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DUSP4 (dual specificity phosphatase 4)

Identity

Alias_symbol (synonym)HVH2
MKP-2
TYP
Other aliasMKP2
HGNC (Hugo) DUSP4
LocusID (NCBI) 1846
Atlas_Id 40375
Location 8p12  [Link to chromosome band 8p12]
Location_base_pair Starts at 29333062 and ends at 29350750 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DUSP4 (8p12) / SRSF5 (14q24.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DUSP4   3070
Cards
Entrez_Gene (NCBI)DUSP4  1846  dual specificity phosphatase 4
AliasesHVH2; MKP-2; MKP2; TYP
GeneCards (Weizmann)DUSP4
Ensembl hg19 (Hinxton)ENSG00000120875 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000120875 [Gene_View]  chr8:29333062-29350750 [Contig_View]  DUSP4 [Vega]
ICGC DataPortalENSG00000120875
TCGA cBioPortalDUSP4
AceView (NCBI)DUSP4
Genatlas (Paris)DUSP4
WikiGenes1846
SOURCE (Princeton)DUSP4
Genetics Home Reference (NIH)DUSP4
Genomic and cartography
GoldenPath hg38 (UCSC)DUSP4  -     chr8:29333062-29350750 -  8p12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DUSP4  -     8p12   [Description]    (hg19-Feb_2009)
EnsemblDUSP4 - 8p12 [CytoView hg19]  DUSP4 - 8p12 [CytoView hg38]
Mapping of homologs : NCBIDUSP4 [Mapview hg19]  DUSP4 [Mapview hg38]
OMIM602747   
Gene and transcription
Genbank (Entrez)AI123616 AK314820 AL137704 BC002671 BC012900
RefSeq transcript (Entrez)NM_001394 NM_057158
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DUSP4
Cluster EST : UnigeneHs.417962 [ NCBI ]
CGAP (NCI)Hs.417962
Alternative Splicing GalleryENSG00000120875
Gene ExpressionDUSP4 [ NCBI-GEO ]   DUSP4 [ EBI - ARRAY_EXPRESS ]   DUSP4 [ SEEK ]   DUSP4 [ MEM ]
Gene Expression Viewer (FireBrowse)DUSP4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1846
GTEX Portal (Tissue expression)DUSP4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13115   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13115  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13115
Splice isoforms : SwissVarQ13115
PhosPhoSitePlusQ13115
Domaine pattern : Prosite (Expaxy)RHODANESE_3 (PS50206)    TYR_PHOSPHATASE_1 (PS00383)    TYR_PHOSPHATASE_2 (PS50056)    TYR_PHOSPHATASE_DUAL (PS50054)   
Domains : Interpro (EBI)Dual-sp_phosphatase_cat-dom    DUSP    MKP    Prot-tyrosine_phosphatase-like    Rhodanese-like_dom    Tyr_Pase_AS    Tyr_Pase_cat    TYR_PHOSPHATASE_dom    TYR_PHOSPHATASE_DUAL_dom   
Domain families : Pfam (Sanger)DSPc (PF00782)    Rhodanese (PF00581)   
Domain families : Pfam (NCBI)pfam00782    pfam00581   
Domain families : Smart (EMBL)DSPc (SM00195)  PTPc_motif (SM00404)  RHOD (SM00450)  
Conserved Domain (NCBI)DUSP4
DMDM Disease mutations1846
Blocks (Seattle)DUSP4
PDB (SRS)3EZZ   
PDB (PDBSum)3EZZ   
PDB (IMB)3EZZ   
PDB (RSDB)3EZZ   
Structural Biology KnowledgeBase3EZZ   
SCOP (Structural Classification of Proteins)3EZZ   
CATH (Classification of proteins structures)3EZZ   
SuperfamilyQ13115
Human Protein AtlasENSG00000120875
Peptide AtlasQ13115
HPRD04123
IPIIPI00011860   IPI00012811   
Protein Interaction databases
DIP (DOE-UCLA)Q13115
IntAct (EBI)Q13115
FunCoupENSG00000120875
BioGRIDDUSP4
STRING (EMBL)DUSP4
ZODIACDUSP4
Ontologies - Pathways
QuickGOQ13115
Ontology : AmiGOinactivation of MAPK activity  endoderm formation  protein tyrosine phosphatase activity  protein tyrosine phosphatase activity  nucleus  nucleoplasm  nucleoplasm  protein tyrosine/threonine phosphatase activity  dephosphorylation  phosphatase activity  MAP kinase tyrosine/serine/threonine phosphatase activity  peptidyl-tyrosine dephosphorylation  peptidyl-threonine dephosphorylation  negative regulation of ERK1 and ERK2 cascade  MAP kinase threonine phosphatase activity  
Ontology : EGO-EBIinactivation of MAPK activity  endoderm formation  protein tyrosine phosphatase activity  protein tyrosine phosphatase activity  nucleus  nucleoplasm  nucleoplasm  protein tyrosine/threonine phosphatase activity  dephosphorylation  phosphatase activity  MAP kinase tyrosine/serine/threonine phosphatase activity  peptidyl-tyrosine dephosphorylation  peptidyl-threonine dephosphorylation  negative regulation of ERK1 and ERK2 cascade  MAP kinase threonine phosphatase activity  
Pathways : BIOCARTARegulation of MAP Kinase Pathways Through Dual Specificity Phosphatases [Genes]   
Pathways : KEGGMAPK signaling pathway   
NDEx NetworkDUSP4
Atlas of Cancer Signalling NetworkDUSP4
Wikipedia pathwaysDUSP4
Orthology - Evolution
OrthoDB1846
GeneTree (enSembl)ENSG00000120875
Phylogenetic Trees/Animal Genes : TreeFamDUSP4
HOVERGENQ13115
HOGENOMQ13115
Homologs : HomoloGeneDUSP4
Homology/Alignments : Family Browser (UCSC)DUSP4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDUSP4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DUSP4
dbVarDUSP4
ClinVarDUSP4
1000_GenomesDUSP4 
Exome Variant ServerDUSP4
ExAC (Exome Aggregation Consortium)DUSP4 (select the gene name)
Genetic variants : HAPMAP1846
Genomic Variants (DGV)DUSP4 [DGVbeta]
DECIPHERDUSP4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDUSP4 
Mutations
ICGC Data PortalDUSP4 
TCGA Data PortalDUSP4 
Broad Tumor PortalDUSP4
OASIS PortalDUSP4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDUSP4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDUSP4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DUSP4
DgiDB (Drug Gene Interaction Database)DUSP4
DoCM (Curated mutations)DUSP4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DUSP4 (select a term)
intoGenDUSP4
Cancer3DDUSP4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602747   
Orphanet
MedgenDUSP4
Genetic Testing Registry DUSP4
NextProtQ13115 [Medical]
TSGene1846
GENETestsDUSP4
Target ValidationDUSP4
Huge Navigator DUSP4 [HugePedia]
snp3D : Map Gene to Disease1846
BioCentury BCIQDUSP4
ClinGenDUSP4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1846
Chemical/Pharm GKB GenePA27527
Clinical trialDUSP4
Miscellaneous
canSAR (ICR)DUSP4 (select the gene name)
Probes
Litterature
PubMed47 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDUSP4
EVEXDUSP4
GoPubMedDUSP4
iHOPDUSP4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:00:01 CEST 2017

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