EIF6 (eukaryotic translation initiation factor 6)

2007-02-01  

Identity

HGNC
LOCATION
20q11.22
LOCUSID
ALIAS
CAB,EIF3A,ITGB4BP,b(2)gcn,eIF-6,p27(BBP),p27BBP
FUSION GENES

Other Information

Locus ID:

NCBI: 3692
MIM: 602912
HGNC: 6159
Ensembl: ENSG00000242372

Variants:

dbSNP: 3692
ClinVar: 3692
TCGA: ENSG00000242372
COSMIC: EIF6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000242372ENST00000374436P56537
ENSG00000242372ENST00000374443P56537
ENSG00000242372ENST00000374450P56537
ENSG00000242372ENST00000415116F8WDS6
ENSG00000242372ENST00000440766F8WD20
ENSG00000242372ENST00000447927A0A0B4J1Y7
ENSG00000242372ENST00000456600B7ZBH1

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
Ribosome biogenesis in eukaryotesKEGGko03008
Ribosome biogenesis in eukaryotesKEGGhsa03008

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
175079292007MicroRNA silencing through RISC recruitment of eIF6.178
146548452003Release of eIF6 (p27BBP) from the 60S subunit allows 80S ribosome assembly.149
215367322011Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome.94
183272112008Altered eIF6 and Dicer expression is associated with clinicopathological features in ovarian serous carcinoma patients.29
231152722012Impaired ribosomal subunit association in Shwachman-Diamond syndrome.26
205466122010The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature.19
210842952011Opposing action of casein kinase 1 and calcineurin in nucleo-cytoplasmic shuttling of mammalian translation initiation factor eIF6.17
222958582012Deletion of chromosome 20 in bone marrow of patients with Shwachman-Diamond syndrome, loss of the EIF6 gene and benign prognosis.15
252521592015eIF6 anti-association activity is required for ribosome biogenesis, translational control and tumor progression.15
151226572004Overexpression of p27BBP in head and neck carcinomas and their lymph node metastases.8

Citation

Dessen P

EIF6 (eukaryotic translation initiation factor 6)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43756/eif6