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DSTN (destrin, actin depolymerizing factor)

Identity

Alias_namesdestrin (actin depolymerizing factor)
Alias_symbol (synonym)ADF
ACTDP
Other aliasHEL32
bA462D18.2
HGNC (Hugo) DSTN
LocusID (NCBI) 11034
Atlas_Id 49860
Location 20p12.1  [Link to chromosome band 20p12]
Location_base_pair Starts at 17569954 and ends at 17608007 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DSTN (20p12.1) / CCDC127 (5p15.33)DSTN (20p12.1) / DSTN (20p12.1)DSTN (20p12.1) / DTD1 (20p11.23)
DSTN (20p12.1) / DZANK1 (20p11.23)DSTN (20p12.1) / FBXO31 (16q24.2)DSTN (20p12.1) / TCFL5 (20q13.33)
DSTN 20p12.1 C20orf12DSTN 20p12.1 / CCDC127 5p15.33DSTN 20p12.1 / DTD1 20p11.23
DSTN 20p12.1 / TCFL5 20q13.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]
  t(5;20)(p15;p12) DSTN/CCDC127
t(20;20)(p11;p12) DSTN/DZANK1
t(20;20)(p11;p12) DSTN/DTD1
t(20;20)(p12;q13) DSTN/TCFL5


External links

Nomenclature
HGNC (Hugo)DSTN   15750
Cards
Entrez_Gene (NCBI)DSTN  11034  destrin, actin depolymerizing factor
AliasesACTDP; ADF; HEL32; bA462D18.2
GeneCards (Weizmann)DSTN
Ensembl hg19 (Hinxton)ENSG00000125868 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000125868 [Gene_View]  ENSG00000125868 [Sequence]  chr20:17569954-17608007 [Contig_View]  DSTN [Vega]
ICGC DataPortalENSG00000125868
TCGA cBioPortalDSTN
AceView (NCBI)DSTN
Genatlas (Paris)DSTN
WikiGenes11034
SOURCE (Princeton)DSTN
Genetics Home Reference (NIH)DSTN
Genomic and cartography
GoldenPath hg38 (UCSC)DSTN  -     chr20:17569954-17608007 +  20p12.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DSTN  -     20p12.1   [Description]    (hg19-Feb_2009)
EnsemblDSTN - 20p12.1 [CytoView hg19]  DSTN - 20p12.1 [CytoView hg38]
Mapping of homologs : NCBIDSTN [Mapview hg19]  DSTN [Mapview hg38]
OMIM609114   
Gene and transcription
Genbank (Entrez)AI597935 AK302338 AK308562 AK312645 AK315994
RefSeq transcript (Entrez)NM_001011546 NM_006870
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DSTN
Cluster EST : UnigeneHs.705996 [ NCBI ]
CGAP (NCI)Hs.705996
Alternative Splicing GalleryENSG00000125868
Gene ExpressionDSTN [ NCBI-GEO ]   DSTN [ EBI - ARRAY_EXPRESS ]   DSTN [ SEEK ]   DSTN [ MEM ]
Gene Expression Viewer (FireBrowse)DSTN [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11034
GTEX Portal (Tissue expression)DSTN
Human Protein AtlasENSG00000125868-DSTN [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP60981   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP60981  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP60981
Splice isoforms : SwissVarP60981
PhosPhoSitePlusP60981
Domaine pattern : Prosite (Expaxy)ADF_H (PS51263)   
Domains : Interpro (EBI)ADF-H    ADF-H/Gelsolin-like_dom    ADF/Cofilin    Dstn   
Domain families : Pfam (Sanger)Cofilin_ADF (PF00241)   
Domain families : Pfam (NCBI)pfam00241   
Domain families : Smart (EMBL)ADF (SM00102)  
Conserved Domain (NCBI)DSTN
DMDM Disease mutations11034
Blocks (Seattle)DSTN
SuperfamilyP60981
Human Protein Atlas [tissue]ENSG00000125868-DSTN [tissue]
Peptide AtlasP60981
HPRD16446
IPIIPI00473014   IPI00845388   IPI00982578   
