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ERBB4 (erb-b2 receptor tyrosine kinase 4)

Identity

Alias (NCBI)ALS19
HER4
p180erbB4
HGNC (Hugo) ERBB4
HGNC Alias symbALS19
HER4
HGNC Alias namehuman epidermal growth factor receptor 4
HGNC Previous namev-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4
 v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4
LocusID (NCBI) 2066
Atlas_Id 40480
Location 2q34  [Link to chromosome band 2q34]
Location_base_pair Starts at 211375717 and ends at 212538802 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ATAD2 (8q24.13)::ERBB4 (2q34)ATP2B4 (1q32.1)::ERBB4 (2q34)ERBB4 (2q34)::CSDE1 (1p13.2)
ERBB4 (2q34)::FUS (16p11.2)ERBB4 (2q34)::IKZF2 (2q34)ERBB4 (2q34)::KCNAB1 (3q25.31)
EZR (6q25.3)::ERBB4 (2q34)KANSL1L (2q34)::ERBB4 (2q34)LCLAT1 (2p23.1)::ERBB4 (2q34)
NFIB (9p23)::ERBB4 (2q34)EZR 6q25.3::ERBB4 2q34ATAD2 8q24.13::ERBB4 2q34
ATP2B4 1q32.1::ERBB4 2q34C2orf67 ERBB4 2q34

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)ERBB4   3432
Cards
Entrez_Gene (NCBI)ERBB4    erb-b2 receptor tyrosine kinase 4
AliasesALS19; HER4; p180erbB4
GeneCards (Weizmann)ERBB4
Ensembl hg19 (Hinxton)ENSG00000178568 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000178568 [Gene_View]  ENSG00000178568 [Sequence]  chr2:211375717-212538802 [Contig_View]  ERBB4 [Vega]
ICGC DataPortalENSG00000178568
TCGA cBioPortalERBB4
AceView (NCBI)ERBB4
Genatlas (Paris)ERBB4
SOURCE (Princeton)ERBB4
Genetics Home Reference (NIH)ERBB4
Genomic and cartography
GoldenPath hg38 (UCSC)ERBB4  -     chr2:211375717-212538802 -  2q34   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ERBB4  -     2q34   [Description]    (hg19-Feb_2009)
GoldenPathERBB4 - 2q34 [CytoView hg19]  ERBB4 - 2q34 [CytoView hg38]
ImmunoBaseENSG00000178568
Genome Data Viewer NCBIERBB4 [Mapview hg19]  
OMIM600543   615515   
Gene and transcription
Genbank (Entrez)AB209697 AF007153 AI793060 AK024204 AK126298
RefSeq transcript (Entrez)NM_001042599 NM_005235
Consensus coding sequences : CCDS (NCBI)ERBB4
Gene ExpressionERBB4 [ NCBI-GEO ]   ERBB4 [ EBI - ARRAY_EXPRESS ]   ERBB4 [ SEEK ]   ERBB4 [ MEM ]
Gene Expression Viewer (FireBrowse)ERBB4 [ Firebrowse - Broad ]
GenevisibleExpression of ERBB4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2066
GTEX Portal (Tissue expression)ERBB4
Human Protein AtlasENSG00000178568-ERBB4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15303   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15303  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15303
Catalytic activity : Enzyme2.7.10.1 [ Enzyme-Expasy ]   2.7.10.12.7.10.1 [ IntEnz-EBI ]   2.7.10.1 [ BRENDA ]   2.7.10.1 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ15303
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)   
Domains : Interpro (EBI)Furin-like_Cys-rich_dom    Furin_repeat    GF_recep_IV    Growth_fac_rcpt_cys_sf    Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Rcpt_L-dom    Rcpt_L-dom_sf    Ser-Thr/Tyr_kinase_cat_dom    Tyr_kinase_AS    Tyr_kinase_cat_dom    Tyr_kinase_EGF/ERB/XmrK_rcpt   
Domain families : Pfam (Sanger)Furin-like (PF00757)    GF_recep_IV (PF14843)    PK_Tyr_Ser-Thr (PF07714)    Recep_L_domain (PF01030)   
Domain families : Pfam (NCBI)pfam00757    pfam14843    pfam07714    pfam01030   
Domain families : Smart (EMBL)FU (SM00261)  TyrKc (SM00219)  
Conserved Domain (NCBI)ERBB4
PDB (RSDB)2AHX    2L2T    2LCX    2R4B    3BBT    3BBW    3BCE    3U2P    3U7U    3U9U   
PDB Europe2AHX    2L2T    2LCX    2R4B    3BBT    3BBW    3BCE    3U2P    3U7U    3U9U   
PDB (PDBSum)2AHX    2L2T    2LCX    2R4B    3BBT    3BBW    3BCE    3U2P    3U7U    3U9U   
PDB (IMB)2AHX    2L2T    2LCX    2R4B    3BBT    3BBW    3BCE    3U2P    3U7U    3U9U   
