Identity
HGNC
LOCATION
8p21.2
LOCUSID
ALIAS
ABHD20,CEH,SEH
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 2053
MIM: 132811
HGNC: 3402
Ensembl: ENSG00000120915
Variants:
dbSNP: 2053
ClinVar: 2053
TCGA: ENSG00000120915
COSMIC: EPHX2
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA447199 | Bipolar Disorder | Disease | ClinicalAnnotation | associated | PD | 29121268 | |
| PA450243 | lithium | Chemical | ClinicalAnnotation | associated | PD | 29121268 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36470481 | 2023 | Wide-spread enhancer effect of SNP rs2279590 on regulating epoxide hydrolase-2 and protein tyrosine kinase 2-beta gene expression. | 2 |
| 36636821 | 2023 | Targeting soluble epoxide hydrolase promotes osteogenic-angiogenic coupling via activating SLIT3/HIF-1α signalling pathway. | 2 |
| 38013165 | 2023 | Role of soluble epoxide hydrolase in the abnormal activation of fibroblast-like synoviocytes from patients with rheumatoid arthritis. | 0 |
| 36470481 | 2023 | Wide-spread enhancer effect of SNP rs2279590 on regulating epoxide hydrolase-2 and protein tyrosine kinase 2-beta gene expression. | 2 |
| 36636821 | 2023 | Targeting soluble epoxide hydrolase promotes osteogenic-angiogenic coupling via activating SLIT3/HIF-1α signalling pathway. | 2 |
| 38013165 | 2023 | Role of soluble epoxide hydrolase in the abnormal activation of fibroblast-like synoviocytes from patients with rheumatoid arthritis. | 0 |
| 35183688 | 2022 | A hypothesis-driven study to comprehensively investigate the association between genetic polymorphisms in EPHX2 gene and cardiovascular diseases: Findings from the UK Biobank. | 3 |
| 35183688 | 2022 | A hypothesis-driven study to comprehensively investigate the association between genetic polymorphisms in EPHX2 gene and cardiovascular diseases: Findings from the UK Biobank. | 3 |
| 32687069 | 2021 | Clinical significance of EPHX2 deregulation in prostate cancer. | 6 |
| 33512081 | 2021 | No impact of soluble epoxide hydrolase rs4149243, rs2234914 and rs751142 genetic variants on the development of type II diabetes and its hypertensive complication among Jordanian patients. | 3 |
| 33580125 | 2021 | Preservation of epoxyeicosatrienoic acid bioavailability prevents renal allograft dysfunction and cardiovascular alterations in kidney transplant recipients. | 3 |
| 34040693 | 2021 | Association of rs11780592 Polymorphism in the Human Soluble Epoxide Hydrolase Gene (EPHX2) with Oxidized LDL and Mortality in Patients with Diabetic Chronic Kidney Disease. | 8 |
| 34278494 | 2021 | Identification and validation of EPHX2 as a prognostic biomarker in hepatocellular carcinoma. | 8 |
| 32687069 | 2021 | Clinical significance of EPHX2 deregulation in prostate cancer. | 6 |
| 33512081 | 2021 | No impact of soluble epoxide hydrolase rs4149243, rs2234914 and rs751142 genetic variants on the development of type II diabetes and its hypertensive complication among Jordanian patients. | 3 |
Citation
Dessen P
EPHX2 (epoxide hydrolase 2)
Atlas Genet Cytogenet Oncol Haematol. 2003-08-01
Online version: http://atlasgeneticsoncology.org/gene/40473/ephx2