Protein Interaction databases
DIP (DOE-UCLA)P60981
IntAct (EBI)P60981
FunCoupENSG00000125868
BioGRIDDSTN
STRING (EMBL)DSTN
ZODIACDSTN
Ontologies - Pathways
QuickGOP60981
Ontology : AmiGOprotein binding  actin polymerization or depolymerization  actin cytoskeleton  actin filament depolymerization  actin filament fragmentation  positive regulation of actin filament depolymerization  cortical actin cytoskeleton  actin filament severing  actin filament binding  extracellular exosome  
Ontology : EGO-EBIprotein binding  actin polymerization or depolymerization  actin cytoskeleton  actin filament depolymerization  actin filament fragmentation  positive regulation of actin filament depolymerization  cortical actin cytoskeleton  actin filament severing  actin filament binding  extracellular exosome  
NDEx NetworkDSTN
Atlas of Cancer Signalling NetworkDSTN
Wikipedia pathwaysDSTN
Orthology - Evolution
OrthoDB11034
GeneTree (enSembl)ENSG00000125868
Phylogenetic Trees/Animal Genes : TreeFamDSTN
HOVERGENP60981
HOGENOMP60981
Homologs : HomoloGeneDSTN
Homology/Alignments : Family Browser (UCSC)DSTN
Gene fusions - Rearrangements
Fusion : MitelmanDSTN/CCDC127 [20p12.1/5p15.33]  
Fusion : MitelmanDSTN/DTD1 [20p12.1/20p11.23]  [t(20;20)(p11;p12)]  
Fusion : MitelmanDSTN/DZANK1 [20p12.1/20p11.23]  [t(20;20)(p11;p12)]  
Fusion : MitelmanDSTN/TCFL5 [20p12.1/20q13.33]  [t(20;20)(p12;q13)]  
Fusion PortalDSTN 20p12.1 C20orf12 LUAD
Fusion PortalDSTN 20p12.1 CCDC127 5p15.33 GBM
Fusion PortalDSTN 20p12.1 DTD1 20p11.23 PRAD
Fusion PortalDSTN 20p12.1 TCFL5 20q13.33 BRCA
Fusion : QuiverDSTN
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDSTN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DSTN
dbVarDSTN
ClinVarDSTN
1000_GenomesDSTN 
Exome Variant ServerDSTN
ExAC (Exome Aggregation Consortium)ENSG00000125868
GNOMAD BrowserENSG00000125868
Genetic variants : HAPMAP11034
Genomic Variants (DGV)DSTN [DGVbeta]
DECIPHERDSTN [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDSTN 
Mutations
ICGC Data PortalDSTN 
TCGA Data PortalDSTN 
Broad Tumor PortalDSTN
OASIS PortalDSTN [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDSTN  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDSTN
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DSTN
DgiDB (Drug Gene Interaction Database)DSTN
DoCM (Curated mutations)DSTN (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DSTN (select a term)
intoGenDSTN
Cancer3DDSTN(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609114   
Orphanet
DisGeNETDSTN
MedgenDSTN
Genetic Testing Registry DSTN
NextProtP60981 [Medical]
TSGene11034
GENETestsDSTN
Target ValidationDSTN
Huge Navigator DSTN [HugePedia]
snp3D : Map Gene to Disease11034
BioCentury BCIQDSTN
ClinGenDSTN
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11034
Chemical/Pharm GKB GenePA27509
Clinical trialDSTN
Miscellaneous
canSAR (ICR)DSTN (select the gene name)
Probes
Litterature
PubMed42 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDSTN
EVEXDSTN
GoPubMedDSTN
iHOPDSTN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 22 16:23:21 CEST 2018

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