Structural Biology KnowledgeBase2AHX    2L2T    2LCX    2R4B    3BBT    3BBW    3BCE    3U2P    3U7U    3U9U   
SCOP (Structural Classification of Proteins)2AHX    2L2T    2LCX    2R4B    3BBT    3BBW    3BCE    3U2P    3U7U    3U9U   
CATH (Classification of proteins structures)2AHX    2L2T    2LCX    2R4B    3BBT    3BBW    3BCE    3U2P    3U7U    3U9U   
SuperfamilyQ15303
AlphaFold pdb e-kbQ15303   
Human Protein Atlas [tissue]ENSG00000178568-ERBB4 [tissue]
HPRD02767
Protein Interaction databases
DIP (DOE-UCLA)Q15303
IntAct (EBI)Q15303
BioGRIDERBB4
STRING (EMBL)ERBB4
ZODIACERBB4
Ontologies - Pathways
QuickGOQ15303
Ontology : AmiGOtranscription cis-regulatory region binding  neural crest cell migration  positive regulation of protein phosphorylation  protein serine/threonine/tyrosine kinase activity  protein tyrosine kinase activity  transmembrane receptor protein tyrosine kinase activity  transmembrane receptor protein tyrosine kinase activity  epidermal growth factor receptor binding  epidermal growth factor receptor binding  protein binding  ATP binding  extracellular region  nucleus  nucleoplasm  mitochondrion  mitochondrial matrix  cytosol  plasma membrane  integral component of plasma membrane  signal transduction  transmembrane receptor protein tyrosine kinase signaling pathway  transmembrane receptor protein tyrosine kinase signaling pathway  multicellular organism development  nervous system development  synapse assembly  heart development  lactation  positive regulation of cell population proliferation  positive regulation of cell population proliferation  negative regulation of cell population proliferation  embryonic pattern specification  basal plasma membrane  positive regulation of phosphatidylinositol 3-kinase signaling  basolateral plasma membrane  cell migration  peptidyl-tyrosine phosphorylation  central nervous system morphogenesis  olfactory bulb interneuron differentiation  regulation of cell migration  positive regulation of kinase activity  positive regulation of tyrosine phosphorylation of STAT protein  protein homodimerization activity  receptor complex  receptor complex  mitochondrial fragmentation involved in apoptotic process  cell fate commitment  postsynaptic membrane  positive regulation of transcription, DNA-templated  positive regulation of receptor signaling pathway via JAK-STAT  protein autophosphorylation  positive regulation of cardiac muscle cell proliferation  mammary gland epithelial cell differentiation  mammary gland alveolus development  cardiac muscle tissue regeneration  positive regulation of ERK1 and ERK2 cascade  cellular response to epidermal growth factor stimulus  establishment of planar polarity involved in nephron morphogenesis  glutamatergic synapse  GABA-ergic synapse  integral component of presynaptic membrane  integral component of postsynaptic density membrane  positive regulation of protein localization to cell surface  
Ontology : EGO-EBItranscription cis-regulatory region binding  neural crest cell migration  positive regulation of protein phosphorylation  protein serine/threonine/tyrosine kinase activity  protein tyrosine kinase activity  transmembrane receptor protein tyrosine kinase activity  transmembrane receptor protein tyrosine kinase activity  epidermal growth factor receptor binding  epidermal growth factor receptor binding  protein binding  ATP binding  extracellular region  nucleus  nucleoplasm  mitochondrion  mitochondrial matrix  cytosol  plasma membrane  integral component of plasma membrane  signal transduction  transmembrane receptor protein tyrosine kinase signaling pathway  transmembrane receptor protein tyrosine kinase signaling pathway  multicellular organism development  nervous system development  