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EPHX2 (epoxide hydrolase 2)

Identity

Alias_namesepoxide hydrolase 2
Other aliasCEH
SEH
HGNC (Hugo) EPHX2
LocusID (NCBI) 2053
Atlas_Id 40473
Location 8p21.2  [Link to chromosome band 8p21]
Location_base_pair Starts at 27491002 and ends at 27544922 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
EPHX2 (8p21.2) / BNIP3L (8p21.2)EPHX2 (8p21.2) / PTK2B (8p21.2)ESCO2 (8p21.1) / EPHX2 (8p21.2)
EPHX2 8p21.2 / BNIP3L 8p21.2EPHX2 8p21.2 / PTK2B 8p21.2ESCO2 8p21.1 / EPHX2 8p21.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)EPHX2   3402
Cards
Entrez_Gene (NCBI)EPHX2  2053  epoxide hydrolase 2
AliasesCEH; SEH
GeneCards (Weizmann)EPHX2
Ensembl hg19 (Hinxton)ENSG00000120915 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000120915 [Gene_View]  chr8:27491002-27544922 [Contig_View]  EPHX2 [Vega]
ICGC DataPortalENSG00000120915
TCGA cBioPortalEPHX2
AceView (NCBI)EPHX2
Genatlas (Paris)EPHX2
WikiGenes2053
SOURCE (Princeton)EPHX2
Genetics Home Reference (NIH)EPHX2
Genomic and cartography
GoldenPath hg38 (UCSC)EPHX2  -     chr8:27491002-27544922 +  8p21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EPHX2  -     8p21.2   [Description]    (hg19-Feb_2009)
EnsemblEPHX2 - 8p21.2 [CytoView hg19]  EPHX2 - 8p21.2 [CytoView hg38]
Mapping of homologs : NCBIEPHX2 [Mapview hg19]  EPHX2 [Mapview hg38]
OMIM132811   143890   
Gene and transcription
Genbank (Entrez)AF233334 AF233335 AF233336 AK094393 AK096089
RefSeq transcript (Entrez)NM_001256482 NM_001256483 NM_001256484 NM_001979
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)EPHX2
Cluster EST : UnigeneHs.212088 [ NCBI ]
CGAP (NCI)Hs.212088
Alternative Splicing GalleryENSG00000120915
Gene ExpressionEPHX2 [ NCBI-GEO ]   EPHX2 [ EBI - ARRAY_EXPRESS ]   EPHX2 [ SEEK ]   EPHX2 [ MEM ]
Gene Expression Viewer (FireBrowse)EPHX2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2053
GTEX Portal (Tissue expression)EPHX2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP34913   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP34913  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP34913
Splice isoforms : SwissVarP34913
Catalytic activity : Enzyme3.3.2.10 [ Enzyme-Expasy ]   3.3.2.103.3.2.10 [ IntEnz-EBI ]   3.3.2.10 [ BRENDA ]   3.3.2.10 [ KEGG ]   
PhosPhoSitePlusP34913
Domains : Interpro (EBI)AB_hydrolase    AB_hydrolase_1    Epox_hydrolase-like    HAD-like_dom    HAD-SF_hydro_IA    HAD-SF_ppase_IA/epoxid_hydro_N    PGP_dom2   
Domain families : Pfam (Sanger)Abhydrolase_1 (PF00561)    HAD_2 (PF13419)   
Domain families : Pfam (NCBI)pfam00561    pfam13419   
Conserved Domain (NCBI)EPHX2
DMDM Disease mutations2053
Blocks (Seattle)EPHX2
PDB (SRS)###############################################################################################################################################################################################################################################################   
PDB (PDBSum)###############################################################################################################################################################################################################################################################   
PDB (IMB)###############################################################################################################################################################################################################################################################   
PDB (RSDB)###############################################################################################################################################################################################################################################################   
Structural Biology KnowledgeBase###############################################################################################################################################################################################################################################################   
SCOP (Structural Classification of Proteins)###############################################################################################################################################################################################################################################################   
CATH (Classification of proteins structures)###############################################################################################################################################################################################################################################################   
