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F2R (coagulation factor II thrombin receptor)

Identity

Alias_namescoagulation factor II (thrombin) receptor
Alias_symbol (synonym)TR
CF2R
PAR1
PAR-1
Other aliasHTR
HGNC (Hugo) F2R
LocusID (NCBI) 2149
Atlas_Id 40521
Location 5q13.3  [Link to chromosome band 5q13]
Location_base_pair Starts at 76716043 and ends at 76735780 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ADAMTS4 (1q23.3) / F2R (5q13.3)AKIP1 (11p15.4) / F2R (5q13.3)F2R (5q13.3) / SERINC3 (20q13.12)
MIR548G (3q12.1) / F2R (5q13.3)SKIV2L2 (5q11.2) / F2R (5q13.3)SKIV2L2 5q11.2 / F2R 5q13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)F2R   3537
LRG (Locus Reference Genomic)LRG_641
Cards
Entrez_Gene (NCBI)F2R  2149  coagulation factor II thrombin receptor
AliasesCF2R; HTR; PAR-1; PAR1; 
TR
GeneCards (Weizmann)F2R
Ensembl hg19 (Hinxton)ENSG00000181104 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000181104 [Gene_View]  chr5:76716043-76735780 [Contig_View]  F2R [Vega]
ICGC DataPortalENSG00000181104
TCGA cBioPortalF2R
AceView (NCBI)F2R
Genatlas (Paris)F2R
WikiGenes2149
SOURCE (Princeton)F2R
Genetics Home Reference (NIH)F2R
Genomic and cartography
GoldenPath hg38 (UCSC)F2R  -     chr5:76716043-76735780 +  5q13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)F2R  -     5q13.3   [Description]    (hg19-Feb_2009)
EnsemblF2R - 5q13.3 [CytoView hg19]  F2R - 5q13.3 [CytoView hg38]
Mapping of homologs : NCBIF2R [Mapview hg19]  F2R [Mapview hg38]
OMIM187930   
Gene and transcription
Genbank (Entrez)AK297131 AK308169 AK314202 AY771596 BC002464
RefSeq transcript (Entrez)NM_001311313 NM_001992
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)F2R
Cluster EST : UnigeneHs.482562 [ NCBI ]
CGAP (NCI)Hs.482562
Alternative Splicing GalleryENSG00000181104
Gene ExpressionF2R [ NCBI-GEO ]   F2R [ EBI - ARRAY_EXPRESS ]   F2R [ SEEK ]   F2R [ MEM ]
Gene Expression Viewer (FireBrowse)F2R [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2149
GTEX Portal (Tissue expression)F2R
Protein : pattern, domain, 3D structure
UniProt/SwissProtP25116   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP25116  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP25116
Splice isoforms : SwissVarP25116
PhosPhoSitePlusP25116
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)GPCR_Rhodpsn    GPCR_Rhodpsn_7TM    Protea_act_rcpt    Thrmbn_rcpt   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Conserved Domain (NCBI)F2R
DMDM Disease mutations2149
Blocks (Seattle)F2R
PDB (SRS)1NRN    1NRO    1NRP    1NRQ    1NRR    3BEF    3HKI    3HKJ    3LU9    3VW7   
PDB (PDBSum)1NRN    1NRO    1NRP    1NRQ    1NRR    3BEF    3HKI    3HKJ    3LU9    3VW7   
PDB (IMB)1NRN    1NRO    1NRP    1NRQ    1NRR    3BEF    3HKI    3HKJ    3LU9    3VW7   
PDB (RSDB)1NRN    1NRO    1NRP    1NRQ    1NRR    3BEF    3HKI    3HKJ    3LU9    3VW7   
Structural Biology KnowledgeBase1NRN    1NRO    1NRP    1NRQ    1NRR    3BEF    3HKI    3HKJ    3LU9    3VW7   
SCOP (Structural Classification of Proteins)1NRN    1NRO    1NRP    1NRQ    1NRR    3BEF    3HKI    3HKJ    3LU9    3VW7   
CATH (Classification of proteins structures)1NRN    1NRO    1NRP    1NRQ    1NRR    3BEF    3HKI    3HKJ    3LU9    3VW7   
SuperfamilyP25116
Human Protein AtlasENSG00000181104
Peptide AtlasP25116
HPRD01763
IPIIPI00296869   IPI00719325   IPI00966701   
Protein Interaction databases
DIP (DOE-UCLA)P25116
IntAct (EBI)P25116
FunCoupENSG00000181104
BioGRIDF2R
STRING (EMBL)F2R
ZODIACF2R
Ontologies - Pathways
QuickGOP25116
Ontology : AmiGOactivation of MAPKK activity  G-protein alpha-subunit binding  connective tissue replacement involved in inflammatory response wound healing  negative regulation of glomerular filtration  G-protein coupled receptor activity  G-protein coupled receptor activity  receptor binding  protein binding  extracellular region  early endosome  late endosome  Golgi apparatus  plasma membrane  plasma membrane  integral component of plasma membrane  caveola  activation of cysteine-type endopeptidase activity involved in apoptotic process  inflammatory response  G-protein coupled receptor signaling pathway  phospholipase C-activating G-protein coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  protein kinase C-activating G-protein coupled receptor signaling pathway  tyrosine phosphorylation of STAT protein  STAT protein import into nucleus  establishment of synaptic specificity at neuromuscular junction  blood coagulation  positive regulation of cell proliferation  negative regulation of cell proliferation  response to wounding  anatomical structure morphogenesis  cell surface  positive regulation of phosphatidylinositol 3-kinase signaling  thrombin-activated receptor activity  platelet activation  platelet activation  regulation of blood coagulation  positive regulation of blood coagulation  positive regulation of cell migration  platelet dense tubular network  neuromuscular junction  G-protein beta-subunit binding  response to lipopolysaccharide  regulation of interleukin-1 beta production  positive regulation of collagen biosynthetic process  positive regulation of Rho protein signal transduction  positive regulation of Rho protein signal transduction  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  positive regulation of MAPK cascade  negative regulation of neuron apoptotic process  postsynaptic membrane  positive regulation of transcription, DNA-templated  positive regulation of vasoconstriction  positive regulation of smooth muscle contraction  positive regulation of JAK-STAT cascade  homeostasis of number of cells within a tissue  release of sequestered calcium ion into cytosol  positive regulation of release of sequestered calcium ion into cytosol  positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway  positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway  positive regulation of calcium ion transport  regulation of sensory perception of pain  platelet dense granule organization  positive regulation of ERK1 and ERK2 cascade  thrombin-activated receptor signaling pathway  trans-synaptic signaling by endocannabinoid, modulating synaptic transmission  negative regulation of renin secretion into blood stream  positive regulation of interleukin-8 secretion  positive regulation of interleukin-6 secretion  
