ERBB4 (erb-b2 receptor tyrosine kinase 4)

2003-02-01  

Identity

HGNC
LOCATION
2q34
LOCUSID
ALIAS
ALS19,HER4,p180erbB4
FUSION GENES

Other Information

Locus ID:

NCBI: 2066
MIM: 600543
HGNC: 3432
Ensembl: ENSG00000178568

Variants:

dbSNP: 2066
ClinVar: 2066
TCGA: ENSG00000178568
COSMIC: ERBB4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000178568ENST00000260943H3BLT0
ENSG00000178568ENST00000342788Q15303
ENSG00000178568ENST00000402597A0A0A0MSE1
ENSG00000178568ENST00000435846E9PDR1
ENSG00000178568ENST00000436443Q15303

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
10

Pathways

PathwaySourceExternal ID
ErbB signaling pathwayKEGGko04012
Calcium signaling pathwayKEGGko04020
ErbB signaling pathwayKEGGhsa04012
Calcium signaling pathwayKEGGhsa04020
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
PI3K/AKT Signaling in CancerREACTOMER-HSA-2219528
Constitutive Signaling by Aberrant PI3K in CancerREACTOMER-HSA-2219530
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Signaling by the B Cell Receptor (BCR)REACTOMER-HSA-983705
Downstream signaling events of B Cell Receptor (BCR)REACTOMER-HSA-1168372
PIP3 activates AKT signalingREACTOMER-HSA-1257604
Negative regulation of the PI3K/AKT networkREACTOMER-HSA-199418
Innate Immune SystemREACTOMER-HSA-168249
DAP12 interactionsREACTOMER-HSA-2172127
DAP12 signalingREACTOMER-HSA-2424491
RAF/MAP kinase cascadeREACTOMER-HSA-5673001
Fc epsilon receptor (FCERI) signalingREACTOMER-HSA-2454202
FCERI mediated MAPK activationREACTOMER-HSA-2871796
Role of LAT2/NTAL/LAB on calcium mobilizationREACTOMER-HSA-2730905
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-2 signalingREACTOMER-HSA-451927
Interleukin receptor SHC signalingREACTOMER-HSA-912526
Interleukin-3, 5 and GM-CSF signalingREACTOMER-HSA-512988
Signal TransductionREACTOMER-HSA-162582
Signaling by EGFRREACTOMER-HSA-177929
GRB2 events in EGFR signalingREACTOMER-HSA-179812
SHC1 events in EGFR signalingREACTOMER-HSA-180336
GAB1 signalosomeREACTOMER-HSA-180292
Signaling by Insulin receptorREACTOMER-HSA-74752
Insulin receptor signalling cascadeREACTOMER-HSA-74751
IRS-mediated signallingREACTOMER-HSA-112399
SOS-mediated signallingREACTOMER-HSA-112412
Signalling by NGFREACTOMER-HSA-166520
NGF signalling via TRKA from the plasma membraneREACTOMER-HSA-187037
Signalling to ERKsREACTOMER-HSA-187687
Signalling to RASREACTOMER-HSA-167044
Signalling to p38 via RIT and RINREACTOMER-HSA-187706
Prolonged ERK activation eventsREACTOMER-HSA-169893
Frs2-mediated activationREACTOMER-HSA-170968
ARMS-mediated activationREACTOMER-HSA-170984
PI3K/AKT activationREACTOMER-HSA-198203
Signaling by PDGFREACTOMER-HSA-186797
Downstream signal transductionREACTOMER-HSA-186763
Signaling by VEGFREACTOMER-HSA-194138
VEGFA-VEGFR2 PathwayREACTOMER-HSA-4420097
VEGFR2 mediated cell proliferationREACTOMER-HSA-5218921
Signaling by SCF-KITREACTOMER-HSA-1433557
Signaling by ERBB2REACTOMER-HSA-1227986
SHC1 events in ERBB2 signalingREACTOMER-HSA-1250196
GRB2 events in ERBB2 signalingREACTOMER-HSA-1963640
PI3K events in ERBB2 signalingREACTOMER-HSA-1963642
Signaling by ERBB4REACTOMER-HSA-1236394
SHC1 events in ERBB4 signalingREACTOMER-HSA-1250347
PI3K events in ERBB4 signalingREACTOMER-HSA-1250342
Nuclear signaling by ERBB4REACTOMER-HSA-1251985
Downregulation of ERBB4 signalingREACTOMER-HSA-1253288
MAPK family signaling cascadesREACTOMER-HSA-5683057
MAPK1/MAPK3 signalingREACTOMER-HSA-5684996
Signaling by GPCRREACTOMER-HSA-372790
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)REACTOMER-HSA-2404192
IGF1R signaling cascadeREACTOMER-HSA-2428924
IRS-related events triggered by IGF1RREACTOMER-HSA-2428928
Signaling by LeptinREACTOMER-HSA-2586552
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
NCAM signaling for neurite out-growthREACTOMER-HSA-375165
PI5P, PP2A and IER3 Regulate PI3K/AKT SignalingREACTOMER-HSA-6811558
ERBB2 Regulates Cell MotilityREACTOMER-HSA-6785631
ERBB2 Activates PTK6 SignalingREACTOMER-HSA-8847993
Signaling by PTK6REACTOMER-HSA-8848021
RET signalingREACTOMER-HSA-8853659
Downregulation of ERBB2 signalingREACTOMER-HSA-8863795

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA131301952gefitinibChemicalPathwayassociated
PA134687924erlotinibChemicalPathwayassociated
PA152241907lapatinibChemicalPathwayassociated
PA163518919paliperidoneChemicalMultilinkAnnotationassociated25714000
PA29988JAK1GenePathwayassociated
PA33308PIK3CAGenePathwayassociated
PA33309PIK3CBGenePathwayassociated
PA33310PIK3CDGenePathwayassociated
PA33311PIK3CGGenePathwayassociated
PA33312PIK3R1GenePathwayassociated
PA33313PIK3R2GenePathwayassociated
PA33314PIK3R3GenePathwayassociated
PA33392PLCG1GenePathwayassociated
PA33393PLCG2GenePathwayassociated

References

Pubmed IDYearTitleCitations
116796322001gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase.273
167670992006Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophrenia.217
167290432005Phosphotyrosine interactome of the ErbB-receptor kinase family.193
128079032003WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus.175
197363512009Recurrent rearrangements in synaptic and neurodevelopmental genes and shared biologic pathways in schizophrenia, autism, and mental retardation.151
197180252009Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4.143
197180252009Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4.143
170182852006Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain.132
171642652007Disease-associated intronic variants in the ErbB4 gene are related to altered ErbB4 splice-variant expression in the brain in schizophrenia.122
155340012004The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone.108

Citation

Dessen P

ERBB4 (erb-b2 receptor tyrosine kinase 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40480/erbb4