SuperfamilyP34913
Human Protein AtlasENSG00000120915
Peptide AtlasP34913
HPRD00582
IPIIPI00104341   IPI00909862   IPI00974119   IPI00984813   IPI00978844   IPI00974432   IPI00977672   
Protein Interaction databases
DIP (DOE-UCLA)P34913
IntAct (EBI)P34913
FunCoupENSG00000120915
BioGRIDEPHX2
STRING (EMBL)EPHX2
ZODIACEPHX2
Ontologies - Pathways
QuickGOP34913
Ontology : AmiGOmagnesium ion binding  epoxide hydrolase activity  epoxide hydrolase activity  receptor binding  peroxisome  cytosol  cytosol  cytosol  xenobiotic metabolic process  cellular calcium ion homeostasis  inflammatory response  regulation of blood pressure  response to toxic substance  positive regulation of gene expression  toxic substance binding  dephosphorylation  phosphatase activity  drug metabolic process  epoxygenase P450 pathway  10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity  lipid phosphatase activity  cholesterol homeostasis  protein homodimerization activity  protein homodimerization activity  stilbene catabolic process  phospholipid dephosphorylation  extracellular exosome  reactive oxygen species metabolic process  regulation of cholesterol metabolic process  positive regulation of blood vessel diameter  
Ontology : EGO-EBImagnesium ion binding  epoxide hydrolase activity  epoxide hydrolase activity  receptor binding  peroxisome  cytosol  cytosol  cytosol  xenobiotic metabolic process  cellular calcium ion homeostasis  inflammatory response  regulation of blood pressure  response to toxic substance  positive regulation of gene expression  toxic substance binding  dephosphorylation  phosphatase activity  drug metabolic process  epoxygenase P450 pathway  10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity  lipid phosphatase activity  cholesterol homeostasis  protein homodimerization activity  protein homodimerization activity  stilbene catabolic process  phospholipid dephosphorylation  extracellular exosome  reactive oxygen species metabolic process  regulation of cholesterol metabolic process  positive regulation of blood vessel diameter  
Pathways : BIOCARTAEicosanoid Metabolism [Genes]   
Pathways : KEGGArachidonic acid metabolism    Peroxisome   
NDEx NetworkEPHX2
Atlas of Cancer Signalling NetworkEPHX2
Wikipedia pathwaysEPHX2
Orthology - Evolution
OrthoDB2053
GeneTree (enSembl)ENSG00000120915
Phylogenetic Trees/Animal Genes : TreeFamEPHX2
HOVERGENP34913
HOGENOMP34913
Homologs : HomoloGeneEPHX2
Homology/Alignments : Family Browser (UCSC)EPHX2
Gene fusions - Rearrangements
Fusion : MitelmanEPHX2/BNIP3L [8p21.2/8p21.2]  
Fusion : MitelmanEPHX2/PTK2B [8p21.2/8p21.2]  [t(8;8)(p21;p21)]  
Fusion : MitelmanESCO2/EPHX2 [8p21.1/8p21.2]  [t(8;8)(p21;p21)]  
Fusion: TCGAEPHX2 8p21.2 BNIP3L 8p21.2 BRCA
Fusion: TCGAEPHX2 8p21.2 PTK2B 8p21.2 BLCA
Fusion: TCGAESCO2 8p21.1 EPHX2 8p21.2 OV
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEPHX2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EPHX2
dbVarEPHX2
ClinVarEPHX2
1000_GenomesEPHX2 
Exome Variant ServerEPHX2
ExAC (Exome Aggregation Consortium)EPHX2 (select the gene name)
Genetic variants : HAPMAP2053
Genomic Variants (DGV)EPHX2 [DGVbeta]
DECIPHEREPHX2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEPHX2 
Mutations
ICGC Data PortalEPHX2 
TCGA Data PortalEPHX2 
Broad Tumor PortalEPHX2
OASIS PortalEPHX2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEPHX2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDEPHX2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EPHX2
DgiDB (Drug Gene Interaction Database)EPHX2
DoCM (Curated mutations)EPHX2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EPHX2 (select a term)
intoGenEPHX2
Cancer3DEPHX2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM132811    143890   
Orphanet
MedgenEPHX2
Genetic Testing Registry EPHX2
NextProtP34913 [Medical]
TSGene2053
GENETestsEPHX2
Target ValidationEPHX2
Huge Navigator EPHX2 [HugePedia]
snp3D : Map Gene to Disease2053
BioCentury BCIQEPHX2
ClinGenEPHX2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2053
Chemical/Pharm GKB GenePA27830
Clinical trialEPHX2
Miscellaneous
canSAR (ICR)EPHX2 (select the gene name)
Probes
Litterature
PubMed118 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEPHX2
EVEXEPHX2
GoPubMedEPHX2
iHOPEPHX2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:00:31 CEST 2017

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