Atlas of Genetics and Cytogenetics in Oncology and Haematology


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DYRK3 (dual specificity tyrosine phosphorylation regulated kinase 3)

Identity

Alias_namesdual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
dual specificity tyrosine-(Y)-phosphorylation regulated kinase 3
Alias_symbol (synonym)RED
REDK
hYAK3-2
Other aliasDYRK5
HGNC (Hugo) DYRK3
LocusID (NCBI) 8444
Atlas_Id 43237
Location 1q32.1  [Link to chromosome band 1q32]
Location_base_pair Starts at 206635536 and ends at 206649197 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DYRK3 (1q32.1) / DYRK3 (1q32.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DYRK3   3094
Cards
Entrez_Gene (NCBI)DYRK3  8444  dual specificity tyrosine phosphorylation regulated kinase 3
AliasesDYRK5; RED; REDK; hYAK3-2
GeneCards (Weizmann)DYRK3
Ensembl hg19 (Hinxton)ENSG00000143479 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000143479 [Gene_View]  chr1:206635536-206649197 [Contig_View]  DYRK3 [Vega]
ICGC DataPortalENSG00000143479
TCGA cBioPortalDYRK3
AceView (NCBI)DYRK3
Genatlas (Paris)DYRK3
WikiGenes8444
SOURCE (Princeton)DYRK3
Genetics Home Reference (NIH)DYRK3
Genomic and cartography
GoldenPath hg38 (UCSC)DYRK3  -     chr1:206635536-206649197 +  1q32.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DYRK3  -     1q32.1   [Description]    (hg19-Feb_2009)
EnsemblDYRK3 - 1q32.1 [CytoView hg19]  DYRK3 - 1q32.1 [CytoView hg38]
Mapping of homologs : NCBIDYRK3 [Mapview hg19]  DYRK3 [Mapview hg38]
OMIM603497   
Gene and transcription
Genbank (Entrez)AF186773 AF186774 AF327561 AK291189 AK308082
RefSeq transcript (Entrez)NM_001004023 NM_003582
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DYRK3
Cluster EST : UnigeneHs.164267 [ NCBI ]
CGAP (NCI)Hs.164267
Alternative Splicing GalleryENSG00000143479
Gene ExpressionDYRK3 [ NCBI-GEO ]   DYRK3 [ EBI - ARRAY_EXPRESS ]   DYRK3 [ SEEK ]   DYRK3 [ MEM ]
Gene Expression Viewer (FireBrowse)DYRK3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8444
GTEX Portal (Tissue expression)DYRK3
Human Protein AtlasENSG00000143479-DYRK3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43781   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43781  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43781
Splice isoforms : SwissVarO43781
PhosPhoSitePlusO43781
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)DYRK3
DMDM Disease mutations8444
Blocks (Seattle)DYRK3
SuperfamilyO43781
Human Protein Atlas [tissue]ENSG00000143479-DYRK3 [tissue]
Peptide AtlasO43781
HPRD04607
IPIIPI00744096   IPI00465459   IPI00644718   IPI00640640   
Protein Interaction databases
DIP (DOE-UCLA)O43781
IntAct (EBI)O43781
FunCoupENSG00000143479
BioGRIDDYRK3
STRING (EMBL)DYRK3
ZODIACDYRK3
Ontologies - Pathways
QuickGOO43781
Ontology : AmiGOmagnesium ion binding  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine/tyrosine kinase activity  protein tyrosine kinase activity  ATP binding  nucleus  nucleoplasm  cytoplasm  cytosol  protein phosphorylation  cytoplasmic stress granule  peptidyl-tyrosine phosphorylation  erythrocyte differentiation  stress granule disassembly  negative regulation of apoptotic process  intracellular membrane-bounded organelle  negative regulation of DNA damage response, signal transduction by p53 class mediator  regulation of cellular response to stress  regulation of TORC1 signaling  
Ontology : EGO-EBImagnesium ion binding  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine/tyrosine kinase activity  protein tyrosine kinase activity  ATP binding  nucleus  nucleoplasm  cytoplasm  cytosol  protein phosphorylation  cytoplasmic stress granule  peptidyl-tyrosine phosphorylation  erythrocyte differentiation  stress granule disassembly  negative regulation of apoptotic process  intracellular membrane-bounded organelle  negative regulation of DNA damage response, signal transduction by p53 class mediator  regulation of cellular response to stress  regulation of TORC1 signaling  
NDEx NetworkDYRK3
Atlas of Cancer Signalling NetworkDYRK3
Wikipedia pathwaysDYRK3
Orthology - Evolution
OrthoDB8444
GeneTree (enSembl)ENSG00000143479
Phylogenetic Trees/Animal Genes : TreeFamDYRK3
HOVERGENO43781
HOGENOMO43781
Homologs : HomoloGeneDYRK3
Homology/Alignments : Family Browser (UCSC)DYRK3
Gene fusions - Rearrangements
Fusion: Tumor Portal DYRK3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDYRK3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DYRK3
dbVarDYRK3
ClinVarDYRK3
1000_GenomesDYRK3 
Exome Variant ServerDYRK3
ExAC (Exome Aggregation Consortium)ENSG00000143479
GNOMAD BrowserENSG00000143479
Genetic variants : HAPMAP8444
Genomic Variants (DGV)DYRK3 [DGVbeta]
DECIPHERDYRK3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDYRK3 
Mutations
ICGC Data PortalDYRK3 
TCGA Data PortalDYRK3 
Broad Tumor PortalDYRK3
OASIS PortalDYRK3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDYRK3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDYRK3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DYRK3
DgiDB (Drug Gene Interaction Database)DYRK3
DoCM (Curated mutations)DYRK3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DYRK3 (select a term)
intoGenDYRK3
Cancer3DDYRK3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603497   
Orphanet
MedgenDYRK3
Genetic Testing Registry DYRK3
NextProtO43781 [Medical]
TSGene8444
GENETestsDYRK3
Target ValidationDYRK3
Huge Navigator DYRK3 [HugePedia]
snp3D : Map Gene to Disease8444
BioCentury BCIQDYRK3
ClinGenDYRK3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8444
Chemical/Pharm GKB GenePA27551
Clinical trialDYRK3
Miscellaneous
canSAR (ICR)DYRK3 (select the gene name)
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDYRK3
EVEXDYRK3
GoPubMedDYRK3
iHOPDYRK3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Nov 9 12:48:12 CET 2017

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