| Nomenclature | | HGNC (Hugo) | ERN1 3449 |
| Entrez_Gene (NCBI) | ERN1 2081 endoplasmic reticulum to nucleus signaling 1 |
| Cards | | GeneCards (Weizmann) | ERN1 |
| Ensembl (Hinxton) | ENSG00000178607 [Gene_View] chr17:62120390-62207502 [Contig_View] ERN1 [Vega] |
| AceView (NCBI) | ERN1 |
| Genatlas (Paris) | ERN1 |
| SOURCE (Stanford) | NM_001433 NM_152461 |
| Genomic and cartography | | GoldenPath (UCSC) | ERN1 - 17q23.3 chr17:62120390-62207502 - 17q23.3 [Description] (hg19-Feb_2009) |
| Ensembl | ERN1 - 17q23.3 [CytoView] |
| Mapping of homologs : NCBI | ERN1 [Mapview] |
| OMIM | 604033 |
| Gene and transcription |
| Genbank (Entrez) | AB209869 AF059198 AI791744 AI792619 AK055561 |
| RefSeq transcript (SRS) | NM_001433 NM_152461 |
| RefSeq transcript (Entrez) | NM_001433 NM_152461 |
| RefSeq genomic (SRS) | AC_000149 NC_000017 NC_018928 NT_010783 NW_001838450 NW_004078092 |
| RefSeq genomic (Entrez) | AC_000149 NC_000017 NC_018928 NT_010783 NW_001838450 NW_004078092 |
| Consensus coding sequences : CCDS (NCBI) | ERN1 |
| Cluster EST : Unigene | Hs.700027 [ SRS ] Hs.700027 [ NCBI ] |
| CGAP (NCI) | Hs.700027 |
| Alternative Splicing : Fast-db (Paris) | GSHG0013655 |
| Alternative Splicing Gallery | ENSG00000178607 |
| Gene Expression | ERN1 [ NCBI-GEO ] ERN1 [ EBI - ARRAY_EXPRESS ] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | O75460 (SRS) O75460 (Uniprot) |
| NextProt | O75460 |
| With graphics : InterPro | O75460 |
| Splice isoforms : SwissVar | O75460(Swissvar) |
| Domaine pattern : Prosite (SRS) | KEN (PS51392) PROTEIN_KINASE_ATP (PS00107) PROTEIN_KINASE_DOM (PS50011) PROTEIN_KINASE_ST (PS00108) |
| Domaine pattern : Prosite (Expaxy) | KEN (PS51392) PROTEIN_KINASE_ATP (PS00107) PROTEIN_KINASE_DOM (PS50011) PROTEIN_KINASE_ST (PS00108) |
| Domains : Interpro (SRS) | KEN_RNase_activator Kinase-like_dom PQQ_beta_propeller_repeat Prot_kinase_cat_dom PUG-dom Quinonprotein_ADH-like Ser/Thr_kinase_AS |
| Domains : Interpro (EBI) | KEN_RNase_activator Kinase-like_dom PQQ_beta_propeller_repeat Prot_kinase_cat_dom PUG-dom Quinonprotein_ADH-like Ser/Thr_kinase_AS |
| Related proteins : CluSTr | O75460 |
| Domain families : Pfam (SRS) | Pkinase (PF00069) Ribonuc_2-5A (PF06479) |
| Domain families : Pfam (Sanger) | Pkinase (PF00069) Ribonuc_2-5A (PF06479) |
| Domain families : Pfam (NCBI) | pfam00069 pfam06479 |
| Domain families : Smart (EMBL) | PQQ (SM00564) PUG (SM00580) |
| DMDM | 2081 |
| Blocks (Seattle) | O75460 |
| PDB (SRS) | 2HZ6 3P23 |
| PDB (PDBSum) | 2HZ6 3P23 |
| PDB (IMB) | 2HZ6 3P23 |
| PDB (RSDB) | 2HZ6 3P23 |
| Human Protein Atlas | ENSG00000178607 |
| HPRD | 04943 |
| IPI | IPI00015974 IPI00873219 IPI00061055 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | O75460 |
| IntAct (EBI) | O75460 |
| FunCoup | ENSG00000178607 |
| REACTOME | ERN1 |
| Protein Interaction Database | 2081 |
| BioGRID | ERN1 |
| InParanoid | O75460 |
| Interologous Interaction database | O75460 |
| IntegromeDB | ERN1 |
| Polymorphism : SNP, mutations, diseases | | SNP Single Nucleotide Polymorphism (NCBI) | ERN1 |
| SNP (GeneSNP Utah) | ERN1 |
| SNP : HGBase | ERN1 |
| Genetic variants : HAPMAP | ERN1 |
| Somatic Mutations in Cancer : COSMIC | ERN1 |
| CONAN: Copy Number Analysis | ERN1 |
| Mutations and Diseases : HGMD | ERN1 |
| OMIM | 604033 |
| GENETests | 604033 |
| Disease Genetic Association | ERN1 |
| Huge Navigator |
ERN1 [HugePedia] ERN1 [HugeCancerGEM] |
| Genomic Variants | ERN1 ERN1 [DGVbeta] |
| snp3D : Map Gene to Disease | 2081 |
| General knowledge |
|---|
| Homologs : HomoloGene | ERN1 |
| Homology/Alignments : Family Browser (UCSC) | ERN1 |
| Phylogenetic Trees/Animal Genes : TreeFam | ERN1 |
| Catalytic activity : Enzyme | 2.7.11.1 [ Enzyme-Expasy ] 2.7.11.1 [ Enzyme-SRS ] 2.7.11.1 [ IntEnz-EBI ] 2.7.11.1 [ BRENDA ] 2.7.11.1 [ KEGG ] |
| Chemical/Protein Interactions : CTD | 2081 |
| Chemical/Pharm GKB Gene | PA27861 |
| Clinical trial | ERN1 |
| Cancer Resource (Charite) | ENSG00000178607 |
| Ontology : AmiGO | magnesium ion binding endoribonuclease activity endoribonuclease activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein binding ATP binding nuclear inner membrane endoplasmic reticulum membrane transcription, DNA-dependent regulation of transcription, DNA-dependent mRNA processing protein phosphorylation apoptotic process induction of apoptosis activation of signaling protein activity involved in unfolded protein response activation of signaling protein activity involved in unfolded protein response cell cycle arrest endoribonuclease activity, producing 5'-phosphomonoesters integral to endoplasmic reticulum membrane endoplasmic reticulum unfolded protein response protein autophosphorylation positive regulation of endoplasmic reticulum unfolded protein response |
| Ontology : EGO-EBI | magnesium ion binding endoribonuclease activity endoribonuclease activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein binding ATP binding nuclear inner membrane endoplasmic reticulum membrane transcription, DNA-dependent regulation of transcription, DNA-dependent mRNA processing protein phosphorylation apoptotic process induction of apoptosis activation of signaling protein activity involved in unfolded protein response activation of signaling protein activity involved in unfolded protein response cell cycle arrest endoribonuclease activity, producing 5'-phosphomonoesters integral to endoplasmic reticulum membrane endoplasmic reticulum unfolded protein response protein autophosphorylation positive regulation of endoplasmic reticulum unfolded protein response |
| Other databases |
| Probes |
|---|
| Litterature | | PubMed | 56 Pubmed reference(s) in Entrez |
| PubGene | ERN1 |
| iHOP | ERN1 |
