ESPL1 (extra spindle pole bodies like 1, separase)

2006-10-01  

Identity

HGNC
ESPL1
LOCATION
12q13.13
LOCUSID
9700
ALIAS
ESP1,SEPA
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9700
MIM: 604143
HGNC: 16856
Ensembl: ENSG00000135476

Variants:

dbSNP: 9700
ClinVar: 9700
TCGA: ENSG00000135476
COSMIC: ESPL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135476ENST00000257934Q14674
ENSG00000135476ENST00000552671H3BM31
ENSG00000135476ENST00000553219H3BRX7

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
Cell cycleKEGGhsa04110
Oocyte meiosisKEGGko04114
Oocyte meiosisKEGGhsa04114
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
197585592009Polo kinase and separase regulate the mitotic licensing of centriole duplication in human cells.119
121948172002Regulation of human separase by securin binding and autocleavage.66
187281942008Overexpression of Separase induces aneuploidy and mammary tumorigenesis.58
225421012012Kendrin is a novel substrate for separase involved in the licensing of centriole duplication.49
126729592003Processing, localization, and requirement of human separase for normal anaphase progression.38
180037022007The complete removal of cohesin from chromosome arms depends on separase.36
193517572009Overexpression and mislocalization of the chromosomal segregation protein separase in multiple human cancers.27
228146042012Separase sensor reveals dual roles for separase coordinating cohesin cleavage and cdk1 inhibition.24
193451912009Separase is recruited to mitotic chromosomes to dissolve sister chromatid cohesion in a DNA-dependent manner.22
122973142002Anaphase specific auto-cleavage of separase.21

Citation

Dessen P

ESPL1 (extra spindle pole bodies like 1, separase)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43249/espl1