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EIF6 (eukaryotic translation initiation factor 6)

Identity

Alias_namesEIF3A
ITGB4BP
integrin beta 4 binding protein
Alias_symbol (synonym)p27BBP
b(2)gcn
Other aliasCAB
eIF-6
p27(BBP)
HGNC (Hugo) EIF6
LocusID (NCBI) 3692
Atlas_Id 43756
Location 20q11.22  [Link to chromosome band 20q11]
Location_base_pair Starts at 33866709 and ends at 33872520 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ATP2A2 (12q24.11) / EIF6 (20q11.22)DDX27 (20q13.13) / EIF6 (20q11.22)EIF6 (20q11.22) / EIF6 (20q11.22)
TTL (2q13) / EIF6 (20q11.22)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)EIF6   6159
Cards
Entrez_Gene (NCBI)EIF6  3692  eukaryotic translation initiation factor 6
AliasesCAB; EIF3A; ITGB4BP; b(2)gcn; 
eIF-6; p27(BBP); p27BBP
GeneCards (Weizmann)EIF6
Ensembl hg19 (Hinxton)ENSG00000242372 [Gene_View]  chr20:33866709-33872520 [Contig_View]  EIF6 [Vega]
Ensembl hg38 (Hinxton)ENSG00000242372 [Gene_View]  chr20:33866709-33872520 [Contig_View]  EIF6 [Vega]
ICGC DataPortalENSG00000242372
TCGA cBioPortalEIF6
AceView (NCBI)EIF6
Genatlas (Paris)EIF6
WikiGenes3692
SOURCE (Princeton)EIF6
Genetics Home Reference (NIH)EIF6
Genomic and cartography
GoldenPath hg19 (UCSC)EIF6  -     chr20:33866709-33872520 -  20q11.22   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)EIF6  -     20q11.22   [Description]    (hg38-Dec_2013)
EnsemblEIF6 - 20q11.22 [CytoView hg19]  EIF6 - 20q11.22 [CytoView hg38]
Mapping of homologs : NCBIEIF6 [Mapview hg19]  EIF6 [Mapview hg38]
OMIM602912   
Gene and transcription
Genbank (Entrez)AB062289 AF022229 AF047433 AF401207 AK296076
RefSeq transcript (Entrez)NM_001267810 NM_002212 NM_181466 NM_181467 NM_181468 NM_181469
RefSeq genomic (Entrez)NC_000020 NC_018931 NG_023238 NT_011362 NW_004929418
Consensus coding sequences : CCDS (NCBI)EIF6
Cluster EST : UnigeneHs.743992 [ NCBI ]
CGAP (NCI)Hs.743992
Alternative Splicing GalleryENSG00000242372
Gene ExpressionEIF6 [ NCBI-GEO ]   EIF6 [ EBI - ARRAY_EXPRESS ]   EIF6 [ SEEK ]   EIF6 [ MEM ]
Gene Expression Viewer (FireBrowse)EIF6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3692
GTEX Portal (Tissue expression)EIF6
Protein : pattern, domain, 3D structure
UniProt/SwissProtP56537   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP56537  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP56537
Splice isoforms : SwissVarP56537
PhosPhoSitePlusP56537
Domains : Interpro (EBI)eIF6   
Domain families : Pfam (Sanger)eIF-6 (PF01912)   
Domain families : Pfam (NCBI)pfam01912   
Domain families : Smart (EMBL)eIF6 (SM00654)  
Conserved Domain (NCBI)EIF6
DMDM Disease mutations3692
Blocks (Seattle)EIF6
SuperfamilyP56537
Human Protein AtlasENSG00000242372
Peptide AtlasP56537
HPRD04221
IPIIPI00010105   IPI00375391   IPI00640731   IPI00893507   IPI00892804   IPI00893107   
Protein Interaction databases
DIP (DOE-UCLA)P56537
IntAct (EBI)P56537
FunCoupENSG00000242372
BioGRIDEIF6
STRING (EMBL)EIF6
ZODIACEIF6
Ontologies - Pathways
QuickGOP56537
Ontology : AmiGOribosomal subunit export from nucleus  maturation of 5.8S rRNA  maturation of LSU-rRNA  translation initiation factor activity  protein binding  nucleus  nucleoplasm  nucleolus  cytoplasm  cytosol  translational initiation  preribosome, large subunit precursor  mature ribosome assembly  ribosome binding  ribosomal large subunit binding  extracellular exosome  assembly of large subunit precursor of preribosome  
Ontology : EGO-EBIribosomal subunit export from nucleus  maturation of 5.8S rRNA  maturation of LSU-rRNA  translation initiation factor activity  protein binding  nucleus  nucleoplasm  nucleolus  cytoplasm  cytosol  translational initiation  preribosome, large subunit precursor  mature ribosome assembly  ribosome binding  ribosomal large subunit binding  extracellular exosome  assembly of large subunit precursor of preribosome  
Pathways : BIOCARTAEukaryotic protein translation [Genes]   
Pathways : KEGGRibosome biogenesis in eukaryotes   
NDEx NetworkEIF6
Atlas of Cancer Signalling NetworkEIF6
Wikipedia pathwaysEIF6
Orthology - Evolution
OrthoDB3692
GeneTree (enSembl)ENSG00000242372
Phylogenetic Trees/Animal Genes : TreeFamEIF6
HOVERGENP56537
HOGENOMP56537
Homologs : HomoloGeneEIF6
Homology/Alignments : Family Browser (UCSC)EIF6
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEIF6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EIF6
dbVarEIF6
ClinVarEIF6
1000_GenomesEIF6 
Exome Variant ServerEIF6
ExAC (Exome Aggregation Consortium)EIF6 (select the gene name)
Genetic variants : HAPMAP3692
Genomic Variants (DGV)EIF6 [DGVbeta]
DECIPHER (Syndromes)20:33866709-33872520  ENSG00000242372
CONAN: Copy Number AnalysisEIF6 
Mutations
ICGC Data PortalEIF6 
TCGA Data PortalEIF6 
Broad Tumor PortalEIF6
OASIS PortalEIF6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEIF6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDEIF6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EIF6
DgiDB (Drug Gene Interaction Database)EIF6
DoCM (Curated mutations)EIF6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EIF6 (select a term)
intoGenEIF6
Cancer3DEIF6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602912   
Orphanet
MedgenEIF6
Genetic Testing Registry EIF6
NextProtP56537 [Medical]
TSGene3692
GENETestsEIF6
Huge Navigator EIF6 [HugePedia]
snp3D : Map Gene to Disease3692
BioCentury BCIQEIF6
ClinGenEIF6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3692
Chemical/Pharm GKB GenePA29958
Clinical trialEIF6
Miscellaneous
canSAR (ICR)EIF6 (select the gene name)
Probes
Litterature
PubMed67 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEIF6
EVEXEIF6
GoPubMedEIF6
iHOPEIF6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 14:59:57 CEST 2017

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