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EFNA5 (ephrin A5)

Identity

Alias (NCBI)AF1
EFL5
EPLG7
GLC1M
LERK7
RAGS
HGNC (Hugo) EFNA5
HGNC Alias symbAF1
LERK7
HGNC Alias nameEPH-related receptor tyrosine kinase ligand 7
HGNC Previous nameEPLG7
HGNC Previous nameephrin-A5
LocusID (NCBI) 1946
Atlas_Id 40414
Location 5q21.3  [Link to chromosome band 5q21]
Location_base_pair Starts at 107376894 and ends at 107670937 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
EFNA5 (5q21.3) / FBXL17 (5q21.3)EFNA5 (5q21.3) / FGD4 (12p11.21)EFNA5 (5q21.3) / IQGAP1 (15q26.1)
EFNA5 (5q21.3) / RPS23 (5q14.2)FAM172A (5q15) / EFNA5 (5q21.3)KMT2A (11q23.3) / EFNA5 (5q21.3)
FAM172A 5q15 / EFNA5 5q21.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)EFNA5   3225
Cards
Entrez_Gene (NCBI)EFNA5    ephrin A5
AliasesAF1; EFL5; EPLG7; GLC1M; 
LERK7; RAGS
GeneCards (Weizmann)EFNA5
Ensembl hg19 (Hinxton)ENSG00000184349 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000184349 [Gene_View]  ENSG00000184349 [Sequence]  chr5:107376894-107670937 [Contig_View]  EFNA5 [Vega]
ICGC DataPortalENSG00000184349
TCGA cBioPortalEFNA5
AceView (NCBI)EFNA5
Genatlas (Paris)EFNA5
SOURCE (Princeton)EFNA5
Genetics Home Reference (NIH)EFNA5
Genomic and cartography
GoldenPath hg38 (UCSC)EFNA5  -     chr5:107376894-107670937 -  5q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EFNA5  -     5q21.3   [Description]    (hg19-Feb_2009)
GoldenPathEFNA5 - 5q21.3 [CytoView hg19]  EFNA5 - 5q21.3 [CytoView hg38]
ImmunoBaseENSG00000184349
Genome Data Viewer NCBIEFNA5 [Mapview hg19]  
OMIM601535   
Gene and transcription
Genbank (Entrez)AK025909 AK308672 BC075054 BC075055 U26403
RefSeq transcript (Entrez)NM_001962
Consensus coding sequences : CCDS (NCBI)EFNA5
Gene ExpressionEFNA5 [ NCBI-GEO ]   EFNA5 [ EBI - ARRAY_EXPRESS ]   EFNA5 [ SEEK ]   EFNA5 [ MEM ]
Gene Expression Viewer (FireBrowse)EFNA5 [ Firebrowse - Broad ]
GenevisibleExpression of EFNA5 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1946
GTEX Portal (Tissue expression)EFNA5
Human Protein AtlasENSG00000184349-EFNA5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP52803   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP52803  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP52803
PhosPhoSitePlusP52803
Domaine pattern : Prosite (Expaxy)EPHRIN_RBD_1 (PS01299)    EPHRIN_RBD_2 (PS51551)   
Domains : Interpro (EBI)Cupredoxin    Ephrin    Ephrin-A_Ecto    Ephrin_CS    Ephrin_RBD   
Domain families : Pfam (Sanger)Ephrin (PF00812)   
Domain families : Pfam (NCBI)pfam00812   
Conserved Domain (NCBI)EFNA5
PDB (RSDB)2X11    3MX0    4BK5    4BKA    4L0P    4M4R   
PDB Europe2X11    3MX0    4BK5    4BKA    4L0P    4M4R   
PDB (PDBSum)2X11    3MX0    4BK5    4BKA    4L0P    4M4R   
PDB (IMB)2X11    3MX0    4BK5    4BKA    4L0P    4M4R   
Structural Biology KnowledgeBase2X11    3MX0    4BK5    4BKA    4L0P    4M4R   
SCOP (Structural Classification of Proteins)2X11    3MX0    4BK5    4BKA    4L0P    4M4R   
CATH (Classification of proteins structures)2X11    3MX0    4BK5    4BKA    4L0P    4M4R   
SuperfamilyP52803
AlphaFold pdb e-kbP52803   
Human Protein Atlas [tissue]ENSG00000184349-EFNA5 [tissue]
HPRD03324
Protein Interaction databases
DIP (DOE-UCLA)P52803
IntAct (EBI)P52803
BioGRIDEFNA5
STRING (EMBL)EFNA5
ZODIACEFNA5
Ontologies - Pathways
QuickGOP52803
Ontology : AmiGOpositive regulation of protein phosphorylation  neurotrophin TRKA receptor binding  neurotrophin TRKB receptor binding  neurotrophin TRKC receptor binding  protein binding  plasma membrane  plasma membrane  plasma membrane  caveola  apoptotic process  activation of transmembrane receptor protein tyrosine kinase activity  nervous system development  axon guidance  regulation of cell-cell adhesion  regulation of cell-cell adhesion  regulation of cell morphogenesis  transmembrane receptor protein tyrosine kinase activator activity  anchored component of external side of plasma