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EME2 (essential meiotic structure-specific endonuclease subunit 2)

Identity

Alias_namesessential meiotic endonuclease 1 homolog 2 (S. pombe)
Alias_symbol (synonym)FLJ00151
SLX2B
Other aliasgs125
HGNC (Hugo) EME2
LocusID (NCBI) 197342
Atlas_Id 50227
Location 16p13.3  [Link to chromosome band 16p13]
Location_base_pair Starts at 1823229 and ends at 1826239 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
MXD3 (5q35.3) / EME2 (16p13.3)SRP14 (15q15.1) / EME2 (16p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)EME2   27289
Cards
Entrez_Gene (NCBI)EME2  197342  essential meiotic structure-specific endonuclease subunit 2
AliasesSLX2B; gs125
GeneCards (Weizmann)EME2
Ensembl hg19 (Hinxton)ENSG00000197774 [Gene_View]  chr16:1823229-1826239 [Contig_View]  EME2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000197774 [Gene_View]  chr16:1823229-1826239 [Contig_View]  EME2 [Vega]
ICGC DataPortalENSG00000197774
TCGA cBioPortalEME2
AceView (NCBI)EME2
Genatlas (Paris)EME2
WikiGenes197342
SOURCE (Princeton)EME2
Genetics Home Reference (NIH)EME2
Genomic and cartography
GoldenPath hg19 (UCSC)EME2  -     chr16:1823229-1826239 +  16p13.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)EME2  -     16p13.3   [Description]    (hg38-Dec_2013)
EnsemblEME2 - 16p13.3 [CytoView hg19]  EME2 - 16p13.3 [CytoView hg38]
Mapping of homologs : NCBIEME2 [Mapview hg19]  EME2 [Mapview hg38]
OMIM610886   
Gene and transcription
Genbank (Entrez)AK074080 BC041011 BC167808 EF452422
RefSeq transcript (Entrez)NM_001010865 NM_001257370
RefSeq genomic (Entrez)NC_000016 NC_018927 NT_010393 NW_004929400
Consensus coding sequences : CCDS (NCBI)EME2
Cluster EST : UnigeneHs.7247 [ NCBI ]
CGAP (NCI)Hs.7247
Alternative Splicing GalleryENSG00000197774
Gene ExpressionEME2 [ NCBI-GEO ]   EME2 [ EBI - ARRAY_EXPRESS ]   EME2 [ SEEK ]   EME2 [ MEM ]
Gene Expression Viewer (FireBrowse)EME2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)197342
GTEX Portal (Tissue expression)EME2
Protein : pattern, domain, 3D structure
UniProt/SwissProtA4GXA9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtA4GXA9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProA4GXA9
Splice isoforms : SwissVarA4GXA9
PhosPhoSitePlusA4GXA9
Domains : Interpro (EBI)ERCC4_domain   
Domain families : Pfam (Sanger)ERCC4 (PF02732)   
Domain families : Pfam (NCBI)pfam02732   
Domain families : Smart (EMBL)ERCC4 (SM00891)  
Conserved Domain (NCBI)EME2
DMDM Disease mutations197342
Blocks (Seattle)EME2
SuperfamilyA4GXA9
Human Protein AtlasENSG00000197774
Peptide AtlasA4GXA9
HPRD16859
IPIIPI00885210   IPI00939390   IPI00174440   
Protein Interaction databases
DIP (DOE-UCLA)A4GXA9
IntAct (EBI)A4GXA9
FunCoupENSG00000197774
BioGRIDEME2
STRING (EMBL)EME2
ZODIACEME2
Ontologies - Pathways
QuickGOA4GXA9
Ontology : AmiGODNA binding  endonuclease activity  nucleus  DNA repair  DNA recombination  nucleic acid phosphodiester bond hydrolysis  
Ontology : EGO-EBIDNA binding  endonuclease activity  nucleus  DNA repair  DNA recombination  nucleic acid phosphodiester bond hydrolysis  
Pathways : KEGGFanconi anemia pathway   
NDEx NetworkEME2
Atlas of Cancer Signalling NetworkEME2
Wikipedia pathwaysEME2
Orthology - Evolution
OrthoDB197342
GeneTree (enSembl)ENSG00000197774
Phylogenetic Trees/Animal Genes : TreeFamEME2
HOVERGENA4GXA9
HOGENOMA4GXA9
Homologs : HomoloGeneEME2
Homology/Alignments : Family Browser (UCSC)EME2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEME2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EME2
dbVarEME2
ClinVarEME2
1000_GenomesEME2 
Exome Variant ServerEME2
ExAC (Exome Aggregation Consortium)EME2 (select the gene name)
Genetic variants : HAPMAP197342
Genomic Variants (DGV)EME2 [DGVbeta]
DECIPHER (Syndromes)16:1823229-1826239  ENSG00000197774
CONAN: Copy Number AnalysisEME2 
Mutations
ICGC Data PortalEME2 
TCGA Data PortalEME2 
Broad Tumor PortalEME2
OASIS PortalEME2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEME2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDEME2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EME2
DgiDB (Drug Gene Interaction Database)EME2
DoCM (Curated mutations)EME2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EME2 (select a term)
intoGenEME2
Cancer3DEME2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610886   
Orphanet
MedgenEME2
Genetic Testing Registry EME2
NextProtA4GXA9 [Medical]
TSGene197342
GENETestsEME2
Huge Navigator EME2 [HugePedia]
snp3D : Map Gene to Disease197342
BioCentury BCIQEME2
ClinGenEME2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD197342
Chemical/Pharm GKB GenePA134863517
Clinical trialEME2
Miscellaneous
canSAR (ICR)EME2 (select the gene name)
Probes
Litterature
PubMed8 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEME2
EVEXEME2
GoPubMedEME2
iHOPEME2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:00:04 CEST 2017

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