DSC3 (desmocollin 3)

2003-11-01  

Identity

HGNC
LOCATION
18q12.1
LOCUSID
ALIAS
CDHF3,DSC,DSC1,DSC2,DSC4,HT-CP
FUSION GENES

Other Information

Locus ID:

NCBI: 1825
MIM: 600271
HGNC: 3037
Ensembl: ENSG00000134762

Variants:

dbSNP: 1825
ClinVar: 1825
TCGA: ENSG00000134762
COSMIC: DSC3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134762ENST00000360428Q14574
ENSG00000134762ENST00000434452Q14574
ENSG00000134762ENST00000584980J3QRL9

Expression (GTEx)

0
50
100
150
200
250
300
350

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
KeratinizationREACTOMER-HSA-6805567
Formation of the cornified envelopeREACTOMER-HSA-6809371

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
161681122005Epigenetic silencing of DSC3 is a common event in human breast cancer.40
127892712003Mutant p53 and aberrant cytosine methylation cooperate to silence gene expression.36
197175672009Desmocollin 3-mediated binding is crucial for keratinocyte cohesion and is impaired in pemphigus.31
206286242010Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".29
170889062006Desmocollin switching in colorectal cancer.24
224380682012Loss of desmocollin 1-3 and homeobox genes PITX1 and CDX2 are associated with tumor progression and survival in colorectal carcinoma.23
178467852007Altered expression of desmocollin 3, desmoglein 3, and beta-catenin in oral squamous cell carcinoma: correlation with lymph node metastasis and cell proliferation.22
209525842010Autoimmunity to desmocollin 3 in pemphigus vulgaris.22
229410602012The p53 target gene desmocollin 3 acts as a novel tumor suppressor through inhibiting EGFR/ERK pathway in human lung cancer.20

Citation

Dessen P

DSC3 (desmocollin 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40364/dsc3