membrane  anchored component of external side of plasma membrane  regulation of actin cytoskeleton organization  regulation of actin cytoskeleton organization  regulation of GTPase activity  regulation of GTPase activity  ephrin receptor binding  ephrin receptor binding  ephrin receptor signaling pathway  ephrin receptor signaling pathway  ephrin receptor signaling pathway  positive regulation of peptidyl-tyrosine phosphorylation  regulation of focal adhesion assembly  regulation of insulin secretion involved in cellular response to glucose stimulus  regulation of microtubule cytoskeleton organization  negative regulation of substrate adhesion-dependent cell spreading  
Ontology : EGO-EBIpositive regulation of protein phosphorylation  neurotrophin TRKA receptor binding  neurotrophin TRKB receptor binding  neurotrophin TRKC receptor binding  protein binding  plasma membrane  plasma membrane  plasma membrane  caveola  apoptotic process  activation of transmembrane receptor protein tyrosine kinase activity  nervous system development  axon guidance  regulation of cell-cell adhesion  regulation of cell-cell adhesion  regulation of cell morphogenesis  transmembrane receptor protein tyrosine kinase activator activity  anchored component of external side of plasma membrane  anchored component of external side of plasma membrane  regulation of actin cytoskeleton organization  regulation of actin cytoskeleton organization  regulation of GTPase activity  regulation of GTPase activity  ephrin receptor binding  ephrin receptor binding  ephrin receptor signaling pathway  ephrin receptor signaling pathway  ephrin receptor signaling pathway  positive regulation of peptidyl-tyrosine phosphorylation  regulation of focal adhesion assembly  regulation of insulin secretion involved in cellular response to glucose stimulus  regulation of microtubule cytoskeleton organization  negative regulation of substrate adhesion-dependent cell spreading  
Pathways : KEGGRas signaling pathway    Rap1 signaling pathway    PI3K-Akt signaling pathway    Axon guidance   
NDEx NetworkEFNA5
Atlas of Cancer Signalling NetworkEFNA5
Wikipedia pathwaysEFNA5
Orthology - Evolution
OrthoDB1946
GeneTree (enSembl)ENSG00000184349
Phylogenetic Trees/Animal Genes : TreeFamEFNA5
Homologs : HomoloGeneEFNA5
Homology/Alignments : Family Browser (UCSC)EFNA5
Gene fusions - Rearrangements
Fusion : MitelmanFAM172A/EFNA5 [5q15/5q21.3]  
Fusion : QuiverEFNA5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEFNA5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EFNA5
dbVarEFNA5
ClinVarEFNA5
MonarchEFNA5
1000_GenomesEFNA5 
Exome Variant ServerEFNA5
GNOMAD BrowserENSG00000184349
Varsome BrowserEFNA5
ACMGEFNA5 variants
VarityP52803
Genomic Variants (DGV)EFNA5 [DGVbeta]
DECIPHEREFNA5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEFNA5 
Mutations
ICGC Data PortalEFNA5 
TCGA Data PortalEFNA5 
Broad Tumor PortalEFNA5
OASIS PortalEFNA5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEFNA5  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DEFNA5
Mutations and Diseases : HGMDEFNA5
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaEFNA5
DgiDB (Drug Gene Interaction Database)EFNA5
DoCM (Curated mutations)EFNA5
CIViC (Clinical Interpretations of Variants in Cancer)EFNA5
Cancer3DEFNA5
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601535   
Orphanet
DisGeNETEFNA5
MedgenEFNA5
Genetic Testing Registry EFNA5
NextProtP52803 [Medical]
GENETestsEFNA5
Target ValidationEFNA5
Huge Navigator EFNA5 [HugePedia]
ClinGenEFNA5
Clinical trials, drugs, therapy
MyCancerGenomeEFNA5
Protein Interactions : CTDEFNA5
Pharm GKB GenePA27660
PharosP52803
Clinical trialEFNA5
Miscellaneous
canSAR (ICR)EFNA5
HarmonizomeEFNA5
DataMed IndexEFNA5
Probes
Litterature
PubMed63 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXEFNA5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:07:46 CEST 2021

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