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E2F8 (E2F transcription factor 8)

Identity

Alias_symbol (synonym)FLJ23311
Other aliasE2F-8
HGNC (Hugo) E2F8
LocusID (NCBI) 79733
Atlas_Id 51400
Location 11p15.1  [Link to chromosome band 11p15]
Location_base_pair Starts at 19224063 and ends at 19241620 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
E2F8 (11p15.1) / ZNF638 (2p13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)E2F8   24727
Cards
Entrez_Gene (NCBI)E2F8  79733  E2F transcription factor 8
AliasesE2F-8
GeneCards (Weizmann)E2F8
Ensembl hg19 (Hinxton)ENSG00000129173 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000129173 [Gene_View]  chr11:19224063-19241620 [Contig_View]  E2F8 [Vega]
ICGC DataPortalENSG00000129173
TCGA cBioPortalE2F8
AceView (NCBI)E2F8
Genatlas (Paris)E2F8
WikiGenes79733
SOURCE (Princeton)E2F8
Genetics Home Reference (NIH)E2F8
Genomic and cartography
GoldenPath hg38 (UCSC)E2F8  -     chr11:19224063-19241620 -  11p15.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)E2F8  -     11p15.1   [Description]    (hg19-Feb_2009)
EnsemblE2F8 - 11p15.1 [CytoView hg19]  E2F8 - 11p15.1 [CytoView hg38]
Mapping of homologs : NCBIE2F8 [Mapview hg19]  E2F8 [Mapview hg38]
OMIM612047   
Gene and transcription
Genbank (Entrez)AB231781 AB231782 AB231783 AK026964 AK055206
RefSeq transcript (Entrez)NM_001256371 NM_001256372 NM_024680
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)E2F8
Cluster EST : UnigeneHs.523526 [ NCBI ]
CGAP (NCI)Hs.523526
Alternative Splicing GalleryENSG00000129173
Gene ExpressionE2F8 [ NCBI-GEO ]   E2F8 [ EBI - ARRAY_EXPRESS ]   E2F8 [ SEEK ]   E2F8 [ MEM ]
Gene Expression Viewer (FireBrowse)E2F8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79733
GTEX Portal (Tissue expression)E2F8
Protein : pattern, domain, 3D structure
UniProt/SwissProtA0AVK6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtA0AVK6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProA0AVK6
Splice isoforms : SwissVarA0AVK6
PhosPhoSitePlusA0AVK6
Domains : Interpro (EBI)E2F    E2F_WHTH_DNA-bd_dom    WHTH_DNA-bd_dom   
Domain families : Pfam (Sanger)E2F_TDP (PF02319)   
Domain families : Pfam (NCBI)pfam02319   
Domain families : Smart (EMBL)E2F_TDP (SM01372)  
Conserved Domain (NCBI)E2F8
DMDM Disease mutations79733
Blocks (Seattle)E2F8
PDB (SRS)4YO2   
PDB (PDBSum)4YO2   
PDB (IMB)4YO2   
PDB (RSDB)4YO2   
Structural Biology KnowledgeBase4YO2   
SCOP (Structural Classification of Proteins)4YO2   
CATH (Classification of proteins structures)4YO2   
SuperfamilyA0AVK6
Human Protein AtlasENSG00000129173
Peptide AtlasA0AVK6
HPRD10981
IPIIPI00296318   IPI00873754   IPI00983696   IPI00983085   
Protein Interaction databases
DIP (DOE-UCLA)A0AVK6
IntAct (EBI)A0AVK6
FunCoupENSG00000129173
BioGRIDE2F8
STRING (EMBL)E2F8
ZODIACE2F8
Ontologies - Pathways
QuickGOA0AVK6
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  negative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core promoter proximal region sequence-specific DNA binding  core promoter binding  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  placenta development  sprouting angiogenesis  transcription factor activity, sequence-specific DNA binding  transcription corepressor activity  protein binding  nucleus  transcription factor complex  nucleolus  cytosol  transcription, DNA-templated  cell proliferation  negative regulation of cytokinesis  positive regulation of DNA endoreduplication  cell cycle comprising mitosis without cytokinesis  protein homodimerization activity  positive regulation of transcription from RNA polymerase II promoter  trophoblast giant cell differentiation  chorionic trophoblast cell differentiation  hepatocyte differentiation  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  negative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core promoter proximal region sequence-specific DNA binding  core promoter binding  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  placenta development  sprouting angiogenesis  transcription factor activity, sequence-specific DNA binding  transcription corepressor activity  protein binding  nucleus  transcription factor complex  nucleolus  cytosol  transcription, DNA-templated  cell proliferation  negative regulation of cytokinesis  positive regulation of DNA endoreduplication  cell cycle comprising mitosis without cytokinesis  protein homodimerization activity  positive regulation of transcription from RNA polymerase II promoter  trophoblast giant cell differentiation  chorionic trophoblast cell differentiation  hepatocyte differentiation  
NDEx NetworkE2F8
Atlas of Cancer Signalling NetworkE2F8
Wikipedia pathwaysE2F8
Orthology - Evolution
OrthoDB79733
GeneTree (enSembl)ENSG00000129173
Phylogenetic Trees/Animal Genes : TreeFamE2F8
HOVERGENA0AVK6
HOGENOMA0AVK6
Homologs : HomoloGeneE2F8
Homology/Alignments : Family Browser (UCSC)E2F8
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerE2F8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)E2F8
dbVarE2F8
ClinVarE2F8
1000_GenomesE2F8 
Exome Variant ServerE2F8
ExAC (Exome Aggregation Consortium)E2F8 (select the gene name)
Genetic variants : HAPMAP79733
Genomic Variants (DGV)E2F8 [DGVbeta]
DECIPHERE2F8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisE2F8 
Mutations
ICGC Data PortalE2F8 
TCGA Data PortalE2F8 
Broad Tumor PortalE2F8
OASIS PortalE2F8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICE2F8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDE2F8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch E2F8
DgiDB (Drug Gene Interaction Database)E2F8
DoCM (Curated mutations)E2F8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)E2F8 (select a term)
intoGenE2F8
Cancer3DE2F8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612047   
Orphanet
MedgenE2F8
Genetic Testing Registry E2F8
NextProtA0AVK6 [Medical]
TSGene79733
GENETestsE2F8
Target ValidationE2F8
Huge Navigator E2F8 [HugePedia]
snp3D : Map Gene to Disease79733
BioCentury BCIQE2F8
ClinGenE2F8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD79733
Chemical/Pharm GKB GenePA142671918
Clinical trialE2F8
Miscellaneous
canSAR (ICR)E2F8 (select the gene name)
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineE2F8
EVEXE2F8
GoPubMedE2F8
iHOPE2F8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:06:20 CEST 2017

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