synapse assembly  heart development  lactation  positive regulation of cell population proliferation  positive regulation of cell population proliferation  negative regulation of cell population proliferation  embryonic pattern specification  basal plasma membrane  positive regulation of phosphatidylinositol 3-kinase signaling  basolateral plasma membrane  cell migration  peptidyl-tyrosine phosphorylation  central nervous system morphogenesis  olfactory bulb interneuron differentiation  regulation of cell migration  positive regulation of kinase activity  positive regulation of tyrosine phosphorylation of STAT protein  protein homodimerization activity  receptor complex  receptor complex  mitochondrial fragmentation involved in apoptotic process  cell fate commitment  postsynaptic membrane  positive regulation of transcription, DNA-templated  positive regulation of receptor signaling pathway via JAK-STAT  protein autophosphorylation  positive regulation of cardiac muscle cell proliferation  mammary gland epithelial cell differentiation  mammary gland alveolus development  cardiac muscle tissue regeneration  positive regulation of ERK1 and ERK2 cascade  cellular response to epidermal growth factor stimulus  establishment of planar polarity involved in nephron morphogenesis  glutamatergic synapse  GABA-ergic synapse  integral component of presynaptic membrane  integral component of postsynaptic density membrane  positive regulation of protein localization to cell surface  
Pathways : BIOCARTABIOCARTA_ERBB4PATHWAY    BIOCARTA_HER2PATHWAY   
Pathways : KEGGKEGG_ERBB_SIGNALING    KEGG_CALCIUM_SIGNALING    KEGG_ENDOCYTOSIS   
NDEx NetworkERBB4
Atlas of Cancer Signalling NetworkERBB4
Wikipedia pathwaysERBB4
Orthology - Evolution
OrthoDB2066
GeneTree (enSembl)ENSG00000178568
Phylogenetic Trees/Animal Genes : TreeFamERBB4
Homologs : HomoloGeneERBB4
Homology/Alignments : Family Browser (UCSC)ERBB4
Gene fusions - Rearrangements
Fusion : MitelmanATAD2::ERBB4 [8q24.13/2q34]  
Fusion : MitelmanATP2B4::ERBB4 [1q32.1/2q34]  
Fusion : MitelmanLCLAT1::ERBB4 [2p23.1/2q34]  
Fusion : QuiverERBB4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerERBB4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ERBB4
dbVarERBB4
ClinVarERBB4
MonarchERBB4
1000_GenomesERBB4 
Exome Variant ServerERBB4
GNOMAD BrowserENSG00000178568
Varsome BrowserERBB4
ACMGERBB4 variants
VarityQ15303
Genomic Variants (DGV)ERBB4 [DGVbeta]
DECIPHERERBB4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisERBB4 
Mutations
ICGC Data PortalERBB4 
TCGA Data PortalERBB4 
Broad Tumor PortalERBB4
OASIS PortalERBB4 [ Somatic mutations - Copy number]
Cancer Gene: CensusERBB4 
Somatic Mutations in Cancer : COSMICERBB4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DERBB4
Mutations and Diseases : HGMDERBB4
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaERBB4
DgiDB (Drug Gene Interaction Database)ERBB4
DoCM (Curated mutations)ERBB4
CIViC (Clinical Interpretations of Variants in Cancer)ERBB4
Cancer3DERBB4
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600543    615515   
Orphanet106   
DisGeNETERBB4
MedgenERBB4
Genetic Testing Registry ERBB4
NextProtQ15303 [Medical]
GENETestsERBB4
Target ValidationERBB4
Huge Navigator ERBB4 [HugePedia]
ClinGenERBB4
Clinical trials, drugs, therapy
MyCancerGenomeERBB4
Protein Interactions : CTDERBB4
Pharm GKB GenePA27847
Pharm GKB PathwaysPA162356267   
PharosQ15303
Clinical trialERBB4
Miscellaneous
canSAR (ICR)ERBB4
HarmonizomeERBB4
ARCHS4ERBB4
DataMed IndexERBB4
Probes
Litterature
PubMed358 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXERBB4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jan 20 12:32:24 CET 2022

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