DPYSL5 (dihydropyrimidinase like 5)

2008-05-01  

Identity

HGNC
DPYSL5
LOCATION
2p23.3
LOCUSID
56896
ALIAS
CRAM,CRMP-5,CRMP5,CV2,Ulip6
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 56896
MIM: 608383
HGNC: 20637
Ensembl: ENSG00000157851

Variants:

dbSNP: 56896
ClinVar: 56896
TCGA: ENSG00000157851
COSMIC: DPYSL5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000157851ENST00000288699Q9BPU6
ENSG00000157851ENST00000401478Q9BPU6
ENSG00000157851ENST00000431402E7EWB4
ENSG00000157851ENST00000434719E7ESV0
ENSG00000157851ENST00000450961E9PHT0
ENSG00000157851ENST00000614712Q9BPU6

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Semaphorin interactionsREACTOMER-HSA-373755
CRMPs in Sema3A signalingREACTOMER-HSA-399956

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
128385192003Paraneoplastic autoimmune optic neuritis with retinitis defined by CRMP-5-IgG.33
189310142009Onco-neural antibodies and tumour type determine survival and neurological symptoms in paraneoplastic neurological syndromes with Hu or CV2/CRMP5 antibodies.31
261228472015CRMP5 Controls Glioblastoma Cell Proliferation and Survival through Notch-Dependent Signaling.14
233737492013Insights into the oligomerization of CRMPs: crystal structure of human collapsin response mediator protein 5.11
183062412008Autoimmune myelopathy associated with collapsin response-mediator protein-5 immunoglobulin G.10
187693322008Extensive expression of collapsin response mediator protein 5 (CRMP5) is a specific marker of high-grade lung neuroendocrine carcinoma.8
243242682014Collapsin response mediator protein 5 (CRMP5) induces mitophagy, thereby regulating mitochondrion numbers in dendrites.7
232989462013Identification of a new CRMP5 isoform present in the nucleus of cancer cells and enhancing their proliferation.5
183474532008High-titer collapsin response-mediating protein-associated (CRMP-5) paraneoplastic optic neuropathy and Vitritis as the only clinical manifestations in a patient with small cell lung carcinoma.4
283749152017DRP5 is involved in cancer cell growth and predicts poor prognosis in human osteosarcoma.4

Citation

Dessen P

DPYSL5 (dihydropyrimidinase like 5)

Atlas Genet Cytogenet Oncol Haematol. 2008-05-01

Online version: http://atlasgeneticsoncology.org/gene/50119/dpysl5