIDDNAJB12
STRING (EMBL)DNAJB12
ZODIACDNAJB12
Ontologies - Pathways
QuickGOQ9NXW2
Ontology : AmiGOendoplasmic reticulum  endoplasmic reticulum membrane  membrane  integral component of endoplasmic reticulum membrane  ubiquitin-dependent ERAD pathway  Hsp70 protein binding  Hsp70 protein binding  nuclear membrane  cellular protein-containing complex assembly  ERAD pathway  chaperone cofactor-dependent protein refolding  chaperone cofactor-dependent protein refolding  cellular response to misfolded protein  cellular response to misfolded protein  
Ontology : EGO-EBIendoplasmic reticulum  endoplasmic reticulum membrane  membrane  integral component of endoplasmic reticulum membrane  ubiquitin-dependent ERAD pathway  Hsp70 protein binding  Hsp70 protein binding  nuclear membrane  cellular protein-containing complex assembly  ERAD pathway  chaperone cofactor-dependent protein refolding  chaperone cofactor-dependent protein refolding  cellular response to misfolded protein  cellular response to misfolded protein  
Pathways : KEGGProtein processing in endoplasmic reticulum   
NDEx NetworkDNAJB12
Atlas of Cancer Signalling NetworkDNAJB12
Wikipedia pathwaysDNAJB12
Orthology - Evolution
OrthoDB54788
GeneTree (enSembl)ENSG00000148719
Phylogenetic Trees/Animal Genes : TreeFamDNAJB12
HOGENOMQ9NXW2
Homologs : HomoloGeneDNAJB12
Homology/Alignments : Family Browser (UCSC)DNAJB12
Gene fusions - Rearrangements
Fusion : MitelmanDNAJB12/SLC25A16 [10q22.1/10q21.3]  
Fusion PortalDNAJB12 10q22.1 SLC25A16 10q21.3 BRCA
Fusion : QuiverDNAJB12
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDNAJB12 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DNAJB12
dbVarDNAJB12
ClinVarDNAJB12
1000_GenomesDNAJB12 
Exome Variant ServerDNAJB12
ExAC (Exome Aggregation Consortium)ENSG00000148719
GNOMAD BrowserENSG00000148719
Varsome BrowserDNAJB12
Genetic variants : HAPMAP54788
Genomic Variants (DGV)DNAJB12 [DGVbeta]
DECIPHERDNAJB12 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDNAJB12 
Mutations
ICGC Data PortalDNAJB12 
TCGA Data PortalDNAJB12 
Broad Tumor PortalDNAJB12
OASIS PortalDNAJB12 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDNAJB12  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDNAJB12
Mutations and Diseases : HGMDDNAJB12
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DNAJB12
DgiDB (Drug Gene Interaction Database)DNAJB12
DoCM (Curated mutations)DNAJB12 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DNAJB12 (select a term)
intoGenDNAJB12
Cancer3DDNAJB12(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608376   
Orphanet
DisGeNETDNAJB12
MedgenDNAJB12
Genetic Testing Registry DNAJB12
NextProtQ9NXW2 [Medical]
TSGene54788
GENETestsDNAJB12
Target ValidationDNAJB12
Huge Navigator DNAJB12 [HugePedia]
snp3D : Map Gene to Disease54788
BioCentury BCIQDNAJB12
ClinGenDNAJB12
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD54788
Chemical/Pharm GKB GenePA27414
Clinical trialDNAJB12
Miscellaneous
canSAR (ICR)DNAJB12 (select the gene name)
DataMed IndexDNAJB12
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDNAJB12
EVEXDNAJB12
GoPubMedDNAJB12
iHOPDNAJB12
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 17:40:39 CET 2019
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