| Nomenclature |
|---|
| HGNC (Hugo) | E2F8 24727 |
| Cards |
|---|
| Entrez_Gene (NCBI) | E2F8 E2F transcription factor 8 |
| Aliases | E2F-8 |
| GeneCards (Weizmann) | E2F8 |
| Ensembl hg19 (Hinxton) | ENSG00000129173 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000129173 [Gene_View] ENSG00000129173 [Sequence] chr11:19224063-19240945 [Contig_View] E2F8 [Vega] |
| ICGC DataPortal | ENSG00000129173 |
| TCGA cBioPortal | E2F8 |
| AceView (NCBI) | E2F8 |
| Genatlas (Paris) | E2F8 |
| SOURCE (Princeton) | E2F8 |
| Genetics Home Reference (NIH) | E2F8 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | E2F8 - chr11:19224063-19240945 - 11p15.1 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | E2F8 - 11p15.1 [Description] (hg19-Feb_2009) |
| GoldenPath | E2F8 - 11p15.1 [CytoView hg19] E2F8 - 11p15.1 [CytoView hg38] |
| ImmunoBase | ENSG00000129173 |
| genome Data Viewer NCBI | E2F8 [Mapview hg19] |
| OMIM | 612047 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AB231781 AB231782 AB231783 AK026964 AK055206 |
| RefSeq transcript (Entrez) | NM_001256371 NM_001256372 NM_024680 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | E2F8 |
| Alternative Splicing Gallery | ENSG00000129173 |
| Gene Expression | E2F8 [ NCBI-GEO ] E2F8 [ EBI - ARRAY_EXPRESS ]
E2F8 [ SEEK ] E2F8 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | E2F8 [ Firebrowse - Broad ] |
| Genevisible | Expression of E2F8 in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 79733 |
| GTEX Portal (Tissue expression) | E2F8 |
| Human Protein Atlas | ENSG00000129173-E2F8 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | A0AVK6 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | A0AVK6 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | A0AVK6 |
| Splice isoforms : SwissVar | A0AVK6 |
| PhosPhoSitePlus | A0AVK6 |
| Domains : Interpro (EBI) | E2F E2F_WHTH_DNA-bd_dom WH-like_DNA-bd_sf WH_DNA-bd_sf |
| Domain families : Pfam (Sanger) | E2F_TDP (PF02319) |
| Domain families : Pfam (NCBI) | pfam02319 |
| Domain families : Smart (EMBL) | E2F_TDP (SM01372) |
| Conserved Domain (NCBI) | E2F8 |
| Blocks (Seattle) | E2F8 |
| PDB (RSDB) | 4YO2 |
| PDB Europe | 4YO2 |
| PDB (PDBSum) | 4YO2 |
| PDB (IMB) | 4YO2 |
| Structural Biology KnowledgeBase | 4YO2 |
| SCOP (Structural Classification of Proteins) | 4YO2 |
| CATH (Classification of proteins structures) | 4YO2 |
| Superfamily | A0AVK6 |
| Human Protein Atlas [tissue] | ENSG00000129173-E2F8 [tissue] |
| Peptide Atlas | A0AVK6 |
| HPRD | 10981 |
| IPI | IPI00296318 IPI00873754 IPI00983696 IPI00983085 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | A0AVK6 |
| IntAct (EBI) | A0AVK6 |
| BioGRID | E2F8 |
| STRING (EMBL) | E2F8 |
| ZODIAC | E2F8 |
| Ontologies - Pathways |
|---|
| QuickGO | A0AVK6 |
| Ontology : AmiGO | negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II nuclear chromatin RNA polymerase II proximal promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific proximal promoter sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific placenta development sprouting angiogenesis DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity transcription corepressor activity protein binding nucleus nucleoplasm nucleoplasm nucleolus cytosol DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest transcription factor binding cell proliferation negative regulation of cytokinesis positive regulation of DNA endoreduplication cell cycle comprising mitosis without cytokinesis identical protein binding sequence-specific DNA binding positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II regulation of cell cycle trophoblast giant cell differentiation chorionic trophoblast cell differentiation hepatocyte differentiation RNA polymerase II transcription factor complex |
| Ontology : EGO-EBI | negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II nuclear chromatin RNA polymerase II proximal promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific proximal promoter sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific placenta development sprouting angiogenesis DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity transcription corepressor activity protein binding nucleus nucleoplasm nucleoplasm nucleolus cytosol DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest transcription factor binding cell proliferation negative regulation of cytokinesis positive regulation of DNA endoreduplication cell cycle comprising mitosis without cytokinesis identical protein binding sequence-specific DNA binding positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II regulation of cell cycle trophoblast giant cell differentiation chorionic trophoblast cell differentiation hepatocyte differentiation RNA polymerase II transcription factor complex |
| NDEx Network | E2F8 |
| Atlas of Cancer Signalling Network | E2F8 |
| Wikipedia pathways | E2F8 |
| Orthology - Evolution |
|---|
| OrthoDB | 79733 |
| GeneTree (enSembl) | ENSG00000129173 |
| Phylogenetic Trees/Animal Genes : TreeFam | E2F8 |
| HOGENOM | A0AVK6 |
| Homologs : HomoloGene | E2F8 |
| Homology/Alignments : Family Browser (UCSC) | E2F8 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Quiver | E2F8 |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | E2F8 [hg38] |
| dbVar | E2F8 |
| ClinVar | E2F8 |
| Monarch | E2F8 |
| 1000_Genomes | E2F8 |
| Exome Variant Server | E2F8 |
| GNOMAD Browser | ENSG00000129173 |
| Varsome Browser | E2F8 |
| Genomic Variants (DGV) | E2F8 [DGVbeta] |
| DECIPHER | E2F8 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | E2F8 |
| Mutations |
|---|
| ICGC Data Portal | E2F8 |
| TCGA Data Portal | E2F8 |
| Broad Tumor Portal | E2F8 |
| OASIS Portal | E2F8 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | E2F8 [overview] [genome browser] [tissue] [distribution] |
| Somatic Mutations in Cancer : COSMIC3D | E2F8 |
| Mutations and Diseases : HGMD | E2F8 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search E2F8 |
| DgiDB (Drug Gene Interaction Database) | E2F8 |
| DoCM (Curated mutations) | E2F8 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | E2F8 (select a term) |
| intoGen | E2F8 |
| Cancer3D | E2F8(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 612047 |
| Orphanet | |
| DisGeNET | E2F8 |
| Medgen | E2F8 |
| Genetic Testing Registry | E2F8
|
| NextProt | A0AVK6 [Medical] |
| GENETests | E2F8 |
| Target Validation | E2F8 |
| Huge Navigator |
E2F8 [HugePedia] |
| ClinGen | E2F8 |
| Clinical trials, drugs, therapy |
|---|
| MyCancerGenome | E2F8 |
| Protein Interactions : CTD | |
| Pharm GKB Gene | PA142671918 |
| Pharos | A0AVK6 |
| Clinical trial | E2F8 |
| Miscellaneous |
|---|
| canSAR (ICR) | E2F8 (select the gene name) |
| Harmonizome | E2F8 |
| DataMed Index | E2F8 |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 34 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| EVEX | E2F8 |
