EME2 (essential meiotic structure-specific endonuclease subunit 2)

2008-07-01  

Identity

HGNC
LOCATION
16p13.3
LOCUSID
ALIAS
SLX2B,gs125
FUSION GENES

Other Information

Locus ID:

NCBI: 197342
MIM: 610886
HGNC: 27289
Ensembl: ENSG00000197774

Variants:

dbSNP: 197342
ClinVar: 197342
TCGA: ENSG00000197774
COSMIC: EME2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197774ENST00000561903H3BV62
ENSG00000197774ENST00000564182H3BSZ6
ENSG00000197774ENST00000568449A4GXA9

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Fanconi anemia pathwayKEGGko03460
Fanconi anemia pathwayKEGGhsa03460
DNA RepairREACTOMER-HSA-73894
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
Homology Directed RepairREACTOMER-HSA-5693538
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)REACTOMER-HSA-5693567
HDR through Homologous Recombination (HRR)REACTOMER-HSA-5685942
Resolution of D-Loop StructuresREACTOMER-HSA-5693537
Resolution of D-loop Structures through Holliday Junction IntermediatesREACTOMER-HSA-5693568
Fanconi Anemia PathwayREACTOMER-HSA-6783310

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
248138862014MUS81-EME2 promotes replication fork restart.39
268049042016Signaling from Mus81-Eme2-Dependent DNA Damage Elicited by Chk1 Deficiency Modulates Replication Fork Speed and Origin Usage.23
243712682014Substrate specificity of the MUS81-EME2 structure selective endonuclease.18
246926622014Human MUS81-EME2 can cleave a variety of DNA structures including intact Holliday junction and nicked duplex.8

Citation

Dessen P

EME2 (essential meiotic structure-specific endonuclease subunit 2)

Atlas Genet Cytogenet Oncol Haematol. 2008-07-01

Online version: http://atlasgeneticsoncology.org/gene/50227/eme2