F2RL3 (F2R like thrombin or trypsin receptor 3)

2007-02-01  

Identity

HGNC
LOCATION
19p13.11
LOCUSID
ALIAS
PAR4
FUSION GENES

Other Information

Locus ID:

NCBI: 9002
MIM: 602779
HGNC: 3540
Ensembl: ENSG00000127533

Variants:

dbSNP: 9002
ClinVar: 9002
TCGA: ENSG00000127533
COSMIC: F2RL3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000127533ENST00000248076Q96RI0
ENSG00000127533ENST00000599210M0R0Y0

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Complement and coagulation cascadesKEGGko04610
Neuroactive ligand-receptor interactionKEGGhsa04080
Complement and coagulation cascadesKEGGhsa04610
Pathways in cancerKEGGhsa05200
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Platelet activationKEGGhsa04611
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Thrombin signalling through proteinase activated receptors (PARs)REACTOMER-HSA-456926
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA157F2GenePathwayassociated20938371
PA174GNAQGenePathwayassociated20938371
PA176GNB3GenePathwayassociated20938371
PA28764GNA11GenePathwayassociated20938371
PA28765GNA12GenePathwayassociated20938371
PA28766GNA13GenePathwayassociated20938371
PA28768GNA15GenePathwayassociated20938371

References

Pubmed IDYearTitleCitations
169529952006Protease-activated receptors in cardiovascular diseases.92
119071222002Activation of protease-activated receptor (PAR)-1, PAR-2, and PAR-4 stimulates IL-6, IL-8, and prostaglandin E2 release from human respiratory epithelial cells.86
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
242167522013Racial differences in human platelet PAR4 reactivity reflect expression of PCTP and miR-376c.70
225116532012Smoking, F2RL3 methylation, and prognosis in stable coronary heart disease.54
196670882009Complement protease MASP-1 activates human endothelial cells: PAR4 activation is a link between complement and endothelial function.46
280531572017Blockade of protease-activated receptor-4 (PAR4) provides robust antithrombotic activity with low bleeding.39
168374562006PAR4, but not PAR1, signals human platelet aggregation via Ca2+ mobilization and synergistic P2Y12 receptor activation.38
252937792014Common variants in the human platelet PAR4 thrombin receptor alter platelet function and differ by race.32
136784202003Protease-activated receptor-4 uses dual prolines and an anionic retention motif for thrombin recognition and cleavage.30

Citation

Dessen P

F2RL3 (F2R like thrombin or trypsin receptor 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43864/f2rl3