EPHX2 (epoxide hydrolase 2)

2003-08-01  

Identity

HGNC
LOCATION
8p21.2
LOCUSID
ALIAS
ABHD20,CEH,SEH
FUSION GENES

Other Information

Locus ID:

NCBI: 2053
MIM: 132811
HGNC: 3402
Ensembl: ENSG00000120915

Variants:

dbSNP: 2053
ClinVar: 2053
TCGA: ENSG00000120915
COSMIC: EPHX2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000120915ENST00000380476P34913
ENSG00000120915ENST00000517536E5RFH6
ENSG00000120915ENST00000518328E5RI53
ENSG00000120915ENST00000518379E5RFU2
ENSG00000120915ENST00000521400P34913
ENSG00000120915ENST00000521684H0YAW7
ENSG00000120915ENST00000521780P34913

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Arachidonic acid metabolismKEGGko00590
Arachidonic acid metabolismKEGGhsa00590
PeroxisomeKEGGko04146
PeroxisomeKEGGhsa04146
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Arachidonic acid metabolismREACTOMER-HSA-2142753
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)REACTOMER-HSA-2142670

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA447199Bipolar DisorderDiseaseClinicalAnnotationassociatedPD29121268
PA450243lithiumChemicalClinicalAnnotationassociatedPD29121268

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
174950272007Angiotensin II up-regulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo.69
165956072006Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) study.68
165956072006Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) study.68
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
174600772007Polymorphisms in the human soluble epoxide hydrolase gene EPHX2 linked to neuronal survival after ischemic injury.57
147327572004Polymorphism of the soluble epoxide hydrolase is associated with coronary artery calcification in African-American subjects: The Coronary Artery Risk Development in Young Adults (CARDIA) study.55
269765692016Gene deficiency and pharmacological inhibition of soluble epoxide hydrolase confers resilience to repeated social defeat stress.49
183192712008Distribution and expression of soluble epoxide hydrolase in human brain.42
161158162005The soluble epoxide hydrolase gene harbors sequence variation associated with susceptibility to and protection from incident ischemic stroke.39

Citation

Dessen P

EPHX2 (epoxide hydrolase 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40473/ephx2