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EGR3 (early growth response 3)

Identity

Alias_symbol (synonym)PILOT
Other aliasEGR-3
HGNC (Hugo) EGR3
LocusID (NCBI) 1960
Atlas_Id 40420
Location 8p21.3  [Link to chromosome band 8p21]
Location_base_pair Starts at 22687661 and ends at 22692389 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
EGR3 (8p21.3) / PLAA (9p21.2)EGR3 (8p21.3) / UBXN11 (1p36.11)FLAD1 (1q21.3) / EGR3 (8p21.3)
RPL18 (19q13.33) / EGR3 (8p21.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)EGR3   3240
Cards
Entrez_Gene (NCBI)EGR3  1960  early growth response 3
AliasesEGR-3; PILOT
GeneCards (Weizmann)EGR3
Ensembl hg19 (Hinxton)ENSG00000179388 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000179388 [Gene_View]  chr8:22687661-22692389 [Contig_View]  EGR3 [Vega]
ICGC DataPortalENSG00000179388
TCGA cBioPortalEGR3
AceView (NCBI)EGR3
Genatlas (Paris)EGR3
WikiGenes1960
SOURCE (Princeton)EGR3
Genetics Home Reference (NIH)EGR3
Genomic and cartography
GoldenPath hg38 (UCSC)EGR3  -     chr8:22687661-22692389 -  8p21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EGR3  -     8p21.3   [Description]    (hg19-Feb_2009)
EnsemblEGR3 - 8p21.3 [CytoView hg19]  EGR3 - 8p21.3 [CytoView hg38]
Mapping of homologs : NCBIEGR3 [Mapview hg19]  EGR3 [Mapview hg38]
OMIM602419   
Gene and transcription
Genbank (Entrez)AK292464 AK294968 AK295134 AK295834 AK313604
RefSeq transcript (Entrez)NM_001199880 NM_001199881 NM_004430
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)EGR3
Cluster EST : UnigeneHs.534313 [ NCBI ]
CGAP (NCI)Hs.534313
Alternative Splicing GalleryENSG00000179388
Gene ExpressionEGR3 [ NCBI-GEO ]   EGR3 [ EBI - ARRAY_EXPRESS ]   EGR3 [ SEEK ]   EGR3 [ MEM ]
Gene Expression Viewer (FireBrowse)EGR3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1960
GTEX Portal (Tissue expression)EGR3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ06889   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ06889  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ06889
Splice isoforms : SwissVarQ06889
PhosPhoSitePlusQ06889
Domaine pattern : Prosite (Expaxy)ZINC_FINGER_C2H2_1 (PS00028)    ZINC_FINGER_C2H2_2 (PS50157)   
Domains : Interpro (EBI)DUF3446    Znf_C2H2    Znf_C2H2-like    Znf_C2H2/integrase_DNA-bd   
Domain families : Pfam (Sanger)DUF3446 (PF11928)   
Domain families : Pfam (NCBI)pfam11928   
Domain families : Smart (EMBL)ZnF_C2H2 (SM00355)  
Conserved Domain (NCBI)EGR3
DMDM Disease mutations1960
Blocks (Seattle)EGR3
SuperfamilyQ06889
Human Protein AtlasENSG00000179388
Peptide AtlasQ06889
HPRD03881
IPIIPI00300178   IPI00908353   IPI00975574   IPI00984563   IPI00974057   
Protein Interaction databases
DIP (DOE-UCLA)Q06889
IntAct (EBI)Q06889
FunCoupENSG00000179388
BioGRIDEGR3
STRING (EMBL)EGR3
ZODIACEGR3
Ontologies - Pathways
QuickGOQ06889
Ontology : AmiGOpositive regulation of endothelial cell proliferation  cell migration involved in sprouting angiogenesis  DNA binding  transcription factor activity, sequence-specific DNA binding  nucleus  transcription, DNA-templated  regulation of transcription, DNA-templated  neuromuscular synaptic transmission  peripheral nervous system development  muscle organ development  circadian rhythm  positive regulation of T cell differentiation in thymus  endothelial cell chemotaxis  cellular response to vascular endothelial growth factor stimulus  negative regulation of apoptotic process  cellular response to fibroblast growth factor stimulus  regulation of gamma-delta T cell differentiation  metal ion binding  
Ontology : EGO-EBIpositive regulation of endothelial cell proliferation  cell migration involved in sprouting angiogenesis  DNA binding  transcription factor activity, sequence-specific DNA binding  nucleus  transcription, DNA-templated  regulation of transcription, DNA-templated  neuromuscular synaptic transmission  peripheral nervous system development  muscle organ development  circadian rhythm  positive regulation of T cell differentiation in thymus  endothelial cell chemotaxis  cellular response to vascular endothelial growth factor stimulus  negative regulation of apoptotic process  cellular response to fibroblast growth factor stimulus  regulation of gamma-delta T cell differentiation  metal ion binding  
Pathways : BIOCARTANeuropeptides VIP and PACAP inhibit the apoptosis of activated T cells [Genes]   
Pathways : KEGGHepatitis B    Viral carcinogenesis   
NDEx NetworkEGR3
Atlas of Cancer Signalling NetworkEGR3
Wikipedia pathwaysEGR3
Orthology - Evolution
OrthoDB1960
GeneTree (enSembl)ENSG00000179388
Phylogenetic Trees/Animal Genes : TreeFamEGR3
HOVERGENQ06889
HOGENOMQ06889
Homologs : HomoloGeneEGR3
Homology/Alignments : Family Browser (UCSC)EGR3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEGR3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EGR3
dbVarEGR3
ClinVarEGR3
1000_GenomesEGR3 
Exome Variant ServerEGR3
ExAC (Exome Aggregation Consortium)EGR3 (select the gene name)
Genetic variants : HAPMAP1960
Genomic Variants (DGV)EGR3 [DGVbeta]
DECIPHEREGR3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEGR3 
Mutations
ICGC Data PortalEGR3 
TCGA Data PortalEGR3 
Broad Tumor PortalEGR3
OASIS PortalEGR3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEGR3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDEGR3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EGR3
DgiDB (Drug Gene Interaction Database)EGR3
DoCM (Curated mutations)EGR3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EGR3 (select a term)
intoGenEGR3
Cancer3DEGR3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602419   
Orphanet
MedgenEGR3
Genetic Testing Registry EGR3
NextProtQ06889 [Medical]
TSGene1960
GENETestsEGR3
Target ValidationEGR3
Huge Navigator EGR3 [HugePedia]
snp3D : Map Gene to Disease1960
BioCentury BCIQEGR3
ClinGenEGR3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1960
Chemical/Pharm GKB GenePA27675
Clinical trialEGR3
Miscellaneous
canSAR (ICR)EGR3 (select the gene name)
Probes
Litterature
PubMed40 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEGR3
EVEXEGR3
GoPubMedEGR3
iHOPEGR3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:32:15 CEST 2017

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