| Nomenclature |
|---|
| HGNC (Hugo) | E2F8 24727 |
| Cards |
|---|
| Entrez_Gene (NCBI) | E2F8 79733 E2F transcription factor 8 |
| Aliases | E2F-8 |
| GeneCards (Weizmann) | E2F8 |
| Ensembl hg19 (Hinxton) | ENSG00000129173 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000129173 [Gene_View] chr11:19224063-19241620 [Contig_View] E2F8 [Vega] |
| ICGC DataPortal | ENSG00000129173 |
| TCGA cBioPortal | E2F8 |
| AceView (NCBI) | E2F8 |
| Genatlas (Paris) | E2F8 |
| WikiGenes | 79733 |
| SOURCE (Princeton) | E2F8 |
| Genetics Home Reference (NIH) | E2F8 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | E2F8 - chr11:19224063-19241620 - 11p15.1 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | E2F8 - 11p15.1 [Description] (hg19-Feb_2009) |
| Ensembl | E2F8 - 11p15.1 [CytoView hg19] E2F8 - 11p15.1 [CytoView hg38] |
| Mapping of homologs : NCBI | E2F8 [Mapview hg19] E2F8 [Mapview hg38] |
| OMIM | 612047 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AB231781 AB231782 AB231783 AK026964 AK055206 |
| RefSeq transcript (Entrez) | NM_001256371 NM_001256372 NM_024680 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | E2F8 |
| Cluster EST : Unigene | Hs.523526 [ NCBI ] |
| CGAP (NCI) | Hs.523526 |
| Alternative Splicing Gallery | ENSG00000129173 |
| Gene Expression | E2F8 [ NCBI-GEO ] E2F8 [ EBI - ARRAY_EXPRESS ]
E2F8 [ SEEK ] E2F8 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | E2F8 [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevisible | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 79733 |
| GTEX Portal (Tissue expression) | E2F8 |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | A0AVK6 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | A0AVK6 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | A0AVK6 |
| Splice isoforms : SwissVar | A0AVK6 |
| PhosPhoSitePlus | A0AVK6 |
| Domains : Interpro (EBI) | E2F E2F_WHTH_DNA-bd_dom WHTH_DNA-bd_dom |
| Domain families : Pfam (Sanger) | E2F_TDP (PF02319) |
| Domain families : Pfam (NCBI) | pfam02319 |
| Domain families : Smart (EMBL) | E2F_TDP (SM01372) |
| Conserved Domain (NCBI) | E2F8 |
| DMDM Disease mutations | 79733 |
| Blocks (Seattle) | E2F8 |
| PDB (SRS) | 4YO2 |
| PDB (PDBSum) | 4YO2 |
| PDB (IMB) | 4YO2 |
| PDB (RSDB) | 4YO2 |
| Structural Biology KnowledgeBase | 4YO2 |
| SCOP (Structural Classification of Proteins) | 4YO2 |
| CATH (Classification of proteins structures) | 4YO2 |
| Superfamily | A0AVK6 |
| Human Protein Atlas | ENSG00000129173 |
| Peptide Atlas | A0AVK6 |
| HPRD | 10981 |
| IPI | IPI00296318 IPI00873754 IPI00983696 IPI00983085 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | A0AVK6 |
| IntAct (EBI) | A0AVK6 |
| FunCoup | ENSG00000129173 |
| BioGRID | E2F8 |
| STRING (EMBL) | E2F8 |
| ZODIAC | E2F8 |
| Ontologies - Pathways |
|---|
| QuickGO | A0AVK6 |
| Ontology : AmiGO | negative regulation of transcription from RNA polymerase II promoter negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding core promoter binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding placenta development sprouting angiogenesis transcription factor activity, sequence-specific DNA binding transcription corepressor activity protein binding nucleus transcription factor complex nucleolus cytosol transcription, DNA-templated cell proliferation negative regulation of cytokinesis positive regulation of DNA endoreduplication cell cycle comprising mitosis without cytokinesis protein homodimerization activity positive regulation of transcription from RNA polymerase II promoter trophoblast giant cell differentiation chorionic trophoblast cell differentiation hepatocyte differentiation |
| Ontology : EGO-EBI | negative regulation of transcription from RNA polymerase II promoter negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding core promoter binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding placenta development sprouting angiogenesis transcription factor activity, sequence-specific DNA binding transcription corepressor activity protein binding nucleus transcription factor complex nucleolus cytosol transcription, DNA-templated cell proliferation negative regulation of cytokinesis positive regulation of DNA endoreduplication cell cycle comprising mitosis without cytokinesis protein homodimerization activity positive regulation of transcription from RNA polymerase II promoter trophoblast giant cell differentiation chorionic trophoblast cell differentiation hepatocyte differentiation |
| NDEx Network | E2F8 |
| Atlas of Cancer Signalling Network | E2F8 |
| Wikipedia pathways | E2F8 |
| Orthology - Evolution |
|---|
| OrthoDB | 79733 |
| GeneTree (enSembl) | ENSG00000129173 |
| Phylogenetic Trees/Animal Genes : TreeFam | E2F8 |
| HOVERGEN | A0AVK6 |
| HOGENOM | A0AVK6 |
| Homologs : HomoloGene | E2F8 |
| Homology/Alignments : Family Browser (UCSC) | E2F8 |
| Gene fusions - Rearrangements |
|---|
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | E2F8 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | E2F8 |
| dbVar | E2F8 |
| ClinVar | E2F8 |
| 1000_Genomes | E2F8 |
| Exome Variant Server | E2F8 |
| ExAC (Exome Aggregation Consortium) | E2F8 (select the gene name) |
| Genetic variants : HAPMAP | 79733 |
| Genomic Variants (DGV) | E2F8 [DGVbeta] |
| DECIPHER | E2F8 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | E2F8 |
| Mutations |
|---|
| ICGC Data Portal | E2F8 |
| TCGA Data Portal | E2F8 |
| Broad Tumor Portal | E2F8 |
| OASIS Portal | E2F8 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | E2F8 [overview] [genome browser] [tissue] [distribution] |
| Mutations and Diseases : HGMD | E2F8 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search E2F8 |
| DgiDB (Drug Gene Interaction Database) | E2F8 |
| DoCM (Curated mutations) | E2F8 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | E2F8 (select a term) |
| intoGen | E2F8 |
| Cancer3D | E2F8(select the gene name) |
| Impact of mutations | [PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 612047 |
| Orphanet | |
| Medgen | E2F8 |
| Genetic Testing Registry | E2F8
|
| NextProt | A0AVK6 [Medical] |
| TSGene | 79733 |
| GENETests | E2F8 |
| Target Validation | E2F8 |
| Huge Navigator |
E2F8 [HugePedia] |
| snp3D : Map Gene to Disease | 79733 |
| BioCentury BCIQ | E2F8 |
| ClinGen | E2F8 |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 79733 |
| Chemical/Pharm GKB Gene | PA142671918 |
| Clinical trial | E2F8 |
| Miscellaneous |
|---|
| canSAR (ICR) | E2F8 (select the gene name) |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 20 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | E2F8 |
| EVEX | E2F8 |
| GoPubMed | E2F8 |
| iHOP | E2F8 |