Ontology : EGO-EBIactivation of MAPKK activity  G-protein alpha-subunit binding  connective tissue replacement involved in inflammatory response wound healing  negative regulation of glomerular filtration  G-protein coupled receptor activity  G-protein coupled receptor activity  receptor binding  protein binding  extracellular region  early endosome  late endosome  Golgi apparatus  plasma membrane  plasma membrane  integral component of plasma membrane  caveola  activation of cysteine-type endopeptidase activity involved in apoptotic process  inflammatory response  G-protein coupled receptor signaling pathway  phospholipase C-activating G-protein coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  protein kinase C-activating G-protein coupled receptor signaling pathway  tyrosine phosphorylation of STAT protein  STAT protein import into nucleus  establishment of synaptic specificity at neuromuscular junction  blood coagulation  positive regulation of cell proliferation  negative regulation of cell proliferation  response to wounding  anatomical structure morphogenesis  cell surface  positive regulation of phosphatidylinositol 3-kinase signaling  thrombin-activated receptor activity  platelet activation  platelet activation  regulation of blood coagulation  positive regulation of blood coagulation  positive regulation of cell migration  platelet dense tubular network  neuromuscular junction  G-protein beta-subunit binding  response to lipopolysaccharide  regulation of interleukin-1 beta production  positive regulation of collagen biosynthetic process  positive regulation of Rho protein signal transduction  positive regulation of Rho protein signal transduction  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  positive regulation of MAPK cascade  negative regulation of neuron apoptotic process  postsynaptic membrane  positive regulation of transcription, DNA-templated  positive regulation of vasoconstriction  positive regulation of smooth muscle contraction  positive regulation of JAK-STAT cascade  homeostasis of number of cells within a tissue  release of sequestered calcium ion into cytosol  positive regulation of release of sequestered calcium ion into cytosol  positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway  positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway  positive regulation of calcium ion transport  regulation of sensory perception of pain  platelet dense granule organization  positive regulation of ERK1 and ERK2 cascade  thrombin-activated receptor signaling pathway  trans-synaptic signaling by endocannabinoid, modulating synaptic transmission  negative regulation of renin secretion into blood stream  positive regulation of interleukin-8 secretion  positive regulation of interleukin-6 secretion  
Pathways : BIOCARTA [Genes]   
Pathways : KEGG   
NDEx NetworkF2R
Atlas of Cancer Signalling NetworkF2R
Wikipedia pathwaysF2R
Orthology - Evolution
OrthoDB2149
GeneTree (enSembl)ENSG00000181104
Phylogenetic Trees/Animal Genes : TreeFamF2R
HOVERGENP25116
HOGENOMP25116
Homologs : HomoloGeneF2R
Homology/Alignments : Family Browser (UCSC)F2R
Gene fusions - Rearrangements
Fusion : MitelmanSKIV2L2/F2R [5q11.2/5q13.3]  [t(5;5)(q11;q13)]  
Fusion: TCGASKIV2L2 5q11.2 F2R 5q13.3 PRAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerF2R [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)F2R
dbVarF2R
ClinVarF2R
1000_GenomesF2R 
Exome Variant ServerF2R
ExAC (Exome Aggregation Consortium)F2R (select the gene name)
Genetic variants : HAPMAP2149
Genomic Variants (DGV)F2R [DGVbeta]
DECIPHERF2R [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisF2R 
Mutations
ICGC Data PortalF2R 
TCGA Data PortalF2R 
Broad Tumor PortalF2R
OASIS PortalF2R [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICF2R  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDF2R
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch F2R
DgiDB (Drug Gene Interaction Database)F2R
DoCM (Curated mutations)F2R (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)F2R (select a term)
intoGenF2R
Cancer3DF2R(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM187930   
Orphanet
MedgenF2R
Genetic Testing Registry F2R
NextProtP25116 [Medical]
TSGene2149
GENETestsF2R
Target ValidationF2R
Huge Navigator F2R [HugePedia]
snp3D : Map Gene to Disease2149
BioCentury BCIQF2R
ClinGenF2R
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2149
Chemical/Pharm GKB GenePA27946
Clinical trialF2R
Miscellaneous
canSAR (ICR)F2R (select the gene name)
Probes
Litterature
PubMed350 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineF2R
EVEXF2R
GoPubMedF2R
iHOPF2R
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Tue Aug 1 17:00:46 CEST 2017

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