ERN1 (endoplasmic reticulum to nucleus signaling 1)

2006-10-01  

Identity

HGNC
ERN1
LOCATION
17q23.3
LOCUSID
2081
ALIAS
IRE1,IRE1P,IRE1a,hIRE1p
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2081
MIM: 604033
HGNC: 3449
Ensembl: ENSG00000178607

Variants:

dbSNP: 2081
ClinVar: 2081
TCGA: ENSG00000178607
COSMIC: ERN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000178607ENST00000433197O75460
ENSG00000178607ENST00000606895O75460

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
ApoptosisKEGGko04210
Alzheimer's diseaseKEGGko05010
Autophagy - animalKEGGhsa04140
ApoptosisKEGGhsa04210
Alzheimer's diseaseKEGGhsa05010
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
Non-alcoholic fatty liver disease (NAFLD)KEGGhsa04932
Non-alcoholic fatty liver disease (NAFLD)KEGGko04932
Metabolism of proteinsREACTOMER-HSA-392499
Unfolded Protein Response (UPR)REACTOMER-HSA-381119
IRE1alpha activates chaperonesREACTOMER-HSA-381070

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
179918562007IRE1 signaling affects cell fate during the unfolded protein response.572
230422942012IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2.208
223154142012The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule.192
207983502010Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering.135
231100432012ER stress activates NF-κB by integrating functions of basal IKK activity, IRE1 and PERK.100
214821182011Modulating stress responses by the UPRosome: a matter of life and death.96
229175052012Unfolded protein response.91
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
207027652010Inositol-requiring enzyme 1alpha is a key regulator of angiogenesis and invasion in malignant glioma.75
213858772011Dengue virus modulates the unfolded protein response in a time-dependent manner.75

Citation

Dessen P

ERN1 (endoplasmic reticulum to nucleus signaling 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43247/ern1