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F2RL3 (F2R like thrombin/trypsin receptor 3)

Identity

Alias_namescoagulation factor II (thrombin) receptor-like 3
Alias_symbol (synonym)PAR4
Other alias
HGNC (Hugo) F2RL3
LocusID (NCBI) 9002
Atlas_Id 43864
Location 19p13.11  [Link to chromosome band 19p13]
Location_base_pair Starts at 16999826 and ends at 17002830 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
F2RL3 (19p13.11) / RPL14 (3p22.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)F2RL3   3540
Cards
Entrez_Gene (NCBI)F2RL3  9002  F2R like thrombin/trypsin receptor 3
AliasesPAR4
GeneCards (Weizmann)F2RL3
Ensembl hg19 (Hinxton)ENSG00000127533 [Gene_View]  chr19:16999826-17002830 [Contig_View]  F2RL3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000127533 [Gene_View]  chr19:16999826-17002830 [Contig_View]  F2RL3 [Vega]
ICGC DataPortalENSG00000127533
TCGA cBioPortalF2RL3
AceView (NCBI)F2RL3
Genatlas (Paris)F2RL3
WikiGenes9002
SOURCE (Princeton)F2RL3
Genetics Home Reference (NIH)F2RL3
Genomic and cartography
GoldenPath hg19 (UCSC)F2RL3  -     chr19:16999826-17002830 +  19p13.11   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)F2RL3  -     19p13.11   [Description]    (hg38-Dec_2013)
EnsemblF2RL3 - 19p13.11 [CytoView hg19]  F2RL3 - 19p13.11 [CytoView hg38]
Mapping of homologs : NCBIF2RL3 [Mapview hg19]  F2RL3 [Mapview hg38]
OMIM602779   
Gene and transcription
Genbank (Entrez)AF055917 AF080214 AY431102 BC074782
RefSeq transcript (Entrez)NM_003950
RefSeq genomic (Entrez)NC_000019 NC_018930 NG_032894 NT_011295 NW_004929414
Consensus coding sequences : CCDS (NCBI)F2RL3
Cluster EST : UnigeneHs.137574 [ NCBI ]
CGAP (NCI)Hs.137574
Alternative Splicing GalleryENSG00000127533
Gene ExpressionF2RL3 [ NCBI-GEO ]   F2RL3 [ EBI - ARRAY_EXPRESS ]   F2RL3 [ SEEK ]   F2RL3 [ MEM ]
Gene Expression Viewer (FireBrowse)F2RL3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9002
GTEX Portal (Tissue expression)F2RL3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96RI0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96RI0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96RI0
Splice isoforms : SwissVarQ96RI0
PhosPhoSitePlusQ96RI0
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)GPCR_Rhodpsn    GPCR_Rhodpsn_7TM    Prot_act_rcpt_4    Protea_act_rcpt   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Conserved Domain (NCBI)F2RL3
DMDM Disease mutations9002
Blocks (Seattle)F2RL3
PDB (SRS)2ZPK    3QDZ   
PDB (PDBSum)2ZPK    3QDZ   
PDB (IMB)2ZPK    3QDZ   
PDB (RSDB)2ZPK    3QDZ   
Structural Biology KnowledgeBase2ZPK    3QDZ   
SCOP (Structural Classification of Proteins)2ZPK    3QDZ   
CATH (Classification of proteins structures)2ZPK    3QDZ   
SuperfamilyQ96RI0
Human Protein AtlasENSG00000127533
Peptide AtlasQ96RI0
HPRD04148
IPIIPI00022557   
Protein Interaction databases
DIP (DOE-UCLA)Q96RI0
IntAct (EBI)Q96RI0
FunCoupENSG00000127533
BioGRIDF2RL3
STRING (EMBL)F2RL3
ZODIACF2RL3
Ontologies - Pathways
QuickGOQ96RI0
Ontology : AmiGOG-protein coupled receptor activity  extracellular region  plasma membrane  integral component of plasma membrane  signal transduction  phospholipase C-activating G-protein coupled receptor signaling pathway  blood coagulation  response to wounding  thrombin receptor activity  platelet activation  positive regulation of release of sequestered calcium ion into cytosol  platelet dense granule organization  thrombin receptor signaling pathway  
Ontology : EGO-EBIG-protein coupled receptor activity  extracellular region  plasma membrane  integral component of plasma membrane  signal transduction  phospholipase C-activating G-protein coupled receptor signaling pathway  blood coagulation  response to wounding  thrombin receptor activity  platelet activation  positive regulation of release of sequestered calcium ion into cytosol  platelet dense granule organization  thrombin receptor signaling pathway  
Pathways : BIOCARTAAspirin Blocks Signaling Pathway Involved in Platelet Activation [Genes]    Thrombin signaling and protease-activated receptors [Genes]   
Pathways : KEGGRap1 signaling pathway    Neuroactive ligand-receptor interaction   
NDEx NetworkF2RL3
Atlas of Cancer Signalling NetworkF2RL3
Wikipedia pathwaysF2RL3
Orthology - Evolution
OrthoDB9002
GeneTree (enSembl)ENSG00000127533
Phylogenetic Trees/Animal Genes : TreeFamF2RL3
HOVERGENQ96RI0
HOGENOMQ96RI0
Homologs : HomoloGeneF2RL3
Homology/Alignments : Family Browser (UCSC)F2RL3
Gene fusions - Rearrangements
Fusion Cancer (Beijing)F2RL3 [19p13.11]  -  RPL14 [3p22.1]  [FUSC003072]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerF2RL3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)F2RL3
dbVarF2RL3
ClinVarF2RL3
1000_GenomesF2RL3 
Exome Variant ServerF2RL3
ExAC (Exome Aggregation Consortium)F2RL3 (select the gene name)
Genetic variants : HAPMAP9002
Genomic Variants (DGV)F2RL3 [DGVbeta]
DECIPHER (Syndromes)19:16999826-17002830  ENSG00000127533
CONAN: Copy Number AnalysisF2RL3 
Mutations
ICGC Data PortalF2RL3 
TCGA Data PortalF2RL3 
Broad Tumor PortalF2RL3
OASIS PortalF2RL3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICF2RL3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDF2RL3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch F2RL3
DgiDB (Drug Gene Interaction Database)F2RL3
DoCM (Curated mutations)F2RL3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)F2RL3 (select a term)
intoGenF2RL3
Cancer3DF2RL3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602779   
Orphanet
MedgenF2RL3
Genetic Testing Registry F2RL3
NextProtQ96RI0 [Medical]
TSGene9002
GENETestsF2RL3
Huge Navigator F2RL3 [HugePedia]
snp3D : Map Gene to Disease9002
BioCentury BCIQF2RL3
ClinGenF2RL3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9002
Chemical/Pharm GKB GenePA27949
Clinical trialF2RL3
Miscellaneous
canSAR (ICR)F2RL3 (select the gene name)
Probes
Litterature
PubMed77 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineF2RL3
EVEXF2RL3
GoPubMedF2RL3
iHOPF2RL3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Mar 30 15:00:34 CEST 2017

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