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DSTN (destrin, actin depolymerizing factor)

Identity

Alias (NCBI)ACTDP
ADF
HEL32
bA462D18.2
HGNC (Hugo) DSTN
HGNC Alias symbADF
ACTDP
HGNC Previous namedestrin (actin depolymerizing factor)
LocusID (NCBI) 11034
Atlas_Id 49860
Location 20p12.1  [Link to chromosome band 20p12]
Location_base_pair Starts at 17570075 and ends at 17609919 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DSTN (20p12.1) / CCDC127 (5p15.33)DSTN (20p12.1) / DSTN (20p12.1)DSTN (20p12.1) / DTD1 (20p11.23)
DSTN (20p12.1) / DZANK1 (20p11.23)DSTN (20p12.1) / FBXO31 (16q24.2)DSTN (20p12.1) / TCFL5 (20q13.33)
DSTN 20p12.1 C20orf12DSTN 20p12.1 / CCDC127 5p15.33DSTN 20p12.1 / DTD1 20p11.23
DSTN 20p12.1 / TCFL5 20q13.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)DSTN   15750
Cards
Entrez_Gene (NCBI)DSTN    destrin, actin depolymerizing factor
AliasesACTDP; ADF; HEL32; bA462D18.2
GeneCards (Weizmann)DSTN
Ensembl hg19 (Hinxton)ENSG00000125868 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000125868 [Gene_View]  ENSG00000125868 [Sequence]  chr20:17570075-17609919 [Contig_View]  DSTN [Vega]
ICGC DataPortalENSG00000125868
TCGA cBioPortalDSTN
AceView (NCBI)DSTN
Genatlas (Paris)DSTN
SOURCE (Princeton)DSTN
Genetics Home Reference (NIH)DSTN
Genomic and cartography
GoldenPath hg38 (UCSC)DSTN  -     chr20:17570075-17609919 +  20p12.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DSTN  -     20p12.1   [Description]    (hg19-Feb_2009)
GoldenPathDSTN - 20p12.1 [CytoView hg19]  DSTN - 20p12.1 [CytoView hg38]
ImmunoBaseENSG00000125868
Genome Data Viewer NCBIDSTN [Mapview hg19]  
OMIM609114   
Gene and transcription
Genbank (Entrez)AI597935 AK302338 AK308562 AK312645 AK315994
RefSeq transcript (Entrez)NM_001011546 NM_006870
Consensus coding sequences : CCDS (NCBI)DSTN
Gene ExpressionDSTN [ NCBI-GEO ]   DSTN [ EBI - ARRAY_EXPRESS ]   DSTN [ SEEK ]   DSTN [ MEM ]
Gene Expression Viewer (FireBrowse)DSTN [ Firebrowse - Broad ]
GenevisibleExpression of DSTN in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11034
GTEX Portal (Tissue expression)DSTN
Human Protein AtlasENSG00000125868-DSTN [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP60981   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP60981  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP60981
PhosPhoSitePlusP60981
Domaine pattern : Prosite (Expaxy)ADF_H (PS51263)   
Domains : Interpro (EBI)ADF-H    ADF-H/Gelsolin-like_dom_sf    ADF/Cofilin    Dstn   
Domain families : Pfam (Sanger)Cofilin_ADF (PF00241)   
Domain families : Pfam (NCBI)pfam00241   
Domain families : Smart (EMBL)ADF (SM00102)  
Conserved Domain (NCBI)DSTN
SuperfamilyP60981
AlphaFold pdb e-kbP60981   
Human Protein Atlas [tissue]ENSG00000125868-DSTN [tissue]
HPRD16446
Protein Interaction databases
DIP (DOE-UCLA)P60981
IntAct (EBI)P60981
BioGRIDDSTN
STRING (EMBL)DSTN
ZODIACDSTN
Ontologies - Pathways
QuickGOP60981
Ontology : AmiGOprotein binding  cytoplasm  actin polymerization or depolymerization  actin cytoskeleton  actin filament depolymerization  actin filament depolymerization  actin filament fragmentation  actin cortical patch  positive regulation of actin filament depolymerization  cortical actin cytoskeleton  cell motility  actin filament severing  actin filament binding  actin filament binding  extracellular exosome  
Ontology : EGO-EBIprotein binding  cytoplasm  actin polymerization or depolymerization  actin cytoskeleton  actin filament depolymerization  actin filament depolymerization  actin filament fragmentation  actin cortical patch  positive regulation of actin filament depolymerization  cortical actin cytoskeleton  cell motility  actin filament severing  actin filament binding  actin filament binding  extracellular exosome  
NDEx NetworkDSTN
Atlas of Cancer Signalling NetworkDSTN
Wikipedia pathwaysDSTN
Orthology - Evolution
OrthoDB11034
GeneTree (enSembl)ENSG00000125868
Phylogenetic Trees/Animal Genes : TreeFamDSTN
Homologs : HomoloGeneDSTN
Homology/Alignments : Family Browser (UCSC)DSTN
Gene fusions - Rearrangements
Fusion : MitelmanDSTN/CCDC127 [20p12.1/5p15.33]  
Fusion : MitelmanDSTN/DTD1 [20p12.1/20p11.23]  
Fusion : MitelmanDSTN/DZANK1 [20p12.1/20p11.23]  
Fusion : MitelmanDSTN/TCFL5 [20p12.1/20q13.33]  
Fusion : QuiverDSTN
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDSTN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DSTN
dbVarDSTN
ClinVarDSTN
MonarchDSTN
1000_GenomesDSTN 
Exome Variant ServerDSTN
GNOMAD BrowserENSG00000125868
Varsome BrowserDSTN
ACMGDSTN variants
VarityP60981
Genomic Variants (DGV)DSTN [DGVbeta]
DECIPHERDSTN [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDSTN 
Mutations
ICGC Data PortalDSTN 
TCGA Data PortalDSTN 
Broad Tumor PortalDSTN
OASIS PortalDSTN [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDSTN  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDSTN
Mutations and Diseases : HGMDDSTN
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaDSTN
DgiDB (Drug Gene Interaction Database)DSTN
DoCM (Curated mutations)DSTN
CIViC (Clinical Interpretations of Variants in Cancer)DSTN
Cancer3DDSTN
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609114   
Orphanet
DisGeNETDSTN
MedgenDSTN
Genetic Testing Registry DSTN
NextProtP60981 [Medical]
GENETestsDSTN
Target ValidationDSTN
Huge Navigator DSTN [HugePedia]
ClinGenDSTN
Clinical trials, drugs, therapy
MyCancerGenomeDSTN
Protein Interactions : CTDDSTN
Pharm GKB GenePA27509
PharosP60981
Clinical trialDSTN
Miscellaneous
canSAR (ICR)DSTN
HarmonizomeDSTN
DataMed IndexDSTN
Probes
Litterature
PubMed68 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXDSTN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:07:23 CEST 2021

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