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EN1 (engrailed homeobox 1)

Identity

Other names-
HGNC (Hugo) EN1
LocusID (NCBI) 2019
Atlas_Id 40450
Location 2q14.2
Location_base_pair Starts at 119599747 and ends at 119605759 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)EN1   3342
Cards
Entrez_Gene (NCBI)EN1  2019  engrailed homeobox 1
Aliases
GeneCards (Weizmann)EN1
Ensembl hg19 (Hinxton)ENSG00000163064 [Gene_View]  chr2:119599747-119605759 [Contig_View]  EN1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000163064 [Gene_View]  chr2:119599747-119605759 [Contig_View]  EN1 [Vega]
ICGC DataPortalENSG00000163064
TCGA cBioPortalEN1
AceView (NCBI)EN1
Genatlas (Paris)EN1
WikiGenes2019
SOURCE (Princeton)EN1
Genomic and cartography
GoldenPath hg19 (UCSC)EN1  -     chr2:119599747-119605759 -  2q14.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)EN1  -     2q14.2   [Description]    (hg38-Dec_2013)
EnsemblEN1 - 2q14.2 [CytoView hg19]  EN1 - 2q14.2 [CytoView hg38]
Mapping of homologs : NCBIEN1 [Mapview hg19]  EN1 [Mapview hg38]
OMIM131290   
Gene and transcription
Genbank (Entrez)BC111840
RefSeq transcript (Entrez)NM_001426
RefSeq genomic (Entrez)NC_000002 NC_018913 NG_007123 NT_005403 NW_004929304
Consensus coding sequences : CCDS (NCBI)EN1
Cluster EST : UnigeneHs.271977 [ NCBI ]
CGAP (NCI)Hs.271977
Alternative Splicing GalleryENSG00000163064
Gene ExpressionEN1 [ NCBI-GEO ]   EN1 [ EBI - ARRAY_EXPRESS ]   EN1 [ SEEK ]   EN1 [ MEM ]
Gene Expression Viewer (FireBrowse)EN1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2019
GTEX Portal (Tissue expression)EN1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ05925 (Uniprot)
NextProtQ05925  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ05925
Splice isoforms : SwissVarQ05925 (Swissvar)
PhosPhoSitePlusQ05925
Domaine pattern : Prosite (Expaxy)ENGRAILED (PS00033)    HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)Homeobox-engrailed_C-terminal    Homeobox_CS    Homeobox_dom    Homeobox_metazoa    Homeodomain-like    Homeodomain_engrailed    Homoebox-engrailed_CS   
Domain families : Pfam (Sanger)Engrail_1_C_sig (PF10525)    Homeobox (PF00046)   
Domain families : Pfam (NCBI)pfam10525    pfam00046   
Domain families : Smart (EMBL)HOX (SM00389)  
DMDM Disease mutations2019
Blocks (Seattle)EN1
SuperfamilyQ05925
Human Protein AtlasENSG00000163064
Peptide AtlasQ05925
HPRD08835
IPIIPI00016734   
Protein Interaction databases
DIP (DOE-UCLA)Q05925
IntAct (EBI)Q05925
FunCoupENSG00000163064
BioGRIDEN1
STRING (EMBL)EN1
ZODIACEN1
Ontologies - Pathways
QuickGOQ05925
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  skeletal system development  nucleus  adult locomotory behavior  anatomical structure morphogenesis  dorsal/ventral pattern formation  proximal/distal pattern formation  cerebellum development  midbrain development  midbrain-hindbrain boundary development  embryonic forelimb morphogenesis  social behavior  multicellular organism growth  drinking behavior  pigmentation  negative regulation of neuron apoptotic process  positive regulation of transcription from RNA polymerase II promoter  neuron development  motor learning  dopaminergic neuron differentiation  embryonic brain development  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  skeletal system development  nucleus  adult locomotory behavior  anatomical structure morphogenesis  dorsal/ventral pattern formation  proximal/distal pattern formation  cerebellum development  midbrain development  midbrain-hindbrain boundary development  embryonic forelimb morphogenesis  social behavior  multicellular organism growth  drinking behavior  pigmentation  negative regulation of neuron apoptotic process  positive regulation of transcription from RNA polymerase II promoter  neuron development  motor learning  dopaminergic neuron differentiation  embryonic brain development  
NDEx Network
Atlas of Cancer Signalling NetworkEN1
Wikipedia pathwaysEN1
Orthology - Evolution
OrthoDB2019
GeneTree (enSembl)ENSG00000163064
Phylogenetic Trees/Animal Genes : TreeFamEN1
Homologs : HomoloGeneEN1
Homology/Alignments : Family Browser (UCSC)EN1
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerEN1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EN1
dbVarEN1
ClinVarEN1
1000_GenomesEN1 
Exome Variant ServerEN1
ExAC (Exome Aggregation Consortium)EN1 (select the gene name)
Genetic variants : HAPMAP2019
Genomic Variants (DGV)EN1 [DGVbeta]
Mutations
ICGC Data PortalEN1 
TCGA Data PortalEN1 
Broad Tumor PortalEN1
OASIS PortalEN1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEN1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EN1
DgiDB (Drug Gene Interaction Database)EN1
DoCM (Curated mutations)EN1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EN1 (select a term)
intoGenEN1
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)2:119599747-119605759  ENSG00000163064
CONAN: Copy Number AnalysisEN1 
Mutations and Diseases : HGMDEN1
OMIM131290   
MedgenEN1
Genetic Testing Registry EN1
NextProtQ05925 [Medical]
TSGene2019
GENETestsEN1
Huge Navigator EN1 [HugePedia]
snp3D : Map Gene to Disease2019
BioCentury BCIQEN1
ClinGenEN1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2019
Chemical/Pharm GKB GenePA27779
Clinical trialEN1
Miscellaneous
canSAR (ICR)EN1 (select the gene name)
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEN1
EVEXEN1
GoPubMedEN1
iHOPEN1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat May 28 11:01:36 CEST 2016

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